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504 results on '"Y-S Lu"'

1. The influence of plant water stress on vegetation–atmosphere exchanges: implications for ozone modelling

Author: T. Emmerichs, Y.-S. Lu, and D. Taraborrelli
Subjects: Ecology, QH540-549.5, Life, QH501-531, Geology, QE1-996.5
Abstract: Evapotranspiration is important for Earth's water and energy cycles as it strongly affects air temperature, cloud cover, and precipitation. Leaf stomata are the conduit of transpiration, and their opening is sensitive to weather and climate conditions. This feedback can exacerbate heat waves and can play a role in their spatiotemporal propagation. Sustained high temperatures strongly favour high ozone levels, with significant negative impacts on air quality and thus on human health. Our study evaluates the process representation of evapotranspiration in the atmospheric chemistry–climate European Centre for Medium-Range Weather Forecasts – Hamburg(ECHAM)/Modular Earth Submodel System (MESSy) Atmospheric Chemistry model. Different water stress parameterizations are implemented in a stomatal model based on CO2 assimilation. The stress factors depend on either soil moisture or leaf water potential, which act on photosynthetic activity, and mesophyll and stomatal conductance. The new functionalities reduce the initial overestimation of evapotranspiration in the model globally by more than an order of magnitude, which is most important in the Southern Hemisphere. The intensity of simulated warm spells over continents is significantly improved. For ozone, we find that a realistic model representation of plant water stress suppresses uptake by vegetation and enhances photochemical production in the troposphere. These effects lead to an overall increase in simulated ground-level ozone, which is most pronounced in the Southern Hemisphere over the continents. More sophisticated land surface models with multi-layer soil schemes could address the uncertainties in representing plant dynamics representation due to too-shallow roots. In regions with low evaporative loss, the representation of precipitation remains the largest uncertainty. more...
Published: 2024
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2. Optimization of weather forecasting for cloud cover over the European domain using the meteorological component of the Ensemble for Stochastic Integration of Atmospheric Simulations version 1.0

Author: Y.-S. Lu, G. H. Good, and H. Elbern
Subjects: Geology, QE1-996.5
Abstract: We present the largest sensitivity study to date for cloud cover using the Weather Forecasting and Research model (WRF V3.7.1) on the European domain. The experiments utilize the meteorological part of a large-ensemble framework, ESIAS-met (Ensemble for Stochastic Integration of Atmospheric Simulations). This work demonstrates the capability and performance of ESIAS for large-ensemble simulations and sensitivity analysis. The study takes an iterative approach by first comparing over 1000 combinations of microphysics, cumulus parameterization, planetary boundary layer (PBL) physics, surface layer physics, radiation scheme, and land surface models on six test cases. We then perform more detailed studies on the long-term and 32-member ensemble forecasting performance of select combinations. The results are compared to CM SAF (Climate Monitoring Satellite Application Facility) satellite images from EUMETSAT (European Organisation for the Exploitation of Meteorological Satellites). The results indicate a high sensitivity of clouds to the chosen physics configuration. The combination of Goddard, WRF single moments 6 (WSM6), or CAM5.1 microphysics with MYNN3 (Mellor–Yamada Nakanishi Niino level 3) or ACM2 (Asymmetrical Convective Model version 2) PBL performed best for simulating cloud cover in Europe. For ensemble-based probabilistic simulations, the combinations of WSM6 and SBU–YLin (Stony Brook University Y. Lin) microphysics with MYNN2 and MYNN3 performed best. more...
Published: 2023
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3. Temporal Structures in Positron Spectra and Charge-Sign Effects in Galactic Cosmic Rays

Author: M. Aguilar, G. Ambrosi, H. Anderson, L. Arruda, N. Attig, C. Bagwell, F. Barao, M. Barbanera, L. Barrin, A. Bartoloni, R. Battiston, N. Belyaev, J. Berdugo, B. Bertucci, V. Bindi, K. Bollweg, J. Bolster, M. Borchiellini, B. Borgia, M. J. Boschini, M. Bourquin, J. Burger, W. J. Burger, X. D. Cai, M. Capell, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, G. R. Chen, H. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, S. Chouridou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, Z. Cui, K. Dadzie, F. D’Angelo, A. Dass, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, C. Díaz, F. Dimiccoli, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, F. Faldi, J. Feng, E. Fiandrini, P. Fisher, V. Formato, C. Gámez, R. J. García-López, C. Gargiulo, H. Gast, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, D. Grandi, M. Graziani, A. N. Guracho, S. Haino, K. C. Han, R. K. Hashmani, Z. H. He, B. Heber, T. H. Hsieh, J. Y. Hu, B. W. Huang, M. Ionica, M. Incagli, Yi Jia, H. Jinchi, G. Karagöz, S. Khan, B. Khiali, Th. Kirn, A. P. Klipfel, O. Kounina, A. Kounine, V. Koutsenko, D. Krasnopevtsev, A. Kuhlman, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, G. LaVecchia, I. Lazzizzera, H. T. Lee, S. C. Lee, H. L. Li, J. Q. Li, M. Li, Q. Li, Q. Y. Li, S. Li, S. L. Li, J. H. Li, Z. H. Li, J. Liang, M. J. Liang, C. H. Lin, T. Lippert, J. H. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, J. Z. Luo, S. D. Luo, Xi Luo, C. Mañá, J. Marín, J. Marquardt, T. Martin, G. Martínez, N. Masi, D. Maurin, T. Medvedeva, A. Menchaca-Rocha, Q. Meng, M. Molero, P. Mott, L. Mussolin, Y. Najafi Jozani, J. Negrete, R. Nicolaidis, N. Nikonov, F. Nozzoli, J. Ocampo-Peleteiro, A. Oliva, M. Orcinha, M. A. Ottupara, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, V. Plyaskin, S. Poluianov, X. Qin, Z. Y. Qu, L. Quadrani, P. G. Rancoita, D. Rapin, A. Reina Conde, E. Robyn, I. Rodríguez-García, L. Romaneehsen, F. Rossi, A. Rozhkov, D. Rozza, R. Sagdeev, E. Savin, S. Schael, A. Schultz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, T. Siedenburg, G. Silvestre, J. W. Song, X. J. Song, R. Sonnabend, L. Strigari, T. Su, Q. Sun, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Y. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, T. Urban, I. Usoskin, V. Vagelli, R. Vainio, M. Valencia-Otero, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, C. X. Wang, L. Wang, L. Q. Wang, N. H. Wang, Q. L. Wang, S. Wang, X. Wang, Yu Wang, Z. M. Wang, J. Wei, Z. L. Weng, H. Wu, Y. Wu, J. N. Xiao, R. Q. Xiong, X. Z. Xiong, W. Xu, Q. Yan, H. T. Yang, Y. Yang, A. Yelland, H. Yi, Y. H. You, Y. M. Yu, Z. Q. Yu, C. Zhang, F. Zhang, F. Z. Zhang, J. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, C. Zheng, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, and P. Zuccon more...
Published: 2023
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4. P123 Optimal Regimen of Neoadjuvant Systemic Therapy for HER2 Positive Early Breast Cancer

Author: C. Lo, M.-Y. Wang, W.-H. Kuo, Y.-H. Lee, L.-W. Tsai, Y.-S. Lu, C.-H. Lin, D.-Y. Chang, W.-W. Chen, and C.-S. Huang
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2023
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5. Properties of Cosmic-Ray Sulfur and Determination of the Composition of Primary Cosmic-Ray Carbon, Neon, Magnesium, and Sulfur: Ten-Year Results from the Alpha Magnetic Spectrometer

Author: M. Aguilar, L. Ali Cavasonza, B. Alpat, G. Ambrosi, L. Arruda, N. Attig, C. Bagwell, F. Barao, L. Barrin, A. Bartoloni, S. Başeğmez-du Pree, R. Battiston, N. Belyaev, J. Berdugo, B. Bertucci, V. Bindi, K. Bollweg, J. Bolster, M. Borchiellini, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, X. D. Cai, M. Capell, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, G. R. Chen, H. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, S. Chouridou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, Z. Cui, K. Dadzie, A. Dass, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, C. Díaz, F. Dimiccoli, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, F. Faldi, J. Feng, E. Fiandrini, P. Fisher, V. Formato, C. Gámez, R. J. García-López, C. Gargiulo, H. Gast, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, A. N. Guracho, S. Haino, K. C. Han, R. K. Hashmani, Z. H. He, B. Heber, T. H. Hsieh, J. Y. Hu, B. W. Huang, M. Incagli, W. Y. Jang, Yi Jia, H. Jinchi, G. Karagöz, B. Khiali, G. N. Kim, Th. Kirn, O. Kounina, A. Kounine, V. Koutsenko, D. Krasnopevtsev, A. Kuhlman, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, G. LaVecchia, I. Lazzizzera, H. T. Lee, S. C. Lee, H. L. Li, J. Q. Li, M. Li, Q. Li, Q. Y. Li, S. Li, S. L. Li, J. H. Li, Z. H. Li, J. Liang, M. J. Liang, C. H. Lin, T. Lippert, J. H. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, J. Z. Luo, S. D. Luo, Xi Luo, F. Machate, C. Mañá, J. Marín, J. Marquardt, T. Martin, G. Martínez, N. Masi, D. Maurin, T. Medvedeva, A. Menchaca-Rocha, Q. Meng, V. V. Mikhailov, M. Molero, P. Mott, L. Mussolin, J. Negrete, N. Nikonov, F. Nozzoli, J. Ocampo-Peleteiro, A. Oliva, M. Orcinha, M. A. Ottupara, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, V. Plyaskin, S. Poluianov, X. Qin, Z. Y. Qu, L. Quadrani, P. G. Rancoita, D. Rapin, A. Reina Conde, E. Robyn, L. Romaneehsen, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, A. Schultz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, T. Siedenburg, J. W. Song, X. J. Song, R. Sonnabend, L. Strigari, T. Su, Q. Sun, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Y. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, T. Urban, I. Usoskin, V. Vagelli, R. Vainio, M. Valencia-Otero, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, C. X. Wang, L. Wang, L. Q. Wang, N. H. Wang, Q. L. Wang, S. Wang, X. Wang, Yu Wang, Z. M. Wang, J. Wei, Z. L. Weng, H. Wu, Y. Wu, J. N. Xiao, R. Q. Xiong, X. Z. Xiong, W. Xu, Q. Yan, H. T. Yang, Y. Yang, I. I. Yashin, A. Yelland, H. Yi, Y. H. You, Y. M. Yu, Z. Q. Yu, M. Zannoni, C. Zhang, F. Zhang, F. Z. Zhang, J. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, C. Zheng, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, and P. Zuccon more...
Published: 2023
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6. Temporal Structures in Electron Spectra and Charge Sign Effects in Galactic Cosmic Rays

Author: M. Aguilar, L. Ali Cavasonza, G. Ambrosi, L. Arruda, N. Attig, C. Bagwell, F. Barao, L. Barrin, A. Bartoloni, S. Başeğmez-du Pree, R. Battiston, M. Behlmann, N. Belyaev, J. Berdugo, B. Bertucci, V. Bindi, K. Bollweg, J. Bolster, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, S. Burmeister, X. D. Cai, M. Capell, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, G. R. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, S. Chouridou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, Z. Cui, K. Dadzie, A. Dass, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, C. Díaz, F. Dimiccoli, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, F. Faldi, J. Feng, E. Fiandrini, P. Fisher, V. Formato, C. Freeman, C. Gámez, R. J. García-López, C. Gargiulo, H. Gast, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, A. N. Guracho, S. Haino, K. C. Han, R. K. Hashmani, Z. H. He, B. Heber, T. H. Hsieh, J. Y. Hu, M. Incagli, W. Y. Jang, Yi Jia, H. Jinchi, G. Karagöz, B. Khiali, G. N. Kim, Th. Kirn, O. Kounina, A. Kounine, V. Koutsenko, D. Krasnopevtsev, A. Kuhlman, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, G. LaVecchia, I. Lazzizzera, H. T. Lee, S. C. Lee, H. L. Li, J. Q. Li, M. Li, Q. Li, Q. Y. Li, S. Li, S. L. Li, J. H. Li, Z. H. Li, J. Liang, M. J. Liang, C. Light, C. H. Lin, T. Lippert, J. H. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, J. Z. Luo, Xi Luo, F. Machate, C. Mañá, J. Marín, J. Marquardt, T. Martin, G. Martínez, N. Masi, D. Maurin, T. Medvedeva, A. Menchaca-Rocha, Q. Meng, V. V. Mikhailov, M. Molero, P. Mott, L. Mussolin, J. Negrete, N. Nikonov, F. Nozzoli, J. Ocampo-Peleteiro, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, V. Plyaskin, M. Pohl, S. Poluianov, X. Qin, Z. Y. Qu, L. Quadrani, P. G. Rancoita, D. Rapin, A. Reina Conde, E. Robyn, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, A. Schultz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, T. Siedenburg, J. W. Song, X. J. Song, R. Sonnabend, L. Strigari, T. Su, Q. Sun, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, T. Urban, I. Usoskin, V. Vagelli, R. Vainio, M. Valencia-Otero, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, C. X. Wang, L. Wang, L. Q. Wang, N. H. Wang, Q. L. Wang, S. Wang, X. Wang, Yu Wang, Z. M. Wang, J. Wei, Z. L. Weng, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, Y. Yang, I. I. Yashin, A. Yelland, H. Yi, Y. M. Yu, Z. Q. Yu, M. Zannoni, C. Zhang, F. Zhang, F. Z. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, C. Zheng, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, and P. Zuccon more...
Published: 2023
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7. Properties of Daily Helium Fluxes

Author: M. Aguilar, L. Ali Cavasonza, G. Ambrosi, L. Arruda, N. Attig, F. Barao, L. Barrin, A. Bartoloni, S. Başeğmez-du Pree, R. Battiston, M. Behlmann, J. Berdugo, B. Bertucci, V. Bindi, K. Bollweg, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, S. Burmeister, X. D. Cai, M. Capell, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, G. R. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, S. Chouridou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, Z. Cui, K. Dadzie, A. Dass, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, C. Díaz, F. Dimiccoli, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, J. Feng, E. Fiandrini, P. Fisher, V. Formato, C. Freeman, C. Gámez, R. J. García-López, C. Gargiulo, H. Gast, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, S. Haino, K. C. Han, R. K. Hashmani, Z. H. He, B. Heber, T. H. Hsieh, J. Y. Hu, M. Incagli, W. Y. Jang, Yi Jia, H. Jinchi, G. Karagöz, B. Khiali, G. N. Kim, Th. Kirn, M. Konyushikhin, O. Kounina, A. Kounine, V. Koutsenko, D. Krasnopevtsev, A. Kuhlman, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, H. T. Lee, S. C. Lee, H. L. Li, J. Q. Li, M. Li, Q. Li, Q. Y. Li, S. Li, S. L. Li, J. H. Li, Z. H. Li, J. Liang, M. J. Liang, C. Light, C. H. Lin, T. Lippert, J. H. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, J. Z. Luo, Xi Luo, F. Machate, C. Mañá, J. Marín, J. Marquardt, T. Martin, G. Martínez, N. Masi, D. Maurin, T. Medvedeva, A. Menchaca-Rocha, Q. Meng, V. V. Mikhailov, M. Molero, P. Mott, L. Mussolin, J. Negrete, N. Nikonov, F. Nozzoli, J. Ocampo-Peleteiro, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, V. Plyaskin, M. Pohl, S. Poluianov, X. Qin, Z. Y. Qu, L. Quadrani, P. G. Rancoita, D. Rapin, A. Reina Conde, E. Robyn, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, A. Schultz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, T. Siedenburg, J. W. Song, X. J. Song, R. Sonnabend, L. Strigari, T. Su, Q. Sun, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, T. Urban, I. Usoskin, V. Vagelli, R. Vainio, M. Valencia-Otero, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, C. X. Wang, L. Wang, L. Q. Wang, N. H. Wang, Q. L. Wang, S. Wang, X. Wang, Yu Wang, Z. M. Wang, J. Wei, Z. L. Weng, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, Y. Yang, I. I. Yashin, H. Yi, Y. M. Yu, Z. Q. Yu, M. Zannoni, C. Zhang, F. Zhang, F. Z. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, C. Zheng, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, and P. Zuccon more...
Published: 2022
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8. Periodicities in the Daily Proton Fluxes from 2011 to 2019 Measured by the Alpha Magnetic Spectrometer on the International Space Station from 1 to 100 GV

Author: M. Aguilar, L. Ali Cavasonza, G. Ambrosi, L. Arruda, N. Attig, F. Barao, L. Barrin, A. Bartoloni, S. Başeğmez-du Pree, R. Battiston, M. Behlmann, B. Beranek, J. Berdugo, B. Bertucci, V. Bindi, K. Bollweg, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, S. Burmeister, X. D. Cai, M. Capell, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, G. R. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, S. Chouridou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, Z. Cui, K. Dadzie, A. Dass, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, C. Díaz, F. Dimiccoli, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, J. Feng, E. Fiandrini, P. Fisher, V. Formato, C. Freeman, C. Gámez, R. J. García-López, C. Gargiulo, H. Gast, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, S. Haino, K. C. Han, R. K. Hashmani, Z. H. He, B. Heber, T. H. Hsieh, J. Y. Hu, M. Incagli, W. Y. Jang, Yi Jia, H. Jinchi, G. Karagöz, B. Khiali, G. N. Kim, Th. Kirn, M. Konyushikhin, O. Kounina, A. Kounine, V. Koutsenko, D. Krasnopevtsev, A. Kuhlman, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, J. Q. Li, M. Li, Q. Li, S. Li, J. H. Li, Z. H. Li, J. Liang, C. Light, C. H. Lin, T. Lippert, J. H. Liu, Z. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, J. Z. Luo, Xi Luo, F. Machate, C. Mañá, J. Marín, J. Marquardt, T. Martin, G. Martínez, N. Masi, D. Maurin, T. Medvedeva, A. Menchaca-Rocha, Q. Meng, V. V. Mikhailov, M. Molero, P. Mott, L. Mussolin, J. Negrete, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, H. D. Phan, V. Plyaskin, M. Pohl, S. Poluianov, X. Qin, Z. Y. Qu, L. Quadrani, P. G. Rancoita, D. Rapin, A. Reina Conde, E. Robyn, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, A. Schultz von Dratzig, G. Schwering, E. S. Seo, Z. Shakfa, B. S. Shan, T. Siedenburg, C. Solano, J. W. Song, X. J. Song, R. Sonnabend, L. Strigari, T. Su, Q. Sun, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, T. Urban, I. Usoskin, V. Vagelli, R. Vainio, M. Valencia-Otero, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, C. X. Wang, L. Wang, L. Q. Wang, N. H. Wang, Q. L. Wang, S. Wang, X. Wang, Yu Wang, Z. M. Wang, J. Wei, Z. L. Weng, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, Y. Yang, I. I. Yashin, H. Yi, Y. M. Yu, Z. Q. Yu, M. Zannoni, C. Zhang, F. Zhang, F. Z. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, C. Zheng, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, and P. Zuccon more...
Published: 2021
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9. Properties of a New Group of Cosmic Nuclei: Results from the Alpha Magnetic Spectrometer on Sodium, Aluminum, and Nitrogen

Author: M. Aguilar, L. Ali Cavasonza, B. Alpat, G. Ambrosi, L. Arruda, N. Attig, F. Barao, L. Barrin, A. Bartoloni, S. Başeğmez-du Pree, R. Battiston, M. Behlmann, B. Beranek, J. Berdugo, B. Bertucci, V. Bindi, K. Bollweg, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, S. Burmeister, X. D. Cai, M. Capell, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, G. R. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, S. Chouridou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, Z. Cui, K. Dadzie, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, C. Díaz, F. Dimiccoli, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, J. Feng, E. Fiandrini, P. Fisher, V. Formato, C. Freeman, C. Gámez, R. J. García-López, C. Gargiulo, H. Gast, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, S. Haino, K. C. Han, R. K. Hashmani, Z. H. He, B. Heber, T. H. Hsieh, J. Y. Hu, M. Incagli, W. Y. Jang, Yi Jia, H. Jinchi, B. Khiali, G. N. Kim, Th. Kirn, M. Konyushikhin, O. Kounina, A. Kounine, V. Koutsenko, D. Krasnopevtsev, A. Kuhlman, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, J. Q. Li, M. Li, Q. Li, S. Li, J. H. Li, Z. H. Li, J. Liang, C. Light, C. H. Lin, T. Lippert, J. H. Liu, Z. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, J. Z. Luo, Xi Luo, F. Machate, C. Mañá, J. Marín, J. Marquardt, T. Martin, G. Martínez, N. Masi, D. Maurin, T. Medvedeva, A. Menchaca-Rocha, Q. Meng, V. V. Mikhailov, M. Molero, P. Mott, L. Mussolin, J. Negrete, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, H. D. Phan, V. Plyaskin, M. Pohl, S. Poluianov, X. Qin, Z. Y. Qu, L. Quadrani, P. G. Rancoita, D. Rapin, A. Reina Conde, E. Robyn, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, A. Schulz von Dratzig, G. Schwering, E. S. Seo, Z. Shakfa, B. S. Shan, T. Siedenburg, C. Solano, J. W. Song, X. J. Song, R. Sonnabend, L. Strigari, T. Su, Q. Sun, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Tüysüz, T. Urban, I. Usoskin, V. Vagelli, R. Vainio, M. Valencia-Otero, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, C. X. Wang, L. Wang, L. Q. Wang, N. H. Wang, Q. L. Wang, S. Wang, X. Wang, Yu Wang, Z. M. Wang, J. Wei, Z. L. Weng, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, Y. Yang, I. I. Yashin, H. Yi, Y. M. Yu, Z. Q. Yu, M. Zannoni, C. Zhang, F. Zhang, F. Z. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, C. Zheng, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, and P. Zuccon more...
Published: 2021
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10. Properties of Heavy Secondary Fluorine Cosmic Rays: Results from the Alpha Magnetic Spectrometer

Author: M. Aguilar, L. Ali Cavasonza, M. S. Allen, B. Alpat, G. Ambrosi, L. Arruda, N. Attig, F. Barao, L. Barrin, A. Bartoloni, S. Başeğmez-du Pree, R. Battiston, M. Behlmann, B. Beranek, J. Berdugo, B. Bertucci, V. Bindi, K. Bollweg, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, S. Burmeister, X. D. Cai, M. Capell, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, G. R. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, S. Chouridou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, Z. Cui, K. Dadzie, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, C. Díaz, F. Dimiccoli, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, J. Feng, E. Fiandrini, P. Fisher, V. Formato, C. Freeman, Y. Galaktionov, C. Gámez, R. J. García-López, C. Gargiulo, H. Gast, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, S. Haino, K. C. Han, R. K. Hashmani, Z. H. He, B. Heber, T. H. Hsieh, J. Y. Hu, M. Incagli, W. Y. Jang, Yi Jia, H. Jinchi, K. Kanishev, B. Khiali, G. N. Kim, Th. Kirn, M. Konyushikhin, O. Kounina, A. Kounine, V. Koutsenko, A. Kuhlman, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, J. Q. Li, M. Li, Q. Li, S. Li, J. H. Li, Z. H. Li, J. Liang, C. Light, C. H. Lin, T. Lippert, J. H. Liu, Z. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, J. Z. Luo, Xi Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, J. Marquardt, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, V. V. Mikhailov, D. C. Mo, M. Molero, P. Mott, L. Mussolin, J. Negrete, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, H. D. Phan, R. Piandani, V. Plyaskin, S. Poluianov, X. Qin, Z. Y. Qu, L. Quadrani, P. G. Rancoita, D. Rapin, A. Reina Conde, E. Robyn, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, A. Schulz von Dratzig, G. Schwering, E. S. Seo, Z. Shakfa, B. S. Shan, T. Siedenburg, C. Solano, J. W. Song, X. J. Song, R. Sonnabend, L. Strigari, T. Su, Q. Sun, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Tüysüz, T. Urban, I. Usoskin, V. Vagelli, R. Vainio, M. Valencia-Otero, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, C. X. Wang, L. Wang, L. Q. Wang, N. H. Wang, Q. L. Wang, S. Wang, X. Wang, Yu Wang, Z. M. Wang, J. Wei, Z. L. Weng, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, Y. Yang, I. I. Yashin, H. Yi, Y. M. Yu, Z. Q. Yu, M. Zannoni, C. Zhang, F. Zhang, F. Z. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, C. Zheng, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, and P. Zuccon more...
Published: 2021
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11. Properties of Iron Primary Cosmic Rays: Results from the Alpha Magnetic Spectrometer

Author: M. Aguilar, L. Ali Cavasonza, M. S. Allen, B. Alpat, G. Ambrosi, L. Arruda, N. Attig, F. Barao, L. Barrin, A. Bartoloni, S. Başeğmez-du Pree, R. Battiston, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, V. Bindi, W. de Boer, K. Bollweg, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, S. Burmeister, X. D. Cai, M. Capell, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, G. R. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, S. Chouridou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, Z. Cui, K. Dadzie, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, C. Díaz, F. Dimiccoli, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, J. Feng, E. Fiandrini, P. Fisher, V. Formato, C. Freeman, Y. Galaktionov, C. Gámez, R. J. García-López, C. Gargiulo, H. Gast, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, S. Haino, K. C. Han, R. K. Hashmani, Z. H. He, B. Heber, T. H. Hsieh, J. Y. Hu, M. Incagli, W. Y. Jang, Yi Jia, H. Jinchi, K. Kanishev, B. Khiali, G. N. Kim, Th. Kirn, M. Konyushikhin, O. Kounina, A. Kounine, V. Koutsenko, A. Kuhlman, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, J. Q. Li, M. Li, Q. Li, S. Li, J. H. Li, Z. H. Li, J. Liang, C. Light, C. H. Lin, T. Lippert, J. H. Liu, Z. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, J. Z. Luo, Xi Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, J. Marquardt, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, V. V. Mikhailov, D. C. Mo, M. Molero, P. Mott, L. Mussolin, J. Negrete, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, H. D. Phan, R. Piandani, V. Plyaskin, S. Poluianov, X. Qin, Z. Y. Qu, L. Quadrani, P. G. Rancoita, D. Rapin, A. Reina Conde, E. Robyn, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, A. Schulz von Dratzig, G. Schwering, E. S. Seo, Z. Shakfa, B. S. Shan, T. Siedenburg, C. Solano, J. W. Song, X. J. Song, R. Sonnabend, L. Strigari, T. Su, Q. Sun, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Tüysüz, T. Urban, I. Usoskin, V. Vagelli, R. Vainio, M. Valencia-Otero, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, C. X. Wang, L. Wang, L. Q. Wang, N. H. Wang, Q. L. Wang, S. Wang, X. Wang, Yu Wang, Z. M. Wang, J. Wei, Z. L. Weng, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, Y. Yang, I. I. Yashin, H. Yi, Y. M. Yu, Z. Q. Yu, M. Zannoni, C. Zhang, F. Zhang, F. Z. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, C. Zheng, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2021
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12. Properties of Neon, Magnesium, and Silicon Primary Cosmic Rays Results from the Alpha Magnetic Spectrometer

Author: M. Aguilar, L. Ali Cavasonza, G. Ambrosi, L. Arruda, N. Attig, F. Barao, L. Barrin, A. Bartoloni, S. Başeğmez-du Pree, R. Battiston, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, V. Bindi, W. de Boer, K. Bollweg, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, S. Burmeister, X. D. Cai, M. Capell, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, S. Chouridou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, Z. Cui, K. Dadzie, Y. M. Dai, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, C. Díaz, F. Dimiccoli, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, J. Feng, E. Fiandrini, P. Fisher, V. Formato, C. Freeman, Y. Galaktionov, C. Gámez, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, K. H. Guo, S. Haino, K. C. Han, R. K. Hashmani, Z. H. He, B. Heber, T. H. Hsieh, J. Y. Hu, Z. C. Huang, M. Incagli, W. Y. Jang, Yi Jia, H. Jinchi, K. Kanishev, B. Khiali, G. N. Kim, Th. Kirn, M. Konyushikhin, O. Kounina, A. Kounine, V. Koutsenko, A. Kuhlman, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, J. Q. Li, M. Li, Q. Li, S. Li, T. X. Li, Z. H. Li, C. Light, C. H. Lin, T. Lippert, Z. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, J. Z. Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, J. Marquardt, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, M. Molero, P. Mott, L. Mussolin, J. Q. Ni, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, H. D. Phan, R. Piandani, V. Plyaskin, S. Poluianov, X. M. Qi, X. Qin, Z. Y. Qu, L. Quadrani, P. G. Rancoita, D. Rapin, A. Reina Conde, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, C. Solano, R. Sonnabend, J. W. Song, Q. Sun, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Tüysüz, T. Urban, I. Usoskin, V. Vagelli, R. Vainio, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, C. Wallmann, L. Q. Wang, N. H. Wang, Q. L. Wang, S. Wang, X. Wang, Z. X. Wang, J. Wei, Z. L. Weng, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, M. Zannoni, C. Zhang, F. Zhang, F. Z. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2020
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13. Properties of Cosmic Helium Isotopes Measured by the Alpha Magnetic Spectrometer

Author: M. Aguilar, L. Ali Cavasonza, G. Ambrosi, L. Arruda, N. Attig, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, S. Başeğmez-du Pree, R. Battiston, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, V. Bindi, W. de Boer, K. Bollweg, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, Z. Cui, K. Dadzie, Y. M. Dai, A. Datta, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, C. Díaz, F. Dimiccoli, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, J. Feng, E. Fiandrini, P. Fisher, V. Formato, Y. Galaktionov, C. Gámez, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, K. H. Guo, S. Haino, K. C. Han, Z. H. He, T. H. Hsieh, H. Huang, Z. C. Huang, M. Incagli, W. Y. Jang, Yi Jia, H. Jinchi, K. Kanishev, B. Khiali, G. N. Kim, Th. Kirn, M. Konyushikhin, O. Kounina, A. Kounine, V. Koutsenko, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, J. Q. Li, Q. Li, T. X. Li, Z. H. Li, C. Light, C. H. Lin, T. Lippert, Z. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, Xi Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, M. Molero, P. Mott, L. Mussolin, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, H. D. Phan, V. Plyaskin, V. Poireau, S. Poluianov, A. Popkow, X. M. Qi, X. Qin, Z. Y. Qu, L. Quadrani, P. G. Rancoita, D. Rapin, A. Reina Conde, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, C. Solano, J. W. Song, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Tüysüz, T. Urban, I. Usoskin, V. Vagelli, R. Vainio, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, L. Q. Wang, N. H. Wang, Q. L. Wang, X. Wang, X. Q. Wang, Z. X. Wang, J. Wei, Z. L. Weng, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, M. Zannoni, S. Zeissler, C. Zhang, F. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2019
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14. Electrospun PVDF fibers on bio-wings using multi-spinnerets.

Author: Chung-Kun Yen, C. H. Tsao, Cheng-Tang Pan, H. C. Wu, Y. C. Lai, Zong-Hsin Liu, Y. L. Lin, Liwei Lin, S. W. Kuo, Y. S. Lu, H. L. Hung, S. W. Mao, C. F. Liu, and Sheng-Chih Shen
Published: 2014
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15. Co-axially electrospun PVDF fibers with hollow wall to enhance potential output.

Author: Y. C. Lai, H. C. Wu, C. T. Pan, C. K. Yen, C. H. Tsao, Liwei Lin, S. W. Kuo, Y. S. Lu, and S. C. Shen
Published: 2014
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16. Towards Understanding the Origin of Cosmic-Ray Electrons

Author: M. Aguilar, L. Ali Cavasonza, B. Alpat, G. Ambrosi, L. Arruda, N. Attig, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, S. Başeğmez-du Pree, R. Battiston, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, V. Bindi, W. de Boer, K. Bollweg, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, M. Crispoltoni, Z. Cui, K. Dadzie, Y. M. Dai, A. Datta, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, V. Di Felice, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, T. Eronen, J. Feng, E. Fiandrini, P. Fisher, V. Formato, Y. Galaktionov, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, K. H. Guo, S. Haino, K. C. Han, Z. H. He, M. Heil, T. H. Hsieh, H. Huang, Z. C. Huang, M. Incagli, Yi Jia, H. Jinchi, K. Kanishev, B. Khiali, Th. Kirn, C. Konak, O. Kounina, A. Kounine, V. Koutsenko, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, J. Q. Li, Q. Li, T. X. Li, Z. H. Li, C. Light, C. H. Lin, T. Lippert, F. Z. Liu, Hu Liu, Z. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, Xi Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, M. Molero, P. Mott, L. Mussolin, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, C. Perrina, H. D. Phan, N. Picot-Clemente, V. Plyaskin, M. Pohl, V. Poireau, A. Popkow, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, P. G. Rancoita, D. Rapin, A. Reina Conde, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, C. Solano, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, J. W. Song, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, T. Urban, V. Vagelli, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, J. Vizán, L. Q. Wang, N. H. Wang, Q. L. Wang, X. Wang, X. Q. Wang, Z. X. Wang, J. Wei, Z. L. Weng, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, M. Zannoni, S. Zeissler, C. Zhang, F. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2019
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17. Towards Understanding the Origin of Cosmic-Ray Positrons

Author: M. Aguilar, L. Ali Cavasonza, G. Ambrosi, L. Arruda, N. Attig, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, S. Başeğmez-du Pree, R. Battiston, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, V. Bindi, W. de Boer, K. Bollweg, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, G. M. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, V. Choutko, C. H. Chung, C. Clark, G. Coignet, C. Consolandi, A. Contin, C. Corti, M. Crispoltoni, Z. Cui, K. Dadzie, Y. M. Dai, A. Datta, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, T. Eronen, J. Feng, E. Fiandrini, P. Fisher, V. Formato, Y. Galaktionov, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, K. H. Guo, S. Haino, K. C. Han, Z. H. He, M. Heil, T. H. Hsieh, H. Huang, Z. C. Huang, M. Incagli, Yi Jia, H. Jinchi, K. Kanishev, B. Khiali, Th. Kirn, C. Konak, O. Kounina, A. Kounine, V. Koutsenko, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, J. Q. Li, Q. Li, T. X. Li, Z. H. Li, C. Light, C. H. Lin, T. Lippert, F. Z. Liu, Hu Liu, Z. Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, Xi Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, M. Molero, P. Mott, L. Mussolin, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, M. Paniccia, A. Pashnin, M. Pauluzzi, S. Pensotti, C. Perrina, H. D. Phan, N. Picot-Clemente, V. Plyaskin, M. Pohl, V. Poireau, A. Popkow, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, P. G. Rancoita, D. Rapin, A. Reina Conde, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, C. Solano, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, J. W. Song, Z. T. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, T. Urban, V. Vagelli, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, J. Vizán, L. Q. Wang, N. H. Wang, Q. L. Wang, X. Wang, X. Q. Wang, Z. X. Wang, J. Wei, Z. L. Weng, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, M. Zannoni, S. Zeissler, C. Zhang, F. Zhang, J. H. Zhang, Z. Zhang, F. Zhao, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2019
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18. Observation of Complex Time Structures in the Cosmic-Ray Electron and Positron Fluxes with the Alpha Magnetic Spectrometer on the International Space Station

Author: M. Aguilar, L. Ali Cavasonza, G. Ambrosi, L. Arruda, N. Attig, S. Aupetit, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, S. Başeğmez-du Pree, M. Battarbee, R. Battiston, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, K. F. Bindel, V. Bindi, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, G. M. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, W. Creus, M. Crispoltoni, Z. Cui, K. Dadzie, Y. M. Dai, A. Datta, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, D. D’Urso, A. Egorov, A. Eline, T. Eronen, J. Feng, E. Fiandrini, P. Fisher, V. Formato, Y. Galaktionov, G. Gallucci, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, K. H. Guo, S. Haino, K. C. Han, Z. H. He, M. Heil, T. H. Hsieh, H. Huang, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, Yi Jia, H. Jinchi, S. C. Kang, K. Kanishev, B. Khiali, G. N. Kim, K. S. Kim, Th. Kirn, C. Konak, O. Kounina, A. Kounine, V. Koutsenko, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. S. Li, J. Q. Li, Q. Li, T. X. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, Hu Liu, V. D. Lordello, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, V. M. Mikuni, D. C. Mo, P. Mott, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, C. Palomares, M. Paniccia, M. Pauluzzi, S. Pensotti, C. Perrina, H. D. Phan, N. Picot-Clemente, F. Pilo, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, D. Son, J. W. Song, M. Tacconi, X. W. Tang, Z. C. Tang, D. Tescaro, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Türkoğlu, T. Urban, V. Vagelli, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, L. Q. Wang, N. H. Wang, Q. L. Wang, X. Wang, X. Q. Wang, Z. X. Wang, C. C. Wei, Z. L. Weng, K. Whitman, H. Wu, X. Wu, R. Q. Xiong, W. Xu, Q. Yan, J. Yang, M. Yang, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, M. Zannoni, S. Zeissler, C. Zhang, F. Zhang, J. Zhang, J. H. Zhang, S. W. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2018
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19. Precision Measurement of Cosmic-Ray Nitrogen and its Primary and Secondary Components with the Alpha Magnetic Spectrometer on the International Space Station

Author: M. Aguilar, L. Ali Cavasonza, B. Alpat, G. Ambrosi, L. Arruda, N. Attig, S. Aupetit, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, S. Başeğmez-du Pree, M. Battarbee, R. Battiston, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, K. F. Bindel, V. Bindi, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, F. Cervelli, Y. H. Chang, A. I. Chen, G. M. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, W. Creus, M. Crispoltoni, Z. Cui, K. Dadzie, Y. M. Dai, A. Datta, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, A. Egorov, A. Eline, T. Eronen, J. Feng, E. Fiandrini, P. Fisher, V. Formato, Y. Galaktionov, G. Gallucci, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, K. H. Guo, S. Haino, K. C. Han, Z. H. He, M. Heil, T. H. Hsieh, H. Huang, Z. C. Huang, M. Incagli, Yi Jia, H. Jinchi, K. Kanishev, B. Khiali, Th. Kirn, C. Konak, O. Kounina, A. Kounine, V. Koutsenko, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. S. Li, J. Q. Li, Q. Li, T. X. Li, Z. H. Li, Z. Y. Li, C. H. Lin, P. Lipari, T. Lippert, D. Liu, Hu Liu, Z. Liu, V. D. Lordello, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, V. M. Mikuni, D. C. Mo, P. Mott, L. Mussolin, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, C. Palomares, M. Paniccia, M. Pauluzzi, S. Pensotti, C. Perrina, H. D. Phan, N. Picot-Clemente, F. Pilo, V. Plyaskin, M. Pohl, V. Poireau, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, J. W. Song, M. Tacconi, X. W. Tang, Z. C. Tang, D. Tescaro, J. Tian, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, T. Urban, V. Vagelli, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, L. Q. Wang, N. H. Wang, Q. L. Wang, X. Wang, X. Q. Wang, Z. X. Wang, C. C. Wei, J. Wei, Z. L. Weng, K. Whitman, H. Wu, R. Q. Xiong, W. Xu, Q. Yan, M. Yang, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, M. Zannoni, S. Zeissler, C. Zhang, F. Zhang, J. Zhang, J. H. Zhang, S. W. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2018
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20. Observation of Fine Time Structures in the Cosmic Proton and Helium Fluxes with the Alpha Magnetic Spectrometer on the International Space Station

Author: M. Aguilar, L. Ali Cavasonza, B. Alpat, G. Ambrosi, L. Arruda, N. Attig, S. Aupetit, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, S. Başeğmez-du Pree, M. Battarbee, R. Battiston, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, K. F. Bindel, V. Bindi, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, G. M. Chen, H. S. Chen, Y. Chen, L. Cheng, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, W. Creus, M. Crispoltoni, Z. Cui, K. Dadzie, Y. M. Dai, A. Datta, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, D. D’Urso, A. Egorov, A. Eline, T. Eronen, J. Feng, E. Fiandrini, P. Fisher, V. Formato, Y. Galaktionov, G. Gallucci, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, K. H. Guo, S. Haino, K. C. Han, Z. H. He, M. Heil, J. Hoffman, T. H. Hsieh, H. Huang, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, Yi Jia, H. Jinchi, S. C. Kang, K. Kanishev, B. Khiali, G. N. Kim, K. S. Kim, Th. Kirn, C. Konak, O. Kounina, A. Kounine, V. Koutsenko, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. S. Li, J. Q. Li, Q. Li, T. X. Li, Z. H. Li, Z. Y. Li, C. Light, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, Hu Liu, V. D. Lordello, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, X. Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, V. M. Mikuni, D. C. Mo, P. Mott, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, C. Palomares, M. Paniccia, M. Pauluzzi, S. Pensotti, C. Perrina, H. D. Phan, N. Picot-Clemente, F. Pilo, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, A. Popkow, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, D. Son, J. W. Song, M. Tacconi, X. W. Tang, Z. C. Tang, D. Tescaro, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Türkoğlu, T. Urban, V. Vagelli, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, L. Q. Wang, N. H. Wang, Q. L. Wang, X. Wang, X. Q. Wang, Z. X. Wang, C. C. Wei, Z. L. Weng, K. Whitman, H. Wu, X. Wu, R. Q. Xiong, W. Xu, Q. Yan, J. Yang, M. Yang, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, M. Zannoni, S. Zeissler, C. Zhang, F. Zhang, J. Zhang, J. H. Zhang, S. W. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2018
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21. Observation of New Properties of Secondary Cosmic Rays Lithium, Beryllium, and Boron by the Alpha Magnetic Spectrometer on the International Space Station

Author: M. Aguilar, L. Ali Cavasonza, G. Ambrosi, L. Arruda, N. Attig, S. Aupetit, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, S. Başeğmez-du Pree, M. Battarbee, R. Battiston, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, K. F. Bindel, V. Bindi, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, G. M. Chen, H. S. Chen, L. Cheng, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, W. Creus, M. Crispoltoni, Z. Cui, K. Dadzie, Y. M. Dai, A. Datta, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, D. D’Urso, A. Egorov, A. Eline, T. Eronen, J. Feng, E. Fiandrini, P. Fisher, V. Formato, Y. Galaktionov, G. Gallucci, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, K. H. Guo, S. Haino, K. C. Han, Z. H. He, M. Heil, T. H. Hsieh, H. Huang, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, Yi Jia, H. Jinchi, S. C. Kang, K. Kanishev, B. Khiali, G. N. Kim, K. S. Kim, Th. Kirn, C. Konak, O. Kounina, A. Kounine, V. Koutsenko, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. S. Li, J. Q. Li, Q. Li, T. X. Li, Y. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, Hu Liu, V. D. Lordello, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, V. M. Mikuni, D. C. Mo, P. Mott, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, M. Palermo, F. Palmonari, C. Palomares, M. Paniccia, M. Pauluzzi, S. Pensotti, C. Perrina, H. D. Phan, N. Picot-Clemente, F. Pilo, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, D. Son, J. W. Song, M. Tacconi, X. W. Tang, Z. C. Tang, D. Tescaro, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Türkoğlu, T. Urban, V. Vagelli, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, V. Vitale, L. Q. Wang, N. H. Wang, Q. L. Wang, X. Wang, X. Q. Wang, Z. X. Wang, C. C. Wei, Z. L. Weng, K. Whitman, H. Wu, X. Wu, R. Q. Xiong, W. Xu, Q. Yan, J. Yang, M. Yang, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, M. Zannoni, S. Zeissler, C. Zhang, F. Zhang, J. Zhang, J. H. Zhang, S. W. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2018
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22. Observation of the Identical Rigidity Dependence of He, C, and O Cosmic Rays at High Rigidities by the Alpha Magnetic Spectrometer on the International Space Station

Author: M. Aguilar, L. Ali Cavasonza, B. Alpat, G. Ambrosi, L. Arruda, N. Attig, S. Aupetit, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, S. Başeğmez-du Pree, M. Battarbee, R. Battiston, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, K. F. Bindel, V. Bindi, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, W. J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, G. M. Chen, H. S. Chen, L. Cheng, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, W. Creus, M. Crispoltoni, Z. Cui, K. Dadzie, Y. M. Dai, A. Datta, C. Delgado, S. Della Torre, O. Demakov, M. B. Demirköz, L. Derome, S. Di Falco, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, D. D’Urso, A. Egorov, A. Eline, T. Eronen, J. Feng, E. Fiandrini, P. Fisher, V. Formato, Y. Galaktionov, G. Gallucci, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, F. Giovacchini, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, K. H. Guo, S. Haino, K. C. Han, Z. H. He, M. Heil, J. Hoffman, T. H. Hsieh, H. Huang, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, Yi Jia, H. Jinchi, S. C. Kang, K. Kanishev, B. Khiali, G. N. Kim, K. S. Kim, Th. Kirn, C. Konak, O. Kounina, A. Kounine, V. Koutsenko, A. Kulemzin, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. S. Li, J. Q. Li, Q. Li, T. X. Li, Y. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, Hu Liu, V. D. Lordello, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lyu, F. Machate, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, V. M. Mikuni, D. C. Mo, P. Mott, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, F. Palmonari, C. Palomares, M. Paniccia, M. Pauluzzi, S. Pensotti, C. Perrina, H. D. Phan, N. Picot-Clemente, F. Pilo, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, D. Son, J. W. Song, M. Tacconi, X. W. Tang, Z. C. Tang, D. Tescaro, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Türkoğlu, T. Urban, V. Vagelli, E. Valente, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, V. Vitale, S. Vitillo, L. Q. Wang, N. H. Wang, Q. L. Wang, X. Wang, X. Q. Wang, Z. X. Wang, C. C. Wei, Z. L. Weng, K. Whitman, H. Wu, X. Wu, R. Q. Xiong, W. Xu, Q. Yan, J. Yang, M. Yang, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, M. Zannoni, S. Zeissler, C. Zhang, F. Zhang, J. Zhang, J. H. Zhang, S. W. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2017
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23. 192MO DESTINY-Breast04 subgroup analyses of trastuzumab deruxtecan (T-DXd) vs treatment of physician’s choice (TPC) in patients (pts) with human epidermal growth factor 2 (HER2)-low, estrogen-receptor (ER) expression immunohistochemistry (IHC) 0-10% metastatic breast cancer (mBC)

Author: D.A.A. Cameron, W. Jacot, T. Yamashita, M.J. Vidal Losada, P. Schmid, K.S. Lee, M. De Laurentiis, F. Zagouri, N.T. Ueno, A. Prat, N. Harbeck, R. Yerushalmi, Y-S. Lu, A. Gombos, C.M.A. Orbegoso, F-C. Cheng, L. Yung, R. Rajagopalan, J. Tsurutani, and S. Modi more...
Subjects: Cancer Research, Oncology
Published: 2023
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24. Transcriptome and metabolome analyses of the immune response to light stress in the hybrid grouper (Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀)

Author: Z M, Zhong, J, Zhang, B G, Tang, F F, Yu, Y S, Lu, G, Hou, J Y, Chen, and Z X, Du
Subjects: Light intensity, Enrichment analysis, Gene Expression Profiling, Stress response, Immunity, Metabolomic, SF1-1100, Animal culture, Transcriptomic, Metabolome, Animals, Bass, Animal Science and Zoology, Transcriptome
Abstract: Light intensity is an important environmental factor that affects fish growth and health through multiple physiological activities and metabolism and eventually impacts aquaculture harvest. There is a need to evaluate the fish stress response to light intensities, which will benefit aquaculture. Here, hybrid grouper (Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀) was treated with three light intensities for evaluation of the light stress response, including high light intensity (1 250 lx), low light intensity (10 lx) and moderate light intensity (250 lx). Transcriptome analysis showed that a total of 71 318 unigene sequences were obtained with an N50 of 2 589 bp. Compared to the control group (250 lx), 1 697 differentially expressed genes (DEGs), a considerable quantity, were detected in the 1 250 lx group. Among those genes, 548 were upregulated, and the remaining 149 genes showed decreased expression. Comparatively small numbers of DEGs were detected in the 10 lx group; 54 out of 103 genes exhibited upregulated expression, and 49 genes showed downregulation. For further KEGG analysis, 82 DEGs were enriched in nine common signalling pathways in immunity, of which 73 DEGs were significantly inhibited in the 1 250 lx group. In contrast, only 11 DEGs were enriched in three immunity pathways, with nine DEGs showing a significant increase in the 10 lx group. The metabolome analysis revealed 59 and 44 differential metabolites (DMs) from the 1 250 lx and 10 lx groups, respectively. Of note, those DMs from the 1 250 lx-treated group were tendentiously involved in amino acid metabolism and lipid metabolism pathways, while the purine metabolism, amino acid metabolism and lipid metabolism pathways were mostly found in the 10 lx treatment group. In summary, our data indicated that high light intensity significantly inhibited the immune response in hybrid grouper, while low light intensity presented low stimulation of immune activity. In addition, both high and low light intensity could inhibit protein synthesis and amino acid metabolism. Taken together, hybrid grouper exhibited a much milder stress response to low light intensity than to high light intensity. more...
Published: 2022

25. Observation of Z>2 trapped nuclei by AMS on ISS

Author: Giovacchini, F., Oliva, A., Valencia-Otero, M., Aguilar, M., Ali Cavasonza, L., Allen, M. S., Alpat, B., Ambrosi, G., Arruda, L., Attig, N., Barao, F., Barrin, L., Bartoloni, A., Basegmez-Du Pree, S., Battiston, R., Behlmann, M., Beranek, B., Berdugo, J., Bertucci, B., Bindi, V., Bollweg, K., Borgia, B., Boschini, M. J., Bourquin, M., Bueno, E. F., Burger, J., Burger, W. J., Burmeister, S., Cai, X. D., Capell, M., Casaus, J., Castellini, G., Cervelli, F., Chang, Y. H., Chen, G. M., Chen, G. R., Chen, H. S., Chen, Y., Cheng, L., Chou, H. Y., Chouridou, S., Choutko, V., Chung, C. H., Clark, C., Coignet, G., Consolandi, C., Contin, A., Corti, C., Cui, Z., Dadzie, K., Delgado, C., Della Torre, S., Demirkoz, M. B., Derome, L., Di Falco, S., Di Felice, V., Diaz, C., Dimiccoli, F., von Doetinchem, P., Dong, F., Donnini, F., Duranti, M., Egorov, A., Eline, A., Feng, J., Fiandrini, E., Fisher, P., Formato, V., Freeman, C., Galaktionov, Y., Gamez, C., Garcia-Lopez, R. J., Gargiulo, C., Gast, H., Gervasi, M., Gomez-Coral, D. M., Gong, J., Goy, C., Grabski, V., Grandi, D., Graziani, M., Haino, S., Han, K. C., Hashmani, R. K., Z. H., He, Heber, B., Hsieh, T. H., J. Y., Hu, Incagli, M., Jang, W. Y., Jia, Y., Jinchi, H., Kanishev, K., Khiali, B., Kim, G. N., Kirn, Th., Konyushikhin, M., Kounina, O., Kounine, A., Koutsenko, V., Kuhlman, A., Kulemzin, A., La Vacca, G., Laudi, E., Laurenti, G., Lazzizzera, I., Lebedev, A., Lee, H. T., Lee, S. C., J. Q., Li, Li, M., Li, Q., Li, S., J. H., Li, Z. H., Li, Liang, J., Light, C., Lin, C. H., Lippert, T., Liu, J. H., Liu, Z., S. Q., Lu, Y. S., Lu, Luebelsmeyer, K., Luo, J. Z., Luo, X., Lyu, S. S., Machate, F., Mana, C., Marin, J., Marquardt, J., Martin, T., Martinez, G., Masi, N., Maurin, D., Menchaca-Rocha, A., Meng, Q., Mikhailov, V. V., D. C., Mo, Molero, M., Mott, P., Mussolin, L., Negrete, J., Nikonov, N., Nozzoli, F., Orcinha, M., Palermo, M., Palmonari, F., Paniccia, M., Pashnin, A., Pauluzzi, M., Pensotti, S., Phan, H. D., Piandani, R., Plyaskin, V., Poluianov, S., Qin, X., Z. Y., Qu, Quadrani, L., Rancoita, P. G., Rapin, D., Reina Conde, A., Robyn, E., Rosier-Lees, S., Rozhkov, A., Rozza, D., Sagdeev, R., Schael, S., Schulz von Dratzig, A., Schwering, G., Seo, E. S., Shakfa, Z., Shan, B. S., Siedenburg, T., Song, J. W., Song, X. J., Sonnabend, R., Strigari, L., Su, T., Sun, Q., Sun, Z. T., Tacconi, M., Tang, X. W., Tang, Z. C., Tian, J., Ting, S. C. C., Ting, S. M., Tomassetti, N., Torsti, J., Tuysuz, C., Urban, T., Usoskin, I., Vagelli, V., Vainio, R., Valente, E., Valtonen, E., Vazquez Acosta, M., Vecchi, M., Velasco, M., Vialle, J. P., Wang, C. X., Wang, L., Wang, L. Q., Wang, N. H., Wang, Q. L., Wang, S., Wang, X., Wang, Y., Wang, Z. M., Wei, J., Weng, Z. L., Wu, H., Xiong, R. Q., Xu, W., Yan, Q., Yang, Y., Yashin, I. I., Yi, H., Y. M., Yu, Z. Q., Yu, Zannoni, M., Zhang, C., Zhang, F., Zhang, F. Z., Zhang, J. H., Zhang, Z., Zhao, F., Zheng, C., Zheng, Z. M., Zhuang, H. L., Zhukov, V., Zichichi, A., Zuccon, P., Giovacchini, F, Oliva, A, Valencia-Otero, M, Aguilar, M, Ali Cavasonza, L, Allen, M, Alpat, B, Ambrosi, G, Arruda, L, Attig, N, Barao, F, Barrin, L, Bartoloni, A, Basegmez-Du Pree, S, Battiston, R, Behlmann, M, Beranek, B, Berdugo, J, Bertucci, B, Bindi, V, Bollweg, K, Borgia, B, Boschini, M, Bourquin, M, Bueno, E, Burger, J, Burger, W, Burmeister, S, Cai, X, Capell, M, Casaus, J, Castellini, G, Cervelli, F, Chang, Y, Chen, G, Chen, H, Chen, Y, Cheng, L, Chou, H, Chouridou, S, Choutko, V, Chung, C, Clark, C, Coignet, G, Consolandi, C, Contin, A, Corti, C, Cui, Z, Dadzie, K, Delgado, C, Della Torre, S, Demirkoz, M, Derome, L, Di Falco, S, Di Felice, V, Diaz, C, Dimiccoli, F, von Doetinchem, P, Dong, F, Donnini, F, Duranti, M, Egorov, A, Eline, A, Feng, J, Fiandrini, E, Fisher, P, Formato, V, Freeman, C, Galaktionov, Y, Gamez, C, Garcia-Lopez, R, Gargiulo, C, Gast, H, Gervasi, M, Gomez-Coral, D, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, M, Haino, S, Han, K, Hashmani, R, He, Z, Heber, B, Hsieh, T, Hu, J, Incagli, M, Jang, W, Jia, Y, Jinchi, H, Kanishev, K, Khiali, B, Kim, G, Kirn, T, Konyushikhin, M, Kounina, O, Kounine, A, Koutsenko, V, Kuhlman, A, Kulemzin, A, La Vacca, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, H, Lee, S, Li, J, Li, M, Li, Q, Li, S, Li, Z, Liang, J, Light, C, Lin, C, Lippert, T, Liu, J, Liu, Z, Lu, S, Lu, Y, Luebelsmeyer, K, Luo, J, Luo, X, Lyu, S, Machate, F, Mana, C, Marin, J, Marquardt, J, Martin, T, Martinez, G, Masi, N, Maurin, D, Menchaca-Rocha, A, Meng, Q, Mikhailov, V, Mo, D, Molero, M, Mott, P, Mussolin, L, Negrete, J, Nikonov, N, Nozzoli, F, Orcinha, M, Palermo, M, Palmonari, F, Paniccia, M, Pashnin, A, Pauluzzi, M, Pensotti, S, Phan, H, Piandani, R, Plyaskin, V, Poluianov, S, Qin, X, Qu, Z, Quadrani, L, Rancoita, P, Rapin, D, Reina Conde, A, Robyn, E, Rosier-Lees, S, Rozhkov, A, Rozza, D, Sagdeev, R, Schael, S, Schulz von Dratzig, A, Schwering, G, Seo, E, Shakfa, Z, Shan, B, Siedenburg, T, Song, J, Song, X, Sonnabend, R, Strigari, L, Su, T, Sun, Q, Sun, Z, Tacconi, M, Tang, X, Tang, Z, Tian, J, Ting, S, Tomassetti, N, Torsti, J, Tuysuz, C, Urban, T, Usoskin, I, Vagelli, V, Vainio, R, Valente, E, Valtonen, E, Vazquez Acosta, M, Vecchi, M, Velasco, M, Vialle, J, Wang, C, Wang, L, Wang, N, Wang, Q, Wang, S, Wang, X, Wang, Y, Wang, Z, Wei, J, Weng, Z, Wu, H, Xiong, R, Xu, W, Yan, Q, Yang, Y, Yashin, I, Yi, H, Yu, Y, Yu, Z, Zannoni, M, Zhang, C, Zhang, F, Zhang, J, Zhang, Z, Zhao, F, Zheng, C, Zheng, Z, Zhuang, H, Zhukov, V, Zichichi, A, and Zuccon, P more...
Subjects: FIS/05 - ASTRONOMIA E ASTROFISICA, Alpha magnetic spectrometer, South atlantic anomalies, International Space station, High-energy particle physic, Particle physics experiment
Abstract: The Alpha Magnetic Spectrometer (AMS-02) is a high energy particle physics experiment operating continuously aboard the International Space Station (ISS) since the 19th of May of 2011. A component of trapped Z>2 ions located in the South Atlantic Anomaly (SAA) has been detected traversing the instrument both in down-going and up-going directions. more...
Published: 2022

26. Precision Measurement of the Boron to Carbon Flux Ratio in Cosmic Rays from 1.9 GV to 2.6 TV with the Alpha Magnetic Spectrometer on the International Space Station

Author: M. Aguilar, L. Ali Cavasonza, G. Ambrosi, L. Arruda, N. Attig, S. Aupetit, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, S. Başeğmez-du Pree, M. Battarbee, R. Battiston, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, K. F. Bindel, V. Bindi, G. Boella, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, G. M. Chen, H. S. Chen, L. Cheng, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, W. Creus, M. Crispoltoni, Z. Cui, Y. M. Dai, C. Delgado, S. Della Torre, O. Demakov, M. B. Demirköz, L. Derome, S. Di Falco, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, D. D’Urso, A. Egorov, A. Eline, T. Eronen, J. Feng, E. Fiandrini, E. Finch, P. Fisher, V. Formato, Y. Galaktionov, G. Gallucci, B. García, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, F. Giovacchini, P. Goglov, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, K. H. Guo, S. Haino, K. C. Han, Z. H. He, M. Heil, J. Hoffman, T. H. Hsieh, H. Huang, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, H. Jinchi, S. C. Kang, K. Kanishev, G. N. Kim, K. S. Kim, Th. Kirn, C. Konak, O. Kounina, A. Kounine, V. Koutsenko, M. S. Krafczyk, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. S. Li, J. Q. Li, Q. Li, T. X. Li, W. Li, Y. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, Hu Liu, V. D. Lordello, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lv, F. Machate, R. Majka, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, V. M. Mikuni, D. C. Mo, L. Morescalchi, P. Mott, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, A. Oliva, M. Orcinha, F. Palmonari, C. Palomares, M. Paniccia, M. Pauluzzi, S. Pensotti, R. Pereira, N. Picot-Clemente, F. Pilo, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, A. Putze, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, J. Sandweiss, P. Saouter, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, D. Son, J. W. Song, W. H. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, L. Tao, D. Tescaro, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Türkoğlu, T. Urban, V. Vagelli, E. Valente, C. Vannini, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, V. Vitale, S. Vitillo, L. Q. Wang, N. H. Wang, Q. L. Wang, X. Wang, X. Q. Wang, Z. X. Wang, C. C. Wei, Z. L. Weng, K. Whitman, J. Wienkenhöver, H. Wu, X. Wu, X. Xia, R. Q. Xiong, W. Xu, Q. Yan, J. Yang, M. Yang, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, S. Zeissler, C. Zhang, J. Zhang, J. H. Zhang, S. D. Zhang, S. W. Zhang, Z. Zhang, Z. M. Zheng, Z. Q. Zhu, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2016
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27. Antiproton Flux, Antiproton-to-Proton Flux Ratio, and Properties of Elementary Particle Fluxes in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station

Author: M. Aguilar, L. Ali Cavasonza, B. Alpat, G. Ambrosi, L. Arruda, N. Attig, S. Aupetit, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, S. Başeǧmez-du Pree, M. Battarbee, R. Battiston, J. Bazo, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, V. Bindi, G. Boella, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, M. J. Boschini, M. Bourquin, E. F. Bueno, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, I. Cernuda, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, G. M. Chen, H. S. Chen, L. Cheng, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, B. Coste, W. Creus, M. Crispoltoni, Z. Cui, Y. M. Dai, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Dong, F. Donnini, M. Duranti, D. D’Urso, A. Egorov, A. Eline, T. Eronen, J. Feng, E. Fiandrini, E. Finch, P. Fisher, V. Formato, Y. Galaktionov, G. Gallucci, B. García, R. J. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, F. Giovacchini, P. Goglov, D. M. Gómez-Coral, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, I. Guerri, K. H. Guo, M. Habiby, S. Haino, K. C. Han, Z. H. He, M. Heil, J. Hoffman, T. H. Hsieh, H. Huang, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, H. Jinchi, S. C. Kang, K. Kanishev, G. N. Kim, K. S. Kim, Th. Kirn, C. Konak, O. Kounina, A. Kounine, V. Koutsenko, M. S. Krafczyk, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. S. Li, J. Q. Li, Q. Li, T. X. Li, W. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, Hu Liu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lv, R. Majka, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, L. Morescalchi, P. Mott, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, P. Nunes, A. Oliva, M. Orcinha, F. Palmonari, C. Palomares, M. Paniccia, M. Pauluzzi, S. Pensotti, R. Pereira, N. Picot-Clemente, F. Pilo, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, A. Putze, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, I. Rodríguez, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, J. Sandweiss, P. Saouter, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, E. S. Seo, B. S. Shan, J. Y. Shi, T. Siedenburg, D. Son, J. W. Song, W. H. Sun, M. Tacconi, X. W. Tang, Z. C. Tang, L. Tao, D. Tescaro, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Türkoğlu, T. Urban, V. Vagelli, E. Valente, C. Vannini, E. Valtonen, M. Vázquez Acosta, M. Vecchi, M. Velasco, J. P. Vialle, V. Vitale, S. Vitillo, L. Q. Wang, N. H. Wang, Q. L. Wang, X. Wang, X. Q. Wang, Z. X. Wang, C. C. Wei, Z. L. Weng, K. Whitman, J. Wienkenhöver, M. Willenbrock, H. Wu, X. Wu, X. Xia, R. Q. Xiong, W. Xu, Q. Yan, J. Yang, M. Yang, Y. Yang, H. Yi, Y. J. Yu, Z. Q. Yu, S. Zeissler, C. Zhang, J. Zhang, J. H. Zhang, S. D. Zhang, S. W. Zhang, Z. Zhang, Z. M. Zheng, Z. Q. Zhu, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2016
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28. Precision Measurement of the Helium Flux in Primary Cosmic Rays of Rigidities 1.9 GV to 3 TV with the Alpha Magnetic Spectrometer on the International Space Station

Author: M. Aguilar, D. Aisa, B. Alpat, A. Alvino, G. Ambrosi, K. Andeen, L. Arruda, N. Attig, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, M. Battarbee, R. Battiston, J. Bazo, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, V. Bindi, S. Bizzaglia, M. Bizzarri, G. Boella, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, S. Borsini, M. J. Boschini, M. Bourquin, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casaus, G. Castellini, I. Cernuda, D. Cerreta, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, G. M. Chen, H. Chen, H. S. Chen, L. Cheng, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, E. Cortina Gil, B. Coste, W. Creus, M. Crispoltoni, Z. Cui, Y. M. Dai, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, L. Di Masso, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Donnini, M. Duranti, D. D’Urso, A. Egorov, A. Eline, F. J. Eppling, T. Eronen, Y. Y. Fan, L. Farnesini, J. Feng, E. Fiandrini, A. Fiasson, E. Finch, P. Fisher, V. Formato, Y. Galaktionov, G. Gallucci, B. García, R. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, F. Giovacchini, P. Goglov, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, C. Guandalini, I. Guerri, K. H. Guo, D. Haas, M. Habiby, S. Haino, K. C. Han, Z. H. He, M. Heil, J. Hoffman, T. H. Hsieh, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, H. Jinchi, K. Kanishev, G. N. Kim, K. S. Kim, Th. Kirn, M. A. Korkmaz, R. Kossakowski, O. Kounina, A. Kounine, V. Koutsenko, M. S. Krafczyk, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. L. Li, J. Q. Li, Q. Li, T. X. Li, W. Li, Y. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, H. Liu, Hu Liu, M. Lolli, T. Lomtadze, M. J. Lu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lv, R. Majka, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, L. Morescalchi, P. Mott, M. Müller, T. Nelson, J. Q. Ni, N. Nikonov, F. Nozzoli, P. Nunes, A. Obermeier, A. Oliva, M. Orcinha, F. Palmonari, C. Palomares, M. Paniccia, A. Papi, M. Pauluzzi, E. Pedreschi, S. Pensotti, R. Pereira, N. Picot-Clemente, F. Pilo, A. Piluso, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, A. Putze, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, I. Rodríguez, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, J. Sandweiss, P. Saouter, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, G. Scolieri, E. S. Seo, B. S. Shan, Y. H. Shan, J. Y. Shi, X. Y. Shi, Y. M. Shi, T. Siedenburg, D. Son, J. W. Song, F. Spada, F. Spinella, W. Sun, W. H. Sun, M. Tacconi, C. P. Tang, X. W. Tang, Z. C. Tang, L. Tao, D. Tescaro, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Türkoğlu, T. Urban, V. Vagelli, E. Valente, C. Vannini, E. Valtonen, S. Vaurynovich, M. Vecchi, M. Velasco, J. P. Vialle, V. Vitale, S. Vitillo, L. Q. Wang, N. H. Wang, Q. L. Wang, R. S. Wang, X. Wang, Z. X. Wang, Z. L. Weng, K. Whitman, J. Wienkenhöver, M. Willenbrock, H. Wu, X. Wu, X. Xia, M. Xie, S. Xie, R. Q. Xiong, N. S. Xu, W. Xu, Q. Yan, J. Yang, M. Yang, Y. Yang, Q. H. Ye, H. Yi, Y. J. Yu, Z. Q. Yu, S. Zeissler, C. Zhang, J. H. Zhang, M. T. Zhang, S. D. Zhang, S. W. Zhang, X. B. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, and P. Zuccon more...
Published: 2015
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29. Precision Measurement of the Proton Flux in Primary Cosmic Rays from Rigidity 1 GV to 1.8 TV with the Alpha Magnetic Spectrometer on the International Space Station

Author: M. Aguilar, D. Aisa, B. Alpat, A. Alvino, G. Ambrosi, K. Andeen, L. Arruda, N. Attig, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, M. Battarbee, R. Battiston, J. Bazo, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, G. Bigongiari, V. Bindi, S. Bizzaglia, M. Bizzarri, G. Boella, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, S. Borsini, M. J. Boschini, M. Bourquin, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casaus, V. Cascioli, G. Castellini, I. Cernuda, D. Cerreta, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, H. Chen, G. M. Cheng, H. S. Chen, L. Cheng, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, E. Cortina Gil, B. Coste, W. Creus, M. Crispoltoni, Z. Cui, Y. M. Dai, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, L. Di Masso, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Donnini, W. J. Du, M. Duranti, D. D’Urso, A. Eline, F. J. Eppling, T. Eronen, Y. Y. Fan, L. Farnesini, J. Feng, E. Fiandrini, A. Fiasson, E. Finch, P. Fisher, Y. Galaktionov, G. Gallucci, B. García, R. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, W. Gillard, F. Giovacchini, P. Goglov, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, C. Guandalini, I. Guerri, K. H. Guo, D. Haas, M. Habiby, S. Haino, K. C. Han, Z. H. He, M. Heil, J. Hoffman, T. H. Hsieh, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, H. Jinchi, K. Kanishev, G. N. Kim, K. S. Kim, Th. Kirn, R. Kossakowski, O. Kounina, A. Kounine, V. Koutsenko, M. S. Krafczyk, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, G. Levi, H. L. Li, J. Q. Li, Q. Li, T. X. Li, W. Li, Y. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, H. Liu, M. Lolli, T. Lomtadze, M. J. Lu, S. Q. Lu, Y. S. Lu, K. Luebelsmeyer, J. Z. Luo, S. S. Lv, R. Majka, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, L. Morescalchi, P. Mott, M. Müller, J. Q. Ni, N. Nikonov, F. Nozzoli, P. Nunes, A. Obermeier, A. Oliva, M. Orcinha, F. Palmonari, C. Palomares, M. Paniccia, A. Papi, M. Pauluzzi, E. Pedreschi, S. Pensotti, R. Pereira, N. Picot-Clemente, F. Pilo, A. Piluso, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, E. Postaci, A. Putze, L. Quadrani, X. M. Qi, X. Qin, Z. Y. Qu, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, I. Rodríguez, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, J. Sandweiss, P. Saouter, C. Sbarra, S. Schael, S. M. Schmidt, A. Schulz von Dratzig, G. Schwering, G. Scolieri, E. S. Seo, B. S. Shan, Y. H. Shan, J. Y. Shi, X. Y. Shi, Y. M. Shi, T. Siedenburg, D. Son, F. Spada, F. Spinella, W. Sun, W. H. Sun, M. Tacconi, C. P. Tang, X. W. Tang, Z. C. Tang, L. Tao, D. Tescaro, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Türkoğlu, T. Urban, V. Vagelli, E. Valente, C. Vannini, E. Valtonen, S. Vaurynovich, M. Vecchi, M. Velasco, J. P. Vialle, V. Vitale, S. Vitillo, L. Q. Wang, N. H. Wang, Q. L. Wang, R. S. Wang, X. Wang, Z. X. Wang, Z. L. Weng, K. Whitman, J. Wienkenhöver, H. Wu, X. Wu, X. Xia, M. Xie, S. Xie, R. Q. Xiong, G. M. Xin, N. S. Xu, W. Xu, Q. Yan, J. Yang, M. Yang, Q. H. Ye, H. Yi, Y. J. Yu, Z. Q. Yu, S. Zeissler, J. H. Zhang, M. T. Zhang, X. B. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, P. Zuccon, and C. Zurbach more...
Published: 2015
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30. 272TiP HARMONIA SOLTI-2101 / AFT-58: A head-to-head phase III study comparing ribociclib (RIB) and palbociclib (PAL) in patients (pts) with hormone receptor-positive/HER2-negative/HER2-enriched (HR+/HER2-/HER2-E) advanced breast cancer (ABC)

Author: T. Pascual, D.G. Stover, A. Thuerigen, C.M. Perou, E.M. Ciruelos, A. Casas Fernandez Tejerina, P. Spears, E. Roux, H. Hu, Y-S. Lu, S.M. Tolaney, A. Partridge, G. Villacampa Javierre, J.M. Ferrero Cafiero, L. Carey, and A. Prat more...
Subjects: Oncology, Hematology
Published: 2022
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31. Abstract P6-18-04: Ribociclib with a non-steroidal aromatase inhibitor and goserelin in premenopausal women with hormone receptor-positive, HER2-negative advanced breast cancer: MONALEESA-7 age subgroup analysis

Author: Debu Tripathy, S Hurvitz, Fabio Franke, Y-S Lu, Fatima Cardoso, I Diaz-Padilla, FM Cruz, A. Gaur, Saúl Campos-Gómez, Aditya Bardia, Paul Wheatley-Price, O Kong, M. Miller, and Roberto Hegg
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Aromatase inhibitor, business.industry, medicine.drug_class, Letrozole, Hazard ratio, Goserelin, Cancer, Anastrozole, medicine.disease, Breast cancer, Internal medicine, medicine, business, Tamoxifen, medicine.drug
Abstract: Background: Younger patients (pts) with breast cancer may experience more aggressive disease and are more likely to die from their cancer vs older pts. In the Phase III MONALEESA-7 study (NCT02278120), the addition of ribociclib (RIB; cyclin-dependent kinase 4/6 inhibitor) to a non-steroidal aromatase inhibitor (NSAI) or tamoxifen (TAM) + goserelin significantly prolonged progression-free survival (PFS) in premenopausal women with hormone receptor-positive (HR+), HER2-negative (HER2–) advanced breast cancer (ABC; hazard ratio 0.553; p Methods: Pre- or perimenopausal women with HR+, HER2– ABC who had received no prior endocrine therapy and ≤1 line of chemotherapy for ABC were enrolled. Of the 672 pts randomized, 495 (74%) received RIB (600 mg/day, 3-weeks-on/1-week-off) or PBO + an NSAI (letrozole [2.5 mg/day] or anastrozole [1 mg/day]) and goserelin (3.6 mg every 28 days). The primary endpoint was locally assessed PFS; secondary endpoints included overall response rate (ORR), clinical benefit rate (CBR), and safety. A prespecified subgroup analysis was performed in pts aged Results: A total of 144 pts were aged 480 ms (RIB vs PBO arm) occurred in 3% vs 2% of pts aged Conclusions: Consistent treatment benefit was observed with RIB + NSAI vs PBO + NSAI in premenopausal women with HR+, HER2– ABC irrespective of age. RIB + NSAI had a manageable safety profile in pts aged Citation Format: Tripathy D, Campos-Gomez S, Lu Y-S, Franke F, Bardia A, Wheatley-Price P, Cruz FM, Hegg R, Cardoso F, Gaur A, Kong O, Diaz-Padilla I, Miller M, Hurvitz S. Ribociclib with a non-steroidal aromatase inhibitor and goserelin in premenopausal women with hormone receptor-positive, HER2-negative advanced breast cancer: MONALEESA-7 age subgroup analysis [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P6-18-04. more...
Published: 2019
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32. Abstract GS3-08: Alpelisib + fulvestrant for advanced breast cancer: Subgroup analyses from the phase III SOLAR-1 trial

Author: A-S Longin, IA Mayer, Dejan Juric, S. Loibl, Eva Ciruelos, F Andre, Toshinari Yamashita, HS Rugo, Kenichi Inoue, Zsuzsanna Papai, David Mills, G. Rubovszky, Bella Kaufman, Pierfranco Conte, Y-S Lu, Masato Takahashi, H. Iwata, C. Wilke, M. Campone, and Dalila Sellami more...
Subjects: 0301 basic medicine, Cancer Research, medicine.medical_specialty, Randomization, Fulvestrant, business.industry, Hazard ratio, Cancer, medicine.disease, Placebo, Gastroenterology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Oncology, 030220 oncology & carcinogenesis, Internal medicine, Cohort, medicine, Clinical endpoint, business, medicine.drug
Abstract: Background: Hyperactivation of the phosphatidylinositol-3-kinase (PI3K) pathway can occur due to PIK3CA mutations, present in ~40% of patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2—) ABC. SOLAR-1, a Phase 3 randomized, double-blind trial (NCT02437318), investigated efficacy and safety of ALP (α-specific PI3K inhibitor) + FUL in pts with HR+, HER2— ABC. ALP+FUL met the primary endpoint by significantly extending progression-free survival (PFS) vs placebo (PBO) + FUL in the PIK3CA-mutant cohort (hazard ratio [HR] 0.65; 95% CI 0.50—0.85; p=0.00065; median 11.0 vs 5.7 months). Here we report overall survival (OS), subgroup data and safety in the PIK3CA-mutant cohort, and PFS by circulating tumor (ct)DNA PIK3CA mutation status in the total population. Methods: Enrollment was open to men/postmenopausal women with PIK3CA-mutant HR+, HER2— ABC and 1 prior line of endocrine therapy. Pts were randomized (1:1) to ALP (300mg/day) + FUL (500mg every 28 days and Cycle 1 Day 15) or PBO+FUL. OS was the key secondary endpoint. PFS was analyzed by PIK3CA mutant status in ctDNA, and in important prognostic subgroups, including line of treatment in ABC and prior cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) use. Safety was analyzed in the PIK3CA-mutant cohort. Results: 341 pts in the PIK3CA-mutant cohort received ALP+FUL (n=169) or PBO+FUL (n=172). Median follow-up from randomization to data cut-off was 20.0 months. At data cut-off, 92 deaths had occurred (52% of the total 178 pts planned for final OS analysis); 40 for ALP+FUL (24%) and 52 for PBO+FUL (30%). OS results were immature at data cut-off (HR 0.73; 95% CI 0.48—1.10; p=0.06; median not estimable vs 26.9 months). There was a 45% risk reduction in PFS for pts with ctDNA PIK3CA mutations (HR 0.55; 95% CI 0.39—0.79; n=186); 20% for pts without (HR 0.80; 95% CI 0.60—1.06; n=363). PFS treatment effect for ALP+FUL vs PBO+FUL was generally consistent across subgroups of interest, with a risk reduction of 29% for pts receiving first-line (1L) treatment (HR 0.71; 95% CI 0.49—1.03; n=177), and 39% for 2L treatment (HR 0.61; 95% CI 0.42—0.89; n=161); 52% in pts with prior CDK4/6i (HR 0.48; 95% CI 0.17—1.36; n=20) and 33% in pts without (HR 0.67; 95% CI 0.51—0.87; n=321). Most frequent all-grade adverse events (AEs; ≥40% in either arm by single preferred term; ALP+FUL vs PBO+FUL) were hyperglycemia (65% vs 9%), diarrhea (54% vs 11%), nausea (46% vs 20%), and rash (40% vs 6%). Grade 3/4 AEs in ≥10% pts in either arm were hyperglycemia (fasting plasma glucose >250mg/dL; 37% for ALP+FUL vs Conclusions: ALP+FUL showed consistent clinically meaningful treatment benefit for pts with ctDNA PIK3CA mutant status, and across pt subgroups, including pts with/without prior treatment for ABC and prior CDK4/6i use. OS data were not yet mature at the data cut-off, but OS appeared numerically longer for ALP+FUL vs PBO+FUL after 52% of events. Key words: advanced breast cancer; PI3K; alpelisib; endocrine therapy Citation Format: Juric D, Ciruelos E, Rubovszky G, Campone M, Loibl S, Rugo HS, Iwata H, Conte P, Mayer IA, Kaufman B, Yamashita T, Lu Y-S, Inoue K, Takahashi M, Pápai Z, Longin A-S, Mills D, Wilke C, Sellami D, Andre F. Alpelisib + fulvestrant for advanced breast cancer: Subgroup analyses from the phase III SOLAR-1 trial [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr GS3-08. more...
Published: 2019
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33. Abstract P6-21-01: Xentuzumab (BI 836845), an insulin-like growth factor (IGF)-neutralizing antibody (Ab), combined with exemestane and everolimus in hormone receptor-positive (HR+) locally advanced/metastatic breast cancer (LA/mBC): Randomized phase 2 results

Author: R-M Espadero, Joop P. W. van den Bergh, Jose Alejandro Perez-Fidalgo, A. Gonçalves, Serafin Morales, Peter Schmid, D Adamson, KS Lee, Aleix Prat, Patrick Neven, Noelia Martínez, G. Jerusalem, Y-S Lu, S-A Im, J. Cortés, J.P. Crown, L Schlieker, Thomas Bogenrieder, D Chin-Lun Huang, and M.P. Sablin more...
Subjects: 0301 basic medicine, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Population, Urology, 03 medical and health sciences, chemistry.chemical_compound, Insulin-like growth factor, 0302 clinical medicine, Breast cancer, Exemestane, Medicine, education, education.field_of_study, Everolimus, business.industry, Cancer, medicine.disease, Interim analysis, Metastatic breast cancer, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, business, medicine.drug
Abstract: Background: Xentuzumab (Xen), an IGF-1/-2-neutralizing Ab, binds IGF-1 and IGF-2, inhibits their growth-promoting signaling, and suppresses AKT activation by everolimus (Ev). This Phase 1b/2 trial evaluates Xen in combination with Ev and exemestane (Ex) in HR+/HER2− LA/mBC. Methods: The two-arm, open-label, randomized Phase 2 part enrolled female patients (pts) with HR+/HER2− LA/mBC not amenable to curative therapy and refractory to nonsteroidal aromatase inhibitors. Pts were randomized (1:1) to: oral Ev (10 mg/d) + Ex (25 mg/d); or Xen (1000 mg/wk iv) + Ev (10 mg/d) + Ex (25 mg/d). Randomization was stratified by visceral metastases (VM; Y vs N). Treatment continued in 28-day cycles until progression, intolerable adverse events (AEs) or other reasons for discontinuation. Primary endpoint was progression-free survival (PFS), with an interim futility analysis incorporated in the study design. Results: Following the results of the interim analysis, the Data Monitoring Committee (DMC) advised early termination of the trial and discontinuation of Xen treatment. Thus, Xen treatment exposure time and time-to-event data for the Xen+Ev+Ex arm are limited. Of the 139 women treated (Xen+Ev+Ex 70; Ev+Ex 69), 77% had VM. Median PFS was not significantly different between arms (Xen+Ev+Ex vs Ev+Ex, 7.3 vs 5.6 months; HR [95% CI] 0.97 [0.57–1.65]; p=0.91). In a pre-specified subgroup of pts without VM, Xen+Ev+Ex showed favorable PFS vs Ev+Ex (HR 0.21 [0.05–0.98]; Pint=0.0141). Pint values Conclusion: In the overall population, PFS did not improve with the addition of Xen to Ev+Ex and the trial was therefore discontinued early. Nevertheless, a favorable signal was observed in the pre-specified subgroup of pts without VM when treated with Xen+Ev+Ex, which warrants additional investigation. The safety profile was comparable between arms. Citation Format: Crown J, Sablin M-P, Cortés J, Bergh J, Im S-A, Lu Y-S, Martínez N, Neven P, Lee KS, Morales S, Pérez-Fidalgo JA, Adamson D, Goncalves A, Prat A, Jerusalem G, Schlieker L, Espadero R-M, Bogenrieder T, Chin-Lun Huang D, Schmid P. Xentuzumab (BI 836845), an insulin-like growth factor (IGF)-neutralizing antibody (Ab), combined with exemestane and everolimus in hormone receptor-positive (HR+) locally advanced/metastatic breast cancer (LA/mBC): Randomized phase 2 results [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P6-21-01. more...
Published: 2019
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34. Abstract PD1-11: nextMONARCH 1: Phase 2 study of abemaciclib plus tamoxifen or abemaciclib alone in HR+, HER2- advanced breast cancer

Author: Véronique Diéras, J. Cortés, M.M. Bear, Ozgur Ozyilkan, Alexey Manikhas, K. Petrakova, S-C Chen, Erika Hamilton, Erica L. Johnston, Roberto Hegg, G. Jerusalem, M. Martin, and Y-S Lu
Subjects: 0301 basic medicine, Cancer Research, medicine.medical_specialty, Loperamide, Chemotherapy, business.industry, medicine.medical_treatment, Hazard ratio, Phases of clinical research, Cancer, medicine.disease, Gastroenterology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Oncology, 030220 oncology & carcinogenesis, Internal medicine, medicine, Progression-free survival, business, Tamoxifen, medicine.drug
Abstract: Background Abemaciclib is a selective CDK4 & 6 inhibitor approved on a continuous dosing schedule for HR+, HER2- advanced breast cancer (ABC) as monotherapy (MONARCH 1) and in combination with endocrine therapy (ET). A previous Phase 1b (NCT01394016) cohort of HR+ ABC patients (pts) demonstrated efficacy of abemaciclib monotherapy (150mg and 200mg Q12H starting dose); given the small sample size and nonrandomized design the impact of the starting dose was unclear. nextMONARCH 1 (NCT02747004) evaluated abemaciclib in 2 monotherapy arms, in a randomized setting. Abemaciclib has been associated with dose-dependent early onset diarrhea that is well managed with antidiarrheal therapy. nextMONARCH 1 also explored the 200mg Q12H abemaciclib dose in combination with prophylactic loperamide to reduce incidence/severity of diarrhea and dose adjustments. A third arm evaluated abemaciclib + tamoxifen as a strategy to overcome endocrine resistance. Methods nextMONARCH 1 is a multicenter, randomized, open-label, Phase 2 study of abemaciclib or abemaciclib + tamoxifen in women with HR+, HER2- ABC who have progressed on or after prior ET and previously received chemotherapy. Pts were stratified by presence of liver metastases and prior use of tamoxifen in the advanced setting. Randomization was 1:1:1 to abemaciclib 150mg Q12H + daily tamoxifen 20mg (Arm A) or abemaciclib 150mg Q12H (Arm B); or abemaciclib 200mg Q12H + prophylactic loperamide (Arm C). Key eligibilities were ≥2 chemotherapy regimens (1-2 administered in metastatic setting), measurable disease and no prior treatment with CDK4 & 6 inhibitors. Primary objective was progression free survival (PFS). Key secondary objectives included objective response rate (ORR), dclinical benefit rate (CBR), and safety. PFS analysis tested superiority of Arm A to C at ∼110 events across the 2 arms assuming a hazard ratio (HR) of 0.667 to achieve ∼80% power. Arm B would be considered non-inferior to Arm C if the observed PFS HR is Results 234 pts were randomized to Arms A (n=78), B (n=79) and C (n=77). 166 PFS events have been observed (A: 57; B: 54; C: 55). Median PFS was 9.1 months in Arm A, 6.5 in Arm B and 7.4 in Arm C (A vs C: HR=.815, 95% CI, .556-1.193, p=.293; B vs C: HR=1.045, 95% CI, .711-1.535 p=.811). Investigator-assessed ORR was 34.6%, 24.1% and 32.5% (confirmed ORR: 25.6%, 19.0%, 28.6%) and CBR was 61.5%, 49.4% and 51.9% in Arms A, B and C, respectively. Prophylactic loperamide reduced the incidence and severity of diarrhea (C: 62.3%, Gr 3: 7.8%) compared to MONARCH 1 (90.2%, Gr 3: 19.7%, Dickler et al. 2017) resulting in similar rates of diarrhea with 150mg abemaciclib without prophylaxis (A: 53.8%, Gr 3: 1.3%; B: 67.1%, Gr 3: 3.8%). The adverse event profile across arms was generally consistent with other breast studies of abemaciclib. Conclusions nextMONARCH 1 confirmed single-agent activity of abemaciclib in heavily pretreated pts with HR+, HER2- ABC. Efficacy of abemaciclib monotherapy at 150mg was similar to 200mg. Combining tamoxifen with abemaciclib did not demonstrate a statistically significant improvement in PFS compared to abemaciclib monotherapy. Addition of prophylactic loperamide to abemaciclib 200mg resulted in diarrhea similar to 150mg without prophylaxis. Citation Format: Hamilton E, Cortes J, Dieras V, Ozyilkan O, Chen S-C, Petrakova K, Manikhas A, Jerusalem G, Hegg R, Lu Y, Bear MM, Johnston EL, Martin M. nextMONARCH 1: Phase 2 study of abemaciclib plus tamoxifen or abemaciclib alone in HR+, HER2- advanced breast cancer [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr PD1-11. more...
Published: 2019
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35. Precision Measurement of the(e++e−)Flux in Primary Cosmic Rays from 0.5 GeV to 1 TeV with the Alpha Magnetic Spectrometer on the International Space Station

Author: M. Aguilar, D. Aisa, B. Alpat, A. Alvino, G. Ambrosi, K. Andeen, L. Arruda, N. Attig, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, M. Battarbee, R. Battiston, J. Bazo, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, G. Bigongiari, V. Bindi, S. Bizzaglia, M. Bizzarri, G. Boella, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, S. Borsini, M. J. Boschini, M. Bourquin, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casaus, V. Cascioli, G. Castellini, I. Cernuda, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, H. Chen, G. M. Cheng, H. S. Chen, L. Cheng, A. Chikanian, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, B. Coste, M. Crispoltoni, Z. Cui, M. Dai, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, L. Di Masso, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Donnini, W. J. Du, M. Duranti, D. D’Urso, A. Eline, F. J. Eppling, T. Eronen, Y. Y. Fan, L. Farnesini, J. Feng, E. Fiandrini, A. Fiasson, E. Finch, P. Fisher, Y. Galaktionov, G. Gallucci, B. García, R. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, W. Gillard, F. Giovacchini, P. Goglov, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, C. Guandalini, I. Guerri, K. H. Guo, M. Habiby, S. Haino, K. C. Han, Z. H. He, M. Heil, J. Hoffman, T. H. Hsieh, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, H. Jinchi, K. Kanishev, G. N. Kim, K. S. Kim, Th. Kirn, R. Kossakowski, O. Kounina, A. Kounine, V. Koutsenko, M. S. Krafczyk, S. Kunz, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. L. Li, J. Q. Li, Q. Li, T. X. Li, W. Li, Y. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, H. Liu, T. Lomtadze, M. J. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lv, R. Majka, A. Malinin, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, L. Morescalchi, P. Mott, M. Müller, J. Q. Ni, N. Nikonov, F. Nozzoli, P. Nunes, A. Obermeier, A. Oliva, M. Orcinha, F. Palmonari, C. Palomares, M. Paniccia, A. Papi, M. Pauluzzi, E. Pedreschi, S. Pensotti, R. Pereira, F. Pilo, A. Piluso, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, E. Postaci, A. Putze, L. Quadrani, X. M. Qi, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, I. Rodríguez, S. Rosier-Lees, A. Rozhkov, D. Rozza, R. Sagdeev, J. Sandweiss, P. Saouter, C. Sbarra, S. Schael, S. M. Schmidt, D. Schuckardt, A. Schulz von Dratzig, G. Schwering, G. Scolieri, E. S. Seo, B. S. Shan, Y. H. Shan, J. Y. Shi, X. Y. Shi, Y. M. Shi, T. Siedenburg, D. Son, F. Spada, F. Spinella, W. Sun, W. H. Sun, M. Tacconi, C. P. Tang, X. W. Tang, Z. C. Tang, L. Tao, D. Tescaro, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Türkoğlu, T. Urban, V. Vagelli, E. Valente, C. Vannini, E. Valtonen, S. Vaurynovich, M. Vecchi, M. Velasco, J. P. Vialle, L. Q. Wang, Q. L. Wang, R. S. Wang, X. Wang, Z. X. Wang, Z. L. Weng, K. Whitman, J. Wienkenhöver, H. Wu, X. Xia, M. Xie, S. Xie, R. Q. Xiong, G. M. Xin, N. S. Xu, W. Xu, Q. Yan, J. Yang, M. Yang, Q. H. Ye, H. Yi, Y. J. Yu, Z. Q. Yu, S. Zeissler, J. H. Zhang, M. T. Zhang, X. B. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, P. Zuccon, and C. Zurbach more...
Published: 2014
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36. 309P Antineoplastic (ANP) therapies (Tx) after alpelisib (ALP) or placebo (PBO) + fulvestrant (FUL) in patients (Pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–), PIK3CA-mutated (Mut) advanced breast cancer (ABC): An analysis from SOLAR-1

Author: G. Rubovsky, H. Hu, Ines Lorenzo, Y-S Lu, Eva Ciruelos, F Andre, HS Rugo, Toshinari Yamashita, Dejan Juric, M. Miller, and Salomon M. Stemmer
Subjects: Fulvestrant, business.industry, Advanced breast, Cancer, Hematology, medicine.disease, Placebo, Oncology, Hormone receptor, Cancer research, medicine, In patient, business, Human Epidermal Growth Factor Receptor 2, medicine.drug
Published: 2021
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37. First Result from the Alpha Magnetic Spectrometer on the International Space Station: Precision Measurement of the Positron Fraction in Primary Cosmic Rays of 0.5–350 GeV

Author: M. Aguilar, G. Alberti, B. Alpat, A. Alvino, G. Ambrosi, K. Andeen, H. Anderhub, L. Arruda, P. Azzarello, A. Bachlechner, F. Barao, B. Baret, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, A. Basili, L. Batalha, J. Bates, R. Battiston, J. Bazo, R. Becker, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, P. Berges, B. Bertucci, G. Bigongiari, A. Biland, V. Bindi, S. Bizzaglia, G. Boella, W. de Boer, K. Bollweg, J. Bolmont, B. Borgia, S. Borsini, M. J. Boschini, G. Boudoul, M. Bourquin, P. Brun, M. Buénerd, J. Burger, W. Burger, F. Cadoux, X. D. Cai, M. Capell, D. Casadei, J. Casaus, V. Cascioli, G. Castellini, I. Cernuda, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, C. R. Chen, H. Chen, G. M. Cheng, H. S. Chen, L. Cheng, N. Chernoplyiokov, A. Chikanian, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, V. Commichau, C. Consolandi, A. Contin, C. Corti, M. T. Costado Dios, B. Coste, D. Crespo, Z. Cui, M. Dai, C. Delgado, S. Della Torre, B. Demirkoz, P. Dennett, L. Derome, S. Di Falco, X. H. Diao, A. Diago, L. Djambazov, C. Díaz, P. von Doetinchem, W. J. Du, J. M. Dubois, R. Duperay, M. Duranti, D. D’Urso, A. Egorov, A. Eline, F. J. Eppling, T. Eronen, J. van Es, H. Esser, A. Falvard, E. Fiandrini, A. Fiasson, E. Finch, P. Fisher, K. Flood, R. Foglio, M. Fohey, S. Fopp, N. Fouque, Y. Galaktionov, M. Gallilee, L. Gallin-Martel, G. Gallucci, B. García, J. García, R. García-López, L. García-Tabares, C. Gargiulo, H. Gast, I. Gebauer, S. Gentile, M. Gervasi, W. Gillard, F. Giovacchini, L. Girard, P. Goglov, J. Gong, C. Goy-Henningsen, D. Grandi, M. Graziani, A. Grechko, A. Gross, I. Guerri, C. de la Guía, K. H. Guo, M. Habiby, S. Haino, F. Hauler, Z. H. He, M. Heil, J. Heilig, R. Hermel, H. Hofer, Z. C. Huang, W. Hungerford, M. Incagli, M. Ionica, A. Jacholkowska, W. Y. Jang, H. Jinchi, M. Jongmanns, L. Journet, L. Jungermann, W. Karpinski, G. N. Kim, K. S. Kim, Th. Kirn, R. Kossakowski, A. Koulemzine, O. Kounina, A. Kounine, V. Koutsenko, M. S. Krafczyk, E. Laudi, G. Laurenti, C. Lauritzen, A. Lebedev, M. W. Lee, S. C. Lee, C. Leluc, H. León Vargas, V. Lepareur, J. Q. Li, Q. Li, T. X. Li, W. Li, Z. H. Li, P. Lipari, C. H. Lin, D. Liu, H. Liu, T. Lomtadze, Y. S. Lu, S. Lucidi, K. Lübelsmeyer, J. Z. Luo, W. Lustermann, S. Lv, J. Madsen, R. Majka, A. Malinin, C. Mañá, J. Marín, T. Martin, G. Martínez, F. Masciocchi, N. Masi, D. Maurin, A. McInturff, P. McIntyre, A. Menchaca-Rocha, Q. Meng, M. Menichelli, I. Mereu, M. Millinger, D. C. Mo, M. Molina, P. Mott, A. Mujunen, S. Natale, P. Nemeth, J. Q. Ni, N. Nikonov, F. Nozzoli, P. Nunes, A. Obermeier, S. Oh, A. Oliva, F. Palmonari, C. Palomares, M. Paniccia, A. Papi, W. H. Park, M. Pauluzzi, F. Pauss, A. Pauw, E. Pedreschi, S. Pensotti, R. Pereira, E. Perrin, G. Pessina, G. Pierschel, F. Pilo, A. Piluso, C. Pizzolotto, V. Plyaskin, J. Pochon, M. Pohl, V. Poireau, S. Porter, J. Pouxe, A. Putze, L. Quadrani, X. N. Qi, P. G. Rancoita, D. Rapin, Z. L. Ren, J. S. Ricol, E. Riihonen, I. Rodríguez, U. Roeser, S. Rosier-Lees, L. Rossi, A. Rozhkov, D. Rozza, A. Sabellek, R. Sagdeev, J. Sandweiss, B. Santos, P. Saouter, M. Sarchioni, S. Schael, D. Schinzel, M. Schmanau, G. Schwering, A. Schulz von Dratzig, G. Scolieri, E. S. Seo, B. S. Shan, J. Y. Shi, Y. M. Shi, T. Siedenburg, R. Siedling, D. Son, F. Spada, F. Spinella, M. Steuer, K. Stiff, W. Sun, W. H. Sun, X. H. Sun, M. Tacconi, C. P. Tang, X. W. Tang, Z. C. Tang, L. Tao, J. Tassan-Viol, Samuel C. C. Ting, S. M. Ting, C. Titus, N. Tomassetti, F. Toral, J. Torsti, J. R. Tsai, J. C. Tutt, J. Ulbricht, T. Urban, V. Vagelli, E. Valente, C. Vannini, E. Valtonen, M. Vargas Trevino, S. Vaurynovich, M. Vecchi, M. Vergain, B. Verlaat, C. Vescovi, J. P. Vialle, G. Viertel, G. Volpini, D. Wang, N. H. Wang, Q. L. Wang, R. S. Wang, X. Wang, Z. X. Wang, W. Wallraff, Z. L. Weng, M. Willenbrock, M. Wlochal, H. Wu, K. Y. Wu, Z. S. Wu, W. J. Xiao, S. Xie, R. Q. Xiong, G. M. Xin, N. S. Xu, W. Xu, Q. Yan, J. Yang, M. Yang, Q. H. Ye, H. Yi, Y. J. Yu, Z. Q. Yu, S. Zeissler, J. G. Zhang, Z. Zhang, M. M. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, P. Zuccon, and C. Zurbach more...
Published: 2013
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38. Abstract P1-09-01: A phase 1b study of abemaciclib plus pembrolizumab for patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC)

Author: HS Rugo, WJ John, Y-S Lu, Maura N. Dickler, Sara M. Tolaney, Peter Kabos, S Young, and I Smith
Subjects: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, business.industry, Cancer, Pembrolizumab, medicine.disease, Metastatic breast cancer, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Pharmacokinetics, chemistry, 030220 oncology & carcinogenesis, Internal medicine, medicine, Dosing, business, Adverse effect, Abemaciclib
Abstract: Background: Abemaciclib is a selective and potent small molecule inhibitor of CDK4 and 6, with evidence of single-agent antitumor activity, and a safety profile that enables dosing on a continuous schedule. Abemaciclib demonstrated anti-tumor activity as a single agent with a 19.7% objective response rate for women with previously treated HR+, HER2- MBC1. In the phase 1b study JPBH, abemaciclib demonstrated a tolerable safety profile when combined with endocrine or HER2 targeted agents for MBC2. Abemaciclib given BID in combination with pembrolizumab also demonstrated a tolerable safety profile in phase 1b study of stage IV NSCLC3. Methods: JPCE is a multicenter, nonrandomized, open-label, phase 1b study of abemaciclib plus pembrolizumab for patients with HR+, HER2- MBC or NSCLC (ClinicalTrials.gov NCT02779751). The study has 3 disease-specific cohorts, each with approximately 25 patients (N=75); the HR+, HER2- MBC cohort (part C) will be presented here. The primary objective was to characterize safety of the abemaciclib and pembrolizumab combination. Secondary objectives included efficacy endpoints (objective response rate, disease control rate, duration of response, progression-free survival, and overall survival), pharmacokinetics of abemaciclib plus pembrolizumab, and changes in patient-reported pain and disease-related symptoms. Patients received 150 mg of abemaciclib orally Q12H plus pembrolizumab 200 mg as a 30-minute IV infusion on Day 1 every 21 days. Eligible patients included women with confirmed HR+, HER2- MBC who have previously received at least 1 but no more than 2 prior chemotherapy regimens for MBC; are able to provide tumor tissue at baseline and at cycle 3, day 1; have measurable disease (RECIST v.1.1), adequate organ function, ECOG PS ≤1, are able to swallow oral medications; and have not received treatment with CDK4 & 6 or PD-1/ PD-L1 inhibitors. Results: At the time of abstract submission, study JPCE part C cohort (HR+, HER2- MBC) was fully enrolled at 25 patients. Data to be presented include patient demographics, baseline disease characteristics, adverse events by frequency and by grade, and preliminary efficacy of the abemaciclib plus pembrolizumab combination in HR+, HER2- MBC. References: 1. Dickler et al, Clin Cancer Res. 2017 2. Goetz et al. poster presented at SABCS, 2015 3. Goldman et al. poster presented at IASLC 2016 Citation Format: Rugo HS, Kabos P, Dickler MN, John WJ, Smith I, Lu Y, Young S, Tolaney SM. A phase 1b study of abemaciclib plus pembrolizumab for patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC) [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P1-09-01. more...
Published: 2018
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39. Abstract GS2-05: First-line ribociclib vs placebo with goserelin and tamoxifen or a non-steroidal aromatase inhibitor in premenopausal women with hormone receptor-positive, HER2-negative advanced breast cancer: Results from the randomized phase III MONALEESA-7 trial

Author: Jung Ho Sohn, Aditya Bardia, Gary Carlson, Lwc Chow, Gareth Hughes, R. Villanueva Vázquez, S Hirawat, Y-S Lu, Fabio Franke, Marco Colleoni, Debu Tripathy, Nadia Harbeck, KS Lee, S Hurvitz, C. Germa, Saúl Campos-Gómez, Kyung Hwa Jung, S-A Im, and I Diaz-Padilla more...
Subjects: 0301 basic medicine, Cancer Research, medicine.medical_specialty, Aromatase inhibitor, medicine.drug_class, business.industry, Letrozole, Goserelin, Anastrozole, medicine.disease, Placebo, Gastroenterology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Oncology, 030220 oncology & carcinogenesis, Internal medicine, medicine, business, Febrile neutropenia, Tamoxifen, medicine.drug
Abstract: Background:Endocrine therapy (ET) with ovarian function suppression is an established first-line treatment for pre- and peri-menopausal women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer (ABC). Addition of ribociclib (orally bioavailable, selective cyclin-dependent kinase [CDK] 4/6 inhibitor) to first-line ET prolonged progression-free survival (PFS) in a Phase III trial of postmenopausal women with HR+, HER2– ABC (MONALEESA-2). Here we report results from MONALEESA-7 (NCT02278120), the first double-blind, randomized, Phase III trial evaluating ribociclib + tamoxifen/non-steroidal aromatase inhibitor (NSAI) and goserelin specifically in pre- and peri-menopausal patients. Methods: Pre- or peri-menopausal women with HR+, HER2– ABC who had received ≤1 line of chemotherapy and no prior ET for ABC were randomized (1:1) to ribociclib (600 mg/day, 3-weeks-on/1-week-off) or placebo in combination with either tamoxifen (20 mg/day) or an NSAI (letrozole [2.5 mg/day] or anastrozole [1 mg/day]) + goserelin (3.6 mg every 28 days). The primary endpoint was locally assessed PFS. Secondary endpoints included overall response rate (ORR), clinical benefit rate (CBR), and safety. Results: 672 patients were enrolled. Baseline patient characteristics were balanced between treatment arms. The primary analysis was conducted after 318 events had occurred; median time from randomization to data cut-off date was 19.2 months. The study met its primary objective: PFS was significantly improved in the ribociclib arm (median PFS = 23.8 months; 95% CI: 19.2–not reached) vs the placebo arm (median PFS = 13.0 months; 95% CI: 11.0–16.4), with a hazard ratio of 0.553 (95% CI: 0.441–0.694; p=9.83×10–8). Subgroup analyses demonstrated consistent PFS benefits for ribociclib vs placebo. In patients with measurable disease at baseline, ORR was 51% vs 36% (ribociclib vs placebo arm; p=3.17×10–4) and CBR was 80% vs 67% (p=3.40×10–4). The most frequent all-grade adverse events (Aes; ≥25% of patients; ribociclib vs placebo arm) were neutropenia (76% vs 8%), hot flush (34% vs 34%), nausea (32% vs 20%), leukopenia (31% vs 6%), and arthralgia (30% vs 27%). Of these, neutropenia (61% vs 4%) and leukopenia (14% vs 1%) were the only Grade 3/4 events reported in ≥5% of patients (ribociclib vs placebo arm). Febrile neutropenia (ribociclib vs placebo arm) occurred in 2% vs Conclusions: MONALEESA-7, the first dedicated trial investigating a CDK4/6 inhibitor in pre- and peri-menopausal women with HR+, HER2– ABC, demonstrated that addition of ribociclib to first-line ET (tamoxifen/NSAI + goserelin) significantly prolonged PFS and had a manageable safety profile. The trial validates the clinical utility of ribociclib with multiple endocrine therapies, including tamoxifen, in premenopausal women with HR+, HER2– ABC. Citation Format: Tripathy D, Sohn J, Im S-A, Colleoni M, Franke F, Bardia A, Harbeck N, Hurvitz S, Chow L, Lee KS, Campos-Gomez S, Villanueva Vazquez R, Jung KH, Carlson G, Hughes G, Diaz-Padilla I, Germa C, Hirawat S, Lu Y-S. First-line ribociclib vs placebo with goserelin and tamoxifen or a non-steroidal aromatase inhibitor in premenopausal women with hormone receptor-positive, HER2-negative advanced breast cancer: Results from the randomized phase III MONALEESA-7 trial [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr GS2-05. more...
Published: 2018
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40. 330P Comparative effectiveness of ribociclib plus fulvestrant (RIB+FUL) versus palbociclib plus letrozole (PAL+LET) as first-line (1L) treatment (Tx) of HR+/HER2− advanced breast cancer (ABC) assessed by matching-adjusted indirect comparison (MAIC)

Author: R. DeBoer, Sara A. Hurvitz, A. Moynahan, David Chandiwana, H. Hu, Thomas E. Delea, A. Thuerigen, Y-S Lu, Peter A. Fasching, Brad Lanoue, and Joyce O'Shaughnessy
Subjects: Oncology, medicine.medical_specialty, Matching (statistics), Fulvestrant, business.industry, First line, Letrozole, Advanced breast, Cancer, Ribociclib, Hematology, Palbociclib, medicine.disease, Internal medicine, medicine, business, medicine.drug
Published: 2020
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41. 329P Ribociclib (RIB) in patients (pts) with HR+/HER2− advanced breast cancer (ABC) and resistance to prior endocrine therapy (ET) in the MONALEESA (ML) -3 and -7 trials

Author: Gabe S. Sonke, Agnes Lteif, Sara A. Hurvitz, G. Jerusalem, Y-S Lu, S-A. Im, S. Campos, H. Hu, Stephen Chia, Yirong Wang, Karen Rodriguez-Lorenc, and S.C. Lee
Subjects: Oncology, medicine.medical_specialty, business.industry, Advanced breast, Endocrine therapy, Cancer, Ribociclib, Hematology, medicine.disease, Internal medicine, medicine, In patient, business
Published: 2020
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42. LBA18 Overall survival (os) results from SOLAR-1, a phase III study of alpelisib (ALP) + fulvestrant (FUL) for hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer (ABC)

Author: G. Rubovszky, David Mills, M. Kaper, Dejan Juric, Hope S. Rugo, M. Campone, Fabrice Andre, H. Iwata, Ingrid A. Mayer, Bella Kaufman, Farhat Ghaznawi, S. Loibl, M. Miller, Toshinari Yamashita, Eva Ciruelos, Kenichi Inoue, Pierfranco Conte, Y-S Lu, Zsuzsanna Papai, and Masato Takahashi more...
Subjects: Fulvestrant, business.industry, Advanced breast, Cancer, Hematology, medicine.disease, Oncology, Hormone receptor, Cancer research, Overall survival, Medicine, business, Human Epidermal Growth Factor Receptor 2, medicine.drug
Published: 2020
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43. 93MO Overall survival (OS) results by age subgroup from the phase III MONALEESA-7 (ML-7) trial of premenopausal patients (pts) with HR+/HER2− advanced breast cancer (ABC) treated with endocrine therapy (ET) ± ribociclib (RIB)

Author: M.A. Colleoni, Ruth O'Regan, Arunava Chakravartty, Juan Pablo Zarate, Y-S Lu, Debu Tripathy, Yirong Wang, Fabio Franke, Fatima Cardoso, N.S. El Saghir, S-A. Im, Craig Wang, Saúl Campos-Gómez, and Sara A. Hurvitz more...
Subjects: Oncology, medicine.medical_specialty, business.industry, Advanced breast, Endocrine therapy, Cancer, Ribociclib, Hematology, medicine.disease, Internal medicine, medicine, Overall survival, business
Published: 2021
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44. Abstract OT1-04-03: Randomized phase II study of induction bevacizumab, etoposide and cisplatin followed by whole brain radiotherapy (WBRT) versus WBRT alone in breast cancer with untreated brain metastases (A-PLUS)

Author: L-M Tseng, J-C Yu, C-S Huang, Tw-W Chen, D-Y Chang, S-C Chen, T-C Chao, K-M Rau, T-Y Chao, C-H Lin, S-M Huang, A-L Cheng, C-F Chiu, Y-C Chang, and Y-S Lu
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Chemotherapy, Bevacizumab, business.industry, medicine.medical_treatment, Standard treatment, Phases of clinical research, medicine.disease, Regimen, Breast cancer, Internal medicine, medicine, Progression-free survival, business, Etoposide, medicine.drug
Abstract: Background For breast cancer (BC) patients with brain metastases (BM) who are not suitable for surgery/radiosurgery, whole brain radiotherapy (WBRT) remained the only standard treatment. Recently, we have demonstrated that bevacizumab preconditioning followed by etoposide and cisplatin (BEEP) is a highly effective treatment for BM of BC progressing from WBRT (Clin Cancer Res. 2015;21(8):1851). The CNS objective response rate is 77.1% according to volumetric criteria, and 60% according to RECIST 1.1. It has been demonstrated that enlarged brain tumor size is a predictor of WBRT failure. We hypothesized that, for BC with BM, induction BEEP treatment could decrease the size of brain metastases and thereby enhance effectiveness of WBRT. Methods This is a Phase II, randomized, open-labelled study (NCT02185352). Key inclusion criteria: BC with measurable brain metastatic tumor who had not received WBRT and not suitable for surgery or radiosurgery; KPS ≥30%. Key exclusion criteria: patients who had leptomeningeal metastases; history of disease progression during prior cisplatin treatment. In the experimental arm, patients will be treated by induction BEEP for three cycles followed by WBRT. In the control arm, patients will receive upfront WBRT for brain metastases. The BEEP regimen consist of bevacizumab (15 mg/kg) on Day 1 and, with a 1 day window period, followed by etoposide (70 mg/m2/day, Day 2 to Day 4) and cisplatin (70 mg/m2, Day 2), in a 21-day cycle. Stratification is based on the Graded Prognostic Assessment (GPA) score. Primary endpoint: brain-specific progression free survival (PFS) according to RECIST 1.1; key secondary endpoint: the 2-month brain-specific objective response rate (BS-ORR) of BEEP alone and WBRT alone. Other secondary endpoints include overall survival, extra-CNS tumor PFS, safety, time-to-improvement of neurological function,brain-specific PFS according to volumetric criteria, and BS-ORR. Approximately 126 patients will be 2:1 randomized. Multi-center recruitment is ongoing. To our knowledge this is the first randomized trial investigating a targeted therapy plus chemotherapy as induction regimen followed by WBRT as first line treatment for BC with BM. Citation Format: Lu Y-S, Tseng L-M, Yu J-C, Rau K-M, Chao T-Y, Chen S-C, Chiu C-F, Chang Y-C, Chen TW-W, Lin C-H, Chang D-Y, Chao T-C, Huang S-M, Huang C-S, Cheng A-L. Randomized phase II study of induction bevacizumab, etoposide and cisplatin followed by whole brain radiotherapy (WBRT) versus WBRT alone in breast cancer with untreated brain metastases (A-PLUS) [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr OT1-04-03. more...
Published: 2017
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45. Abstract P4-22-12: Ribociclib + fulvestrant in postmenopausal women with HR+, HER2– advanced breast cancer (ABC)

Author: Jason R. Dobson, Sara M. Tolaney, Thomas Bachelot, Andres Forero-Torres, Becker Hewes, S Chin Lee, Y-S Lu, Angelica Fasolo, Valentina Boni, C Pan, M Motta, and M Maur
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Fulvestrant, business.industry, Buparlisib, Cancer, Neutropenia, medicine.disease, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Breast cancer, chemistry, Pharmacokinetics, 030220 oncology & carcinogenesis, Internal medicine, medicine, Adverse effect, business, Progressive disease, medicine.drug
Abstract: Background: Endocrine therapy (ET) is the treatment backbone for hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) ABC, but efficacy is limited by ET resistance. The cyclin-dependent kinase (CDK) 4/6–cyclin D (CCND1)–retinoblastoma (Rb) and phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathways have been implicated in ET resistance. CDK4/6 and PI3K/mTOR inhibitors act synergistically with ET in preclinical and clinical studies of HR+ breast cancer. Ribociclib (LEE011; CDK4/6 inhibitor) + fulvestrant ± alpelisib (BYL719) or buparlisib (BKM120) in HR+, HER2– ABC is being investigated in a Phase Ib/II study (NCT02088684). Here, we present results from the ribociclib + fulvestrant combination, with intermittent and continuous ribociclib dosing. Methods: Postmenopausal patients (pts) with HR+, HER2– ABC refractory to aromatase inhibitors received ribociclib intermittently (600 mg/day, 3-weeks-on/1-week-off; Arm A) or continuously (400 mg/day; Arm B; following Arm A safety evaluation) + fulvestrant (500 mg; Cycle 1 Day 1 and 15; subsequent cycles Day 1). Primary objective: dose-limiting toxicities (DLTs) to confirm the recommended Phase II dose of ribociclib + fulvestrant. Secondary objectives: safety, pharmacokinetics, and preliminary antitumor activity (RECIST v1.1); biomarkers that may correlate with response were also assessed. Results: As of March 10, 2016, 24 pts received ribociclib + fulvestrant (Arm A, n=13; Arm B, n=11); 4 pts in Arm B were ongoing; median duration of exposure was 7.4 (Arm A) and 4.5 (Arm B) months. Median number of prior regimens: 4 (Arm A) and 3 (Arm B). Treatment discontinuation (n; Arm A, Arm B) was due to disease progression (11, 4), physician decision (1, 2), and adverse events (AEs; 1, 1). DLTs in Cycle 1 (n; Arm A, Arm B) were Grade [G] 3 pulmonary embolism (1, 0) and G3 aspartate aminotransferase elevation (0, 1). The most common G3/4 drug-related AE (Arm A, Arm B) was neutropenia (62%, 36%); 5 pts had QTcF prolongation >60 ms (n; 4, 1). Common all-Grade drug-related AEs (>35% pts) n (%)Arm A (n=13)Arm B (n=11)Neutropenia10 (77)7 (64)Fatigue9 (69)3 (27)Nausea6 (46)5 (46)Anemia6 (46)0 (0)Reduced appetite5 (39)1 (9) Best overall responses (BORs; n; Arm A, Arm B): partial response (PR; 3, 1), stable disease (SD; 9, 6), and neither complete response nor progressive disease (NCRNPD; non-measurable disease; 1, 4). Overall response rate: 23% (Arm A) and 9% (Arm B); disease control rate (BOR of complete response, PR, SD, or NCRNPD): 100% in both arms. Next-generation sequencing data (n; Arm A, Arm B) were available for 16 pts (7, 9): 5 pts had CCND1 alterations (PR [1, 0], SD [2, 1], and NCRNPD [0, 1]); 11 pts had PIK3CA alterations (PR [1, 0], SD [3, 4], and NCRNPD [1, 2]); 2 of these pts had both CCND1 and PIK3CA alterations (SD [1, 0] and NCRNPD [0, 1]). Conclusions: Ribociclib + fulvestrant has a manageable safety profile and shows preliminary clinical activity in pretreated pts with HR+, HER2– ABC. Both ribociclib intermittent and continuous dosing schedules were well tolerated. Clinical responses were observed in tumors with and without CDK4/6–cyclin D–Rb and PI3K/mTOR pathway alterations. Citation Format: Tolaney SM, Forero-Torres A, Boni V, Bachelot T, Lu Y-S, Maur M, Fasolo A, Motta M, Pan C, Dobson J, Hewes B, Chin Lee S. Ribociclib + fulvestrant in postmenopausal women with HR+, HER2– advanced breast cancer (ABC) [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P4-22-12. more...
Published: 2017
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46. 47MO Efficacy and quality of life (QOL) in premenopausal Asian patients (pts) with hormone receptor–positive (HR+), HER2-negative (HER2-) advanced breast cancer (ABC) treated in the MONALEESA (ML)-7 study

Author: S-A. Im, M-C. Liu, Vichien Srimuninnimit, Joohyuk Sohn, KS Lee, Kyung Hwa Jung, Yirong Wang, Y-S Yap, Lwc Chow, Y-S Lu, A. Gaur, M. Gao, and Govind Babu
Subjects: Oncology, medicine.medical_specialty, business.industry, Advanced breast, HER2 negative, Cancer, Hematology, medicine.disease, Quality of life, Hormone receptor, Internal medicine, medicine, business
Published: 2020
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47. 301P Sodium-glucose cotransporter-2 (SGLT-2) inhibitors for alpelisib (ALP)-induced hyperglycemia: A report of 6 cases from SOLAR-1

Author: J. Ponce Lorenzo, M. Ruiz Borrego, Joanne Wing Yan Chiu, Antonia Ridolfi, F. Gaudenzi, M. Airoldi, Farhat Ghaznawi, M. Margeli Vila, Y-S Lu, and Ines Lorenzo
Subjects: medicine.medical_specialty, Endocrinology, Oncology, business.industry, Sodium/Glucose Cotransporter 2, Internal medicine, medicine, Hematology, business
Published: 2020
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48. Abstract P4-14-23: A phase I/II study of the combination of lapatinib and oral vinorelbine in HER2 positive metastatic breast cancer

Author: Lwc Chow, T-Y Chao, S-M Huang, C-S Huang, A-L Cheng, Y-S Lu, Y-Y Hsieh, C-H Lin, Tw-W Chen, and D-C Yeh
Subjects: Gynecology, Cancer Research, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Cancer, Neutropenia, Lapatinib, medicine.disease, Vinorelbine, Metastatic breast cancer, Gastroenterology, Breast cancer, Oncology, Tolerability, Internal medicine, medicine, business, medicine.drug
Abstract: Background The combination of lapatinib and oral vinorelbine for HER2 positive metastatic breast cancer (MBC) is appealing due to the convenience of oral combinations, but the overlapping toxicities may be of concern. A phase I/II study was designed to understand the tolerability and efficacy of this combination treatment. Methods Female MBC patients (pts) with HER2 positive, but regardless of ER status, were eligible. In the phase I part, pts refractory to HER2-targeted treatment or chemotherapy were eligible. In the phase II part, only pts who had not exposed to HER2-targted treatment in the metastatic setting were eligible. Hormonal treatments were not allowed during the study for ER positive pts. Lapatinib was given once daily and oral vinorelbine was given on days 1 and 8 of a 21-day cycle. A 3+3 standard dose escalation rule was applied in phase I part (Table 1). The maximum tolerated dose (MTD) was the highest dose level with less than 33% of pts experiencing dose limiting toxicity (DLT) and will used as starting dose for phase II part. The primary endpoint of the phase II part was progression-free survival (PFS). Tumor response was assessed according to RECIST 1.1. Pt number estimation in the phase II part was based on Simon 2 stage design. Results From 2009 Jun to 2013 Feb, a total of 46 pts were enrolled in phase I (n=15) and II (n=31) parts. The median age was 52.8 (range 34.3-84.0) and the median follow-up time was 39.2 months (range 6.1-62.2). Twenty-eight (60.9%) pts were ER positive. In the phase I part, 2 pts in dose level III had DLTs (Grade 3 neutropenia and grade 3 diarrhea (n=1), prolonged neutropenia delaying next cycle treatment (n=1)). Other common ≥40% grade 1/2 adverse events (AE) in the first-cycle include diarrhea (80.0%), skin rash (66.7%), fatigue (60.0%), and vomiting (40.0%). The MTD was determined at lapatinib 1000 mg plus oral vinorelbine 50 mg/m2. In the phase II part, 11 pts had intra-patient dose escalation of vinorelbine from 50 to 60 mg/m2 after first-cycle if no major toxicities were noted. Grade 3/4 AEs in the first-cycle include neutropenia, diarrhea, and infection in 12.9%, 3.2% and 3.2%, respectively. Grade 1/2 AEs were similar to the phase I results. Persistent treatment (in 8 cycles) increased the rate of grade 3/4 neutropenia (22.6%) and ALT/AST elevation (6.5%).The median PFS was 5.6 months (95% CI 5.2-5.9); 6 (19.4%) pts had PR, and the clinical benefit rate (CBR) was 38.7%. A higher dose (level III vs. level II) of vinorelbine was not associated with a better CBR (p=0.71), PFS (p=0.73), or OS (p=0.11). Among pts who had disease progression records, 13.2% (5/38) had brain metastasis progression. Long-term disease control (under treatment for more than 2 years) were achieved in 13.0% (6/46, 2 ER positive, 4 ER negative) pts. Conclusion The combination of lapatinib 1000 mg and oral vinorelbine 60 mg/m2 was general tolerable with manageable toxicities. Clinical efficacy was demonstrated with long-term responders observed. Table 1 Vinorelbine D1 & D8/21-day cycleLapatinib Daily/21-day cycleNo. of pt recruitedNo. of pt with grade 3/4 toxicities in first-cycle mg/m2mgN=15(I)+31(II)NLevel 030100030Level I40100030Level II5010006+206(II)Level III6010003+112(I)Level IV60125000 Citation Format: Chen TW-W, Yeh D-C, Chao T-Y, Lin C-H, Chow LW-C, Hsieh Y-Y, Huang S-M, Cheng A-L, Huang C-S, Lu Y-S. A phase I/II study of the combination of lapatinib and oral vinorelbine in HER2 positive metastatic breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-14-23. more...
Published: 2016
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49. Abstract P4-13-27: A phase Ib dose de-escalation study of combined tamoxifen and goserelin acetate with alpelisib (BYL719) or buparlisib (BKM120) in premenopausal patients with HR+/HER2– locally advanced or metastatic breast cancer

Author: Roberta Valenti, A Canatar, I Chitapanarux, J Ro, Young-Ae Park, H Salomon, L-M Tseng, Y-S Lu, and T-Y Chao
Subjects: Gynecology, Cancer Research, medicine.medical_specialty, business.industry, Goserelin Acetate, Goserelin, Buparlisib, Common Terminology Criteria for Adverse Events, medicine.disease, Metastatic breast cancer, Gastroenterology, chemistry.chemical_compound, Breast cancer, Oncology, chemistry, Tolerability, Response Evaluation Criteria in Solid Tumors, Internal medicine, medicine, business, medicine.drug
Abstract: Background: Growing evidence suggests that concomitant inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin pathway could enhance and extend the clinical benefit of endocrine therapies in hormone receptor-positive (HR+) metastatic breast cancer (mBC). In this Phase Ib study (NCT02058381), alpelisib (a p110α-selective inhibitor) or buparlisib (a pan-PI3K inhibitor) was combined with tamoxifen and goserelin acetate in premenopausal women with mBC, a more prevalent patient population in Asian vs Western countries. Methods: Premenopausal women with HR+/human epidermal growth factor receptor 2-negative (HER2–) locally advanced or mBC and no prior endocrine therapy for metastatic disease were recruited in Taiwan, Republic of Korea, and Thailand. Patients (pts) received tamoxifen (20 mg once daily [QD]) and goserelin (3.6 mg Q28D) with either alpelisib (350 mg QD; Group 1) or buparlisib (100 mg QD; Group 2) on a continuous dosing schedule in 28-day cycles. The primary objective was to define the recommended Phase II dose (RP2D) for each combination, based on dose-limiting toxicities (DLTs) observed during Cycle 1, using a dose de-escalation design. Secondary objectives included pharmacokinetics, safety and tolerability (per Common Terminology Criteria for Adverse Events v4.03), efficacy (per Response Evaluation Criteria In Solid Tumors v1.1), and impact on quality of life. Results: As of February 2, 2015, 12 pts, all Asian, have been treated in the first cohort. In Group 1, 6 pts with a median age of 43 were treated with alpelisib (350 mg starting dose), and no DLTs were observed in Cycle 1. In Group 2, 6 pts with a median age of 47 were treated with buparlisib (100 mg starting dose), and 1 DLT of Grade (G) 3 alanine aminotransferase/aspartate aminotransferase elevation was observed. In Group 1, significant toxicities included hypokalemia (G3: 1 pt), rash (G3: 1 pt; G1/2: 2 pts), anemia (G3: 1 pt), leukopenia (G3: 1 pt), and infections (G3: 1 pt; G1/2: 1 pt); no G4 toxicities were reported. In Group 2, significant toxicities included liver toxicity (G4: 1 pt; G3: 1 pt; G1/2: 2 pts), psychiatric disorders (G4: 1 pt; G3: 1 pt; G1/2: 1 pt), rash (G3: 1 pt; G1/2: 2 pts), hypertension (G3: 1 pt; G1/2: 1 pt), and hyperglycemia (G3: 1 pt). No pts in Group 1, and 5/6 pts in Group 2, have discontinued treatment due to adverse events (AEs). Median treatment duration was 110 days in Group 1 and 71 days in Group 2. Conclusions: The combination of alpelisib (350 mg) with tamoxifen and goserelin resulted in a manageable toxicity profile. Meanwhile, the same combination with full-dose buparlisib (100 mg) was less well tolerated; despite the appearance of only one DLT during Cycle 1, the majority of pts subsequently stopped treatment due to AEs. An expansion phase is ongoing, and results will be integrated with safety, tolerability, and efficacy results for the first 15 pts enrolled in each group. PIK3CA status at baseline will also be assessed. Citation Format: Lu Y-S, Ro J, Tseng L-M, Chao T-Y, Chitapanarux I, Valenti R, Canatar A, Salomon H, Park YH. A phase Ib dose de-escalation study of combined tamoxifen and goserelin acetate with alpelisib (BYL719) or buparlisib (BKM120) in premenopausal patients with HR+/HER2– locally advanced or metastatic breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-13-27. more...
Published: 2016
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50. Search for a Higgs boson decaying into two photons in e(+)e(-) interactions at root s=189 GeV

Author: M. Vivargent, D. Piccolo, Vladimir Andreev, R. Ramelli, C. C. Samuel Ting, D.W. Schmitz, P. de Jong, N. Shivarov, R. van Gulik, P. Extermann, Salvatore Mele, Christoph Schäfer, B. Z. Yang, H. Hofer, S. S. Gau, K. L. Tung, Peter Denes, Robert Clare, Lamberto Luminari, Paolo Bagnaia, W. G. Ma, Thomas Hebbeker, G. Ambrosi, M. Rescigno, A. Barczyk, M. Gataullin, T. Sztaricskai, Paul Lecoq, R. W. Kraemer, M. Napolitano, A. Oulianov, C. Palomares, P. Wienemann, Adrian Biland, Egidio Longo, V. Plyaskin, Pierre Lecomte, F. Pierella, Federico Cindolo, A. Stone, Georgi Sultanov, T. S. Dai, R. A. Khan, S. Pensotti, Valery Schegelsky, Antonino Zichichi, C. Dionisi, Nicola Cavallo, H. K. Park, D. Duchesneau, H. S. Chen, L. Servoli, R. Leiste, Christoph Paus, Dimitri Bourilkov, P. Spillantini, Pablo Garcia-Abia, Werner Lustermann, Charles Timmermans, M. Dierckxsens, S. C. Tonwar, H. Rykaczewski, Frank Filthaut, Giovanni Organtini, Alain Hervé, T. Paul, H. Wilkens, G. Castellini, M. Chemarin, A. Bay, Ren-Yuan Zhu, B. Petersen, Thomas Ferguson, A. Malinin, A. Bajo, Alexei Raspereza, M. T. Dova, G. S. Muanza, I. Vodopianov, E. Fiandrini, Igor Vorobiev, J. A. van Dalen, A. Engler, G. M. Chen, G. Forconi, M. Pohl, S. Vlachos, Z. F. Gong, Gyorgy Vesztergombi, Peter Raics, M. Capell, H. S. Fesefeldt, E. Pistolesi, Luca Malgeri, Carlo Civinini, G. Raven, L. Xia, Aaron Dominguez, Jean Fay, M. Aguilar-Benitez, O. Grimm, Felicitas Pauss, Herwig Schopper, M. Pedace, S. C. Blyth, Marco Meschini, J. Rodin, T. Niessen, S. Rosier-Lees, P. Le Coultre, M. Basile, An. Zalite, A. De Salvo, P. Bartalini, A. Krüger, J. G. Branson, Kajari Mazumdar, X. D. Cai, Alessandra Doria, A. Gurtu, S. Villa, P. Duinker, P. Levtchenko, Panos A Razis, Christopher George Tully, S. N. Ganguli, A. Degré, H. Postema, W. J. Burger, Michael Dittmar, M. N. Kienzle-Focacci, A. Seganti, Harvey B Newman, M. Musy, R. Barillère, Jozsef Toth, Claudio Luci, D. Pandoulas, F. C. Erné, Wolfgang Lohmann, H. Vogt, B. Bertucci, F. Anselmo, Nicanor Colino, A. Lebedev, D. Mangeol, D. Luckey, B. Musicar, Roberto Battiston, Gerjan Bobbink, B. Borgia, G. Schwering, A. Csilling, J. Ulbricht, Dong-Chul Son, C. Furetta, M. Lebeau, J.P. Martin, Simonetta Gentile, S. R. Hou, M. Wadhwa, A. Balandras, D. J. Schotanus, K. Freudenreich, B. Tellili, J. Berdugo, J. J. Blaising, Marco Pieri, J. Hirschfelder, Stefano Giagu, J. D. Swain, A. Hasan, Raffaello D'Alessandro, F. Cesaroni, A. Buijs, Leonardo Merola, E. J. Sanchez, Maurizio Biasini, Pierluigi Paolucci, Marta Felcini, Peter H. Fisher, A. Klimentov, L. Lugnier, W. Kittel, I. Clare, G. Cara Romeo, B. P. Roe, S. Reucroft, S. V. Baldew, D. O. Prokofiev, Francesco Becattini, L. Tauscher, X. L. Wang, S. Cucciarelli, M. Pauluzzi, G. Marian, Aleandro Nisati, F. Brochu, C. Maña, D. della Volpe, H. J. Lee, Marcella Diemoz, G. Landi, M. Fabre, Jasper Kirkby, M. A. Falagan, I. Vetlitsky, Giovanni Passaleva, Joseph Quartieri, E. Delmeire, U. K. Chaturvedi, T. Azemoon, M. Zöller, Mingming Yang, H. F. Chen, An.A. Vorobyov, A. Böhm, Simone Paoletti, Y. S. Lu, Riccardo Paramatti, A. Favara, D. Ren, Anna Katharina Kopp, Zheng Wang, H. J. Yang, R. Ofierzynski, P. G. Rancoita, Pàl Hidas, Zhenyu Zhang, A. J.M. Muijs, S. Bhattacharya, L. Baksay, F. Cotorobai, B. De La Cruz, A. Shvorob, R. Ranieri, S. Likhoded, A. Kunin, Marcos Cerrada, B. N. Jin, Manjit Kaur, G. Ruggiero, A. C. Weber, L. Z. Sun, O. Adriani, Z. Szillasi, Hafeez R Hoorani, S. Wynhoff, C-Q. Li, A. Rosca, V. K. Gupta, H. Nowak, G. Chiefari, D. Vicinanza, S. Shevchenko, J. H. Field, Imad Baptiste Laktineh, V. Koutsenko, Lucas Taylor, Francesca Cavallari, M. G. Alviggi, E. Valente, M. E. Sarakinos, F. Behner, Yu. Galaktionov, L. Bellucci, Z. A. Liu, A. Vorvolakos, F. DeNotaristefani, W. J. Metzger, B. Stoyanov, S. Schmidt-Kaerst, T. Angelescu, G. Mirabelli, W. Wallraff, J. Alcaraz, G. Y. Zhu, E. Shumilov, P. Déglon, P. Ladron de Guevara, G. Viertel, S. Banerjee, K. Lübelsmeyer, S. Saremi, J. Casaus, V. Shoutko, K. Sudhakar, Ya Han Hu, D. Haas, Manas Maity, Jeremy Mans, Tariq Aziz, Claudia Cecchi, M. von der Mey, P. Berges, Hans J. Vogel, A. Buffini, A. Mihul, J. B. Ye, G. Alemanni, J. K. Kim, F. L. Linde, C. G. Yang, J. Pothier, Yu. Zalite, M. Acciarri, Guo-Ming Chen, J. M. Le Goff, J. Yamamoto, N. Gheordanescu, W. T. Lin, S. Costantini, S. C. Yeh, J. A. Rubio, A. Chen, D. van Dierendonck, J. Salicio, Crisostomo Sciacca, B. Zimmermann, D. Kiss, Konrad Deiters, G. B. Mohanty, Alberto Aloisio, Ph. Lebrun, X. W. Tang, P. A. Piroué, M. W. Gruenewald, M. Chamizo, I. Josa-Mutuberria, M. Kräber, Dong-Hyun Kim, G. Zilizi, R. Berbeco, A. Arefiev, R. R. McNeil, G. Carlino, G. Holzner, K. Riles, F. Marzano, G. Coignet, W. Krenz, S. X. Wu, Inkyu Park, M. Steuer, M. A. Rahaman, D. Perret-Gallix, D. Prokofiev, Luisa Cifarelli, L. J. Gutay, U. Becker, I. Duran, F. J. Eppling, L. W. Jones, S. M. Ting, J.V. Allaby, S. Patricelli, D. Hatzifotiadou, Laszlo Boldizsar, L. Romero, S. Sarkar, M. Bourquin, G. J. Grenier, Joachim Mnich, P. Achard, H. Milcent, T. Moulik, A. M. Cartacci, A. C. König, D. P. Stickland, Y. H. Chang, Francesca Nessi-Tedaldi, J. D. Burger, T. Siedenburg, G. Rahal-Callot, N. Raja, D. Dufournaud, H. Suter, Ia Iashvili, Z. Z. Xu, C. H. Lin, V. Pojidaev, Y. Uchida, Minhong Wang, M. P. Sanders, B. L. Betev, Speranza Falciano, A. Straessner, Luca Lista, Sabine Riemann, H. Anderhub, Michele Guida, B. Smith, S. Braccini, R. de Asmundis, I. Fisk, H. El Mamouni, Oleg Fedin, Max Weber, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CMS, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), L3, Achard, Pablo, Ambrosi, Giovanni, Bourquin, Maurice, Braccini, Saverio, Chamizo Llatas, Maria, Deglon, Patrick, Delmeire, Evelyne, Extermann, Pierre, Field, John, Kienzle, Maria-Novella, Pohl, Martin, Acciarri, M., Achard, P., Adriani, O., Aguilar Benitez, M., Alcaraz, J., Alemanni, G., Allaby, J., Aloisio, Alberto, Alviggi, Mariagrazia, Ambrosi, G., Anderhub, H., Andreev, V. P., Angelescu, T., Anselmo, F., Arefiev, A., Azemoon, T., Aziz, T., Bagnaia, P., Bajo, A., Baksay, L., Balandras, A., Baldew, S. V., Banerjee, S., Barczyk, A., Barillere, R., Bartalini, P., Basile, M., Battiston, R., Bay, A., Becattini, F., Becker, U., Behner, F., Bellucci, L., Berbeco, R., Berdugo, J., Berges, P., Bertucci, B., Betev, B. L., Bhattacharya, S., Biasini, M., Biland, A., Blaising, J. J., Blyth, S. C., Bobbink, G. J., Bohm, A., Boldizsar, L., Borgia, B., Bourilkov, D., Bourquin, M., Braccini, S., Branson, J. G., Brochu, F., Buffini, A., Buijs, A., Burger, J. D., Burger, W. J., Cai, X. D., Capell, M., Romeo, G. C., Carlino, G., Cartacci, A. M., Casaus, J., Castellini, G., Cavallari, F., Cavallo, N., Cecchi, C., Cerrada, M., Cesaroni, F., Chamizo, M., Chang, Y. H., Chaturvedi, U. K., Chemarin, M., Chen, A., Chen, G., Chen, G. M., Chen, H. F., Chen, H. S., Chiefari, Giovanni, Cifarelli, L., Cindolo, F., Civinini, C., Clare, I., Clare, R., Coignet, G., Colino, N., Costantini, S., Cotorobai, F., B. d., La, Csilling, A., Cucciarelli, S., Dai, T. S., Van, J. A., D'Alessandro, R., Asmundis, R. d., Deglon, P., Degre, A., Deiters, K., DELLA VOLPE, Domenico, Delmeire, E., Denes, P., Denotaristefani, F., Salvo, A. D., Diemoz, M., Dierckxsens, M., Dierendonck, D. v., Dionisi, C., Dittmar, M., Dominguez, A., Doria, A., Dova, M. T., Duchesneau, D., Dufournaud, D., Duinker, P., Duran, I., Mamouni, H. E., Engler, A., Eppling, F. J., Erne, F. C., Extermann, P., Fabre, M., Falagan, M. A., Falciano, S., Favara, A., Fay, J., Fedin, O., Felcini, M., Ferguson, T., Fesefeldt, H., Fiandrini, E., Field, J. H., Filthaut, F., Fisher, P. H., Fisk, I., Forconi, G., Freudenreich, K., Furetta, C., Galaktionov, Y., Ganguli, S. N., Garcia Abia, P., Gataullin, M., Gau, S. S., Gentile, S., Gheordanescu, N., Giagu, S., Gong, Z. F., Grenier, G., Grimm, O., Gruenewald, M. W., Guida, M., Gulik, R. v., Gupta, V. K., Gurtu, A., Gutay, L. J., Haas, D., Hasan, A., Hatzifotiadou, D., Hebbeker, T., Herve, A., Hidas, P., Hirschfelder, J., Hofer, H., Holzner, G., Hoorani, H., Hou, S. R., Hu, Y., Iashvili, I., Jin, B. N., Jones, L. W., Jong, P. d., Josa Mutuberria, I., Khan, R. A., Kaur, M., Kienzle Focacci, M. N., Kim, D., Kim, J. K., Kirkby, J., Kiss, D., Kittel, W., Klimentov, A., Konig, A. C., Kopp, A., Koutsenko, V., Kraber, M., Kraemer, R. W., Krenz, W., Kruger, A., Kunin, A., P. L., De, Laktineh, I., Landi, G., Lebeau, M., Lebedev, A., Lebrun, P., Lecomte, P., Lecoq, P., Coultre, P. L., Lee, H. J., J. M., Le, Leiste, R., Levtchenko, P., Li, C., Likhoded, S., Lin, C. H., Lin, W. T., Linde, F. L., Lista, L., Liu, Z. A., Lohmann, W., Longo, E., Y. S., Lu, Lubelsmeyer, K., Luci, C., Luckey, D., Lugnier, L., Luminari, L., Lustermann, W., W. G., Ma, Maity, M., Malgeri, L., Malinin, A., Mana, C., Mangeol, D., Mans, J., Marian, G., Martin, J. P., Marzano, F., Mazumdar, K., Mcneil, R. R., Mele, S., Merola, Leonardo, Meschini, M., Metzger, W. J., Der, M. v., Mihul, A., Milcent, H., Mirabelli, G., Mnich, J., Mohanty, G. B., Moulik, T., Muanza, G. S., A. J. M., Musicar, B., Musy, M., Napolitano, Marco, Nessi Tedaldi, F., Newman, H., Niessen, T., Nisati, A., Nowak, H., Ofierzynski, R., Organtini, G., Oulianov, A., Palomares, C., Pandoulas, D., Paoletti, S., Paolucci, P., Paramatti, R., Park, H. K., Park, I. H., Passaleva, G., Patricelli, Sergio, Paul, T., Pauluzzi, M., Paus, C., Pauss, F., Pedace, M., Pensotti, S., Perret Gallix, D., Petersen, B., Piccolo, D., Pierella, F., Pieri, M., Piroue, P. A., Pistolesi, E., Plyaskin, V., Pohl, M., Pojidaev, V., Postema, H., Pothier, J., Prokofiev, D. O., Prokofiev, D., Quartieri, J., Rahal Callot, G., Rahaman, M. A., Raics, P., Raja, N., Ramelli, R., Rancoita, P. G., Ranieri, R., Raspereza, A., Raven, G., Razis, P., Ren, D., Rescigno, M., Reucroft, S., Riemann, S., Riles, K., Rodin, J., Roe, B. P., Romero, L., Rosca, A., Rosier Lees, S., Rubio, J. A., Ruggiero, G., Rykaczewski, H., Saremi, S., Sarkar, S., Salicio, J., Sanchez, E., Sanders, M. P., Sarakinos, M. E., Schafer, C., Schegelsky, V., Schmidt Kaerst, S., Schmitz, D., Schopper, H., Schotanus, D. J., Schwering, G., Sciacca, Crisostomo, Seganti, A., Servoli, L., Shevchenko, S., Shivarov, N., Shoutko, V., Shumilov, E., Shvorob, A., Siedenburg, T., Son, D., Smith, B., Spillantini, P., Steuer, M., Stickland, D. P., Stone, A., Stoyanov, B., Straessner, A., Sudhakar, K., Sultanov, G., Sun, L. Z., Suter, H., Swain, J. D., Szillasi, Z., Sztaricskai, T., Tang, X. W., Tauscher, L., Taylor, L., Tellili, B., Timmermans, C., S. C. C., Ting, S. M., Tonwar, S. C., Toth, J., Tully, C., Tung, K. L., Uchida, Y., Ulbricht, J., Valente, E., Vesztergombi, G., Vetlitsky, I., Vicinanza, D., Viertel, G., Villa, S., Vivargent, M., Vlachos, S., Vodopianov, I., Vogel, H., Vogt, H., Vorobiev, I., Vorobyov, A. A., Vorvolakos, A., Wadhwa, M., Wallraff, W., Wang, M., Wang, X. L., Wang, Z. M., Weber, A., Weber, M., Wienemann, P., Wilkens, H., S. X., Wu, Wynhoff, S., Xia, L., Z. Z., Xu, Yamamoto, J., Yang, B. Z., Yang, C. G., Yang, H. J., Yang, M., J. B., Ye, Yeh, S. C., Zalite, A., Zalite, Y., Zhang, Z. P., Zhu, G. Y., Zhu, R. Y., Zichichi, A., Zilizi, G., Zimmermann, B., and Zoller, M. more...
Subjects: COLLISIONS, Z boson, Nuclear and High Energy Physics, Particle physics, Photon, Higgs boson, L3 data collected at LEP, Electron–positron annihilation, STANDARD MODEL, 2 PHOTONS, FOS: Physical sciences, ddc:500.2, 01 natural sciences, 7. Clean energy, Lower limit, High Energy Physics - Experiment, Standard Model, W-PAIR PRODUCTION, Nuclear physics, BHABHA SCATTERING, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, MONTE-CARLO PROGRAM, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], PARTICLES, TEVATRON, 010306 general physics, DETECTOR, Ciencias Exactas, L3 EXPERIMENT, Physics, 010308 nuclear & particles physics, Branching fraction, High Energy Physics::Phenomenology, Física, Function (mathematics), Scalar boson, High Energy Physics::Experiment, Particle Physics - Experiment
Abstract: A search is performed for a Higgs boson produced in association with a Z boson and decaying into two photons, using the L3 data collected at LEP at a centre-of-mass energy of 189 GeV. All decay modes of the Z are considered. No signal is observed and limits on the branching fraction of the Higgs boson decay into two photons as a function of the Higgs mass are derived assuming a Standard Model production rate. A lower limit on the mass of a fermiophobic Higgs is set at 94.9 GeV at 95% confidence level., Facultad de Ciencias Exactas more...
Published: 2016
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