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Objective Modify hydroxyapatite whisker (HAPw) by nano zinc oxide(ZnO) to synthesize a kind of antibacterial implant bone compound material, and study its degradation and substantial changing in extreme environment. Methods Nano ZnO was prepared through sol-gel method, and modified HAPw by nano ZnO to achieve nano ZnO-HAPw compound material. According to ISO 10993-14 standards,the degradation rate of nano ZnO-HAPw was tested after soaked in citrate buffer solution, the surface morphology change was examined with by scanning electric microscope(SEM) and XRD analysis. Results The degradation rate was 25.44% (HAPw/n-ZnO),18.59% (HAPw), respectively. SEMshowed apparently that HAPw fractured and the quantities of nano ZnO particles significantly reduced after soaking. XRD analysis indicated that the three strong peaks of HAPw lowered. Conclusion Nano ZnO-HAPw is a low soluble materials. [ABSTRACT FROM AUTHOR]