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PURPOSE: To observe and evaluate the clinical features and treatment strategies of IV myelosuppression after induction chemotherapy of oral mucosa squamous cell carcinoma under conventional dosage. METHODS: Twenty-nine patients of oral mucosa squamous cell carcinoma pathologically diagnosed between 2006 and 2012 were enrolled into this study. The patients received induction chemotherapy with docetaxel-cisplatin-5-fluorouracil (TPF) and suffered from grade IV myelosuppression. Regulations and treatment strategies of the bone marrow myelosuppression were analyzed, retrospectively. RESULTS: Twenty-nine cases had bone marrow suppression 9-14 days after induction chemotherapy, and the median time was 10 days, with a "U"-shaped fluctuation pattern. There were 26 cases with colony-stimulating factor (CSF) therapy completing treatment according to the schedule and 2 cases were required to radiotherapy because of unsatisfied effect of CSF therapy. One case died and the death rate after chemotherapy was 0.68% in this group. CONCLUSIONS: The incidence of grade IV myelosuppression is normal and fatal. This study shows the starting time of the "U"-shaped fluctuation and the necessaries of adding CSF therapy at the same time. The emergency treatment of myelosuppression should be used including single disinfected ward mouthwash and therapy of CSF drug. [ABSTRACT FROM AUTHOR]

PURPOSE: To study the hemostatic mechanism of the inorganic active element bone scaffold materials in vitro. METHODS: The specific surface area, along with the permeability ratio and expansion degree of the inorganic active element bone scaffold materials were evaluated in vitro. Experiments o alteration of hemorheology and platelet aggregation were done to detect the change of blood viscosity and activity of platelet aggregation after immersion of bone scaffold materials in the blood, and platelet adhesion with bone scaffold materials were observed under scanning electron microscope (SEM). The results were analyzed by using SPSs11.0 software package for paired t test. RESULTS: The specific surface area of the inorganic active element bone scaffold materials was 210m²/g, porous ratio was 90%, permeability ratio was 34% and expansion degree was 5.6%. The inorganic active element bone scaffold materials could increase the blood viscosity at median shear rate and high shear rate after immersion in the blood (P<0.05) and induce the aggregation and adhesion of the platelet. CONCLUSION: The inorganic active element bone scaffold materials possesses favorable hemostatis characteristics, which makes it one of the high potential scaffold materials of bone tissue engineering. Supported by Key Science and Technology Project of Anhui Province (Grant No.06013131B). Key Scientific Research Foundation of Anhui Province (Grant No.04088009). [ABSTRACT FROM AUTHOR]

PURPOSE: To discuss the diagnosis and comprehensive treatment based on operation and close observation of canceration of oral lichen planus (OLP). METHODS: Sixty-four patients with cancerous OLP were retrospectively analyzed, who were clinically diagnosed and pathologically confirmed to be OLP canceration from 1998 to 2007. Only patients who had buccal mucosal lesions were selected. After 21 days of PVP induction chemotherapy, all the patients underwent radical resection. RESULTS: The 1- and 3-year survival rate was 87.50% and 75.00%, respectively; regional recurrences occurred in 11 patients (17.18%). CONCLUSIONS: A criteria of OLP canceration was established, which solved the disagreement with OLP canceration by Krutchkoff et al; treatment of OLP canceration should be comprehensive. [ABSTRACT FROM AUTHOR]

Purpose: To study the medium or long-term survival rates of different methods used in the treatment of advanced squamous cell carcinoma of the maxillary sinus (SCMS)., Methods: Patients were treated by one of the following methods: 231 patients were treated with induction chemotherapy, followed by radical resection and radiotherapy (CSR); 128 patients were treated with preoperative irradiation (RS), and 87 patients underwent adjuvant radiotherapy (RSR). A total of 446 cases of SCMS from June 1985 to December 2008 were managed with unscheduled application of the above 3 kinds of treatment options. The dose of 231 patients with CSR and 128 patients with RS was 60-70 Gy/30-35 times/5-7 week and 40-50 gy/20-25 times/4-5 week, respectively. Dose in RSR accounted for half of that in CSR. The number of cases undergoing total resection of maxilla, subtotal resection of maxilla and extended excision of maxilla were 299, 111 and 36, respectively (13 cases had orbital exenteration). The number of patients with therapeutic radical neck dissection, functional neck dissection and supraomohyoid neck dissection were 49, 73 and 56, respectively. The data was analyzed with SPSS16.0 software package., Results: Five-year survival rate in 446 cases was 45.96% (205/446), and 220 patients died of tumors, among which 84.09% (185/220) of death were due to local recurrences. The 5-year survival rate of CSR, RS, and RSR were 45.88% (106/23), 46.09% (59/128) and 45.97% (40/87), respectively; Totally 83.33% of CSR, 85.71% of RS and 83.72% of RSR died of local recurrences. There was no significant difference in the survival rates among CSR, RS and RSR., Conclusions: Unscheduled comprehensive treatment have a higher 5-year survival rate in this advanced SCMS. Elective neck irradiation and neck dissection are necessary for medium or advanced squamous cell carcinoma of maxillary sinus.

Purpose: To observe and evaluate the clinical features and treatment strategies of IV myelosuppression after induction chemotherapy of oral mucosa squamous cell carcinoma under conventional dosage., Methods: Twenty-nine patients of oral mucosa squamous cell carcinoma pathologically diagnosed between 2006 and 2012 were enrolled into this study. The patients received induction chemotherapy with docetaxel-cisplatin-5-fluorouracil (TPF) and suffered from grade IV myelosuppression. Regulations and treatment strategies of the bone marrow myelosuppression were analyzed, retrospectively., Results: Twenty-nine cases had bone marrow suppression 9-14 days after induction chemotherapy, and the median time was 10 days, with a "U"-shaped fluctuation pattern. There were 26 cases with colony-stimulating factor(CSF) therapy completing treatment according to the schedule and 2 cases were required to radiotherapy because of unsatisfied effect of CSF therapy. One case died and the death rate after chemotherapy was 0.68% in this group., Conclusions: The incidence of grade IV myelosuppression is normal and fatal. This study shows the starting time of the "U"-shaped fluctuation and the necessaries of adding CSF therapy at the same time. The emergency treatment of myelosuppression should be used including single disinfected ward mouthwash and therapy of CSF drug.