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787 results on '"YOO, CHUL-GYU"'

7. Analysis of PM2.5 inorganic and organic constituents to resolve contributing sources in Seoul, South Korea and Beijing, China and their possible associations with cytokine IL-8

Author

Park, Jieun, primary, Lee, Kyoung-Hee, additional, Kim, Hyewon, additional, Woo, Jisu, additional, Heo, Jongbae, additional, Jeon, Kwonho, additional, Lee, Chang-Hoon, additional, Yoo, Chul-Gyu, additional, Hopke, Philip K., additional, Koutrakis, Petros, additional, and Yi, Seung-Muk, additional

Published
2023
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33. YPL-001 Shows Various Beneficial Effects against Cigarette Smoke Extract-Induced Emphysema Formation: Anti-Inflammatory, Anti-Oxidative, and Anti-Apoptotic Effects.

Author

Lee, Kyoung-Hee, Woo, Jisu, Kim, Jiyeon, Lee, Chang-Hoon, and Yoo, Chul-Gyu

Subjects
CIGARETTE smoke, SMOKING, CHRONIC obstructive pulmonary disease, DNA structure, HEME oxygenase, NAD (Coenzyme)
Abstract

Inflammation, oxidative stress, and apoptosis are thought to be important causes of chronic obstructive pulmonary disease (COPD). We investigated the effect of YPL-001 (under phase 2a study, ClinicalTrials.gov identifier NCT02272634), a drug derived from Pseudolysimachion rotundum var. subintegrum, on cigarette smoke extract (CSE)-induced inflammation, the anti-oxidative pathway, and apoptosis in human lung epithelial cells and on CSE-induced emphysema in mice. YPL-001 suppressed CSE-induced expression of IL8 mRNA and protein. This was due to the reduction in NF-κB transcriptional activity by YPL-001, which resulted from the blockade of acetylation of the NF-κB subunit p65 (Lys310). Histone deacetylases (HDACs) prevent gene transcription by condensing the DNA structure and affecting NF-κB nuclear binding. YPL-001 alone increased HDAC2 activity and enhanced CSE-induced activation of HDAC2. YPL-001-induced suppression of NF-κB transcriptional activity might be caused by increased HDAC2 activity. YPL-001 increased nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression via both degradation of its inhibitory protein, Kelch-like ECH-associated protein 1, and an increase in de novo protein synthesis. YPL-001 increased the DNA binding activity of Nrf2. Consequently, YPL-001 upregulated the expression of Nrf2-targeted anti-oxidant genes such as NAD(P)H quinone dehydrogenase 1 and heme oxygenase 1. Moreover, YPL-001 significantly suppressed CSE-induced apoptotic cell death. In vivo study showed that CSE-induced emphysematous changes, neutrophilic inflammation, protein leakage into bronchoalveolar space, and lung cell apoptosis in mice were suppressed by YPL-001 treatment. Taken together, these results suggest that YPL-001 is a good therapeutic candidate for the treatment of COPD by blocking inflammation and apoptosis and activating the anti-oxidative pathway. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Prognostic Value of Central Venous Oxygen Saturation and Blood Lactate Levels Measured Simultaneously in the Same Patients with Severe Systemic Inflammatory Response Syndrome and Severe Sepsis

Author

Park, Ju-Hee, Lee, Jinwoo, Park, Young Sik, Lee, Chang-Hoon, Lee, Sang-Min, Yim, Jae-Joon, Kim, Young Whan, Han, Sung Koo, and Yoo, Chul-Gyu

Subjects
Sepsis -- Research -- Diagnosis -- Prognosis, Lactates -- Research -- Physiological aspects, Active oxygen -- Research -- Physiological aspects, Health
Abstract

Background Blood lactate levels and central venous oxygen saturation (ScvO.sub.2) are known to be useful indicators of global tissue hypoxia. However, it is unclear whether ScvO.sub.2 correlates with lactate levels when measured simultaneously and whether changes in ScvO.sub.2 or lactate levels in serial measurements have prognostic value. We investigated the correlation between ScvO.sub.2 and lactate levels measured simultaneously and their association with clinical outcomes. Methods We performed a prospective observational study of patients with severe systemic inflammatory response syndrome (SIRS) and severe sepsis who were admitted to the medical intensive care unit. ScvO.sub.2 and lactate levels were measured simultaneously at the time of study enrollment, every 6 h for 24 h, and then every 24 h until the goal was reached. Results Twenty-five patients were enrolled in the study; 13 have died and 12 have survived. There was no correlation between lactate levels and ScvO.sub.2. Neither lactate levels nor ScvO.sub.2 at the time of admission differed between nonsurvivors and survivors. Normalization of lactate levels within 48 h was significantly associated with survival. Conclusions In patients with severe SIRS and severe sepsis, simultaneously measured ScvO.sub.2 and lactate levels showed no correlation, and normalization of lactate levels within 48 h was a predictive factor for survival., Author(s): Ju-Hee Park[sup.1] , Jinwoo Lee[sup.1] , Young Sik Park[sup.1] , Chang-Hoon Lee[sup.1] , Sang-Min Lee[sup.1] , Jae-Joon Yim[sup.1] , Young Whan Kim[sup.1] , Sung Koo Han[sup.1] , Chul-Gyu Yoo[sup.1] [...]

Published
2014
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48. Additional file 1 of Developmental endothelial locus-1 as a potential biomarker for the incidence of acute exacerbation in patients with chronic obstructive pulmonary disease

Author

Joo, Dong-Hyun, Lee, Kyoung-Hee, Lee, Chang-Hoon, Woo, Jisu, Kim, Jiyeon, Park, Seoung Ju, Rhee, Chin Kook, Lee, Won-Yeon, Park, Dongil, Lee, Jae Seung, Jung, Ki-Suck, Yoo, Kwang Ha, and Yoo, Chul-Gyu

Subjects
Data_FILES
Abstract

Additional file 1. Supporting information on methods.

Published
2021
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