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Endocrine disruptors have been reported to be associated with hearing ability. However, the association between personal care and consumer product chemicals, known as commonly detected endocrine disruptors, and age-related hearing loss still remains unclear. This study aimed to examine the association between exposure to 7 personal care and consumer product chemicals and hearing thresholds in middle-aged and elderly people. A nationally representative cross-sectional study was performed. Eight hundred forty-five adults aged over 45 from the National Health and Nutrition Examination Survey (NHANES) were included in this study. Bayesian kernel machine regression (BKMR) and the k-medoid cluster analysis were used to evaluate the mixture effect of exposure to 7 chemicals on pure-tone average (PTA). Exposure to these chemicals was negatively associated with PTA. 2,5-Dichlorophenol had the greatest contribution to the mixture effect. The mixture effect was stronger in women, elderly people. Four pooled clusters were identified according to 7 chemicals exposures. Cluster 4 (high TCS exposure) showed a lower HFPTA (P = 0.00258) than cluster 3 (the lowest exposure cluster, as a reference). Our study provides evidence that exposure to personal care and consumer product chemicals might be inversely associated with PTA. More studies are needed to fully understand the association of exposure to these chemicals with hearing threshold.

High-risk papillary thyroid carcinoma (PTC) patients with BRAF mutation have lymph node and distant metastases and poor prognosis. Therefore, this study aims to develop a targeted ultrasound contrast agent for the BRAFThe targeted lipid nanobubbles carrying BRAFThe targeted lipid nanobubbles revealed uniform, round morphology, and good stability with a nanoscale size. Besides, BRAFThe targeted lipid nanobubbles carrying BRAF

To observe the effect of Tai Ji Quan (TJQ) training on strength and function of lower limbs in the aged.Sixty senile subjects were recruited and assigned to the TJQ group and the control group (imparting health knowledge)by random digit table. Patients in the TJQ group received 24-style TJQ training for 18 months (60 min each time, 5 times per week), while those in the control group were imparted with sarcopenia related causes, pathogeneses, prevention and control measures. The maximum isometric strength of bilateral iliopsoas, quadriceps femoris, tibialis anterior muscle, hamstrings; the time for 5 sitting-up tests and Time Up and Go Test (TUGT), one-leg standing time with closed eyes test; and the score of Berg balance scale were compared between the two groups.Compared with before treatment, muscle strength increased in the TJQ group with an average increased capacity (rate) as follows, bilateral iliopsoas 5.5 kg (16.9%), quadriceps femoris 5.5 kg (26.2%), and tibialis anterior muscle 8.5 kg (36.2%) (all P0.05). The time for TUGT and 5 sitting-up tests was shortened by 1.3 s (16.7%) and 0.9 s (14.5%) respectively in the TJQ group. The time for one-leg standing time with closed eyes test was increased by 8.4 s (left) and 9.1 s (right) respectively. The score of Berg balance scale increased by 4.3% (P0.05). Compared with the control group, bilateral quadriceps femoris and tibialis anterior muscle strength increased significantly (P0.01); the time for TUGT and 5 sitting-up tests, the time for one-leg standing time with closed eyes test, scores of Berg balance scale were all improved in the TJQ group after intervention (P0.05).TJQ training could improve strength of iliopsoas, quadriceps femoris, tibialis anterior muscle in the aged, elevate their balance and locomotor activities, and possibly prevent and treat sarcopenia.

Based on digital technology, flood routing simulation system development is an important component of "digital catchment". Taking QingJiang catchment as a pilot case, in-depth analysis on informatization of Qingjiang catchment management being the basis, aiming at catchment data's multi-source, - dimension, -element, -subject, -layer and -class feature, the study brings the design thought and method of "subject-point-source database" (SPSD) to design system structure in order to realize the unified management of catchments data in great quantity. Using the thought of integrated spatial information technology for reference, integrating hierarchical structure development model of digital catchment is established. The model is general framework of the flood routing simulation system analysis, design and realization. In order to satisfy the demands of flood routing three-dimensional simulation system, the object-oriented spatial data model are designed. We can analyze space-time self-adapting relation between flood routing and catchments topography, express grid data of terrain by using non-directed graph, apply breadth first search arithmetic, set up search method for the purpose of dynamically searching stream channel on the basis of simulated three-dimensional terrain. The system prototype is therefore realized. Simulation results have demonstrated that the proposed approach is feasible and effective in the application.