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17 results on '"Yabe, Kaoru"'

4. Historical control data on developmental toxicity studies in rodents

Author

Ema, Makoto, Endoh, Katsumi, Fukushima, Ryou, Fujii, Sakiko, Hara, Hiroaki, Hirata-Koizumi, Mutsuko, Hirose, Akihiko, Hojo, Hitoshi, Horimoto, Masao, Hoshino, Nobuhito, Hosokawa, Yoshinori, Imai, Yukari, Inada, Hiroshi, Inawaka, Kunifumi, Itoh, Keiichi, Katsumata, Yoshihiro, Izumi, Hiroyuki, Kato, Hirohito, Maeda, Maki, Matsumoto, Kiyoshi, Matsuo, Seiki, Matsuoka, Toshiki, Matsuura, Ikuo, Mineshima, Hiroshi, Miwa, Yoji, Nakano, Nao, Naya, Masato, Noyori, Hiroko, Ohta, Takafumi, Oku, Harutaka, Ono, Atsushi, Shimizu, Tatsuya, Shimomura, Kazuhiro, Takakura, Ikuro, Tanaka, Ryota, Tateishi, Taishi, Tominaga, Yuko, Uesugi, Tohru, Urakawa, Chizuru, Yabe, Kaoru, Yamashita, Akihito, Yamauchi, Toshiaki, and Yokoi, Ryohei

Published
2014
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5. Historical control data on prenatal developmental toxicity studies in rabbits

Author

Ema, Makoto, Aoyama, Hiroaki, Arima, Akihiro, Asano, Yuzo, Chihara, Kazuhiro, Endoh, Katsumi, Fujii, Sakiko, Hara, Hiroaki, Higuchi, Hashihiro, Hishikawa, Atsuko, Hojo, Hitoshi, Horimoto, Masao, Hoshino, Nobuhito, Hosokawa, Yoshinori, Inada, Hiroshi, Inoue, Ayumi, Itoh, Keiichi, Izumi, Hiroyuki, Maeda, Maki, Matsumoto, Kiyoshi, Matsuo, Seiki, Matsuura, Ikuo, Mineshima, Hiroshi, Miwa, Yoji, Miyata, Hidenori, Mizoguchi, Yasumoto, Nakano, Nao, Naya, Masato, Nishizawa, Hanako, Noritake, Ken-ichi, Noyori, Hiroko, Ohta, Takafumi, Oku, Harutaka, Shimizu, Tatsuya, Shimomura, Kazuhiro, Shiozawa, Kei, Takakura, Ikuro, Tanaka, Ryota, Uesugi, Tohru, Yabe, Kaoru, Yamauchi, Toshiaki, and Yokoi, Ryohei

Published
2012
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6. Combined repeated-dose and reproductive/developmental oral toxicity of 3-methylpentane, isooctane, and isononane in rats

Author

Kawashima, Akira, primary, Inoue, Kaoru, additional, Yoshizaki, Yoshiro, additional, Ushida, Kazuo, additional, Kai, Kaoru, additional, Suzuki, Hiroshi, additional, Takano, Masao, additional, Fujii, Sakiko, additional, Yabe, Kaoru, additional, Matsumoto, Mariko, additional, Yamada, Takashi, additional, and Hirose, Akihiko, additional

Published
2020
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9. Historical control data on developmental toxicity studies in rats

Author

Kuwagata, Makiko, primary, Sakai, Yuko, additional, Tanaka, Sho, additional, Takashima, Hiromasa, additional, Katagiri, Ryuichi, additional, Matsuoka, Toshiki, additional, Noritake, Kenichi, additional, Senuma, Mika, additional, Shimizu, Tatsuya, additional, Hojo, Hitoshi, additional, Ibi, Kanata, additional, Kudo, Satoshi, additional, Oota, Takafumi, additional, Ube, Masayuki, additional, Miwa, Yoji, additional, Kajita, Shimpei, additional, Uesugi, Tohru, additional, Yabe, Kaoru, additional, Tateishi, Taishi, additional, Nakano, Nao, additional, Taniguchi, Terumasa, additional, Yamashita, Akihito, additional, Hirano, Takayuki, additional, Kirihata, Yuka, additional, Sakai, Yumi, additional, Nishizawa, Shino, additional, Fujiwara, Michio, additional, Mineshima, Hiroshi, additional, Horimoto, Masao, additional, and Ema, Makoto, additional

Published
2018
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11. Historical control data on developmental toxicity studies in rats.

Author

Kuwagata, Makiko, Sakai, Yuko, Tanaka, Sho, Takashima, Hiromasa, Katagiri, Ryuichi, Matsuoka, Toshiki, Noritake, Kenichi, Senuma, Mika, Shimizu, Tatsuya, Hojo, Hitoshi, Ibi, Kanata, Kudo, Satoshi, Oota, Takafumi, Ube, Masayuki, Miwa, Yoji, Kajita, Shimpei, Uesugi, Tohru, Yabe, Kaoru, Tateishi, Taishi, and Nakano, Nao

Subjects
CONTRACT research organizations, CESAREAN section, RATS
Abstract

Historical control data from prenatal developmental toxicity studies in rats have been used to evaluate whether toxicology outcomes were induced by exposure to a chemical or were within the range of spontaneous variation. These data are also important for monitoring animal characteristics. As a follow‐up to historical control data from 1998 to 2010, this study analyzed control data from prenatal developmental studies performed in rats from 2011 to 2015. Data were collected from studies performed by 24 Japanese laboratories, including 15 pharmaceutical and chemical companies and nine contract research organizations, in Sprague‐Dawley and two‐sub‐strains of Wistar Hannover rats. The data included maternal reproductive findings at terminal cesarean section and fetal findings, including incidences of spontaneous external, visceral, and skeletal anomalies. No noticeable differences in maternal reproductive data were observed among laboratories. The inter‐laboratory variations in the incidences of fetal anomalies seemed to be due to differences in the selection of observation parameters, observation criteria, and classification of the findings, as well as to differences in terminology of fetal alterations. These historical control data may be helpful for adequate interpretation of experimental results and for evaluating the reproductive and developmental toxicities of various chemicals. [ABSTRACT FROM AUTHOR]

Published
2019
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12. Developmental toxicity of flucytosine following administration to pregnant rats at a specific time point of organogenesis.

Author

Fujii, Sakiko, Yabe, Kaoru, Kariwano‐Kimura, Yuki, Furukawa, Masatoshi, Itoh, Kouta, Matsuura, Masao, and Horimoto, Masao

Abstract

To investigate the abnormalities that are specific to administration of flucytosine at one time point during embryonic organogenesis, flucytosine was administered orally to pregnant Sprague Dawley (SD) rats in a single dose on day 11 of pregnancy at 25 or 35 mg/kg. Fetuses on day 20 of pregnancy were externally, viscerally, and skeletally examined. Maternal body weight gain and food consumption were suppressed the day after administration of a 35 mg/kg. Fetal examinations revealed various alterations in both dose groups: externally preaxial polydactyly in the hind limb; skeletally fused lumbar centrum, absent sacral centrum, supernumerary sacral vertebra, and absent ribs. Our findings indicated that specific types of external and skeletal anomalies were induced following flucytosine administration on day 11 of pregnancy. [ABSTRACT FROM AUTHOR]

Published
2019
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14. Adaptive DNA Computing Algorithm by Using PCR and Restriction Enzyme.

Author

Jin-Woo Park, Tag- Gon Kim, Yun-Bae Kim, Yuji Kon, Yabe, Kaoru, Rajaee, Nordiana, and Ono, Osamu

Abstract

In this paper, we introduce an adaptive DNA computing algorithm by using polymerase chain reaction (PCR) and restriction enzyme. The adaptive algorithm is designed based on Adleman-Lipton paradigm[3] of DNA computing. In this work, however, unlike the Adleman- Lipton architecture a cutting operation has been introduced to the algorithm and the mechanism in which the molecules used by computation were feedback to the next cycle devised. Moreover, the amplification by PCR is performed in the molecule used by feedback and the difference concentration arisen in the base sequence can be used again. By this operation the molecules which serve as a solution candidate can be reduced down and the optimal solution is carried out in the shortest path problem. The validity of the proposed adaptive algorithm is considered with the logical simulation and finally we go on to propose applying adaptive algorithm to the chemical experiment which used the actual DNA molecules for solving an optimal network problem. [ABSTRACT FROM AUTHOR]

Published
2008
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