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333 results on '"Yadav, Thakur Deen"'

4. Proposal for a new morphological “combined type” of gallbladder cancer: description of radiopathological characteristics and comparison with other morphological types

Author

Chhabra, Manika, Kalage, Daneshwari, Gupta, Pankaj, Siddiqui, Ruby, Singh, Shravya, Yadav, Thakur Deen, Gupta, Vikas, Kaman, Lileswar, Singh, Harjeet, Irrinki, Santosh, Das, Chandan, Prakash, Gaurav, Gupta, Parikshaa, Saikia, Uma Nahar, Nada, Ritambhra, Dutta, Usha, and Sandhu, Manavjit Singh

Published
2024
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14. Multiparametric MR imaging with diffusion-weighted, intravoxel incoherent motion, diffusion tensor, and dynamic contrast-enhanced perfusion sequences to assess gallbladder wall thickening: a prospective study based on surgical histopathology

Author

Kalage, Daneshwari, Gupta, Pankaj, Gulati, Ajay, Yadav, Thakur Deen, Gupta, Vikas, Kaman, Lileswar, Nada, Ritambhra, Singh, Harjeet, Irrinki, Santosh, Gupta, Parikshaa, Das, Chandan, Dutta, Usha, and Sandhu, Manavjit

Published
2023
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22. Aflatoxin exposure is associated with an increased risk of gallbladder cancer.

Author

Yadav, Amit, Gupta, Pankaj, Gupta, Parikshaa, Patil, Amol N., Das, Chandan K., Hooda, Harish, Thakur, Deepa, Sharma, Vishal, Singh, Anupam K., Yadav, Thakur Deen, Kaman, Lileswar, Thakur, Jarnail Singh, Sudini, Hari Kishan, Srinivasan, Radhika, and Dutta, Usha

Subjects
AFLATOXINS, SERUM albumin, HELICOBACTER pylori, HEPATOCELLULAR carcinoma, DISEASE risk factors
Abstract

Gall bladder cancer (GBC) is common among the socioeconomically deprived populations of certain geographical regions. Aflatoxin is a genotoxic hepatocarcinogen, which is recognized to have a role in the pathogenesis of hepatocellular carcinoma. However, the role of aflatoxin in the pathogenesis of GBC is largely unknown. We determined serum AFB1‐Lys albumin adduct (AAA) levels as a marker of aflatoxin exposure in the patients with GBC and compared to those without GBC. The relationship of AAA levels to cytogenetic (TP53mutation&HER2/neu amplification) and radiological characteristics of the tumor was assessed. We included GBC cases (n = 51) and non‐GBC controls (n = 100). Mean serum AAA levels were higher in the GBC group (n = 51) than those without GBC (n = 100) (26.1 ± 12.2 vs. 13.1 ± 11.9 ng/mL; p <.001). HER2/neu expression was associated with higher AAA levels compared to those with equivocal or negative expression (43.9 ± 3 vs. 28.6 ± 10 vs. 19.3 ± 7 ng/mL; p <.001). Older age (age >50 years) (odds ratio [OR] = 3.2 [CI: 1.3–8.2]; p =.013), positive Helicobacter pylori serology (OR = 5.1 [CI: 1.4–17.8]; p =.012), presence of GS (OR = 5 [CI: 1.5–16.9]; p =.009) and detectable AAA levels (OR = 6.8 [CI: 1.3–35.7]; p =.024) were independent risk factors for the presence of the GBC among all study subjects. Among patients harboring GS, older age (age >50 years) (OR = 4.5 [CI: 1.3–14.9]; p =.015), female gender (OR = 3.8 [CI: 1.2–12.5]; p =.027), presence of multiple GS (OR = 21.9 [CI: 4.8–100.4]; p <.001) and high serum AAA levels (OR = 5.3 [CI: 1.6–17.3]; p =.006) were independent risk factors for the presence of the GBC. Elderly age >50 years (OR = 2.6 [CI: 1.3–5.2]; p =.010) and frequent peanut consumption (OR = 2.3 [CI: 1.1–4.9]; p =.030) were independent risk factors for high serum AAA levels. The current study has implications for the prevention of GBC through the reduction of dietary aflatoxin exposure. [ABSTRACT FROM AUTHOR]

Published
2025
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24. Gallbladder reporting and data system (GB-RADS) for risk stratification of gallbladder wall thickening on ultrasonography: an international expert consensus

Author

Gupta, Pankaj, Dutta, Usha, Rana, Pratyaksha, Singhal, Manphool, Gulati, Ajay, Kalra, Naveen, Soundararajan, Raghuraman, Kalage, Daneshwari, Chhabra, Manika, Sharma, Vishal, Gupta, Vikas, Yadav, Thakur Deen, Kaman, Lileshwar, Irrinki, Santosh, Singh, Harjeet, Sakaray, Yashwant, Das, Chandan Krishuna, Saikia, Uma, Nada, Ritambhara, Srinivasan, Radhika, Sandhu, Manavjit Singh, Sharma, Raju, Shetty, Nitin, Eapen, Anu, Kaur, Harmeet, Kambadakone, Avinash, de Haas, Robbert, Kapoor, Vinay K., Barreto, Savio George, Sharma, Atul K., Patel, Amol, Garg, Pramod, Pal, Sujoy K., Goel, Mahesh, Patkar, Shraddha, Behari, Anu, Agarwal, Anil K., Sirohi, Bhawna, Javle, Milind, Garcea, Giuseppe, Nervi, Flavio, Adsay, Volkan, Roa, Juan Carlos, and Han, Ho-Seong

Published
2022
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26. Endoscopic Ultrasound-Guided Rendezvous Technique Versus Precut Sphincterotomy as Salvage Technique in Patients With Benign Biliary Disease and Difficult Biliary Cannulation: A Randomized Controlled Trial.

Author

Choudhury, Arup, Samanta, Jayanta, Muktesh, Gaurav, Dhar, Jahnvi, Kumar, Antriksh, Shah, Jimil, Spadaccini, Marco, Gupta, Pankaj, Fugazza, Alessandro, Gupta, Vikas, Yadav, Thakur Deen, Kochhar, Rakesh, Hassan, Cesare, Repici, Alessandro, and Facciorusso, Antonio

Subjects
BILIOUS diseases & biliousness, BILE ducts, RANDOMIZED controlled trials, ENDOSCOPIC retrograde cholangiopancreatography, RADIATION doses, CATHETERIZATION
Abstract

The standard salvage technique used for difficult bile duct cannulation is precut sphincterotomy, whereas endoscopic ultrasound-guided rendezvous technique is a relatively newer method. This randomized trial compares the outcomes of these 2 techniques in patients with benign biliary obstruction. Visual Abstract. Endoscopic Ultrasound-Guided Rendezvous Technique Versus Precut Sphincterotomy as Salvage Technique in Patients With Benign Biliary Disease and Difficult Biliary Cannulation: The standard salvage technique used for difficult bile duct cannulation is precut sphincterotomy, whereas endoscopic ultrasound-guided rendezvous technique is a relatively newer method. This randomized trial compares the outcomes of these 2 techniques in patients with benign biliary obstruction. Background: The standard salvage technique used for difficult bile duct cannulation is precut sphincterotomy, whereas endoscopic ultrasound-guided rendezvous technique (EUS-RV) is a relatively newer method. Prospective comparative data between these 2 techniques as salvage for biliary access in patients with benign biliary disease and difficult bile duct cannulation is lacking. Objective: To compare EUS-RV and precut sphincterotomy as salvage technique for difficult bile duct cannulation in benign biliary obstruction. Design: Participant-masked, parallel-group, superiority, randomized controlled trial. (Clinical Trials Registry of India: CTRI/2020/07/026613) Setting: Tertiary care academic institute from July 2020 to May 2021. Participants: All patients with benign biliary disease and difficult bile duct cannulation requiring salvage strategy. Intervention: Patients were randomly assigned by computer-generated randomized blocks sequence in 1:1 fashion to either EUS-RV or precut sphincterotomy. Patients with failure in EUS-RV were crossed over to precut sphincterotomy and vice versa. Measurements: The primary outcome measure was technical success. The other outcome measures included procedure time, radiation dose, and adverse events. Results: In total, 100 patients were randomly assigned to EUS-RV (n = 50) and precut sphincterotomy (n = 50). The technical success rate (92% vs. 90%; P = 1.00; relative risk, 1.02 [95% CI, 0.90 to 1.16]), median procedure time (10.1 vs. 9.75 minutes), and overall complication rate (12% vs. 10%; relative risk, 1.20 [CI, 0.39 to 3.68]) were similar between the 2 groups. Five patients (10%) in the EUS-RV group and 5 patients (10%) in the precut sphincterotomy group had developed post–endoscopic retrograde cholangiopancreatography pancreatitis. All failed cases in either salvage group could be successfully cannulated when crossed over to the other group. Limitation: Single center study done by experts. Conclusion: Endoscopic ultrasound-guided rendezvous technique and precut sphincterotomy have similar success rates as salvage techniques in the technically challenging cohort of difficult bile duct cannulation for benign biliary disease, with acceptable complications rates. Primary Funding Source: None. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Multifocality in gallbladder cancer: An imaging-based study.

Author

Pooja, A.B., Kalage, Daneshwari, Aswal, Chandra Shekhar Singh, Yadav, Thakur Deen, Kaman, Lileswar, Irrinki, Santosh, Gupta, Parikshaa, Prakash, Gaurav, Saikia, Uma Nahar, Nada, Ritambhra, Dutta, Usha, and Gupta, Pankaj

Subjects
GALLBLADDER cancer, HISTOPATHOLOGY, MAGNETIC resonance imaging, BILE ducts, CYSTS (Pathology)
Abstract

Aim of the study: Gallbladder cancer (GBC) lesions are usually solitary. The presence of multifocal disease can alter resectability and management. There are no systematic imaging-based studies evaluating multifocality in GBC. Thus, we aimed to evaluate multifocality in GBC based on cross-sectional imaging studies. Material and methods: This retrospective study screened cross-sectional imaging (contrast-enhanced computed tomography [CT] or magnetic resonance imaging [MRI]) of consecutive patients with histopathological or cytological diagnoses of GBC. The CT/MRI images of patients with multifocal disease (defined as the presence of two or more foci of abnormal wall thickening, intraluminal polypoidal lesions or masses in the gallbladder, cystic duct, or the extrahepatic bile ducts with the intervening area of normal gallbladder/extrahepatic bile ducts) were evaluated by two radiologists independently for various imaging findings. Results: Of the 324 patients, 17 (5.2%; 13 females; mean age, 54 ±11 years) had multifocal disease with two sites of involvement in all cases. The most common sites of involvement were the gallbladder fundus and neck region (58.8% of cases), followed by the gallbladder fundus and common bile duct (29.4%). Wall thickening type of GBC was the most common morphological subtype (85.3%), followed by mass forming type (14.7%). The majority (70.6%) of cases showed the same morphology at both sites, while 29.4% showed different morphology. Most (70.6%) of the patients with multifocal GBC were unresectable at the time of diagnosis. Conclusions: Although rare, imaging-based diagnosis of multifocal GBC may allow appropriate management. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Plastic versus metal stents for transmural drainage of walled-off necrosis with significant solid debris: a randomized controlled trial

Author

Kakadiya, Rinkal, primary, Muktesh, Gaurav, primary, Samanta, Jayanta, additional, Mandavdhare, Harshal S, additional, Gupta, Pankaj, additional, Shah, Jimil, additional, Sarma, Phulen, additional, Gupta, Vikas, additional, Yadav, Thakur Deen, additional, Jena, Anuraag, additional, Sharma, Vishal, additional, and Kochhar, Rakesh, additional

Published
2023
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41. Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate

Author

Pandey, Akhilesh, Stawiski, Eric W., Durinck, Steffen, Gowda, Harsha, Goldstein, Leonard D., Barbhuiya, Mustafa A., Schröder, Markus S., Sreenivasamurthy, Sreelakshmi K., Kim, Sun-Whe, Phalke, Sameer, Suryamohan, Kushal, Lee, Kayla, Chakraborty, Papia, Kode, Vasumathi, Shi, Xiaoshan, Chatterjee, Aditi, Datta, Keshava, Khan, Aafaque A., Subbannayya, Tejaswini, Wang, Jing, Chaudhuri, Subhra, Gupta, Sanjiv, Shrivastav, Braj Raj, Jaiswal, Bijay S., Poojary, Satish S., Bhunia, Shushruta, Garcia, Patricia, Bizama, Carolina, Rosa, Lorena, Kwon, Wooil, Kim, Hongbeom, Han, Youngmin, Yadav, Thakur Deen, Ramprasad, Vedam L., Chaudhuri, Amitabha, Modrusan, Zora, Roa, Juan Carlos, Tiwari, Pramod Kumar, Jang, Jin-Young, and Seshagiri, Somasekar

Published
2020
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48. Emergency surgical intervention in acute corrosive ingestion: single‐center experience from India.

Author

Gupta, Vikas, Shah, Jimil, Yadav, Thakur Deen, Kumar, Pradeep, Wig, Jai Dev, and Kochhar, Rakesh

Subjects
SURGICAL emergencies, INGESTION, PLASTIC surgery, PULMONARY embolism, MULTIPLE organ failure
Abstract

Background: Surgical intervention for acute corrosive injury is often required. It is associated with considerable morbidity and mortality. Sparce data is available on the types and timing of surgery after acute corrosive ingestion and complications associated with the same. Methods: This is a retrospective single‐center study from a tertiary care center in India. All patients who underwent surgical exploration after acute corrosive intake between January 2003 and June 2014 were enrolled in the study. Data on patients' presentation, their endoscopic findings, indications of surgery, type of surgery and post‐operative follow‐up was retrieved. Results: Out of 170 patients who presented with acute corrosive ingestion, 24 patients (14.11%) required emergency surgery. The mean interval between ingestion and surgery was 9.92 ± 9.03 days. Presence of peritonitis was the most common indication for surgery (n = 10; 41.7%) followed by mediastinitis (n = 7; 29.2%). A total of 17 resectional and 7 non‐resectional procedures were performed. Thirteen (54%) patients succumbed to their illness post‐operatively due to multi‐organ failure (n = 9), refractory shock (n = 3) or pulmonary thromboembolism (n = 1). Patients with early surgery (≤7 days) after corrosive ingestion had similar mortality compared to patients with late surgery (>7 days) (50% versus 67%; P = 0.30). Of the 11 surviving patients, eight patients (72%) underwent successful reconstructive surgery on follow‐up. Conclusions: Emergency surgery after corrosive ingestion carries high morbidity and mortality. However, after the initial stormy acute phase, majority of patients can undergo successful reconstructive surgery on follow‐up. [ABSTRACT FROM AUTHOR]

Published
2023
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50. IDDF2022-ABS-0256 Comparative effects of intravenous diclofenac and buprenorphine for pain relief in patients with acute pancreatitis: a randomized controlled study

Author

Samanta, Jayanta, primary, Saini, Mayank, additional, Choudhury, Arup, additional, Yadav, Ashutosh, additional, Jaffra, Anudeep, additional, Chauhan, Rajeev, additional, Muktesh, Gaurav, additional, Gupta, Pankaj, additional, Gupta, Vikas, additional, Yadav, Thakur Deen, additional, and Kochhar, Rakesh, additional

Published
2022
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