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Abstract Due to the lack of direct assessment metrics, existing studies on the intensity of agricultural policies often utilize indicators such as Gross Domestic Product (GDP) of agriculture or the quantity of agricultural policies as measures. Optimizing methods for analyzing the intensity of agricultural policies will significantly impact parameter selection in agricultural policy research and the evaluation of policy effectiveness. In this study, we constructed a Chinese Agricultural Policy Corpus using agricultural policies released by various governmental agencies at the national level in China from 1982 to April 2023. We quantified the values of agricultural domain terms in the corpus and evaluated the intensity of each agricultural policy document. The validation results of this study indicate a strong correlation between the intensity of agricultural policies and agricultural GDP. The trend in agricultural GDP changes lags behind policy intensity by 2.5 years (at a 95% confidence level), thus validating the rationality of our constructed corpus, agricultural policy scoring dataset, and methodology.

This is an article in the field of metallurgical engineering. In this article, TiH2 powder was selected as the experimental raw material to study the sintering behavior of TiH2 powder under different pressing pressure and holding time in cold isostatic pressing, to reveal the effects of pressing pressure and holding time on the shrinkage as well as the relative density of TiH2 sintered specimens, in order to improve the density of the billet and the performance of the products. The results show that the shrinkage of the sintered sample decreases with the increase of the pressing pressure, and when the pressing pressure reaches 400 MPa, the pressing pressure has little effect on the relative density of the sintered sample. For the consideration of the sample preparation efficiency and the pressing pressure limit of the cold isostatic press, the pressing pressure should not exceed 400 Mpa. The shrinkage of sintered samples decreases with the increase of holding time, and when the holding time reaches 20 min, the relative density of sintered samples changes little with the extension of holding time. For the consideration of sample preparation efficiency, the suitable holding time is 15～20 min.

Additive manufacturing (AM) can endow materials with specific microstructures, inducing anisotropy. In this study, we employed the AM technique to fabricate a dual-phase high-entropy alloy (HEA) and evaluated the damping properties of this alloy cut parallel and perpendicular to the building direction (denoted as BD and TD, respectively) while considering strain amplitude and temperature. Results reveal the presence of two distinct damping peaks as temperature increases. At low temperatures, the damping behavior is primarily controlled by dislocation movements. At moderate and high temperatures, damping performance is governed by phase transformation and grain boundary sliding. The maximum difference of damping capacity between BD and TD samples reached 247.8%. This variation can be attributed to the introduction of columnar grain microstructures along the BD by AM, increasing the average distances for dislocation movement. In addition, the intensification of phase transformation and grain boundary sliding results from more vigorous dislocation movement in BD samples, with rising temperatures, contributing to superior damping performance. Moreover, a model was developed to illustrate the temperature-dependent variations in the damping performance of this dual-phase HEA. This model elucidates the damping mechanisms within different temperature ranges and the origin of damping anisotropy. The insights derived from this study bear significance for the design of innovative HEAs, which can broaden their applications.

Constructing infrastructure on soft soils demands the implementation of ground improvement. This study proposed an eco-friendly method of stabilizing marine soil using a calcium carbide residue (CCR)-activated coal gangue (CG) geopolymer derived from industrial waste. Laboratory experiments were conducted to investigate the mechanical properties, durability performance, and stabilization mechanisms of stabilized marine soils under multiple wetting-dry cycles. The results highlighted the effectiveness of CG-CCR geopolymer by a content of 15% to achieve satisfactory strength gain over the engineering requirements. However, the largest decrease in strength (71.89%) was observed when the initial water content was beyond 1.5 times the liquid limit (LL). The optimum solution was proposed to have a geopolymer content of 15% or an initial water content of 1.25·LL to exhibit the highest resistance to strength decay after 12 cycles. Compared with water intrusion, mass loss had a more significant effect on soil strength deterioration. The formation of noncrystalline or amorphous-phase reaction products effectively filled intergranular pores and reduced the void space between soil particles, improving the mechanical properties. The CG-CCR geopolymer was demonstrated to offer a promising solution for soil improvement in geotechnical engineering and waste reduction in industry as a soil stabilizer.

Summary: The association between visual abnormalities and impairments in cerebral blood flow and brain region potentially results in neural dysfunction of amblyopia. Nevertheless, the differences in the complex mechanisms of brain neural network coupling and its relationship with neurotransmitters remain unclear. Here, the neurovascular coupling mechanism and neurotransmitter activity in children with anisometropic amblyopia (AA) and visual deprivation amblyopia (VDA) was explored. The neurovascular coupling of 17 brain regions in amblyopia children was significantly abnormal than in normal controls. The classification abilities of coupling units in brain regions differed between two types of amblyopia. Correlations between different coupling effects and neurotransmitters were different. The findings of this study demonstrate a correlation between the neurovascular coupling and neurotransmitter in children with AA and VDA, implying their impaired neurovascular coupling function and potential molecular underpinnings. The neuroimaging evidence revealed herein offers potential for the development of neural therapies for amblyopia.

Abstract Despite the enormous potential of millimeter-wave (mmWave) imaging, the high cost of large-scale antenna arrays or stringent prerequisites of the synthetic aperture radar (SAR) principle impedes its widespread application. Here, we report a portable, affordable, and high-resolution 3D mmWave imaging system by overcoming the destructive motion error of handheld SAR imaging. This is achieved by revealing two important phenomenons: spatial asymmetry of motion errors in different directions, and local similarity of phase errors exhibited by different targets, based on which we formulate the challenging phase error estimation problem as a tractable point spread function optimization problem. Experiments demonstrate that our approach can recover high-fidelity 3D mmWave images from severely distorted signals and augment the aperture size by over 50 times. Since our system does not rely on costly massive antennas or bulky motion controllers, it can be applied for diverse applications including security inspection, autonomous driving, and medical monitoring.

Abstract Enveloped viruses encased within a lipid bilayer membrane are highly contagious and can cause many infectious diseases like influenza and COVID-19, thus calling for effective prevention and inactivation strategies. Here, we develop a diatomic iron nanozyme with lipoxidase-like (LOX-like) activity for the inactivation of enveloped virus. The diatomic iron sites can destruct the viral envelope via lipid peroxidation, thus displaying non-specific virucidal property. In contrast, natural LOX exhibits low antiviral performance, manifesting the advantage of nanozyme over the natural enzyme. Theoretical studies suggest that the Fe-O-Fe motif can match well the energy levels of Fe2 minority β-spin d orbitals and pentadiene moiety π* orbitals, and thus significantly lower the activation barrier of cis,cis-1,4-pentadiene moiety in the vesicle membrane. We showcase that the diatomic iron nanozyme can be incorporated into air purifier to disinfect airborne flu virus. The present strategy promises a future application in comprehensive biosecurity control.

CuCrZr alloy has excellent conductivity, thermal conductivity, friction reduction and abrasion resistance, which can satisfy in different fields. Copper alloy porous structure is a new multifunctional structure with both structural and functional properties. Selective laser melting (SLM) technology has certain advantages for the preparation of periodic porous structures with triply periodic minimal surfaces (TPMS). Under the background of SLM technique, the quasi-static compression properties of Diamond and Gyroid porous structures were studied. The whole deformation of structures was captured by digital camera, and the failure mechanism was analyzed by finite element software. The effects of different heat treatments on the microstructure and mechanical properties of the CuCrZr were studied by scanning electron microscopy and compression tests. The microstructure morphologies show that the number of curved grains decreases and the grains become more regular after heat treatment. Heat treatment can optimize the mechanical properties and energy absorption capacity of the material, which is most obvious at 500 °C. These results indicate that specific heat treatment can improve the stability and predictability of the CuCrZr porous structure.

Abstract Carbon-defect engineering in metal single-atom catalysts by simple and robust strategy, boosting their catalytic activity, and revealing the carbon defect-catalytic activity relationship are meaningful but challenging. Herein, we report a facile self-carbon-thermal-reduction strategy for carbon-defect engineering of single Fe-N4 sites in ZnO-Carbon nano-reactor, as efficient catalyst in Fenton-like reaction for degradation of phenol. The carbon vacancies are easily constructed adjacent to single Fe-N4 sites during synthesis, facilitating the formation of C-O bonding and lowering the energy barrier of rate-determining-step during degradation of phenol. Consequently, the catalyst Fe-NCv-900 with carbon vacancies exhibits a much improved activity than the Fe-NC-900 without abundant carbon vacancies, with 13.5 times improvement in the first-order rate constant of phenol degradation. The Fe-NCv-900 shows high activity (97% removal ratio of phenol in only 5 min), good recyclability and the wide-ranging pH universality (pH range 3-9). This work not only provides a rational strategy for improving the Fenton-like activity of metal single-atom catalysts, but also deepens the fundamental understanding on how periphery carbon environment affects the property and performance of metal-N4 sites.

IntroductionThe study addresses challenges in detecting cotton leaf pests and diseases under natural conditions. Traditional methods face difficulties in this context, highlighting the need for improved identification techniques.MethodsThe proposed method involves a new model named CFNet-VoV-GCSP-LSKNet-YOLOv8s. This model is an enhancement of YOLOv8s and includes several key modifications: (1) CFNet Module. Replaces all C2F modules in the backbone network to improve multi-scale object feature fusion. (2) VoV-GCSP Module. Replaces C2F modules in the YOLOv8s head, balancing model accuracy with reduced computational load. (3) LSKNet Attention Mechanism. Integrated into the small object layers of both the backbone and head to enhance detection of small objects. (4) XIoU Loss Function. Introduced to improve the model's convergence performance.ResultsThe proposed method achieves high performance metrics: Precision (P), 89.9%. Recall Rate (R), 90.7%. Mean Average Precision (mAP@0.5), 93.7%. The model has a memory footprint of 23.3MB and a detection time of 8.01ms. When compared with other models like YOLO v5s, YOLOX, YOLO v7, Faster R-CNN, YOLOv8n, YOLOv7-tiny, CenterNet, EfficientDet, and YOLOv8s, it shows an average accuracy improvement ranging from 1.2% to 21.8%.DiscussionThe study demonstrates that the CFNet-VoV-GCSP-LSKNet-YOLOv8s model can effectively identify cotton pests and diseases in complex environments. This method provides a valuable technical resource for the identification and control of cotton pests and diseases, indicating significant improvements over existing methods.

Abstract Background Single nucleotide polymorphisms (SNPs) and insertions/deletions (InDels) are the most abundant genetic variations and widely distribute across the genomes in plant. Development of SNP and InDel markers is a valuable tool for genetics and genomic research in radish (Raphanus sativus L.). Results In this study, a total of 366,679 single nucleotide polymorphisms (SNPs) and 97,973 insertion-deletion (InDel) markers were identified based on genome resequencing between ‘YZH’ and ‘XHT’. In all, 53,343 SNPs and 4,257 InDels were detected in two cultivars by transcriptome sequencing. Among the InDel variations, 85 genomic and 15 transcriptomic InDels were newly developed and validated PCR. The 100 polymorphic InDels markers generated 207 alleles among 200 Chinese radish germplasm, with an average 2.07 of the number of alleles (Na) and with an average 0.33 of the polymorphism information content (PIC). Population structure and phylogenetic relationship revealed that the radish cultivars from northern China were clustered together and the southwest China cultivars were clustered together. RNA-Seq analysis revealed that 11,003 differentially expressed genes (DEGs) were identified between the two cultivars, of which 5,020 were upregulated and 5,983 were downregulated. In total, 145 flowering time-related DGEs were detected, most of which were involved in flowering time integrator, circadian clock/photoperiod autonomous, and vernalization pathways. In flowering time-related DGEs region, 150 transcriptomic SNPs and 9 InDels were obtained. Conclusions The large amount of SNPs and InDels identified in this study will provide a valuable marker resource for radish genetic and genomic studies. The SNPs and InDels within flowering time-related DGEs provide fundamental insight into for dissecting molecular mechanism of bolting and flowering in radish.

Abstract Researches had proven that the occurrence of bladder cancer (BC) is much higher in men than those in women, which induced us to explore whether androgen plays a role in BC. A total of 147 patients who were diagnosed with primary BC by histopathological biopsy were included. Meanwhile 154 non-tumor patients were matched as the control group. The continuous variables were expressed as median (interquartile range, IQR) and compared by Mann–Whitney U test, for the reason that the data were not matched the requirementsthe of normal test. A Chi-square test was used to compare the categorical variables, which were expressed as frequency (percentage). Meanwhile univariate and multivariate logistic regression was done to further evaluating the potential independent factor of BC. P

Sulfur metabolism plays a major role in plant growth and development, environmental adaptation, and material synthesis, and the sulfate transporters are the beginning of sulfur metabolism. We identified 37 potential VcSULTR genes in the blueberry genome, encoding peptides with 534 to 766 amino acids. The genes were grouped into four subfamilies in an evolutionary analysis. The 37 putative VcSULTR proteins ranged in size from 60.03 to 83.87 kDa. These proteins were predicted to be hydrophobic and mostly localize to the plasma membrane. The VcSULTR genes were distributed on 30 chromosomes; VcSULTR3;5b and VcSULTR3;5c were the only tandemly repeated genes. The VcSULTR promoters contained cis-acting elements related to the fungal symbiosis and stress responses. The transcript levels of the VcSULTRs differed among blueberry organs and changed in response to ericoid mycorrhizal fungi and sulfate treatments. A subcellular localization analysis showed that VcSULTR2;1c localized to, and functioned in, the plasma membrane and chloroplast. The virus-induced gene knock-down of VcSULTR2;1c resulted in a significantly decreased endogenous sulfate content, and an up-regulation of genes encoding key enzymes in sulfur metabolism (VcATPS2 and VcSiR1). These findings enhance our understanding of mycorrhizal-fungi-mediated sulfate transport in blueberry, and lay the foundation for further research on blueberry–mycorrhizal symbiosis.

Key factors for assessing the high-temperature resistance of coal gangue concrete are high-temperature residual strength and thermal properties. The high-temperature residual strength, high-temperature thermal conductivity, high-temperature specific heat capacity, and high-temperature density of concrete with various coal gangue coarse aggregate replacement ratios were tested using experimental methods in this paper to study the high-temperature resistance of coal gangue concrete. Thermal density and high-temperature residual strength tests took into account influencing factors like the water-cement ratio (0.50, 0.45, 0.40), aggregate replacement ratio (0, 25 %, 50 %, 75 %, 100 %), and temperature variation (room temperature, 200 °C，300 °C，400 °C，500 °C，600 °C，700 °C，800 °C), while thermal properties tests considered the effects of various coarse aggregate replacement ratios and temperatures. The study showed that when the temperature rises, coal gangue concrete's thermal density falls, mass loss rises, residual strength declines, thermal conductivity rises, and its specific heat capacity fluctuates. At temperatures between 20 °C and 400 °C, concrete's residual strength decreases with an increase in the coal gangue coarse aggregate replacement ratio, while thermal conductivity and specific heat capacity increase. At temperatures between 500 °C and 800 °C, however, concrete's residual strength slightly improves with an increased coal gangue coarse aggregate replacement ratio, while mass loss changes more. The research finally provides the formulae for calculating the high-temperature residual strength and thermal properties of coal gangue concrete based on the test results.

As a highly economic berry fruit crop, blueberry is enjoyed by most people and has various potential health benefits, many of which are attributed to the relatively high concentrations of flavonoids. To obtain more accurate and comprehensive transcripts, the full-length transcriptome of half-highbush blueberry (Vaccinium corymbosum/angustifolium cultivar Northland) obtained using single molecule real-time and next-generation sequencing technologies was reported for the first time. Overall, 147,569 consensus transcripts (average length, 2738 bp; N50, 3176 bp) were obtained. After quality control steps, 63,425 high-quality isoforms were obtained and 5030 novel genes, 3002 long non-coding RNAs, 3946 transcription factor genes (TFs), 30,540 alternative splicing events, and 2285 fusion gene pairs were identified. To better explore the molecular mechanism of flavonoid biosynthesis in mature blueberry fruit, an integrative analysis of the metabolome and transcriptome was performed on the exocarp, sarcocarp, and seed. A relatively complete biosynthesis pathway map of phenylpropanoids, flavonoids, and proanthocyanins in blueberry was constructed. The results of the joint analysis showed that the 228 functional genes and 42 TFs regulated 78 differentially expressed metabolites within the biosynthesis pathway of phenylpropanoids/flavonoids. O2PLS analysis results showed that the key metabolites differentially accumulated in blueberry fruit tissues were albireodelphin, delphinidin 3,5-diglucoside, delphinidin 3-O-rutinoside, and delphinidin 3-O-sophoroside, and 10 structural genes (4 Vc4CLs, 3 VcBZ1s, 1 VcUGT75C1, 1 VcAT, and 1 VcUGAT), 4 transporter genes (1 VcGSTF and 3 VcMATEs), and 10 TFs (1 VcMYB, 2 VcbHLHs, 4 VcWD40s, and 3 VcNACs) exhibited strong correlations with 4 delphinidin glycosides. These findings provide insights into the molecular mechanisms of flavonoid biosynthesis and accumulation in blueberry fruit.

The circulating severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variant presents an ongoing challenge for surveillance and detection. It is important to establish an assay for SARS-CoV-2 antibodies in vaccinated individuals. Numerous studies have demonstrated that binding antibodies (such as S-IgG and N-IgG) and neutralizing antibodies (Nabs) can be detected in vaccinated individuals. However, it is still unclear how to evaluate the consistency and correlation between binding antibodies and Nabs induced by inactivated SARS-CoV-2 vaccines. In this study, serum samples from humans, rhesus macaques, and hamsters immunized with inactivated SARS-CoV-2 vaccines were analyzed for S-IgG, N-IgG, and Nabs. The results showed that the titer and seroconversion rate of S-IgG were significantly higher than those of N-IgG. The correlation between S-IgG and Nabs was higher compared to that of N-IgG. Based on this analysis, we further investigated the titer thresholds of S-IgG and N-IgG in predicting the seroconversion of Nabs. According to the threshold, we can quickly determine the positive and negative effects of the SARS-CoV-2 variant neutralizing antibody in individuals. These findings suggest that the S-IgG antibody is a better supplement to and confirmation of SARS-CoV-2 vaccine immunization.

The sensitivity and accuracy of nanopore sensors are severely hindered by the high noise associated with solid-state nanopores. To mitigate this issue, the deposition of organic polymer materials onto silicon nitride (SiNx) membranes has been effective in obtaining low-noise measurements. Nonetheless, the fabrication of nanopores sub-10 nm on thin polymer membranes remains a significant challenge. This work proposes a method for fabricating nanopores on polymethyl methacrylate (PMMA) membrane by the local high electrical field controlled breakdown, exploring the impact of voltage and current on the breakdown of PMMA membranes and discussing the mechanism underlying the breakdown voltage and current during the formation of nanopores. By improving the electric field application method, transient high electric fields that are one–seven times higher than the breakdown electric field can be utilized to fabricate nanopores. A comparative analysis was performed on the current noise levels of nanopores in PMMA-SiNx composite membranes and SiNx nanopores with a 5 nm diameter. The results demonstrated that the fast fabrication of nanopores on PMMA-SiNx membranes exhibited reduced current noise compared to SiNx nanopores. This finding provides evidence supporting the feasibility of utilizing this technology for efficiently fabricating low-noise nanopores on polymer composite membranes.

Grain legumes play a significant global role and are integral to agriculture and food production worldwide. Therefore, comprehending and analyzing the factors that influence grain legume yield are of paramount importance for guiding agricultural management and decision making. Traditional statistical analysis methods present limitations in interpreting results, but explainable artificial intelligence (AI) provides a visual representation of model results, offering insights into the key factors affecting grain legume yield. In this study, nine typical grain legume species were selected from a published global experimental dataset: garden pea (Pisum sativum), chickpea (Cicer arietinum), cowpea (Vigna unguiculata), garden vetch (Vicia sativa), faba bean (Vicia faba), lentil (Lens culinaris), pigeon pea (Cajanus cajan), peanut (Arachis hypogaea), and white lupine (Lupinus albus). Seven commonly used models were constructed for each legume species, and model performance evaluation was conducted using accuracy, AUC, recall, precision, and F1 score metrics. The best classification model was selected for each grain legume species. Employing Decision Tree analysis, Feature Importance Evaluation, and SHapley Additive exPlanations (SHAP) as explainable techniques, our study conducted both individual and comprehensive analyses of nine leguminous crops. This approach offers a novel perspective, unveiling not only the unique responses of each crop to the influencing factors but also demonstrating the common factors across different crops. According to the experimental results, XGboost (XGB) and Random Forests (RF) are the best-performing models among the nine types of grain legumes, and the classification accuracy of a specific species is as high as 87.33%. Insights drawn from the feature importance map reveal that several factors, including aerial biomass, precipitation, sunshine duration, soil conditions, growth cycle, and fertilization strategy, have a pivotal influence. However, it was found from the SHAP graph that the responses of various crops to these factors are not the same. This research furnishes novel perspectives and insights into understanding the factors influencing grain legume yields. The findings provide a robust scientific foundation for agricultural managers, experts, and policymakers in the pursuit of optimizing pulse yields and advancing agricultural sustainability.

Background: An inactivated poliomyelitis vaccine made from Sabin strains (sIPVs) has widely been used in China since 2015. However, the quantitative data on the instant and persistent inhibition effects of maternal poliovirus antibodies on the immune response to sIPV priming and booster vaccination have not been available yet. Objective: In this study, we aim to explore and quantify the instant and persistent inhibition effect of maternal poliovirus antibodies on the immune response elicited by sIPV primary and booster vaccination. Methods: The immunogenicity data consisting of the days 0 and 30 after the prime and booster vaccination of the sIPV in a phase IV trial were pooled for a quantitative analysis of the inhibition effect of maternal poliovirus antibody. The geometric mean ratio (GMR) was calculated using linear regression models, representing that every 2-fold higher maternal poliovirus antibody titer may result in a (1-GMR) lower postimmunization antibody titer. Results: The GMRs for poliovirus types 1, 2, and 3 were 0.79 (0.77–0.82), 0.85 (0.81–0.89), and 0.87 (0.83–0.91) at 30 days after the priming series, 0.86 (0.83–0.89), 0.81 (0.76–0.85), and 0.86 (0.80–0.93) at one year after the priming series, and 0.96 (0.94–0.99), 0.89 (0.86–0.93), and 0.98 (0.93–1.03) at 30 days after the booster dose. The inhibition effect continued to exist until the booster dose 1 year later, and such a persistent inhibition effect was almost attenuated for poliovirus types 1 and 3, and partly reduced for type 2 at 30 days after the booster dose. Conclusion: A wider interval between the four sIPV doses might be a consideration for reducing the effect of maternal antibodies and subsequently eliciting and maintaining higher antibody levels to protect against poliovirus transmission and infection at the final stage of polio eradication in the global world. This study’s clinical trial registry number is NCT04224519.

AbstractBlueberries are rich in anthocyanins, which are plant-specific secondary metabolites that are a good source of plant nutrients. Although anthocyanins have been investigated, there is a lack of comprehensive detailed research that includes large numbers of blueberry cultivars, and the anthocyanin compositions of some cultivars are still unknown. Consequently, we determined the anthocyanin compositions of 62 cultivars using ultra-performance liquid chromatography–mass spectrometry (UPLC–MS). In total, we identified 30 anthocyanins derived from five kinds of anthocyanidin. We also identified four glycosides having three kinds of modifications. Among the tested cultivars, ‘Rubel’ contained the highest anthocyanin content, at 534.158 mg/100 g fresh weight (FW), whereas ‘Puru’ contained the lowest anthocyanin content at 71.734 mg/100 g FW. ‘Malvidin-gal’ had the highest average content among all the anthocyanin monomers, at 48.95 mg/100 g FW. ‘HL9’ had the greatest methylation degree, at 79.39%, and ‘HL2’ had the greatest acetylation degree, at 25.14%. This study provides detailed anthocyanin compositions and modifications of different blueberry cultivars. These data will aid in breeding high-quality blueberry cultivars and in developing related healthy functional foods.

Abstract Currently, more than 86% of global energy consumption is still mainly dependent on traditional fossil fuels, which causes resource scarcity and even emission of high amounts of carbon dioxide (CO2), resulting in a severe “Greenhouse effect.” Considering this situation, the concept of “carbon neutrality” has been put forward by 125 countries one after another. To achieve the goals of “carbon neutrality,” two main strategies to reduce CO2 emissions and develop sustainable clean energy can be adopted. Notably, these are crucial for the synthesis of advanced single‐atom catalysts (SACs) for energy‐related applications. In this review, we highlight unique SACs for conversion of CO2 into high‐efficiency carbon energy, for example, through photocatalytic, electrocatalytic, and thermal catalytic hydrogenation technologies, to convert CO2 into hydrocarbon fuels (CO, CH4, HCOOH, CH3OH, and multicarbon [C2+] products). In addition, we introduce advanced energy conversion technologies and devices to replace traditional polluting fossil fuels, such as photocatalytic and electrocatalytic water splitting to produce hydrogen energy and a high‐efficiency oxygen reduction reaction (ORR) for fuel cells. Impressively, several representative examples of SACs (including d‐, ds‐, p‐, and f‐blocks) for CO2 conversion, water splitting to H2, and ORR are discussed to describe synthesis methods, characterization, and corresponding catalytic activity. Finally, this review concludes with a description of the challenges and outlooks for future applications of SACs in contributing toward carbon neutrality.

Abstract Transition metal fluorides (TMFs) cathode materials have shown extraordinary promises for electrochemical energy storage, but the understanding of their electrochemical reaction mechanisms is still a matter of debate due to the complicated and continuous changing in the battery internal environment. Here, we design a novel iron fluoride (FeF2) aggregate assembled with cylindrical nanoparticles as cathode material to build FeF2 lithium‐ion batteries (LIBs) and employ advanced in situ magnetometry to detect their intrinsic electronic structure during cycling in real time. The results show that FeF2 cannot be involved in complete conversion reactions when the FeF2 LIBs operate between the conventional voltage range of 1.0–4.0 V, and that the corresponding conversion ratio of FeF2 can be further estimated. Importantly, we first demonstrate that the spin‐polarized surface capacitance exists in the FeF2 cathode by monitoring the magnetic responses over various voltage ranges. The research presents an original and insightful method to examine the conversion mechanism of TMFs and significantly provides an important reference for the future artificial design of energy systems based on spin‐polarized surface capacitance.

This research tackles the intricate challenges of detecting densely distributed maize leaf diseases and the constraints inherent in YOLO-based detection algorithms. It introduces the GhostNet_Triplet_YOLOv8s algorithm, enhancing YOLO v8s by integrating the lightweight GhostNet (Ghost Convolutional Neural Network) structure, which replaces the YOLO v8s backbone. This adaptation involves swapping the head’s C2f (Coarse-to-Fine) and Conv (Convolutional) modules with C3 Ghost and GhostNet, simplifying the model architecture while significantly amplifying detection speed. Additionally, a lightweight attention mechanism, Triplet Attention, is incorporated to refine the accuracy in identifying the post-neck layer output and to precisely define features within disease-affected areas. By introducing the ECIoU_Loss (EfficiCLoss Loss) function, replacing the original CIoU_Loss, the algorithm effectively mitigates issues associated with aspect ratio penalties, resulting in marked improvements in recognition and convergence rates. The experimental outcomes display promising metrics with a precision rate of 87.50%, a recall rate of 87.70%, and an mAP@0.5 of 91.40% all within a compact model size of 11.20 MB. In comparison to YOLO v8s, this approach achieves a 0.3% increase in mean average precision (mAP), reduces the model size by 50.2%, and significantly decreases FLOPs by 43.1%, ensuring swift and accurate maize disease identification while optimizing memory usage. Furthermore, the practical deployment of the trained model on a WeChat developer mini-program underscores its practical utility, enabling real-time disease detection in maize fields to aid in timely agricultural decision-making and disease prevention strategies.

The COVID-19 pandemic has had a profound impact on people’s lives, making accurate prediction of epidemic trends a central focus in COVID-19 research. This study innovatively utilizes a spatiotemporal heterogeneity analysis (GTNNWR) model to predict COVID-19 deaths, simulate pandemic prevention scenarios, and quantitatively assess their preventive effects. The results show that the GTNNWR model exhibits superior predictive capacity to the conventional infectious disease dynamics model (SEIR model), which is approximately 9% higher, and reflects the spatial and temporal heterogeneity well. In scenario simulations, this study established five scenarios for epidemic prevention measures, and the results indicate that masks are the most influential single preventive measure, reducing deaths by 5.38%, followed by vaccination at 3.59%, and social distancing mandates at 2.69%. However, implementing single stringent preventive measures does not guarantee effectiveness across all states and months, such as California in January 2025, Florida in August 2024, and March–April 2024 in the continental U.S. On the other hand, the combined implementation of preventive measures proves 5 to-10-fold more effective than any single stringent measure, reducing deaths by 27.2%. The deaths under combined implementation measures never exceed that of standard preventive measures in any month. The research found that the combined implementation of measures in mask wearing, vaccination, and social distancing during winter can reduce the deaths by approximately 45%, which is approximately 1.5–3-fold higher than in the other seasons. This study provides valuable insights for COVID-19 epidemic prevention and control in America.

(1) Background: Vaccinium vitis-idaea is a nutritionally and economically valuable natural wild plant species that produces berries useful for treating various diseases. There is growing interest in lingonberry, but there is limited information regarding lingonberry reference genes suitable for gene expression analyses of different tissues under various abiotic stress conditions. The objective of this study was to identify stable reference genes suitable for different lingonberry tissues in response to abiotic stress. (2) Methods: The delta Ct method and the GeNorm v3.5 and NormFinder v20 programs were used to comprehensively analyze gene expression stability. (3) Results: Actin Unigene23839 was the best reference gene for analyzing different cultivars, whereas Actin CL5740.Contig2 was the most suitable reference gene for analyzing different tissues and alkali stress. In contrast, 18S rRNA CL5051.Contig1 was the most stable reference gene under drought conditions. (4) Conclusions: These suitable reference genes may be used in future qRT-PCR analyses of different lingonberry tissues and the effects of abiotic stresses. Furthermore, the study data may be useful for functional genomics studies and the molecular breeding of lingonberry. In summary, internal reference genes or internal reference gene combinations should be carefully selected according to the experimental conditions to ensure that the generated gene expression data are accurate.

Abstract To predict disease outcome in muscle-invasive bladder cancer (MIBC), we constructed a prognostic autophagy-related (PAR) lncRNA signature. Comprehensive bioinformatics analyses were performed using data from TCGA and GTEx databases. Univariate Cox, and least absolute shrinkage and selection operator regression analyses were also performed, based on differentially expressed genes, to identify PAR-related lncRNAs to establish the signature. Furthermore, the Kaplan–Meier OS curve and receiver operating characteristic curve analyses were performed and a nomogram was constructed, all of which together confirmed the strong predictive ability of the constructed signature. Patients with MIBC were then divided into high- and low-risk groups. Gene enrichment and immune infiltration analyses revealed the potential mechanisms in MIBC. We also further evaluated the signature of molecules related to immune checkpoints and the sensitivity toward chemotherapeutic agents and antitumor-targeted drugs to find better treatment prescriptions. We identified a number of PAR-related lncRNA signatures, including HCP5, AC024060.1, NEAT1, AC105942.1, XIST, MAFG-DT, and NR2F1-AS1, which could be valuable prognostic tools to develop more efficient, individualized drug therapies for MIBC patients.

Radish (Raphanus sativus L.) is an important root vegetable crop belonging to the Brassicaceae family. Anthocyanin rich radish varieties are popular among consumers because of their bright color and high nutritional value. However, the underlying molecular mechanism responsible for skin and flesh induce anthocyanin biosynthesis in transient overexpression, gene silencing and transcriptome sequencing were used to verify its function in radish anthocyanin accumulation, radish remains unclear. Here, we identified a long noncoding RNA LINC15957, overexpression of LINC15957 was significantly increased anthocyanin accumulation in radish leaves, and the expression levels of structural genes related to anthocyanin biosynthesis were also significantly increased. Anthocyanin accumulation and expression levels of anthocyanin biosynthesis genes were significantly reduced in silenced LINC15957 flesh when compared with control. By the transcriptome sequencing of the overexpressed LINC15957 plants and the control, 5,772 differentially expressed genes were identified. A total of 3,849 differentially expressed transcription factors were identified, of which MYB, bHLH, WD40, bZIP, ERF, WRKY and MATE were detected and differentially expressed in the overexpressed LINC15957 plants. KEGG enrichment analysis revealed the genes were significant enriched in tyrosine, L-Phenylalanine, tryptophan, phenylpropanol, and flavonoid biosynthesis. RT-qPCR analysis showed that 8 differentially expressed genes (DEGs) were differentially expressed in LINC15957-overexpressed plants. These results suggested that LINC15957 involved in regulate anthocyanin accumulation and provide abundant data to investigate the genes regulate anthocyanin biosynthesis in radish.

The Luxi district presents an exceptional research area for the investigation of the significant role played by magma exsolution fluids in the mineralization process of Au–Cu deposits. A particularly noteworthy occurrence within this region is the Yi’nan Tongjing Au–Cu skarn deposit, situated in the central-southern part of the Luxi district. This deposit primarily occurs in the contact zone between the early Cretaceous Tongjing complex and the Proterozoic to Cambrian sequences. The ore formation process observed in this deposit can be categorized into three distinct stages: (I) thermal metamorphism, (II) prograde alteration, and (III) retrograde alteration. The retrograde alteration stage is further divided into four sub-stages: late skarn (III-1), oxide (III-2), sulfide (III-3), and late quartz-calcite (III-4). It is primarily during the III-3 sub-stage that gold mineralization occurs. Petrographic analysis has identified three types of fluid inclusions (FIs) within garnet, quartz, and calcite grains. These include liquid-rich two-phase aqueous FIs, vapor-rich two-phase aqueous FIs, and halite-bearing multi-phase FIs. The homogenization temperatures of fluid inclusions from stages II, III-3, and III-4 range between 430–457 °C, 341–406 °C, and 166–215 °C (first to third quartiles), respectively. The garnet samples from stage II exhibit hydrogen and oxygen isotope compositions (δ18OH2O = 6.8‰ and δD = −73‰) that are indicative of a typical magma source. However, the hydrogen and oxygen isotopes of sub-stages III-1, III-2, and III-3 (δ18OH2O = 7.32‰ to 9.74‰; δD = −107‰ to −81.9‰) fall below the magma water box while the hydrogen and oxygen isotope values of III-4 (δ18OH2O = −5.3‰ to −0.9‰ and δD = −103.8‰ to −67‰) tend to move towards the meteoric water line. Furthermore, the ore-forming fluid displays characteristics of a mixture between the crustal and mantle fluids. The Tongjing complex occurred along a weakened fault zone, initiating a process of thermal metamorphism upon contact with the wall rock. This thermal metamorphism resulted in the formation of diverse assemblages, including hornfels, reaction skarns, and skarnoids. Subsequently, the upward movement of ore-forming fluids triggered exsolution which led to the establishment of a high-temperature, medium-salinity NaCl–H2O system with a single phase at depths ranging from 1–3 km. This marked the formation of the prograde alteration stage. Afterward, the ore-forming fluid underwent water–rock interactions and the admixture of meteoric water at a depth of 1–2 km. These processes facilitated phase separation, commonly referred to as boiling, resulting in the transformation of the ore-forming fluid into higher salinity fluids and lower-density gases. This evolutionary transition ultimately induced the precipitation and liberation of gold and copper from the fluid.

Objective. Recent studies have shown that serine/threonine-protein kinase 24 (STK24) plays an important role in cancer development. However, the significance of STK24 in lung adenocarcinoma (LUAD) remains to be determined. This study is aimed at investigating the significance of STK24 in LUAD. Methods. STK24 was silenced and overexpressed by siRNAs and lentivirus, respectively. Cellular function was assessed by CCK8, colony formation, transwell, apoptosis, and cell cycle. mRNA and protein abundance was checked by qRT-PCR and WB assay, respectively. Luciferase reporter activity was evaluated to examine the regulation of KLF5 on STK24. Various public databases and tools were applied to investigate the immune function and clinical significance of STK24 in LUAD. Results. We found that STK24 was overexpressed in lung adenocarcinoma (LUAD) tissues. High expression of STK24 predicted poor survival of LUAD patients. In vitro, STK24 enhanced the proliferation and colony growth ability of A549 and H1299 cells. STK24 knockdown induced apoptosis and cell cycle arrest at G0/G1 phase. Furthermore, Krüppel-like factor 5 (KLF5) activated STK24 in lung cancer cells and tissues. Enhanced lung cancer cell growth and migration triggered by KLF5 could be reversed by silencing of STK24. Finally, the bioinformatics results showed that STK24 may be involved in the regulation of the immunoregulatory process of LUAD. Conclusion. KLF5 upregulation of STK24 contributes to cell proliferation and migration in LUAD. Moreover, STK24 may participate in the immunomodulatory process of LUAD. Targeting KLF5/STK24 axis may be a potential therapeutic strategy for LUAD.

Gold–Cu skarn deposits are characterized by a diverse mineral assemblage, whose in-situ major/trace elements and isotope compositions can provide key constraints to the migration and enrichment of Au during hydrothermal processes. The Yi’nan Tongjing Au–Cu deposit is located in the central part of the Luxi district, and both skarn and Au–Cu ore bodies occur at the contact between the Early Cretaceous diorite porphyry and the Neoproterozoic to Cambrian carbonate rocks. Five stages of mineralization were identified: 1) early skarn (garnet–diopside–wollastonite); 2) late skarn (magnetite–epidote–actinolite±tremolite); 3) oxide (specularite–hematite); 4) sulfide (pyrite–chalcopyrite–sphalerite–quartz–chlorite); and 5) late quartz–calcite. The mineralization process in the Tongjing Au-Cu deposit was revealed by detailed scanning electron microscope-backscattered electron imaging, electron probe microanalysis, in-situ trace element, sulfur and lead isotope analysis. Magnetite is enriched in chalcophile elements (Cu, Zn, Pb), Co and Ni, probably due to hydrothermal overprint. The substitution of As and other elements in the formation of pyrite is conducive to the entry of Au into pyrite. The increase of Se and As contents in pyrite from stage IVa to IVb indicates that the temperature, salinity and oxygen fugacity of the ore-forming fluid decrease while the pH rises, resulting in the unloading of Au. The temperature of Au mineralization based on the Se content in pyrite does not exceed 300°C. Furthermore, V positively correlated with Ti and Ni/Cr ratios ≥1 in magnetite and most Co/Ni ratios in pyrite >10 all confirm their hydrothermal origins. The restricted sulfur (δ34SV-CDT = −0.5–1.2‰; mean = 0.4‰) and lead (206Pb/204Pb = 17.323–17.383; 207Pb/204Pb = 15.424–15.452; 208Pb/204Pb = 37.367–37.454) isotopic compositions suggest that the deep magma provided the primary mineralized material, accompanied by a relatively small amount of shallow crustal material. The Yi’nan Tongjing Au–Cu skarn deposit was formed in the Early Cretaceous, which is an important metallogenic response to the strong decratonization of the North China Craton induced by the paleo-Pacific Plate roll-back. This study shows that there is a large potential of Early Cretaceous skarn mineralization in the Luxi district.

Abstract A 6.0‐magnitude (Mw) earthquake was reported to have occurred in Jiashi County, Xinjiang at 21:27 on 19 January 2020, Beijing time (13:27 UTC). This study applied a stochastic finite‐fault approach based on the dynamic corner frequency (EXSIM) to simulate 23 near‐field stations within a distance of 120 km from the epicenter. The stochastic finite‐fault approach is the simplest and most effective method for simulating high‐frequency ground motions. According to studies and empirical relationships, we estimated a region‐specific parameter (κ0) for use in simulations. In this study, two different slip models, namely, random and inverted slip models, were used to explain their influence on the simulation results. For most stations, the simulated seismic characteristics, such as the peak ground acceleration (PGA), pseudo spectral acceleration ,and Fourier acceleration spectrum, are highly compatible with the observed values in the frequency range (f > 1 Hz), indicating that the stochastic finite‐fault approach is not highly sensitive to input slip distributions and fault dimensions. The simulation results indicated no significance between the two slip models under high‐frequency conditions. Finally, based on the predicted PGA values of 1891 field points selected near the fault, the acceleration field of the Jiashi earthquake is plotted. The results show that the use of the acceleration time history predicted by modified EXSIM is feasible and practical in the high‐frequency band above 1 Hz.

Background Mitochondrial fusion and fission were identified to play key roles during multiple biology process. Thus, we aim to investigate the roles of OPA1 in mitochondria fusion and immune evasion of non-small cell lung cancer cells. Methods The transcriptional activation of genes related to mitochondrial dynamics was determined by using multi-omics data in lung adenocarcinoma (LUAD). We elucidated the molecular mechanism and roles of OPA1 promoting lung cancer through single-cell sequencing and molecular biological experiments. Results Here, we found that copy number amplification of OPA1 and MFN1 were co-occurring and synergistically activated in tumor epithelial cells in lung cancer tissues. Both of OPA1 and MFN1 were highly expressed in LUAD tumor tissues and OPA1 high expression was associated with poor prognosis. In terms of mechanism, the damaged mitochondria activated the apoptotic signaling pathways, inducing cell cycle arrest and cell apoptosis. More interestingly, OPA1 deficiency damaged mitochondrial dynamics and further blocked the respiratory function to increase the sensitivity of tumor epithelial to CD8+ T cells in non-small cell lung cancer. Conclusions Our study demonstrated the high co-occurrence of copy number amplification and co-expression of OPA1 and MFN1 in LUAD tissue, and further revealed the contribution of OPA1 in maintaining the mitochondria respiratory function and the ability of immune evasion to CD8+ T cells of LUAD.

Abstract The performance of electrode materials depends intensively on the lithium (Li)‐ion storage mechanisms correlating ultimately with the Coulombic efficiency, reversible capacity, and morphology variation of electrode material upon cycling. Transition metal nitrides anode materials have exhibited high‐energy density and superior rate capability; however, the intrinsic mechanism is largely unexplored and still unclear. Here, a typical 3D porous Fe2N micro‐coral anode is prepared and, an intercalation–conversion–heterogeneity hybrid Li‐ion storage mechanism that is beyond the conventional intercalation or conversion reaction is revealed through various characterization techniques and thermodynamic analysis. Interestingly, using advanced in situ magnetometry, the ratio (ca. 24.4%) of the part where conversion reaction occurs to the entire Fe2N can further be quantified. By rationally constructing a Li‐ion capacitor comprising 3D porous Fe2N micro‐corals anode and commercial AC cathode, the hybrid full device delivers a high energy‐density (157 Wh kg−1) and high power‐density (20 000 W kg−1), as well as outstanding cycling stability (93.5% capacitance retention after 5000 cycles). This research provides an original and insightful method to confirm the reaction mechanism of material related to transition metals and a fundamental basis for emerging fast charging electrode materials to be efficiently explored for a next‐generation battery.

The stability of a 1000 mm/1435 mm dual-gauge track is lower than that of a single-gauge track. One of the important factors that affects the stability of the track is the lateral resistance of the track bed. We have established a discrete element simulation model of the dual-gauge sleeper-track bed in PFC to analyse the characteristics of the lateral resistance of the 1000 mm/1435 mm dual-gauge sleeper. With China Type IIIc sleepers as the control group, we carried out the lateral resistance test for the full-scale sleeper model under the same conditions. The research results indicate that the most effective way to increase the lateral resistance of the dual-gauge track bed is to increase the end surface area and bottom area of the sleeper. The application of adjacent sleepers is an effective way to increase the lateral resistance of the track bed further. The research results gained from this study can be used to guide the design of dual-gauge sleepers.

Many laboratory studies have shown that particle size distribution (PSD) affects the liquefaction susceptibility of granular materials. However, few studies have focused on the impact of PSD on coral particles. In this study, two different soil families were prepared: one with three levels of mean particle size (D50) with identical uniformity coefficient (Cu)and the other with four levels of Cu with the same D50 for coral gravelly soils. In addition, a series of undrained cyclic triaxial tests were conducted on coral gravelly particles with two groups of PSDs at a relative density of 40% and an adequate confining pressure of 100 kPa. The test results indicated that D50 with identical Cu can affect the undrained cyclic behavior of coral gravelly particles. In contrast, Cu with identical D50 does not impact the undrained cyclic behavior of coral gravelly particles. The developing pore water pressure was uniform when the sample was subjected to the same cyclic loading. For samples with changing D50 values of 2.35, 4.70, and 7.05 mm, increasing D50 improved the cyclic liquefaction resistance. For samples with changing Cu, increasing Cu in the range of 1.06–5.00 first increased and then decreased the liquefaction resistance.

Rational design and synthesis of superior electrocatalysts for ethanol oxidation is crucial to practical applications of direct ethanol fuel cells. Here, authors report the construction of Pd-Zn dual sites with well exposure and uniformity can improve the efficiency of ethanol electro-oxidation.

Research on the bulk internal electric field (IEF) regulation is significant for designing high-efficiency photocatalysts. Here, the authors report distinctive bismuth oxyhydroxide nanorods photocatalyst and increase the bulk IEF intensity by halogen ions exchange.

It is of great significance to exert the synergistic effect between single atom and support. Here, the authors prepare polyoxometalates-stabilized single-atom site catalysts in confined space with enhanced activity for alkynes diboration.

Abstract The facility location of a competing firm in a market has great importance in supply chain management. The two-stage competitive location model formulates the decision process of an entrant firm facing both location and price competition. In this paper, we incorporated the facility quantity as a decision variable into a two-stage competitive location model with the objective of maximized profit. Sequential location mode and simultaneous location mode were applied to simulate different location behavior. We developed an approximate branch and bound method to accelerate optimal location searching speed under the premise of accuracy. Greedy algorithm and approximate branch and bound method were used in two location modes. From algorithm evaluation, we found that the approximate branch and bound method is an ideal supplement of the traditional branch and bound method, especially for location problems with large-scale potential locations. Compare the results of the two modes, we found when a new firm is going to enter a market with both price and location competition, sequential location mode is an advantage strategy, since it can gain more profit than simultaneous location mode.

Designing atomically monodispersed heterogeneous catalysts with uniform active sites and high atom utilization efficiency is of fundamental and practical interest. Here, the authors report a Pt2/mpg-C3N4 catalyst showing enhanced catalytic performance toward the selective hydrogenation and epoxidation

Abstract In bimetallic heterostructured nanoparticles (NPs), the synergistic effect between their different metallic components leads to higher catalytic activity compared to the activity of the individual components. However, how the dynamic changes through which these NPs adopt catalytically active structures during a reaction and how the restructuring affects their activity are largely unknown. Here, using operando transmission electron microscopy, structural changes are studied in bimetallic Ni–Rh NPs, comprising of a Ni core whose surface is decorated with smaller Rh NPs, during a CO oxidation reaction. The direct atomic‐scale imaging reveals that, under O2‐rich conditions, Ni core partially transforms into NiO, forming a (Ni+NiO)–Rh hollow nanocatalyst with high catalytic activity. Under O2‐poor conditions, Rh NPs alloy with the surface of the core to form a NiRh‐alloy surface, and the NPs display significantly lower activity. The theoretical calculations indicate that NiO component that forms only under O2‐rich conditions enhances the activity by preventing the CO poisoning of the nanocatalysts. The results demonstrate that visualizing the structural changes during reactions is indispensable in identifying the origin of catalytic activity. These insights into the dynamic restructuring of NP catalysts under a reactive environment are critical for the rational design of high‐performance nanocatalysts.

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is an acute respiratory failure syndrome characterized by progressive arterial hypoxemia and dyspnea. Qingfei Litan (QFLT) decoction, as a classic prescription for the treatment of acute respiratory infections, is effective for the treatment of ALI/ARDS. In this study, the compounds, hub targets, and major pathways of QFLT in ALI/ARDS treatment were analyzed using Ultra high performance liquid chromatography coupled with mass spectrometry (UHPLC-MS) and systemic pharmacology strategies. UHPLC-MS identified 47 main components of QFLT. To explore its anti-inflammatory and anti-oxidative mechanisms, gene ontology (Go) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and network pharmacological analysis were conducted based on the main 47 components. KEGG enrichment analysis showed that TNF signaling pathway and Toll-like receptor signaling pathway may be the key pathways of ALI/ARDS. We explored the anti-inflammatory and anti-oxidative pharmacological effects of QFLT in treatment of ALI/ARDS in vivo and in vitro. QFLT suppressed the levels of proinflammatory cytokines and alleviated oxidative stress in LPS-challenged mice. In vitro, QFLT decreased the levels of TNF-α, IL-6, IL-1β secreted by LPS-activated macrophages, increased GSH level and decreased the LPS-activated reactive oxygen species (ROS) in lung epithelial A549 cells. This study suggested that QFLT may have anti-inflammatory and anti-oxidative effects on ALI/ARDS, combining in vivo and in vitro experiments with systemic pharmacology, providing a potential therapeutic strategy option.

Steel formworks are widely used in prefabricated buildings thanks to their good characteristics. With the rapid development of engineering construction in China, steel formwork concrete structures, characterized by convenient construction, good seismic performance, and high strength, are expected to be more extensively applied in engineering practice. However, the bearing capacity of different forms of steel formwork concrete is still unclear. Two prefabricated columns with different internal diaphragm styles were set up for axial compression tests to investigate the performance of steel formwork columns. This study conducts monotonic static loading tests on six prefabricated steel tube column specimens and performs finite element analysis by taking steel tube thickness, rebar diameter, and internal diaphragm style as the influencing parameters. The results show that the prefabricated specimens can work in the test process, and the ultimate bearing capacity is consistent between the tests and numerical simulation. Moreover, the nephograms obtained from numerical simulation also conformed to the failure mode of the specimens in the test process. Therefore, the finite element model proposed in this study can accurately predict the stress performance of steel formwork concrete stub columns. These results offer guidance for future engineering practices.

Abstract Electrocatalysis is viewed as one of the most effective ways to mitigate the energy problems and produce fuels or value‐added chemicals in a gentle manner. However, duo to the limited electrochemical properties of various systems, there is an intensive search for highly efficient electrocatalysts by more rational control over the topographic structure, chemical structure, and electronic structure. At present, the development of electrocatalysts mainly includes two directions: (1) nanoparticle electrocatalysts, and (2) single atom site electrocatalysts (SACs). Nanoparticle and SACs display their own advantages, and have been widely studied in the field of electrocatalysis. Considering the state‐of‐the‐art progress for nanoparticles or SACs, the selection of effective electrocatalysts has been a topic of great research value. Therefore, this paper summarizes the advantages, commonalities, and problems of nanoparticle and SACs, as well as their developing methods and experiences. In addition, the selection of nanoparticle and SACs in electrocatalytic reactions was discussed from the aspects of their respective influencing factors, active sites and synergistic effect. Finally, the research of nanoparticle and single atom sites electrocatalysts were prospected, providing a general guidance for the selection of efficient electrocatalysts.

Abstract Today, Pt/C catalysts are widely used in proton exchange membrane fuel cells (PEMFCs). The practical applications of PEMFCs still face many limitations in the preparation of advanced Pt‐based catalysts, including high cost, limited life‐time, and insufficient power density. A kinetically sluggish oxygen reduction reaction (ORR) is primarily responsible for these issues. The development of advanced Pt‐based catalysts is crucial for solving these problems when the large‐scale application of PEMFCs is to be realized. Herein, we demonstrate the design principle of advanced Pt‐based catalysts with an emphasis on theoretical understandings to practical applications. Generally, three main strategies (including strain effect, electronic effect, and ensemble effect) that governing the initial activity of Pt‐based electrocatalysts are elaborated in detail in this review. Recent advanced Pt‐based ORR catalysts are summarized and we present representative achievements to further reveal the relationship of excellent ORR performance based on theoretical mechanisms. Then we focus on the preparation standards of membrane electrode assembles and testing protocols in practice. Finally, we predict the remaining challenges and present our perspectives with regards to design strategies for improving ORR performance of Pt‐based catalysts in the future.

Abstract Background Caffeic acid O-methyltransferases (COMTs) play an important role in the diversification of natural products, especially in the phenylalanine metabolic pathway of plant. The content of COMT genes in blueberry and relationship between their expression patterns and the lignin content during fruit development have not clearly investigated by now. Results Ninety-two VcCOMTs were identified in Vaccinium corymbosum. According to phylogenetic analyses, the 92 VcCOMTs were divided into 2 groups. The gene structure and conserved motifs within groups were similar which supported the reliability of the phylogenetic structure groupings. Dispersed duplication (DSD) and whole-genome duplication (WGD) were determined to be the major forces in VcCOMTs evolution. The results showed that the results of qRT-PCR and lignin content for 22 VcCOMTs, VcCOMT40 and VcCOMT92 were related to lignin content at different stages of fruit development of blueberry. Conclusion We identified COMT gene family in blueberry, and performed comparative analyses of the phylogenetic relationships in the 15 species of land plant, and gene duplication patterns of COMT genes in 5 of the 15 species. We found 2 VcCOMTs were highly expressed and their relative contents were similar to the variation trend of lignin content during the development of blueberry fruit. These results provide a clue for further study on the roles of VcCOMTs in the development of blueberry fruit and could promisingly be foundations for breeding blueberry clutivals with higher fruit firmness and longer shelf life.

This paper studies the problem of the secure state estimation of cyber-physical systems. The system model we studied is a class of discrete-time systems with state delay and sparse sensor attacks. In the design of the observer, a Projection Operator is utilized to determine the correct attack set, and the gain matrix will be switched accordingly. In this way, the excessive estimation error could be avoided effectively. In addition, based on the generalization of the classical Krasovskii Stability Theorem for stability analysis of time-delay systems, a Lyapunov-Krasovskii functional is chosen and a sufficient condition for the existence of the observer together with its design method is determined. The designed observer overcomes the difficulties caused by state delay and sensor attacks, and has good performance in secure estimation. Finally, two examples are given to verify that the observer can restore the desired estimate in a short time when a sudden attack occurs.

Ru is one of the most active metals for oxygen evolution reaction, but it quickly dissolves in acidic electrolyte particularly in nanosized form. Here the authors show that coral-like solid-solution Ru‒Ir consisting of 3 nm-thick sheets with only 6 at% Ir is a long-lived catalyst with high activity

The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal models. More significantly, the co-delivery of DNA and protein components at the same time elicited full protection against intratracheal challenge of SARS-CoV-2 viruses in immunized rhesus macaques. As both DNA and protein vaccines have been proven safe in previous human studies, and DNA vaccines are capable of eliciting germinal center B cell development, which is critical for high-affinity memory B cell responses, the DNA and protein co-delivery vaccine approach has great potential to serve as a safe and effective approach to develop COVID-19 vaccines that provide long-term protection.