4 results on '"Yahia, Amar Ibrahim Omar"'
Search Results
2. Evaluation of Some Prognostic Biomarkers in Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma.
- Author
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Alabiad, Mohamed Ali, Said, Warda M. M., Adim, Amal M. A., Alorini, Mohammed, Shalaby, Amany Mohamed, Samy, Walaa, Elshorbagy, Shereen, Mandour, Doaa, Saber, Ibrahim Mohamed, Yahia, Amar Ibrahim Omar, and Khairy, Dina Ahmed
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CANCER prognosis , *ONCOLOGIC surgery , *PAPILLOMAVIRUS diseases , *PARANASAL sinus cancer , *VASCULAR endothelial growth factors , *PROTEINS , *LYMPH nodes , *TELOMERASE , *CANCER relapse , *SYMPTOMS , *CHI-squared test , *AGE distribution , *DESCRIPTIVE statistics , *IMMUNOHISTOCHEMISTRY , *KAPLAN-Meier estimator , *METASTASIS , *REVERSE transcriptase inhibitors , *SURVIVAL analysis (Biometry) , *TUMOR classification , *PROGRESSION-free survival , *BIOMARKERS , *PHENOTYPES , *EPIDERMAL growth factor receptors , *NUCLEAR factor E2 related factor , *OVERALL survival , *DISEASE complications - Abstract
Background: Human papillomavirus (HPV)-related multi phenotypic sinonasal carcinoma (HMSC) is a recently described tumor subtype with an unknown prognosis, often misdiagnosed with other sinonasal carcinomas, and associated with highrisk HPV (HR-HPV). The present study aimed to evaluate the expression of vascular endothelial growth factor (VEGF), Bcl-2-associated X protein (BAX), epidermal growth factor receptors (EGFR), ProEx™C, and human telomerase reverse transcriptase (hTERT) and assess their association with survival and clinicopathological characteristics. Methods: Between 2017 and 2022, 40 HMSC patients underwent surgical resection at the School of Medicine, Zagazig University Hospitals (Zagazig, Egypt). Tissue samples were examined for the presence of HR-HPV; absence of myeloblastosis (MYB), MYB proto-oncogene like 1 (MYBL1), and nuclear factor I/B (NFIB) fusions and the presence of myoepithelial proteins (calponin, S100, SMA), squamous differentiation markers (p63, p40, calponin), VEGF, BAX, ProEx™C, and hTERT by immunohistochemistry. All patients were followed up for about 54 months until death or the last known survival data. Data were analyzed using the Chi square test and Kaplan-Meier method. Results: The expression of VEGF, hTERT, and ProEx™C was significantly associated with age, advanced tumor stages, lymph node metastasis, tumor size, mortality, relapse, poor disease-free survival (DFS), and overall survival (OS) (P<0.001). BAX expression was significantly associated with tumor size, age, poor DFS, and relapse (P=0.01, P<0.001, P=0.035, and P=0.002, respectively). Conclusion: HMSC is strongly associated with HR-HPV. The expression of VEGF, EGFR, BAX, hTERT, and ProEx™C is associated with aggressive malignant behavior, poor survival, and poor prognosis, making them novel prognostic biomarkers for targeted therapeutics in HMSC. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-?B Signaling Pathways.
- Author
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Alabiad, Mohamed Ali, Said, Warda M. M., Faraj Saad, Rema H., Balata, Rawda, Mahmoud, Asmaa A., Metwally, Elsayed Anany, Shalaby, Amany Mohamed, Samy, Walaa, Yehia, Ahmed M., Yahia, Amar Ibrahim Omar, Alorini, Mohammed, and Abdelrahman, Doaa I.
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HODGKIN'S disease , *CANCER invasiveness , *NF-kappa B , *JANUS kinases , *CELLULAR signal transduction , *GENE expression , *COMPARATIVE studies , *MESSENGER RNA , *CHI-squared test , *KAPLAN-Meier estimator , *DESCRIPTIVE statistics , *EPSTEIN-Barr virus diseases , *EPIGENOMICS , *LONGITUDINAL method - Abstract
Background: Epstein-Barr virus (EBV) is detected in 40% of patients with Hodgkin lymphoma (HL). During latency, EBV induces epigenetic alterations to the host genome and decreases the expression of pro-apoptotic proteins. The present study aimed to evaluate the expression levels of mRNA molecules and the end product of proteins for the JAK/STAT and NF-κB pathways, and their association with clinicopathological and prognostic parameters in patients with EBV-positive and -negative classical Hodgkin lymphoma (CHL). Methods: A prospective cohort study was conducted from 2017 to 2022 at the Faculty of Medicine, Zagazig University Hospital (Zagazig, Egypt). Biopsy samples of 64 patients with CHL were divided into EBV-positive and EBV-negative groups. The expression levels of mRNA molecules (JAK2, STAT1, IRF-1, PD-L1, IFN-γ, NF-κB, Bcl-xL, COX-2) and the end product of proteins (PD-L1, Bcl-xL, COX-2) were determined and compared with clinicopathological and prognostic parameters. Data were analyzed using the Chi square test and Kaplan-Meier estimate. Results: EBV-positive CHL patients were significantly associated with positive expression of mRNAs molecules (P<0.001) and the end product of proteins (P<0.001) for the JAK/STAT and NF-κB pathways, B-symptoms (P=0.022), extra-nodal involvement (P=0.017), and advanced stage of CHL (P=0.018). These patients were more susceptible to cancer progression, higher incidence of relapse (P=0.008), poor disease-free survival rate (P=0.013), poor overall survival rate (P=0.028), and higher mortality rate (P=0.015). Conclusion: Through the activation of JAK/STAT and NF-κB signaling pathways, EBV-positive CHL is associated with poor clinicopathological parameters, higher incidence of disease progression, relapse, and poor overall survival. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
- View/download PDF
4. Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-κB Signaling Pathways.
- Author
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Alabiad MA, Said WMM, Saad RHF, Balata R, Mahmoud AA, Metwally EA, Shalaby AM, Samy W, Yehia AM, Yahia AIO, Alorini M, and Abdelrahman DI
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- Humans, Herpesvirus 4, Human genetics, Herpesvirus 4, Human metabolism, NF-kappa B metabolism, B7-H1 Antigen, Cyclooxygenase 2 metabolism, Prospective Studies, Signal Transduction, Prognosis, RNA, Messenger, Recurrence, Hodgkin Disease complications, Hodgkin Disease genetics, Hodgkin Disease metabolism, Epstein-Barr Virus Infections complications, Epstein-Barr Virus Infections genetics, Epstein-Barr Virus Infections pathology
- Abstract
Background: Epstein-Barr virus (EBV) is detected in 40% of patients with Hodgkin lymphoma (HL). During latency, EBV induces epigenetic alterations to the host genome and decreases the expression of pro-apoptotic proteins. The present study aimed to evaluate the expression levels of mRNA molecules and the end product of proteins for the JAK/STAT and NF-κB pathways, and their association with clinicopathological and prognostic parameters in patients with EBV-positive and -negative classical Hodgkin lymphoma (CHL)., Methods: A prospective cohort study was conducted from 2017 to 2022 at the Faculty of Medicine, Zagazig University Hospital (Zagazig, Egypt). Biopsy samples of 64 patients with CHL were divided into EBV-positive and EBV-negative groups. The expression levels of mRNA molecules (JAK2, STAT1, IRF-1, PD-L1, IFN-γ, NF-κB, Bcl-xL, COX-2) and the end product of proteins (PD-L1, Bcl-xL, COX-2) were determined and compared with clinicopathological and prognostic parameters. Data were analyzed using the Chi square test and Kaplan-Meier estimate., Results: EBV-positive CHL patients were significantly associated with positive expression of mRNAs molecules (P<0.001) and the end product of proteins (P<0.001) for the JAK/STAT and NF-κB pathways, B-symptoms (P=0.022), extra-nodal involvement (P=0.017), and advanced stage of CHL (P=0.018). These patients were more susceptible to cancer progression, higher incidence of relapse (P=0.008), poor disease-free survival rate (P=0.013), poor overall survival rate (P=0.028), and higher mortality rate (P=0.015)., Conclusion: Through the activation of JAK/STAT and NF-κB signaling pathways, EBV-positive CHL is associated with poor clinicopathological parameters, higher incidence of disease progression, relapse, and poor overall survival. A preprint of this manuscript is available on research square (doi: 10.21203/rs.3.rs-1857436/v1)., Competing Interests: None declared., (Copyright: © Iranian Journal of Medical Sciences.)
- Published
- 2024
- Full Text
- View/download PDF
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