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Dieting is a basic treatment for lowering hyperuricemia. Here, we aimed to determine the optimal amount of dietary food that lowers serum uric acid (SUA) without modifying the dietary ingredients in rats. Increased SUA was found in food-deprived 45-day-old uricase-deficient rats (Kunming-DY rats), and the optimal amount of dietary food (75% dietary intake) to lower SUA was established by controlling the amount of food given daily from 25% to 100% for 2 weeks. In addition to lowering SUA by approximately 22.5 ± 20.5%, the optimal amount of dietary food given for 2 weeks inhibited urine uric acid excretion, lowered the uric acid content in multiple organs, improved renal function, lowered serum triglyceride, alleviated organ injuries (e.g., liver, kidney and intestinal tract) at the histological level, and down-regulated the Kyoto Encyclopedia of Genes and Genome (KEGG) pathway of the cell cycle (ko04110). Taken together, these results demonstrate that 75% dietary food effectively lowers the SUA level without modifying dietary ingredients and alleviates the injuries resulting from uricase deficiency or hyperuricemia, the mechanism of which is associated with the down-regulation of the cell cycle pathway.

There are several sets of source rocks in the Yanchang Formation of Mesozoic in the Ordos Basin. At present, Chang 7 source rock is considered to be the main source rock of the Yanchang Formation, although there are no evaluation methods for hydrocarbon generation and expulsion of other source rocks, as well as the hydrocarbon accumulation contribution of source rocks. Utilizing basin simulation and based on a large number of basic geological data and exploration results, the geological body model and thermal history model are established to carry out simulation research on hydrocarbon generation, expulsion, and accumulation of multi-source layers in the Yanchang Formation under geological constraints. The results show that the conversion rate of hydrocarbon generation of each source rock in the Yanchang Formation is mainly distributed in the range of 45%–75%, indicating that the formation still has significant hydrocarbon generation potential and has the geological conditions for in-situ exploitation of shale oil. At present, accumulative hydrocarbon generation is 123.3 × 109 t while hydrocarbon expulsion is 90 × 109 t, with heavy hydrocarbons of C14+ dominating. The Early Cretaceous had the highest concentration of hydrocarbon generation and expulsion, accounting for 68%–82% of total hydrocarbon generation and expulsion. The simulation of hydrocarbon accumulation revealed that before the deposition of the Cretaceous, only a limited amount of hydrocarbon charging occurred in each layer of the Yanchang Formation, with the early Cretaceous being the key period of hydrocarbon charging and accumulation. The “near-source accumulation” characterizes the upper and lower hydrocarbon source layers, and the basin simulation results are in good agreement with proven oil reservoirs and predicted oil reservoir distribution ranges. The study proposed for the first time that the “Chang 7 source rock make major contribution to multi-layer reservoir” mode could be modified to “proximal hydrocarbon accumulation from diverse source rock” mode to stimulate shale oil production and potential layer exploration in the Yanchang Formation of Mesozoic in the Ordos Basin.

The Gaofen-3 (GF-3) satellite is China's first civilian quad-polarized C-band imaging microwave satellite that can provide high-resolution marine and land observations. Also, it is China's first low Earth orbit remote sensing satellite with a design life of eight years. During the design and development of this satellite, many major challenges have been overcome, such as the design of complex radio frequency channels, difficult system integration, high quantitative requirements, and strict component life requirements. In this article, a series of independent technological innovations in the development of GF-3 is presented. Meanwhile, the on-orbit operation of the satellite in the past five years is introduced, as well as the application of satellite data in marine observation, emergency relief, disaster reduction, surveying and mapping, water conservancy, etc. The further advancement and improvements of the GF-3 satellite are described at the end of this article.

In the Ordos Basin, the Chang 8 oil reservoir of the Triassic Yanchang Formation is the main target of oil exploration and development and there are many factors affecting the hydrocarbon accumulation. Well G20 is an important exploration well in the Yanchi area in the northwestern part of the basin, and the core of the Chang 8 reservoir was sampled and tested to determine the source rocks, trace element composition, mineral composition, reservoir physical properties, and oil-bearing properties. The results show that the rock retrieved exhibits delta plain subfacies; the range of the Chang 8 water body was large, with a gentle slope, and the climate was relatively dry. These findings suggest that this reservoir was deposited in an environment in which sedimentary sand body could easily form. The Chang 8 sandstone reservoir pores are dominated by intergranular pores and feldspar intragranular dissolution pores, indicating that the Chang 8 reservoir is a low-porosity and low-permeability reservoir. Chang 7 source rocks from this area have a type I-II1 hydrocarbon-generating potential, with an average total organic carbon (TOC) content of 5.99% and vitrinite reflectance (Ro) value of 0.48%. Combined with the regional sedimentary evolution, tectonic movement, and reservoir distribution, it is considered that due to the lack of lithologic traps or low-amplitude structural traps, G20 produced water in well testing. The Chang 8 oil reservoir in the Yanchi area can be divided into structural reservoirs and structural-lithologic reservoirs. The conventional oil and gas reservoir exploration ideas of “thick sand belt” and “reservoir sweet spot” are not applicable here. The lithology traps or low-amplitude structural traps and areas with good preservation conditions are the main directions for the next phase of exploration in the northwestern part of the Ordos Basin.

The aim of this study was to provide a sensitive model animal for studying hyperuricemia. Male uricase-deficient rats, named Kunming-DY rats, were raised for 130 days, or orally administered with purines and other chemicals. Serum uric acid (SUA) in the animals was assayed, and the UA level in their organs and their 24-h excretion was determined. Genes in the jejunum, ileum, kidney and liver related to UA synthesis and transportation were detected by quantitative RNA sequencing. Uricase-deficient rats have a high level of SUA and are sensitive to xanthine, adenosine, inosine, allopurinol, and alcohol. Besides, the high level of SUA in male uricase-deficient rats was stable, much higher than that in wild-type rats but similar to that in men. The distribution pattern of UA in uricase-deficient rats’ organs was different from that in wild-type rats. The kidney, liver, and small intestine were the top three organs where UA distributed, but the UA in the small intestine, colon, lung, thymus, and brain was less affected by uricase deficiency, indicating that these organs are constitutive distribution organs in UA. The 24-h UA excreted by a uricase-deficient rat was about five times higher than that excreted by a wild-type rat. However, the 24-h UA excreted through feces was not significantly changed. Both the urine volume and UA in uricase-deficient rats significantly increased, and more than 90% of UA was excreted via urine. The expression of xanthine dehydrogenase was not upregulated. Some genes of transporter associated with uric acid excretion in the kidney were significantly regulated, though not sufficient to explain the increase in SUA. In conclusion, male uricase-deficient rats’ UA metabolism is similar to that of men. The elevation of SUA in uricase-deficient rats is caused by uricase deficiency, and uricase-deficient rats are a sensitive model for studying hyperuricemia.

During the Mesozoic, the T-J1 oil system of the Ordos Basin, whilst the degree of oil enrichment, main production layer, and source rock distribution exhibit strong regional differences, no systematic study has been conducted to investigate these differences. At this time, the total organic carbon abundance and vertical distribution of the eight long core wells in different areas of the basin within the Chang 7 member source layers were calculated by means of the ΔLogR method. According to the industrial oil well and the low production well, the favorable oil distribution areas of the Chang 8, Chang 7, and Chang 6 reservoirs are demarcated. The current study confirmed five distribution styles and strong regional differences in the longitudinal direction of source rocks. To be more specific, the Jiyuan area in the northwestern part of the lake basin is dominated by the bottom rich type and the full section rich type. The northeastern Shaanxi region is mainly dominated by the middle rich type and the top rich type. Meanwhile, the central area of the basin is mainly the interlayered type, and the southwestern Longdong region is mainly the bottom rich type. The comprehensive analysis of source rock type and oil favorable zone revealed that source rock type has a controlling effect on the crude oil distribution. The bottom rich type and full section rich type dominate the Jiyuan area and multiple layer oil production. In northern Shaanxi, the top rich type and middle rich type accumulate on the upper portion. Also, the Chang 6 reservoir was the main production layer. The bottom rich type of the Longdong area accumulates under the source, while the Chang 8 reservoir is the main production layer. The central parts of the lake basin are dominated by the interlayered type with multiple layers of production oil. The close relationship between the distribution pattern of source rocks and oil accumulation indicates an improvement on the distribution law of the continental lake with significance practical implication on the optimization of the field of near-source-in-source oil and gas exploration. Keywords: Ordos basin, Yanchang formation, Patterns of source rocks, Exploration direction

Abstract: Based on analysis of main controlling factors of Chang 9, the source rock, driving force of migration, migration and accumulation modes, reservoir forming stages and model and enrichment law of Chang 9 reservoir were examined. The study showed that the oil of Chang 9 reservoir in the Jiyuan and Longdong (Eastern Gansu) areas came primarily from the source rock of Chang 7 Member, but the oil of Chang 9 reservoir in the Zhidan area came primarily from the source rock of Chang 9 Member. There developed lithologic-structural oil reservoirs in Gufengzhuang-Mahuangshan area in northwest Jiyuan, structural-lithologic oil reservoirs in east Jiyuan, and lithologic reservoirs in Huachi–Qingcheng area and Zhidan area. The overpressure of Chang 7 Member was the driving force of oil migration. The burial history showed that Chang 9 Member experienced two stages of reservoir forming, the reservoir formed in the Late Jurassic was smaller in charging scope and scale, and the Early Cretaceous was the period when the source rock generated oil and gas massively and the Chang 9 reservoir came into being. Along with the tectonic movements, Chang 7 bottom structure turned from high in the west and lower in the East in the sedimentary stage to high in the east and lower in the west in the hydrocarbon accumulation stage and at last to gentle western-leaning monoclinal structure at present. In Early Cretaceous, the Chang 7 bottom structure was the lowest in the west of Huanxian-Huachi-Wuqi-Dingbian areas, so the oil migrated laterally towards the higher positions around after entering the reservoir. In the main reservoir forming period, Chang 7 bottom had an ancient anticline in Mahuangshan-Hongjingzi area of west Jiyuan, controlling the oil reservoir distribution in west Jiyuan. Key words: Ordos Basin, Triassic Yanchang Formation, Chang 9 Member, source rock, driving force of migration, migration and accumulation mode, reservoir accumulation mode, enrichment law

Dieting is a basic treatment for lowering hyperuricemia. Here, we aimed to determine the optimal amount of dietary food that lowers serum uric acid (SUA) without modifying the dietary ingredients in rats. IncreasedSUAwas found in food-deprived 45-day-old uricase-deficient rats (Kunming-DY rats), and the optimal amount of dietary food (75% dietary intake) to lower SUA was established by controlling the amount of food given daily from 25% to 100% for 2 weeks. In addition to lowering SUA by approximately 22.5 ± 20.5%, the optimal amount of dietary food given for 2 weeks inhibited urine uric acid excretion, lowered the uric acid content in multiple organs, improved renal function, lowered serum triglyceride, alleviated organ injuries (e.g., liver, kidney and intestinal tract) at the histological level, and down-regulated the Kyoto Encyclopedia of Genes and Genome (KEGG) pathway of the cell cycle (ko04110). Taken together, these results demonstrate that 75% dietary food effectively lowers the SUA level without modifying dietary ingredients and alleviates the injuries resulting from uricase deficiency or hyperuricemia, the mechanism of which is associated with the down-regulation of the cell cycle pathway. [ABSTRACT FROM AUTHOR]

The oil reservoir of the Chang 3 Member of the Triassic Yanchang Formation is the main oil-producing reservoir in the southwest of Ordos Basin. In recent years, with the deepening of exploration in this area, a major breakthrough has been made in the exploration of the Chang 3 member, Yanchang Formation, and several industrial oil flow Wells have been discovered in this area. Based on the detailed analysis and comparison of the molecular geochemical characteristics of the extracts from crude oil and oil-bearing sandstones, this paper conducts a comparative study on the source rocks of different strata of the Triassic Yanchang Formation according to the combination characteristics of biomarkers and carbon isotope characteristics. Furthermore, the source of crude oil in the Chang 3 Member is discussed. The results show that the oil of the Chang 3 Member and the source rocks of the Chang 6 and 7 Members in the southwest Ordos Basin have similar characteristics in terms of parent properties, sedimentary environment and maturity. At the same time, regional unconformity surface and fracture became the migration channel connecting the Chang 3 reservoir with the Chang 6 and Chang 7 oil sources. The crude oil of the Chang 3 Member of the Yanchang Formation is mainly derived from the source rocks of the Chang 6 and Chang 7 Members. [ABSTRACT FROM AUTHOR]

Bacterial wilt caused by Ralstonia solanacearum is one of the most important diseases in solanaceous plants, including peppers. It generally tends to be more serious under warm−temperature and moist (WM) conditions than at moist room−temperature (RM) conditions. Although immunity mechanisms at room temperature have been intensively studied, the mechanisms underlying WM conditions remain poorly understood. Herein, the pepper cysteine protease CaZingipain2 was expressed and functionally characterized in pepper immunity against R. solanacearum at WM conditions and at room temperature. The results showed that CaZingipain2 localized to the nucleus and was upregulated at the transcript level in pepper plants upon R. solanacearum infection under WM conditions (RSWM). Virus−induced gene silencing of CaZingipain2 significantly increased the susceptibility of pepper plants to RSWM, and was coupled with the downregulation of CaPRP1 and CaMgst3, which are specifically related to pepper immunity against RSWM, according to our previous studies, while its overexpression significantly reduced the susceptibility of N. benethamiana plants to RSWM compared to that of wild−type plants. In addition, our data showed that CaZingipain2 also acts positively in pepper immunity against R. solanacearum infection at room temperature by upregulating the SA− and JA−responsive PR genes, including CaNPR1 and CaDEF1. All these results indicate that CaZingipain2 improves pepper immunity against R. solanacearum under WM conditions and at room temperature by regulating different PR genes.

Abstract Recently, rapidly increased demands of integration and miniaturization continuously challenge energy densities of dielectric capacitors. New materials with high recoverable energy storage densities become highly desirable. Here, by structure evolution between fluorite HfO2 and perovskite hafnate, we create an amorphous hafnium-based oxide that exhibits the energy density of ~155 J/cm3 with an efficiency of 87%, which is state-of-the-art in emergingly capacitive energy-storage materials. The amorphous structure is owing to oxygen instability in between the two energetically-favorable crystalline forms, in which not only the long-range periodicities of fluorite and perovskite are collapsed but also more than one symmetry, i.e., the monoclinic and orthorhombic, coexist in short range, giving rise to a strong structure disordering. As a result, the carrier avalanche is impeded and an ultrahigh breakdown strength up to 12 MV/cm is achieved, which, accompanying with a large permittivity, remarkably enhances the energy storage density. Our study provides a new and widely applicable platform for designing high-performance dielectric energy storage with the strategy exploring the boundary among different categories of materials.

Abstract Personal physiological data is the digital representation of physical features that identify individuals in the Internet of Everything environment. Such data includes characteristics of uniqueness, identification, replicability, irreversibility of damage, and relevance of information, and this data can be collected, shared, and used in a wide range of applications. As facial recognition technology has become prevalent and smarter over time, facial data associated with critical personal information poses a potential security and privacy risk of being leaked in the Internet of Everything application platform. However, current research has not identified a systematic and effective method for identifying these risks. Thus, in this study, we adopted the fault tree analysis method to identify risks. Based on the risks identified, we then listed intermediate events and basic events according to the causal logic, and drew a complete fault tree diagram of facial data breaches. The study determined that personal factors, data management and supervision absence are the three intermediate events. Furthermore, the lack of laws and regulations and the immaturity of facial recognition technology are the two major basic events leading to facial data breaches. We anticipate that this study will explain the manageability and traceability of personal physiological data during its lifecycle. In addition, this study contributes to an understanding of what risks physiological data faces in order to inform individuals of how to manage their data carefully and to guide management parties on how to formulate robust policies and regulations that can ensure data security.

Abstract Salinity is a major abiotic stress that limits plant growth and crop productivity. Indica rice and japonica rice show significant differences in tolerance to abiotic stress, and it is considered a feasible method to breed progeny with stronger tolerance to abiotic stress by crossing indica and japonica rice. We herein developed a high-generation recombinant inbred lines (RILs) from Luohui 9 (indica) X RPY geng (japonica). Based on the high-density bin map of this RILs population, salt tolerance QTLs controlling final survival rates were analyzed by linkage mapping and RTM-GWAS methods. A total of seven QTLs were identified on chromosome 3, 4, 5, 6, and 8. qST-3.1, qST-5.1, qST-6.1, and qST-6.2 were novel salt tolerance QTLs in this study and their function were functionally verified by comparative analysis of parental genotype RILs. The gene aggregation result of these four new QTLs emphasized that the combination of the four QTL synergistic genotypes can significantly improve the salt stress tolerance of rice. By comparing the transcriptomes of the root tissues of the parents’ seedlings, at 3 days and 7 days after salt treatment, we then achieved fine mapping of QTLs based on differentially expressed genes (DEGs) identification and DEGs annotations, namely, LOC_Os06g01250 in qST-6.1, LOC_Os06g37300 in qST-6.2, LOC_Os05g14880 in qST-5.1. The homologous genes of these candidate genes were involved in abiotic stress tolerance in different plants. These results indicated that LOC_Os05g14880, LOC_Os06g01250, and LOC_Os06g37300 were the candidate genes of qST-5.1, qST-6.1, and qST-6.2. Our finding provided novel salt tolerance-related QTLs, candidate genes, and several RILs with better tolerance, which will facilitate breeding for improved salt tolerance of rice varieties and promote the exploration tolerance mechanisms of rice salt stress.

Ammonium (NH4+) is one of the major nitrogen sources for plants. However, excessive ammonium can cause serious harm to the growth and development of plants, i.e., ammonium toxicity. The primary regulatory mechanisms behind ammonium toxicity are still poorly characterized. In this study, we showed that OsCIPK18, a CBL-interacting protein kinase, plays an important role in response to ammonium toxicity by comparative analysis of the physiological and whole transcriptome of the T-DNA insertion mutant (cipk18) and the wild-type (WT). Root biomass and length of cipk18 are less inhibited by excess NH4+ compared with WT, indicating increased resistance to ammonium toxicity. Transcriptome analysis reveals that OsCIPK18 affects the NH4+ uptake by regulating the expression of OsAMT1;2 and other NH4+ transporters, but does not affect ammonium assimilation. Differentially expressed genes induced by excess NH4+ in WT and cipk18 were associated with functions, such as ion transport, metabolism, cell wall formation, and phytohormones signaling, suggesting a fundamental role for OsCIPK18 in ammonium toxicity. We further identified a transcriptional regulatory network downstream of OsCIPK18 under NH4+ stress that is centered on several core transcription factors. Moreover, OsCIPK18 might function as a transmitter in the auxin and abscisic acid (ABA) signaling pathways affected by excess ammonium. These data allowed us to define an OsCIPK18-regulated/dependent transcriptomic network for the response of ammonium toxicity and provide new insights into the mechanisms underlying ammonium toxicity.

Abstract Exploitation of heterosis between indica and japonica has important significance in scientific research and agriculture application. However, the molecular mechanism of grain shape heterosis in indica–japonica hybrid remains unknown in rice (Oryza sativa L.). To reveal the genetic mechanism of grain shape in indica‐‐japonica hybrid, we constructed a high‐generation recombinant inbred line (RIL) population and two testcross hybrid populations derived from the cross of RILs and two cytoplasmic male sterile material (YTA and Z7A) and then performed a bin mapping‐based quantitative trait locus (QTL) mapping of multiple grain shape traits, such as grain length (GL), grain width (GW), and grain length‐to‐width ratio (GLWR). A total of sixteen QTLs and 30 heterosis‐related QTLs of grain shape traits were detected. We found that GS3, GS5, and OsPPKL2 were also correlated with grain shape both in RILs and two testcross hybrid populations. Homologous gene analysis emphasized two candidate grain shape‐associated genes (LOC_Os06g14260 and LOC_Os04g51950). Our findings uncover multiple grain shape heterosis‐related loci and provides a new insight into heterosis mechanism of grain shape in rice.

Abstract Submerged germination ability is a key trait of rice (Oryza sativa L.) in the success of water direct seeding. Therefore, mining submerged germination‐related loci and seeking high tolerant rice germplasms are important for developing rice direct seeding breeding strategies. Here, we treated 272 recombinant inbred lines (RILs, F15) from a cross from Luohui 9 (indica) and RPY geng (japonica) with simulated submergence for 7 days. We successfully bred several superior homozygous RILs with high submergence resistance, namely, R53, R137, R148, R176, and R180, via indica and japonica hybridization strategies. Then, the QTL mapping of coleoptile length trait was performed by R/qtl and IciMapping softwares based on the high‐density bin marker genetic map and two QTLs responsible for coleoptile length were detected in chromosomes 1 (qCL‐1.1) and 3 (qCL‐3.1). The haplotype results of RILs showed that the aggregation of elite alleles of these two QTLs in an individual was beneficial to improving the rice submergence tolerance. According to contrasting genotype of qCL‐1.1 and qCL‐3.1 with different coleoptile lengths, RIL07 (R07) and R180 were selected to further RNA‐seq analysis for analyzing the possible molecular mechanisms of rice under submergence stress. Finally, LOC_Os01g04430, LOC_Os01g04530, and LOC_Os03g22720 for qCL‐1.1 and qCL‐3.1 were characterized to affect submergence stress by the overlapped analysis of two independent sets of RNA‐seq data, qRT‐PCR verification, and gene sequence alignments. In this study, the submerged germination‐related QTLs/genes and high submergence‐tolerant RILs provided new genetic resources for breeding rice varieties suitable for direct seeding via molecular breeding strategies in the immediate future.

Polyol transporters (PLTs), also called polyol/monosaccharide transporters, is of significance in determining plant development and sugar transportation. However, the diverged evolutionary patterns of the PLT gene family in Gramineae crops are still unclear. Here a micro-evolution analysis was performed among the seven Gramineae representative crops using whole-genome sequences, i.e., Brachypodium distachyon (Bd), Hordeum vulgare (Hv), Oryza rufipogon (Or), Oryza sativa (Os), Sorghum bicolor (Sb), Setaria italica (Si), and Zea mays (Zm), leading to the identification of 12, 11, 12, 15, 20, 24, and 20 PLT genes, respectively. In this study, all PLT genes were divided into nine orthogroups (OGs). However, the number of PLT genes and the distribution of PLT OGs were not the same in these seven Gramineae species, and different OGs were also subject to different purification selection pressures. These results indicated that the PLT OGs of the PLT gene family have been expanded or lost unevenly in all tested species. Then, our results of gene duplication events confirmed that gene duplication events promoted the expansion of the PLT gene family in some Gramineous plants, namely, Bd, Or, Os, Si, Sb, and Zm, but the degree of gene family expansion, the type of PLT gene duplication, and the differentiation time of duplicate gene pairs varied greatly among these species. In addition, the sequence alignment and the internal repeat analysis of all PLTs protein sequences implied that the PLT protein sequences may originate from an internal repeat duplication of an ancestral six transmembrane helical units. Besides that, the protein motifs result highlighted that the PLT protein sequences were highly conserved, whereas the functional differentiation of the PLT genes was characterized by different gene structures, upstream elements, as well as co-expression analysis. The gene expression analysis of rice and maize showed that the PLT genes have a wide range of expression patterns, suggesting diverse biological functions. Taken together, our finding provided a perspective on the evolution differences and the functional characterizations of PLT genes in Gramineae representative crops.

Rice (Oryza sativa L.) is a widely cultivated food crop around the world, especially in Asia. However, rice seedlings often suffer from cold stress, which affects their growth and yield. Here, RNA-seq analysis and Meta-QTLs mapping were performed to understand the molecular mechanisms underlying cold tolerance in the roots of 14-day-old seedlings of rice (RPY geng, cold-tolerant genotype). A total of 4779 of the differentially expressed genes (DEGs) were identified, including 2457 up-regulated and 2322 down-regulated DEGs. The GO, COG, KEEG, and Mapman enrichment results of DEGs revealed that DEGs are mainly involved in carbohydrate transport and metabolism, signal transduction mechanisms (plant hormone signal transduction), biosynthesis, transport and catabolism of secondary metabolites (phenylpropanoid biosynthesis), defense mechanisms, and large enzyme families mechanisms. Notably, the AP2/ERF-ERF, NAC, WRKY, MYB, C2H2, and bHLH transcription factors participated in rice’s cold–stress response and tolerance. On the other hand, we mapped the identified DEGs to 44 published cold–stress-related genes and 41 cold-tolerant Meta-QTLs regions. Of them, 12 DEGs were the published cold–stress-related genes and 418 DEGs fell into the cold-tolerant Meta-QTLs regions. In this study, the identified DEGs and the putative molecular regulatory network can provide insights for understanding the mechanism of cold stress tolerance in rice. In addition, DEGs in KEGG term-enriched terms or cold-tolerant Meta-QTLs will help to secure key candidate genes for further functional studies on the molecular mechanism of cold stress response in rice.