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2,557 results on '"Yamaguchi, Ken"'

13. Evaluation of whole genome sequencing utility in identifying driver alterations in cancer genome

Author

Nagashima, Takeshi, Yamaguchi, Ken, Urakami, Kenichi, Shimoda, Yuji, Ohnami, Sumiko, Ohshima, Keiichi, Tanabe, Tomoe, Naruoka, Akane, Kamada, Fukumi, Serizawa, Masakuni, Hatakeyama, Keiichi, Ohnami, Shumpei, Maruyama, Koji, Mochizuki, Tohru, Mizuguchi, Maki, Shiomi, Akio, Ohde, Yasuhisa, Bando, Etsuro, Sugiura, Teiichi, Mukaigawa, Takashi, Nishimura, Seiichiro, Hirashima, Yasuyuki, Mitsuya, Koichi, Yoshikawa, Shusuke, Kiyohara, Yoshio, Tsubosa, Yasuhiro, Katagiri, Hirohisa, Niwakawa, Masashi, Takahashi, Kaoru, Kashiwagi, Hiroya, Yasunaga, Yoshichika, Ishida, Yuji, Sugino, Takashi, Kenmotsu, Hirotsugu, Terashima, Masanori, Takahashi, Mitsuru, Uesaka, Katsuhiko, and Akiyama, Yasuto

Published
2024
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39. Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug-metabolizing enzyme genes

Author

Ohnami, Sumiko, Naruoka, Akane, Isaka, Mitsuhiro, Mizuguchi, Maki, Nakatani, Sou, Kamada, Fukumi, Shimoda, Yuji, Sakai, Ai, Ohshima, Keiichi, Hatakeyama, Keiichi, Maruyama, Kouji, Ohde, Yasuhisa, Kenmotsu, Hirotsugu, Takahashi, Toshiaki, Akiyama, Yasuto, Nagashima, Takeshi, Urakami, Kenichi, Ohnami, Shumpei, and Yamaguchi, Ken

Published
2022
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43. Vaginal Cuff Infection Caused by Ureaplasma parvum After Hysterectomy for Uterine Cervical Cancer: A Case Report.

Author

Chikamatsu, Hayato, Taki, Mana, Kitamura, Sachiko, Sunada, Masumi, Yamanoi, Koji, Murakami, Ryusuke, Yamaguchi, Ken, Horie, Akihito, Tsuchido, Yasuhiro, Hamanishi, Junzo, Mandai, Masaki, and Cui, Dawei

Subjects
CERVICAL cancer, VAGINAL hysterectomy, PREMATURE labor, AMNIOTIC liquid, POLYMERASE chain reaction
Abstract

Ureaplasma parvum is one of the most common endemic mycoplasmas in the genitourinary tract and can cause amniotic fluid infection leading to preterm labor. We report a rare case of Ureaplasma parvum infection ascending from the vagina to the abdominal cavity after hysterectomy, causing vaginal cuff infection, postoperative peritonitis, and small bowel obstruction. A 29‐year‐old nulliparous woman presented with infected uterine cervical cancer. After radical hysterectomy for uterine cervical cancer, the patient had paralytic ileus with ascites and fever. Peritonitis was suspected; however, all cultures were negative, making it difficult to identify the causative organism. Polymerase chain reaction (PCR) of the ascites revealed Ureaplasma parvum, which could be treated with levofloxacin (LVFX). Open drainage to control the infection revealed a necrotic tissue around vaginal cuff and the small intestine encased in cocoon‐like fibers like sclerosing encapsulating peritonitis. After the infection was improved, the bowel obstruction was also improved. Ureaplasma spp. can be difficult to culture. PCR testing for Ureaplasma infection should be considered when urogenital infection is suspected in patients prone to opportunistic infections, such as those with malignant tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Four cancer cases with pathological germline variant RAD51D c.270_271dup.

Author

Ishihara, Eiko, Matsubayashi, Hiroyuki, Nishimura, Seiichiro, Isaka, Mitsuhiro, Konno, Hayato, Goto, Seiya, Yamaguchi, Ken, and Urakami, Kenichi

Subjects
TUMOR risk factors, TUMOR genetics, MOUTH tumors, PHARYNX tumors, GENOMICS, LARYNGEAL tumors, GENETIC counseling, LUNG tumors, CANCER genes, GENETIC mutation, GENETIC testing, SEQUENCE analysis, PHENOTYPES
Abstract

Pathological germline variants (PGVs) of RAD51D increase the risk of breast and ovarian cancer. In East Asia, c.270_271dup is the most frequently detected PGV of RAD51D; however, only a few cases have been reported in Japan. We report four cancer cases with a germline RAD51D c.270_271dup PGV. Three of them (lung cancer: 2, oral cancer: 1) were incidentally identified by whole genome sequencing in patients negative for the associated cancer histories, homologous recombination (HR) deficiency, or a second hit of RAD51D in the cancer DNA. For genetic counseling, we provided information on surveillance and cascade testing based on Western guidelines. The PGVs of moderate‐risk HR‐related genes are difficult to detect based on phenotype, especially in male‐predominant pedigrees. The current spread of cancer genomic analysis will increase opportunities for incidental variant identification. The establishment of Japanese guidelines is expected to aid in the management of PGV carriers of moderate‐risk genes. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Investigation of the clinical implications of anterior cervical invasion in locally advanced cervical squamous cell carcinoma.

Author

Tamura, Saya, Yamanoi, Koji, Inayama, Yoshihide, Kurata, Yasuhisa, Himoto, Yuki, Taki, Mana, Murakami, Ryusuke, Horie, Akihito, Yamaguchi, Ken, Hamanishi, Junzo, and Mandai, Masaki

Subjects
SQUAMOUS cell carcinoma, RISK assessment, CANCER invasiveness, RESEARCH funding, CANCER relapse, MAGNETIC resonance imaging, DESCRIPTIVE statistics, CANCER chemotherapy, COMBINED modality therapy, CERVICAL cancer, OVERALL survival, DISEASE risk factors
Abstract

Purposes: This study investigates the clinical significance of the anterior parametrical invasion in surgically treated patients with cervical squamous cell carcinoma (SCC). Methods: We included patients diagnosed with cervical SCC with local lesions classified as T2b, who were treated at our department between January 2006 and December 2020. We evaluated the degree of anterior invasion using pretreatment magnetic resonance imaging and divided patients into three groups: partial, equivocal, and full invasion. The frequency of recurrence within 3 years (early recurrence) and overall prognosis were assessed. Results: There were 12, 24, and 46 cases in the partial equivocal, and full invasion groups, respectively. Neoadjuvant chemotherapy followed by surgery and adjuvant chemotherapy was the mainstay of treatment across all groups (7, 17, and 27 cases, respectively). Although the frequency of early recurrence tended to be worse in the full group (partial; 2/7 cases, equivocal; 3/17 cases and full; 9/27 cases), all early local recurrence cases in the full group (four cases) responded well to the subsequent treatment. As for overall survival, the full invasion group had the best prognosis among the three groups. Conclusions: In surgical treatment, although full anterior invasion may increase the risk of early local recurrence, it was considered to have little prognostic impact. [ABSTRACT FROM AUTHOR]

Published
2024
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