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129 results on '"Yamakawa, Yasuaki"'

6. Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus

Author

Uotani, Koji, primary, Tazawa, Hiroshi, additional, Hasei, Joe, additional, Fujiwara, Tomohiro, additional, Yoshida, Aki, additional, Yamakawa, Yasuaki, additional, Omori, Toshinori, additional, Sugiu, Kazuhisa, additional, Komatsubara, Tadashi, additional, Kondo, Hiroya, additional, Morita, Takuya, additional, Kiyono, Masahiro, additional, Yokoo, Suguru, additional, Hata, Toshiaki, additional, Kunisada, Toshiyuki, additional, Takeda, Ken, additional, Urata, Yasuo, additional, Fujiwara, Toshiyoshi, additional, and Ozaki, Toshifumi, additional

Published
2024
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11. Supplementary Methods and Figure Legend from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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12. Supplementary Figure 4 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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13. Data from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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14. Supplementary Figure 2 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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15. Supplementary Figure 6 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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16. Supplementary Figure 3 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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17. Supplementary Figure 5 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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18. Supplementary Figure 1 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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24. Reliability of the Garden Alignment Index and Valgus Tilt Measurement for Nondisplaced Femoral Neck Fractures

Author

Yamakawa, Yasuaki, Yamamoto, Norio, Tomita, Yosuke, Okuda, Ryuichiro, Masada, Yasutaka, Shiroshita, Akihiro, Matsumoto, Toshiyuki, Yamakawa, Yasuaki, Yamamoto, Norio, Tomita, Yosuke, Okuda, Ryuichiro, Masada, Yasutaka, Shiroshita, Akihiro, and Matsumoto, Toshiyuki

Abstract

Anteroposterior (AP) alignment assessment for nondisplaced femoral neck fractures is important for determining the treatment strategy and predicting postoperative outcomes. AP alignment is generally measured using the Garden alignment index (GAI). However, its reliability remains unknown. We compared the reliability of GAI and a new AP alignment measurement (valgus tilt measurement [VTM]) using preoperative AP radiographs of nondisplaced femoral neck fractures. The study was designed as an intra- and inter-rater reliability analysis. The raters were four trauma surgeons who assessed 50 images twice. The main outcome was the intraclass correlation coefficient (ICC). To calculate intra- and inter-rater reliability, we used a mixed-effects model considering rater, patient, and time. The overall ICC (95% CI) of GAI and VTM for intra-rater reliability was 0.92 (0.89-0.94) and 0.86 (0.82-0.89), respectively. The overall ICC of GAI and VTM for inter-rater reliability was 0.92 (0.89-0.95), and 0.85 (0.81-0.88), respectively. The intra- and inter-rater reliability of GAI was higher in patients aged <80 years than in patients aged >= 80 years. Our results showed that GAI is a more reliable measurement method than VTM, although both are reliable. Variations in patient age should be considered in GAI measurements.

Published
2022

25. Clinical Results and Technical Note of a Novel Therapeutic Method for Distal Tibial Fracture: A Multicenter Prospective Study on the Use of the Distal Tibial Nail

Author

Yamakawa, Yasuaki, primary, Uehara, Takenori, additional, Shigemoto, Kenji, additional, Kitada, Shimpei, additional, Mogami, Atsuhiko, additional, Shiota, Naofumi, additional, Doi, Takeshi, additional, Yoshimura, Masahide, additional, Noda, Tomoyuki, additional, and Sawaguchi, Takeshi, additional

Published
2022
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26. Reliability of the Garden Alignment Index and Valgus Tilt Measurement for Nondisplaced Femoral Neck Fractures.

Author

Yamakawa, Yasuaki, Yamamoto, Norio, Tomita, Yosuke, Okuda, Ryuichiro, Masada, Yasutaka, Shiroshita, Akihiro, and Matsumoto, Toshiyuki

Subjects
*FEMORAL neck fractures, *FEMUR neck, *INTRACLASS correlation
Abstract

Anteroposterior (AP) alignment assessment for nondisplaced femoral neck fractures is important for determining the treatment strategy and predicting postoperative outcomes. AP alignment is generally measured using the Garden alignment index (GAI). However, its reliability remains unknown. We compared the reliability of GAI and a new AP alignment measurement (valgus tilt measurement [VTM]) using preoperative AP radiographs of nondisplaced femoral neck fractures. The study was designed as an intra- and inter-rater reliability analysis. The raters were four trauma surgeons who assessed 50 images twice. The main outcome was the intraclass correlation coefficient (ICC). To calculate intra- and inter-rater reliability, we used a mixed-effects model considering rater, patient, and time. The overall ICC (95% CI) of GAI and VTM for intra-rater reliability was 0.92 (0.89–0.94) and 0.86 (0.82–0.89), respectively. The overall ICC of GAI and VTM for inter-rater reliability was 0.92 (0.89–0.95), and 0.85 (0.81–0.88), respectively. The intra- and inter-rater reliability of GAI was higher in patients aged <80 years than in patients aged ≥80 years. Our results showed that GAI is a more reliable measurement method than VTM, although both are reliable. Variations in patient age should be considered in GAI measurements. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Oncolytic virotherapy promotes radiosensitivity in soft tissue sarcoma by suppressing anti-apoptotic MCL1 expression

Author

Omori, Toshinori, Tazawa, Hiroshi, Yamakawa, Yasuaki, Osaki, Shuhei, Hasei, Joe, Sugiu, Kazuhisa, Komatsubara, Tadashi, Fujiwara, Tomohiro, Yoshida, Aki, Kunisada, Toshiyuki, Urata, Yasuo, Kagawa, Shunsuke, Ozaki, Toshifumi, Fujiwara, Toshiyoshi, Omori, Toshinori, Tazawa, Hiroshi, Yamakawa, Yasuaki, Osaki, Shuhei, Hasei, Joe, Sugiu, Kazuhisa, Komatsubara, Tadashi, Fujiwara, Tomohiro, Yoshida, Aki, Kunisada, Toshiyuki, Urata, Yasuo, Kagawa, Shunsuke, Ozaki, Toshifumi, and Fujiwara, Toshiyoshi

Abstract

Soft tissue sarcoma (STS) is a rare cancer that develops from soft tissues in any part of the body. Despite major advances in the treatment of STS, patients are often refractory to conventional radiotherapy, leading to poor prognosis. Enhancement of sensitivity to radiotherapy would therefore improve the clinical outcome of STS patients. We previously revealed that the tumor-specific, replication-competent oncolytic adenovirus OBP-301 kills human sarcoma cells. In this study, we investigated the radiosensitizing effect of OBP-301 in human STS cells. The in vitro antitumor effect of OBP-301 and ionizing radiation in monotherapy or combination therapy was assessed using highly radiosensitive (RD-ES and SK-ES-1) and moderately radiosensitive (HT1080 and NMS-2) STS cell lines. The expression of markers for apoptosis and DNA damage were evaluated in STS cells after treatment. The therapeutic potential of combination therapy was further analyzed using SK-ES-1 and HT1080 cells in subcutaneous xenograft tumor models. The combination of OBP-301 and ionizing radiation showed a synergistic antitumor effect in all human STS cell lines tested, including those that show different radiosensitivity. OBP-301 was found to enhance irradiation-induced apoptosis and DNA damage via suppression of anti-apoptotic myeloid cell leukemia 1 (MCL1), which was expressed at higher levels in moderately radiosensitive cell lines. The combination of OBP-301 and ionizing radiation showed a more profound antitumor effect compared to monotherapy in SK-ES-1 (highly radiosensitive) and HT1080 (moderately radiosensitive) subcutaneous xenograft tumors. OBP-301 is a promising antitumor reagent to improve the therapeutic potential of radiotherapy by increasing radiation-induced apoptosis in STS.

Published
2021

28. Oncolytic virotherapy promotes radiosensitivity in soft tissue sarcoma by suppressing anti-apoptotic MCL1 expression

Author

Omori, Toshinori, primary, Tazawa, Hiroshi, additional, Yamakawa, Yasuaki, additional, Osaki, Shuhei, additional, Hasei, Joe, additional, Sugiu, Kazuhisa, additional, Komatsubara, Tadashi, additional, Fujiwara, Tomohiro, additional, Yoshida, Aki, additional, Kunisada, Toshiyuki, additional, Urata, Yasuo, additional, Kagawa, Shunsuke, additional, Ozaki, Toshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2021
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29. Molecular radiosensitization of soft tissue sarcoma by oncolytic virus-mediated MCL1 ablation

Author

Omori, Toshinori, primary, Tazawa, Hiroshi, additional, Yamakawa, Yasuaki, additional, Osaki, Shuhei, additional, Hasei, Joe, additional, Sugiu, Kazuhisa, additional, Komatsubara, Tadashi, additional, Fujiwara, Tomohiro, additional, Yoshida, Aki, additional, Kunisada, Toshiyuki, additional, Urata, Yasuo, additional, Kagawa, Shunsuke, additional, Ozaki, Toshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2020
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34. Role of zoledronic acid in oncolytic virotherapy: Promotion of antitumor effect and prevention of bone destruction

Author

Yamakawa, Yasuaki, primary, Tazawa, Hiroshi, additional, Hasei, Joe, additional, Osaki, Shuhei, additional, Omori, Toshinori, additional, Sugiu, Kazuhisa, additional, Komatsubara, Tadashi, additional, Uotani, Kouji, additional, Fujiwara, Tomohiro, additional, Yoshida, Aki, additional, Kunisada, Toshiyuki, additional, Urata, Yasuo, additional, Kagawa, Shunsuke, additional, Ozaki, Toshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2017
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35. Abstract 5188: Molecular radiosensitization in soft tissue sarcomas by telomerase-specific oncolytic adenovirus

Author

Komatsubara, Tadashi, primary, Omori, Toshinori, additional, Tazawa, Hiroshi, additional, Sugiu, Kazuhisa, additional, Mochizuki, Yusuke, additional, Yamakawa, Yasuaki, additional, Osaki, Shuhei, additional, Hasei, Joe, additional, Fujiwara, Tomohiro, additional, Kunisada, Toshiyuki, additional, Urata, Yasuo, additional, Ozaki, Tsoshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2017
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39. Abstract 4677: Tumor suppressor p53 reactivation by oncolytic adenovirus reverses chemoresistance in human osteosarcomas

Author

Sugiu, Kazuhisa, primary, Tazawa, Hiroshi, additional, Hasei, Joe, additional, Osaki, Shuhei, additional, Yamakawa, Yasuaki, additional, Omori, Toshinori, additional, Komatsubara, Tadashi, additional, Uotani, Kouji, additional, Fujiwara, Tomohiro, additional, Kunisada, Toshiyuki, additional, Urata, Yasuo, additional, Ozaki, Toshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2016
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40. Ablation of MCL1 expression by virally induced microRNA-29 reverses chemoresistance in human osteosarcomas

Author

Osaki, Shuhei, primary, Tazawa, Hiroshi, additional, Hasei, Joe, additional, Yamakawa, Yasuaki, additional, Omori, Toshinori, additional, Sugiu, Kazuhisa, additional, Komatsubara, Tadashi, additional, Fujiwara, Tomohiro, additional, Sasaki, Tsuyoshi, additional, Kunisada, Toshiyuki, additional, Yoshida, Aki, additional, Urata, Yasuo, additional, Kagawa, Shunsuke, additional, Ozaki, Toshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2016
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41. Abstract 1794: Preclinical evaluation of radiotherapy in combination with radio-sensitizing telomerase-specific oncolytic virus for human bone and soft tissue sarcomas

Author

Omori, Toshinori, primary, Yamakawa, Yasuaki, additional, Hasei, Joe, additional, Tazawa, Hiroshi, additional, Osaki, Shuhei, additional, Sasaki, Tusyoshi, additional, Sugiu, Kazuhisa, additional, Fujiwara, Tomohiro, additional, Kunisada, Toshiyuki, additional, Urata, Yasuo, additional, Ozaki, Toshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2015
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43. Abstract 725: Combination therapy of telomerase-specific oncolytic adenovirus and zoledronic acid in human osteosarcoma cells

Author

Yamakawa, Yasuaki, primary, Hasei, Joe, additional, Tazawa, Hiroshi, additional, Omori, Toshinori, additional, Osaki, Shuhei, additional, Sasaki, Tsuyoshi, additional, Yoshida, Aki, additional, Kunisada, Toshiyuki, additional, Urata, Yasuo, additional, Ozaki, Toshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2014
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46. Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, additional, Tazawa, Hiroshi, additional, Osaki, Shuhei, additional, Yamakawa, Yasuaki, additional, Kunisada, Toshiyuki, additional, Yoshida, Aki, additional, Hashimoto, Yuuri, additional, Onishi, Teppei, additional, Uno, Futoshi, additional, Kagawa, Shunsuke, additional, Urata, Yasuo, additional, Ozaki, Toshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2013
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50. Acute Coronary Spasm Following Pelvic Fracture, Bleeding, and Shock in a Trauma Patient.

Author

Yamakawa Y, Miyashita K, Morizane A, Takeuchi M, Kawashima Y, Sugimura T, and Saisaka Y

Subjects
Male, Humans, Aged, Hemorrhage etiology, Hemorrhage therapy, Norepinephrine, Spasm, Coronary Vasospasm, ST Elevation Myocardial Infarction, Fractures, Bone complications, Shock, Heart Arrest
Abstract

We report a case of a patient with severe pelvic fracture who showed concurrent ST elevation on electrocardiogram. A 70-year-old man incurred an unstable pelvic fracture from a motorcycle accident. On admission, he was hemodynamically unstable, and massive transfusion and noradrenaline were administered immediately. Although ST elevation was present in leads II, III, aVF, V5, and V6, cardiac function was preserved; thus, trans-arterial embolization and external fixation for pelvic fracture were given priority. Four days after the injury, he suffered a cardiac arrest, and coronary angiography revealed that the cause of ST elevation and cardiac arrest was coronary vasospasm. Physicians should be aware that pain-related stress and platelet activation as well as use of noradrenaline in severe trauma cases can induce coronary vasospasm., Competing Interests: No potential conflict of interest relevant to this article was reported.

Published
2023
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