34 results on '"Yamana D"'
Search Results
2. Reference lines for oblique axial MR imaging of the brain.
- Author
-
Otake, S, primary, Yamana, D, additional, Mizutani, H, additional, and Ohba, S, additional
- Published
- 1996
- Full Text
- View/download PDF
Catalog
3. Stabilization of a percutaneously implanted port catheter system for hepatic artery chemotherapy infusion.
- Author
-
Shindoh, Noboru, Ozaki, Yutaka, Kyogoku, Shinsuke, Yamana, Daigo, Sumi, Yukiharu, Katayama, Hitoshi, Shindoh, N, Ozaki, Y, Kyogoku, S, Yamana, D, Sumi, Y, and Katayama, H
- Abstract
A port catheter system for hepatic artery infusion chemotherapy was implanted percutaneously via the left subclavian artery in 41 patients for treatment of unresectable liver metastases. The catheter tip was inserted into the gastroduodenal artery (GDA), the end hole was occluded with a guidewire fragment, and a side-hole for infusion was positioned at the bifurcation of the proper hepatic artery and the GDA. The GDA was embolized with steel coils around the infusion catheter tip via a transfemoral catheter. This procedure is designed to reduce the incidence of hepatic artery occlusion and infusion catheter dislocation. [ABSTRACT FROM AUTHOR] more...
- Published
- 1999
- Full Text
- View/download PDF
4. Comparison of postoperative prognoses for resectable colorectal cancer with vs. without oncologic emergency using propensity score‑matched analyses: A single-center retrospective observational study.
- Author
-
Imaizumi K, Kasajima H, Sato K, Ichimura K, Sato A, Yamana D, Tsuruga Y, Umehara M, Kurushima M, and Nakanishi K
- Abstract
While oncological emergencies in colorectal cancer present distinct challenges, existing literature offers conflicting evidence regarding long-term outcomes. Therefore, the present study compared the postoperative prognoses between patients with and without oncological emergencies. A retrospective evaluation was conducted on patients who had undergone radical surgery for pathological stages II and III colorectal cancer at a single center between January 2012 and December 2020. Patients were classified into the non-emergency and oncological emergency groups. The status of oncologic emergency was divided into obstruction and perforation. The outcomes were compared using propensity score matching. The primary objective was to compare the postoperative prognoses between non-emergency and oncological emergency situations. The secondary objectives included comparing prognoses between obstruction and perforation, identifying the type of recurrence depending on the status of oncologic emergency, and assessing the effect of adjuvant chemotherapy for oncologic emergencies. This study included 524 patients. After propensity score matching, the prognoses of oncological emergencies were worse compared with those without any emergency, whereas those of obstruction and perforation did not significantly differ. Regarding the type of recurrence, peritoneal dissemination in obstruction and local recurrence in perforation was more common compared with that in non-emergency cases. Adjuvant chemotherapy improved the recurrence-free survival for cases with oncological emergencies. The prognoses in cases with oncological emergencies could be worse compared with those without any emergency, whereas obstruction and perforation outcomes can be comparable. The administration of adjuvant chemotherapy should be strongly considered for oncological emergencies., Competing Interests: The authors declare that they have no competing interests., (Copyright: © 2024 Imaizumi et al.) more...
- Published
- 2024
- Full Text
- View/download PDF
5. Hybrid robot-assisted abdominoperineal resection supported by simultaneous trans-perineal approach for anal gland adenocarcinoma with vaginal invasion: a case report.
- Author
-
Imaizumi K, Kasajima H, Ito K, Fukasawa T, Odagiri M, Yamana D, Tsuruga Y, Umehara M, Kurushima M, Munakata S, Shimoyama N, and Nakanishi K
- Abstract
Hybrid surgery (abdominal robotic approach with a trans-anal approach) has been reported to improve oncological outcomes in cases involving advanced cancer or technical difficulties. A 74-year-old woman presented with anal pain and stenosis. Examination revealed palpable sclerosis on the anterior wall at the anal verge with possible vaginal invasion. A biopsy revealed an adenocarcinoma. We performed a two-team robot-assisted abdominoperineal resection combined with resection of the vagina supported by a simultaneous trans-perineal approach. After rendezvous at the posterior side, the abdominal team cut the posterior wall of the vaginal vault while the perineal team confirmed the surgical margin. Histopathological findings identified the tumour as an anal gland adenocarcinoma (pT4b [vagina] N0M0 pathological stage IIC) with a negative circumferential resection margin. Hybrid surgery combined with resection of the posterior wall of the vagina may be performed safely and is a valuable surgical option for multimodal treatment of anal adenocarcinomas., Competing Interests: All authors declare they have no conflict of interest., (Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2023.) more...
- Published
- 2023
- Full Text
- View/download PDF
6. Chemical Bowel Preparation Exerts an Independent Preventive Effect Against Surgical Site Infection Following Elective Laparoscopic Colorectal Surgery.
- Author
-
Ichimura K, Imaizumi K, Kasajima H, Sato A, Sato K, Yamana D, Tsuruga Y, Umehara M, Kurushima M, and Nakanishi K
- Subjects
- Humans, Surgical Wound Infection etiology, Surgical Wound Infection prevention & control, Surgical Wound Infection epidemiology, Retrospective Studies, Colectomy adverse effects, Elective Surgical Procedures adverse effects, Colorectal Surgery adverse effects, Laparoscopy adverse effects
- Abstract
Background: We investigated the independent clinical value of mechanical bowel preparations (MBP) and chemical bowel preparations (CBP) for preventing surgical site infection (SSI) in patients undergoing elective laparoscopic colorectal surgery., Materials and Methods: This retrospective cohort study included 475 patients who underwent elective laparoscopic colorectal surgery between January 2018 and March 2022. CBP was introduced in January 2021 and included kanamycin (1 g) and metronidazole (1 g) 2 times a day, the day before surgery. In some cases, MBP was omitted in patients who planned to undergo right-sided colectomy, those with tumor obstruction, and those with poor general conditions, depending on the judgment of the physician. The primary endpoint was the overall SSI incidence, while the secondary endpoints were the incidences of incisional SSI and organ-space SSI, culture from the surgical site, and length of postoperative hospital stay., Results: In total, 136 patients underwent CBP. MBP was omitted in 53 patients. Overall, SSI occurred in 80 patients (16.8%), including 61 cases of incisional SSI (12.8%) and 36 cases of organ-space SSI (7.6%). Multivariate logistic regression revealed that CBP exerted an independent preventive effect on overall and incisional SSI, whereas MBP did not. However, CBP was not associated with a decreased risk of overall SSI in patients who had undergone preoperative therapy, those with benign disease, and those with stoma formation in the subgroup analysis. Levels of Bacteroides species at the surgical site were significantly lower in the CBP group than in the non-CBP group. Postoperative hospital stay was significantly longer in the incisional SSI group than in the non-SSI group and was significantly longer in the organ-space SSI group than in the other groups., Conclusions: CBP, but not MBP, exerts an independent preventive effect on SSI, especially incisional SSI, in patients undergoing elective laparoscopic colorectal surgery., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) more...
- Published
- 2023
- Full Text
- View/download PDF
7. Technique of the single-port laparoscopic Hartmann's reversal via the colostomy site-A Video Vignette.
- Author
-
Sato K, Kasajima H, Yamana D, Imaizumi K, and Nakanishi K
- Subjects
- Humans, Colon surgery, Anastomosis, Surgical methods, Retrospective Studies, Postoperative Complications surgery, Reoperation, Treatment Outcome, Colostomy methods, Laparoscopy methods
- Published
- 2023
- Full Text
- View/download PDF
8. Visualization of Anorectal Lymphatic Flow Using Indocyanine Green Fluorescence Imaging: An Observational Study.
- Author
-
Sato K, Kasajima H, Imaizumi K, Kurushima M, Umehara M, Tsuruga Y, Yamana D, Sato A, Ichimura K, Fukasawa T, Ito K, Isokawa M, and Nakanishi K
- Subjects
- Humans, Fluorescence, Rectum diagnostic imaging, Rectum pathology, Pelvic Floor, Optical Imaging methods, Indocyanine Green, Rectal Neoplasms pathology
- Abstract
Background/aim: Currently, only a small part of functional lymphatic flow around the anorectal region has been anatomically analyzed. Despite the fact that local recurrence is often experienced in the pelvic floor, the functional lymphatic network in this region has rarely been studied due to difficulties in observation. This prospective observational study aimed to observe anorectal lymphatic flow around the pelvic floor using intraoperative indocyanine green fluorescence imaging during laparoscopic or robot-assisted rectal surgery., Patients and Methods: Fourteen patients who underwent laparoscopic (n=7) or robot-assisted (n=7) surgery without any preoperative therapy between April and December 2022 were enrolled. Indocyanine green solution (0.25 mg) was injected into the submucosa at the dentate line of the anterior, posterior, and bilateral walls prior to surgery. During and after total mesorectal excision, lymphatic flow was observed using a near-infrared camera system., Results: Lymphatic flow visualized by indocyanine green was detected not only in the already-known route from the low rectum to the lateral pelvic lymph nodes via the lateral ligament, but also in the novel route from the low rectum to the surface of the levator ani muscle and hiatal ligament. Fluorescence was widely spread in the pelvic floor between the longitudinal muscle of the low rectum and the surface of the levator ani muscle., Conclusion: Even though the results are preliminary since histological analyses were not performed, a novel widespread lymphatic network on the surface of the levator ani muscle originating from the longitudinal muscle fibers of the low rectum was revealed., (Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.) more...
- Published
- 2023
- Full Text
- View/download PDF
9. Short- and long-term outcomes of preservation versus ligation of the inferior mesenteric artery in laparoscopic D3 lymph node dissection for descending colon cancer: a propensity score-matched analysis.
- Author
-
Sato A, Imaizumi K, Kasajima H, Ichimura K, Sato K, Yamana D, Tsuruga Y, Umehara M, Kurushima M, and Nakanishi K
- Subjects
- Humans, Colon, Descending pathology, Mesenteric Artery, Inferior surgery, Retrospective Studies, Propensity Score, Potassium Iodide, Lymph Node Excision, Ligation, Colonic Neoplasms surgery, Colonic Neoplasms pathology, Laparoscopy
- Abstract
Purpose: This study aimed to compare the short- and long-term outcomes of laparoscopic D3 lymph node (LN) dissection between ligation of the inferior mesenteric artery (IMA) (LIMA) and preservation of the IMA (PIMA) for descending colon cancer using propensity score-matched analysis., Methods: This retrospective study included 101 patients with stage I-III descending colon cancer who underwent laparoscopic D3 LN dissection with LIMA (n = 60) or PIMA (n = 41) at a single center between January 2005 and March 2022. After propensity score matching, 64 patients (LIMA, n = 32; PIMA, n = 32) were included in the analysis. The primary endpoint was the long-term outcomes, and the secondary endpoint was the surgical outcomes., Results: In the matched cohort, no significant difference was noted in the surgical outcomes, including the operative time, estimated blood loss, number of harvested LNs, number of harvested LN 253, and complication rate. The long-term outcomes were also not significantly different between the LIMA and PIMA groups (3-year recurrence-free survival, 72.2% vs. 75.6%, P = 0.862; 5-year overall survival, 69.8% vs. 63.4%, P = 0.888; 5-year cancer-specific survival, 84.2% vs. 82.8%, P = 0.607). No recurrence of LN metastasis was observed around the IMA root., Conclusion: Laparoscopic D3 dissection in PIMA was comparable to that in LIMA regarding both short- and long-term outcomes. The optimal LN dissection for descending colon cancer should be investigated in future large-scale studies., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) more...
- Published
- 2023
- Full Text
- View/download PDF
10. Comparison of Short-term Outcomes of a Self-expandable Metallic Stent as a Bridge to Laparoscopic Surgery between Right- and Left-sided Obstructive Colorectal Cancers: A Retrospective Observational Study.
- Author
-
Sato K, Imaizumi K, Kasajima H, Kurushima M, Umehara M, Tsuruga Y, Yamana D, Sato A, Ichimura K, Isokawa M, and Nakanishi K
- Abstract
Objectives: Few studies have compared the tumor-site-based postoperative short-term outcomes of a bridge to surgery using self-expandable metallic stents. This study compared the perioperative outcomes following stent placement between right- and left-sided obstructive colorectal cancers, focusing on patients undergoing laparoscopic surgery., Methods: This study included 127 patients with stage I-IV obstructive colorectal cancer (right-sided, n = 25 [19.7%]; left-sided, n = 102 [80.3%]) who underwent laparoscopic-assisted surgery following stent placement between May 2012 and September 2021. We compared the postoperative complication rates and the success rates of stent placement., Results: The clinical success rate was not significantly different (92% vs. 97.1%, P = 0.254). The rates of all-grade complications (36% vs. 16.7%, P = 0.05) and postoperative ileus or small-bowel obstruction (20% vs. 2%, P = 0.003) were significantly higher in the right-sided group. The rates of the Clavien-Dindo classification ≥ III complications (8% vs. 6.9%, P = 1) and the median durations of postoperative hospital stay (8 days vs. 8 days, P = 1) were not significantly different. On multivariate analysis, right-sided colon cancer was an independent risk factor for postoperative ileus or small-bowel obstruction (odds ratio [OR]: 16.5, 95% confidence interval [CI]: 2.42-112, P = 0.004) but not for all grades of complications (OR: 2.63, 95% CI: 0.976-7.09, P = 0.056)., Conclusions: Although the rates of clinical success, postoperative Clavien-Dindo classification ≥ III severe complications, and postoperative hospital stay were comparable, the bridge to surgery following stent placement for right-sided obstructive colon cancer raises concerns about ileus or small-bowel obstruction., Competing Interests: Conflicts of Interest There are no conflicts of interest., (Copyright © 2022 The Japan Society of Coloproctology.) more...
- Published
- 2022
- Full Text
- View/download PDF
11. Postoperative colon perforation due to the tip of the transanal decompression tube after laparoscopic low anterior resection: A case report.
- Author
-
Sato K, Kasajima H, Imaizumi K, Kurushima M, Umehara M, Tsuruga Y, Yamana D, Sato A, Ichimura K, Isokawa M, and Nakanishi K
- Subjects
- Aged, Anastomosis, Surgical, Anastomotic Leak etiology, Anastomotic Leak prevention & control, Anastomotic Leak surgery, Colon, Sigmoid surgery, Decompression, Humans, Male, Intestinal Perforation etiology, Intestinal Perforation surgery, Laparoscopy adverse effects, Rectal Neoplasms surgery
- Abstract
A 66-year-old man underwent laparoscopic low anterior resection for rectal cancer. A transanal decompression tube (24Fr Nelaton catheter) was placed laparoscopically during the surgery. Contrast enema on postoperative day 5 showed perforation of the sigmoid colon around the tip of the tube, and emergency laparotomy was performed. Perforation of the posterior sigmoid colon located on the proximal side of the colorectal anastomosis at the level of the promontorium was identified. Closure of the perforation site, lavage drainage, and a diverting loop ileostomy were performed. Although a transanal decompression tube is useful in preventing anastomotic leakage, tube-related colon perforation should be noted, and controversies about the safety of laparoscopically transanal decompression tube placement should be resolved. Adequate management for tube placement should be discussed., (© 2022 Asia Endosurgery Task Force and Japan Society of Endoscopic Surgery and John Wiley & Sons Australia, Ltd.) more...
- Published
- 2022
- Full Text
- View/download PDF
12. Short-term outcomes of extracorporeal colo-colonic triangular anastomosis versus functional end-to-end anastomosis in laparoscopic-assisted surgery for left-sided colon cancer: a propensity score matching analysis.
- Author
-
Sato K, Imaizumi K, Kasajima H, Kurushima M, Umehara M, Tsuruga Y, Yamana D, Sato A, Ichimura K, and Nakanishi K
- Subjects
- Anastomosis, Surgical methods, Colectomy adverse effects, Colectomy methods, Humans, Propensity Score, Retrospective Studies, Treatment Outcome, Colonic Neoplasms surgery, Laparoscopy methods
- Abstract
Purpose: To the best of our knowledge, no studies have compared the short-term outcomes between colo-colonic extracorporeal triangular anastomosis (TA) and functional end-to-end anastomosis (FEEA), with a focus on laparoscopic-assisted surgery for left-sided colon cancer. Therefore, this study compared the short-term outcomes of these anastomoses using propensity score matching analysis., Methods: This retrospective study included 129 patients with stage I-IV left-sided colon cancer who underwent laparoscopic-assisted surgery with colo-colonic extracorporeal TA (n = 75) or FEEA (n = 54) between May 2009 and March 2021. After propensity score matching, 84 patients (TA, n = 42; FEEA, n = 42) were included in the analysis. The primary endpoint was the complication rate for all grades, and the secondary endpoints were the rates of Clavien - Dindo grade ≥ 3 complications and anastomotic leakage., Results: In the matched cohort, there were no significant differences in the complication rates for all grades (35.7% vs. 26.2%, p = 0.479), Clavien - Dindo grade ≥ 3 complications (11.9% vs. 11.9%, p = 1), and anastomotic leakage (0% vs. 4.8%, p = 0.494) between the TA and FEEA groups. In the univariate logistic regression analysis, TA did not increase the frequency of complications for any grades compared with FEEA (odds ratio: 1.570, 95% confidence interval: 0.616-3.980, p = 0.347)., Conclusion: Extracorporeal TA demonstrated equivalent short-term outcomes compared with FEEA in cases of laparoscopic-assisted surgery for left-sided colon cancer. TA can be an alternative anastomosis technique in cases wherein FEEA is difficult to perform., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) more...
- Published
- 2022
- Full Text
- View/download PDF
13. Safety of Insertion of Percutaneous Totally Implantable Central Venous Access Devices by Surgical Residents.
- Author
-
Obuchi K, Imaizumi K, Kasajima H, Kurushima M, Umehara M, Tsuruga Y, Yamana D, Sato K, Sato A, Suzuki S, and Nakanishi K
- Subjects
- Catheters, Indwelling adverse effects, Jugular Veins surgery, Subclavian Vein surgery, Catheterization, Central Venous adverse effects, Internship and Residency
- Abstract
Background/aim: To compare the outcomes of totally implantable central venous access device (TIVAD) insertions by surgical residents (SRs) with those by experienced surgeons (ESs) and establish the safety of percutaneous TIVAD insertion by SRs., Patients and Methods: A total of 700 insertions were successfully performed between January 2015 and December 2019 in our Department. The puncture site conversion and complication rates were compared, and risk factors related to complications were analysed., Results: In total, 84 and 616 insertions were performed in the SR and ES groups, respectively. SRs mainly punctured the internal jugular vein (IJV), and ESs punctured the subclavian vein (SV). The conversion rate from the IJV to SV was similar, whereas that from the SV to IJV was higher by SRs than ESs. Overall, early, and delayed complications were similar between the two groups., Conclusion: Percutaneous TIVAD inserted into the IJV by an SR was demonstrated to be safe., (Copyright © 2022, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.) more...
- Published
- 2022
- Full Text
- View/download PDF
14. Short- and long-term outcomes of a self-expandable metallic stent versus a transanal decompression tube for pathological stage II and III left-sided obstructive colorectal cancer: a retrospective observational study.
- Author
-
Sato K, Imaizumi K, Kasajima H, Kurushima M, Umehara M, Tsuruga Y, Yamana D, Obuchi K, Sato A, and Nakanishi K
- Subjects
- Aged, Aged, 80 and over, Colorectal Neoplasms pathology, Decompression, Surgical instrumentation, Female, Humans, Male, Middle Aged, Neoplasm Staging, Retrospective Studies, Time Factors, Treatment Outcome, Colorectal Neoplasms surgery, Decompression, Surgical methods, Self Expandable Metallic Stents
- Abstract
Purpose: Few studies have investigated the long-term oncological outcomes of the self-expandable metallic stent (SEMS) as a bridge to surgery (BTS) for obstructive colorectal cancer (OCRC). We conducted this study to compare the short- and long-term outcomes of the SEMS with those of the traditional transanal decompression tube (TDT) in patients with stage II and III left-sided OCRC., Methods: The subjects of this retrospective study were 78 patients with pathological stage II and III left-sided OCRC who underwent radical surgery after SEMS or TDT placement, between April, 2005 and September, 2019. We compared perioperative data, including decompression success rates and 3-year relapse-free survival (RFS), between the SEMS and TDT groups., Results: A SEMS was placed in 60 (76.9%) patients and a TDT was placed in 18 (23.1%) patients, achieving a clinical success rate of decompression of 98.3% in the SEMS group and 77.8% in the TDT group (P = 0.009). The 3-year RFS of the overall cohort was better in the SEMS group than in the TDT group (74.9% vs. 40.9%, respectively; P = 0.003)., Conclusions: Decompression using a SEMS as the BTS may improve oncological outcomes over those achieved by a TDT in patients with left-sided stage II and III OCRC., (© 2021. Springer Nature Singapore Pte Ltd.) more...
- Published
- 2022
- Full Text
- View/download PDF
15. Comparison of outcomes between laparoscopic and open Hartmann's reversal: A single-center retrospective study in Japan.
- Author
-
Sato A, Imaizumi K, Kasajima H, Obuchi K, Sato K, Yamana D, Tsuruga Y, Umehara M, Kurushima M, and Nakanishi K
- Subjects
- Anastomosis, Surgical, Colostomy, Humans, Japan, Postoperative Complications epidemiology, Retrospective Studies, Treatment Outcome, Laparoscopy
- Abstract
Introduction: Laparoscopic Hartmann's reversal (LHR) has recently been reported to be safer and more feasible than open Hartmann's reversal (OHR); however, there is limited data on the outcomes of LHR compared with those of OHR from Asian countries. Therefore, we aimed to clarify the postoperative outcomes of LHR compared with OHR, and additionally compare the patient outcomes post-LHR according to the previous Hartmann's procedure (HP) approach., Methods: Patients who underwent OHR and LHR between January 2006 and September 2020 in a single center in Japan, were retrospectively evaluated. Patient characteristics and perioperative data were collected from the medical and surgical records and assessed., Results: Overall, 15 and 19 patients underwent OHR and LHR, respectively, between January 2006 and September 2020. LHR was associated with less blood loss (median: 15 mL vs 185 mL; P < .001) and shorter hospital stays (9 days vs 14 days; P = .023) than OHR. There was no significant difference in postoperative complications between LHR and OHR (26.3% vs 40.0%, P = .475). However, two severe anastomotic complications in LHR were observed in patients with the stump below the peritoneal reflection. No significant difference in outcomes was observed between LHR patients who underwent open and laparoscopic HP., Conclusion: LHR resulted in positive outcomes regarding estimated blood loss and postoperative hospitalization, compared with OHR. Although the postoperative complications between LHR and OHR were not significant, patients with the stump below the peritoneal reflection may be at a high risk of anastomotic complications., (© 2021 Asia Endosurgery Task Force and Japan Society of Endoscopic Surgery and John Wiley & Sons Australia, Ltd.) more...
- Published
- 2022
- Full Text
- View/download PDF
16. Comparison of prognostic impact between positive intraoperative peritoneal and lavage cytologies in colorectal cancer.
- Author
-
Sato K, Imaizumi K, Kasajima H, Kurushima M, Umehara M, Tsuruga Y, Yamana D, Obuchi K, Sato A, and Nakanishi K
- Subjects
- Cytodiagnosis, Humans, Neoplasm Staging, Prognosis, Retrospective Studies, Colorectal Neoplasms pathology, Colorectal Neoplasms surgery, Peritoneal Lavage
- Abstract
Background: The prognostic value of positive intraoperative peritoneal cytology and lavage cytology, including the differences in their prognostic impact, in colorectal cancer is controversial. We aimed to investigate the prognostic values of positive peritoneal cytology and lavage cytology findings for colorectal cancer and compare their prognostic impact., Methods: We retrospectively evaluated 592 clinical stage II-IV colorectal cancer patients who underwent peritoneal cytology (n = 225) or lavage cytology (n = 367) between November 1993 and December 2018. The prognostic factors for cancer-specific survival were identified, and the differences in cancer-specific survival were examined between the patients., Results: The cytology-positive rate was 10.8% (64/592), 17.8% (40/225), and 6.5% (24/367) in the overall, peritoneal cytology, and lavage cytology groups, respectively. Both positive peritoneal cytology (hazard ratio: 2.196) and lavage cytology (hazard ratio: 2.319) were independent prognostic factors. The peritoneal cytology-positive group showed significantly poorer cancer-specific survival than the cytology-negative group (5-year: 3.5% vs. 59.5%; 10-year: 3.5% vs. 46.1%, p < 0.001). Similar results were obtained for lavage cytology (5-year: 14.1% vs. 73.9%; 10-year: 4.7% vs. 63.5%, p < 0.001). The cancer-specific survival was not significantly different between the peritoneal cytology-positive and lavage cytology-positive groups (p = 0.058). Both positive peritoneal and lavage cytology were associated with poorer cancer-specific survival across all colorectal cancer stages., Conclusions: Positive peritoneal and lavage cytology are associated with worse cancer-specific survival in colorectal cancer. The prognostic impact was comparable between positive lavage and peritoneal cytology. Thus, cytology should be a standard assessment modality for colorectal cancer. more...
- Published
- 2021
- Full Text
- View/download PDF
17. Laparoscopic repair supplemented with the perineal approach for perineal hernia after abdominoperineal resection - a video vignette.
- Author
-
Imaizumi K, Kasajima H, Yamana D, Sato A, and Nakanishi K
- Subjects
- Hernia etiology, Herniorrhaphy, Humans, Perineum surgery, Postoperative Complications surgery, Surgical Mesh, Laparoscopy, Proctectomy, Rectal Neoplasms surgery
- Published
- 2021
- Full Text
- View/download PDF
18. [A case of pneumatosis cystoides intestinalis after neoadjuvant chemotherapy for esophageal cancer].
- Author
-
Akasaka H, Wajima N, Kimura A, Sakuraba S, Kubo N, Yamana D, Okano K, Ichinohe D, Shimada T, and Hakamada K
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cisplatin administration & dosage, Cisplatin adverse effects, Fluorouracil administration & dosage, Fluorouracil adverse effects, Humans, Male, Antineoplastic Combined Chemotherapy Protocols adverse effects, Esophageal Neoplasms drug therapy, Neoadjuvant Therapy adverse effects, Pneumatosis Cystoides Intestinalis chemically induced
- Abstract
A man in his 60s was diagnosed with esophageal cancer (T3, N0, StageII) and treated with 5-fluorouracil and cisplatin as neoadjuvant chemotherapy (NAC). On day 18 of the second NAC course, the patient developed febrile neutropenia, and a computed tomography (CT) scan showed pneumatosis cystoides intestinalis (PCI) of the ascending and transverse colon, free air around the ascending colon, thickening of the gallbladder wall, pleural effusion, and ascites. Because there were no signs of peritoneal irritation and intestinal perforation was ruled out, conservative treatment was selected. Seven days after PCI was diagnosed, CT showed improvement in PCI and the free air had disappeared, and 26 days after the diagnosis, a subtotal esophagectomy was performed. Observation of the abdomen did not show a thickened wall or stenosis of the ascending or transverse colon. PCI could be treated conservatively, even with free air in the abdominal cavity, by comprehensively assessing not only the imaging but also the physical findings. We were able to perform radical resection of the esophageal cancer without excessive treatment for PCI. more...
- Published
- 2014
19. [A case of malignant peritoneal mesothelioma without deletion of p16].
- Author
-
Kubo N, Wajima N, Kimura A, Akasaka H, Sakuraba S, Yamana D, Nagase H, Ichinohe D, and Hakamada K
- Subjects
- Cyclin-Dependent Kinase Inhibitor p16, Humans, In Situ Hybridization, Fluorescence, Lung Neoplasms genetics, Male, Mesothelioma genetics, Mesothelioma, Malignant, Neoplasm Proteins genetics, Neoplasms, Multiple Primary genetics, Peritoneal Neoplasms genetics, Lung Neoplasms diagnosis, Mesothelioma diagnosis, Neoplasms, Multiple Primary diagnosis, Peritoneal Neoplasms diagnosis
- Abstract
The patient was a man in his 60s with a history of 2 operations for the treatment of malignant neurogenic tumors. Partial resection of the stomach and liver was performed in December 2006, followed by chemotherapy with adriamycin and interferon; resection of a recurrent tumor in the left subphrenic space was performed in December 2007. In June 2011, recurrent tumors were detected in the lesser curvature of the stomach body and left inferior quadrant of the abdomen (12 mm [SUVmax 7.9] and 23 mm [SUVmax 10.5], respectively)by using 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET). The tumors resected in August 2011 were diagnosed as malignant peritoneal mesothelioma on immunohistochemical analysis. In February 2013, FDG-PETrevealed a 20-mm tumor of in the mesentery with a SUVmax of 7.6, and the tumor was resected. This secondary tumor had the same features of the previously resected malignant mesothelioma. Fluorescence in situ hybridization revealed no deletion of the p16 gene, and the patient had had no other recurrence during follow-up. Malignant peritoneal mesothelioma is a rare disease, accounting for 10% of all malignant mesothelioma cases, with low rates of p16 gene deletion compared with malignant pleural mesothelioma. Previous studies have reported that the lack of p16 deletion is associated with better prognosis in malignant pleural mesothelioma. Herein, we report of a patient diagnosed with malignant peritoneal mesothelioma, without deletion of the p16 gene, who survived for over 2 years and 10 months after initial diagnosis of malignant mesothelioma. more...
- Published
- 2014
20. Lectin-like receptor Ly49s3 on dendritic cells contributes to the differentiation of regulatory T cells in the rat thymus.
- Author
-
Yamada T, Nanashima N, Akita M, Shimizu T, Miura T, Yamana D, Sawano T, Sakurai T, and Tsuchida S
- Subjects
- Animals, CD4-Positive T-Lymphocytes cytology, CD4-Positive T-Lymphocytes immunology, CD4-Positive T-Lymphocytes metabolism, Cell Differentiation immunology, Dendritic Cells immunology, Gene Expression, Histocompatibility Antigens Class II immunology, Lymphocyte Count, Male, Rats, T-Lymphocyte Subsets cytology, T-Lymphocyte Subsets immunology, T-Lymphocyte Subsets metabolism, T-Lymphocytes, Regulatory immunology, Thymus Gland immunology, Thymus Gland pathology, Cell Differentiation genetics, Dendritic Cells metabolism, NK Cell Lectin-Like Receptor Subfamily A genetics, T-Lymphocytes, Regulatory cytology, T-Lymphocytes, Regulatory metabolism, Thymus Gland metabolism
- Abstract
Naturally occurring regulatory T cells (nTregs), important for immune regulation and the maintenance of self-tolerance, develop in the thymus. The Hirosaki hairless rat (HHR), derived from the Sprague-Dawley rat (SDR), was shown to have decreased peripheral lymphocyte number, small thymus, and leukocyte infiltration in its dermis. In the HHR thymus, the medulla was underdeveloped and nTreg number was decreased. Array comparative genome hybridization revealed the deletion of an NK cell lectin-like receptor gene, Ly49s3, detecting MHC class I molecules on target cells, in the chromosome 4q42 region in HHRs. The gene was expressed in thymic conventional dendritic cells (cDCs) in SDRs, but not in HHRs. When CD4-single-positive or CD4(+)CD8(-)CD25(-) thymocytes were cultured with thymic cDCs, the expression of nTreg marker genes was lower when these cells were from HHRs than from SDRs, suggesting that HHR cDCs are deficient in the ability to induce and maintain nTreg differentiation. Expression of the genes was recovered when Ly49s3 was expressed on HHR thymic cDCs. Expression levels of MHC class II genes, presumably from cDCs, were parallel to those of nTreg marker genes in mixed-cell cultures. However, in the presence of an anti-MHC class I Ab, blocking interaction between Ly49s3 and MHC class I molecules, the expression of the former genes was upregulated, whereas the latter was downregulated. These results suggest that Ly49s3 contributes to nTreg regulation along with MHC class II molecules, whose effects alone are insufficient, and loss of Ly49s3 from thymic cDCs is the reason for the nTreg deficiency in HHRs. more...
- Published
- 2013
- Full Text
- View/download PDF
21. [A case of malignant lymphoma of the gallbladder after chemotherapy for malignant lymphoma of the skin and right intraocular].
- Author
-
Nakai M, Toyoki Y, Ishido K, Kudo D, Kimura N, Yamana D, and Hakamada K
- Subjects
- Aged, Biopsy, Eye Neoplasms drug therapy, Eye Neoplasms pathology, Female, Gallbladder Neoplasms pathology, Gallbladder Neoplasms surgery, Humans, Lymphoma, T-Cell, Peripheral surgery, Neoplasm Invasiveness, Skin Neoplasms drug therapy, Skin Neoplasms pathology, Gallbladder Neoplasms secondary, Lymphoma, T-Cell, Peripheral pathology
- Abstract
A case is a 65-year-old female. She was diagnosed as T-cell malignant lymphoma (skin and right intraocular). Chemotherapy( THP-COP) was performed for 6 months and she was in remission. A gallbladder tumor was pointed out in August 2010, and she was admitted to our department for the purpose of excision biopsy of the gallbladder tumor. In abdominal US, we confirmed an iso-hypoechoic tumor. The tumor size was 24 × 14 mm. We considered the invasion depth was subserosa. We observed the tumor which had the imaging effectiveness in the body of gallbladder by abdominal CT. The invasion was suspected in the liver bed side. In PET-CT, We observed an accumulation of SUVmax 8 . 5 in the body of gallbladder. The protruded lesion of 33 .5 mm in diameter was detected by MRI to the body of gallbladder, and an invasion was also suspected. Cholecystectomy was performed to this case. By operative US, the gallbladder tumor was SMT and existed in the symmetric side of liver bed. Pathological diagnosises were malignant lymphoma and peripheral T-cell lymphoma. more...
- Published
- 2011
22. Effects of S-1 as a second-line chemotherapy for patients with relapsed pancreatic cancer.
- Author
-
Ishido K, Toyoki Y, Kudo D, Kimura N, Yamana D, Miura T, Tsutsumi S, Muroya T, Yoshikawa T, Ogasawara H, Yonaiyama S, Narumi S, and Hakamada K
- Abstract
Adjuvant chemotherapy with gemcitabine is the standard treatment in Japan for patients who have undergone resection of pancreatic cancer. However, few reports have described suitable regimens for patients who present cancer relapse following adjuvant chemotherapy. In the present study, we retrospectively evaluated the efficacy and safety of S-1, an oral fluoropyrimidine derivative, as a second-line chemotherapy for patients who had suffered relapse of pancreatic cancer following adjuvant chemotherapy with gemcitabine. A total of 51 patients with pancreatic cancer suffered relapse after curative resection and subsequent adjuvant chemotherapy with gemcitabine at our institution. A group of 26 of these patients were administered S-1 orally twice daily after meals at a dose of 80 mg/m(2) for body surface areas for 14 consecutive days, followed by a 7-day rest (S-1 group). The remaining 25 patients received no additional anticancer drugs other than continuation of gemcitabine (GEM/BSC group). During a median follow-up period of 35 months, a significant difference was observed in overall survival (OAS) between the S-1 group and the control group (median OAS, 20.9 vs. 13.7 months; p=0.0157, log-rank test). Furthermore, there was a significant inter-group difference in survival after relapse (SAR) (median SAR, 11.4 vs. 6.20 months; p=0.0025, log-rank test). No increase in grade 3/4 hematological and non-hematological toxicity was observed in the S-1 group. In conclusion, second-line chemotherapy using a combination of S-1 and adjuvant chemotherapy with gemcitabine may be an efficient and beneficial strategy for patients with relapsed pancreatic cancer. more...
- Published
- 2011
- Full Text
- View/download PDF
23. Sustained repression and translocation of Ntcp and expression of Mrp4 for cholestasis after rat 90% partial hepatectomy.
- Author
-
Miura T, Kimura N, Yamada T, Shimizu T, Nanashima N, Yamana D, Hakamada K, and Tsuchida S
- Subjects
- ATP Binding Cassette Transporter, Subfamily B, Member 11, ATP-Binding Cassette Transporters genetics, ATP-Binding Cassette Transporters metabolism, Animals, Bile Acids and Salts blood, Biological Transport, Active, Cholestasis genetics, Cholestasis pathology, Liver Regeneration genetics, Liver Regeneration physiology, Male, Multidrug Resistance-Associated Proteins genetics, Organic Anion Transporters, Sodium-Dependent genetics, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Rats, Sprague-Dawley, Symporters genetics, Time Factors, Transcriptome, Cholestasis etiology, Cholestasis metabolism, Hepatectomy adverse effects, Multidrug Resistance-Associated Proteins metabolism, Organic Anion Transporters, Sodium-Dependent metabolism, Symporters metabolism
- Abstract
Background & Aims: To clarify the mechanism of persistent cholestasis after massive hepatectomy, the relationship between such cholestasis and the expression and localization of organic anion transporters for bile acids was examined in a rat model., Methods: Male Sprague-Dawley rats were subjected to 90% hepatectomy, and tissues were harvested at 0, 1, 3, and 7 days for microarray analysis, quantitative real-time polymerase chain reaction (RT-PCR), Western blotting, and immunohistochemistry to examine the expression of multidrug resistance protein 4 (Mrp4), bile salt export pump (Bsep), and sodium-dependent taurocholate cotransporting polypeptide (Ntcp)., Results: Persistently elevated levels of serum bile acids were observed at days 3 and 7. RT-PCR and Western blotting indicated that the expression of Mrp4, a bile acid export pump located in the basolateral membrane, was increased at day 3. The expression of Ntcp, a transporter used to uptake bile acids from the sinusoids, was significantly decreased throughout the period. The levels of Bsep, an export pump localized to the canalicular membrane, were unchanged. Immunohistochemistry revealed the localization of Mrp4 and Bsep in the basolateral and canalicular membranes, respectively. On the other hand, at days 3 and 7, Ntcp was localized in the cytoplasm and was hardly detected in the basolateral membrane., Conclusions: These results suggested that the sustained repression and translocation of Ntcp and the expression of Mrp4 at the basolateral membrane seem to be responsible for the high blood bile acids levels after massive hepatectomy., (Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.) more...
- Published
- 2011
- Full Text
- View/download PDF
24. Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis.
- Author
-
Yamana D, Shimizu T, Fan Y, Miura T, Nanashima N, Yamada T, Hakamada K, and Tsuchida S
- Subjects
- Actins metabolism, Animals, Biomarkers, Tumor genetics, Biomarkers, Tumor metabolism, Cells, Cultured, DNA, Neoplasm genetics, Gene Expression Profiling, Glutathione Transferase genetics, Humans, Immunoenzyme Techniques, Liver Neoplasms, Experimental metabolism, Male, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Polymorphism, Genetic, Rats, Rats, Sprague-Dawley, Anticholesteremic Agents toxicity, Cell Transformation, Neoplastic drug effects, Clofibrate toxicity, Hepatic Stellate Cells drug effects, Liver Neoplasms, Experimental chemically induced
- Abstract
To examine the possible involvement of nonparenchymal cells in the development of preneoplastic hepatic lesions induced by clofibrate (CF), alterations of these cells were investigated immunohistochemically in glutathione S-transferase M1 gene polymorphic rats (KS and NC types) with different cancer susceptibilities. After CF administration for 8 weeks, α-smooth muscle actin (α-SMA)-positive hepatic stellate cells (HSC) were markedly decreased in sensitive KS-type rats, but not in the NC-type rats. Kupffer cells were decreased with similar extents between them. The sinusoidal endothelial cells were not changed in either type. The other markers for HSC, vimentin and CRBP1, also confirmed the decrease of HSC in the KS type. The decrease of HSC was not observed at 4 weeks of CF administration. Preneoplastic peroxisomal bifunctional enzyme-negative foci were detected in the KS-type rats at 8 weeks of CF administration, but not at 4 weeks. Human HSC were cultured in the presence of clofibric acid and expression of most HSC marker genes, such as vimentin and α-SMA (ACTA2), evaluated by a microarray, was not altered by the treatment, suggesting that HSC loss in the KS-type rats was not due to the direct toxic effect of CF. The expression levels of most HSC marker genes were low in both control and CF-treated rat livers. A possible link between HSC loss and the development of preneoplastic hepatic foci is discussed., (© 2011 Japanese Cancer Association.) more...
- Published
- 2011
- Full Text
- View/download PDF
25. Glutathione S-transferase A4 is a positive marker for rat hepatic foci induced by clofibrate and genotoxic carcinogens.
- Author
-
Shimizu T, Fan Y, Yamana D, Miura T, Nanashima N, Yamada T, and Tsuchida S
- Subjects
- Animals, Glutathione S-Transferase pi analysis, Immunohistochemistry, Liver drug effects, Liver pathology, Liver Neoplasms, Experimental etiology, NF-E2-Related Factor 2 analysis, Precancerous Conditions etiology, Rats, Biomarkers, Tumor analysis, Clofibrate toxicity, Glutathione Transferase analysis, Liver Neoplasms, Experimental enzymology, Precancerous Conditions enzymology
- Abstract
Peroxisome proliferators (PP), including clofibrate (CF), are non-genotoxic rodent carcinogens, and oxidative DNA damages are suggested as a causative event for carcinogenesis. Gene expression profiles differ between hepatic lesions induced by PP and genotoxic carcinogens. Our previous study revealed that expression of L-bifunctional enzyme (enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase, BE) was repressed in preneoplastic lesions induced by PP, whereas it was enhanced in the surrounding tissues. In the present study, we immunohistochemically examined expression of the specific glutathione S-transferase (GST) form, GST-A4, which detoxifies 4-hydroxy-alkenal, the end-product of lipid peroxides, and nuclear factor-erythroid 2-related factor 2 (Nrf2), a transcription factor for many genes encoding drug-metabolizing enzymes and defending enzymes against oxidative stress, during rat hepatocarcinogenesis induced by CF and genotoxic carcinogens. GST-A4 and Nrf2 were not expressed in BE-negative foci at 8 weeks of CF administration, but were expressed in the foci at 60 weeks. GST-A4-positive foci appeared at later stages than BE-negative foci, but its localization was coincidental with that of the latter foci. The areas of GST-A4-positive foci were larger than those of BE-negative foci without GST-A4 expression. Most GST-A4-positive foci were also positive for Nrf2. In rat livers induced by genotoxic carcinogens, GST-P-negative foci as well as GST-P-positive foci were demonstrated. GST-A4 and Nrf2 were expressed in GST-P-negative foci, whereas they were not expressed in most GST-P-positive foci. Thus, GST-A4-positive foci developed in rat livers by CF and genotoxic carcinogen administration, indicating that the enzyme is a positive marker for hepatic foci induced by these different carcinogens. more...
- Published
- 2010
- Full Text
- View/download PDF
26. Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis.
- Author
-
Asano J, Kudo T, Shimizu T, Fan Y, Nanashima N, Yamana D, Miura T, Yamada T, and Tsuchida S
- Subjects
- Acetyl Coenzyme A genetics, Acetyl Coenzyme A metabolism, Acetyl Coenzyme A pharmacology, Acetyl-CoA C-Acetyltransferase genetics, Acetylation, Animals, Cell Transformation, Neoplastic genetics, Cell Transformation, Neoplastic metabolism, Clofibrate, Enzyme Induction, Fatty Acids genetics, Fatty Acids metabolism, Fatty Acids pharmacology, Histones genetics, Histones pharmacology, Liver drug effects, Liver enzymology, Liver Neoplasms, Experimental chemically induced, Male, Nuclear Receptor Coactivator 3 metabolism, PPAR alpha genetics, PPAR alpha metabolism, PPAR alpha pharmacology, Peroxisome Proliferators metabolism, Peroxisome Proliferators pharmacology, Polymorphism, Genetic, Rats, Rats, Sprague-Dawley, Receptors, Steroid genetics, Receptors, Steroid metabolism, Acetyl-CoA C-Acetyltransferase metabolism, Histones metabolism, Liver metabolism, Liver Neoplasms, Experimental metabolism
- Abstract
Peroxisome proliferators (PPs), non-genotoxic rodent carcinogens, cause the induction of the peroxisomal fatty acid beta-oxidation system, including bifunctional enzyme (BE) and 3-ketoacyl-CoA thiolase (TH), in the liver. GST M1 gene is polymorphic in Sprague-Dawley rats, NC- and KS-type. The KS-type rats showed enhanced susceptibility to ethyl-alpha-chlorophenoxyisobutyrate (clofibrate, CF), one of the PPs. The degree of BE induction was higher in the KS-type and preneoplastic foci developed after 6-8 weeks of treatment, whereas no foci developed in the NC-type. In the preset study, factors involved in different BE inducibility were investigated. There were no differences in hepatic peroxisome proliferator-activated receptor (PPAR) alpha levels between them. Among various coactivators for PPARalpha, only steroid receptor coactivator (SRC)-3 level was higher in the KS-type. To investigate the association between PPARalpha and SRC-3 or other proteins, nuclear extracts from CF-treated livers were applied to a PPARalpha column. In the KS-type, 110, 72, and 42 kDa proteins were bound and these were identified as SRC-3, BE, and TH, respectively. EMSA supported the binding of these proteins to PPARalpha associated to the BE enhancer in CF-treated KS-type, but not in the NC-type. Histone H3 acetylation was increased 11-fold in the KS-type by CF treatment but not in the NC-type. As BE and TH are responsible for acetyl-CoA production and SRC-3 possesses a histone acetyltransferase activity, these results suggest that enhanced BE induction in the KS-type livers is due to acetylation-mediated transcriptional activation and epigenetic mechanisms might be involved in CF-induced rat hepatocarcinogenesis. more...
- Published
- 2010
- Full Text
- View/download PDF
27. [Evaluation of aortic aneurysm and dissection by abdominal echography].
- Author
-
Tsuruoka H and Yamana D
- Subjects
- Aortic Dissection classification, Aortic Dissection etiology, Aortic Dissection pathology, Aortic Aneurysm etiology, Aortic Aneurysm pathology, Arteriosclerosis complications, Arteriosclerosis diagnostic imaging, Artifacts, Humans, Thrombosis diagnostic imaging, Ultrasonography, Doppler, Color, Abdomen diagnostic imaging, Aortic Dissection diagnostic imaging, Aortic Aneurysm diagnostic imaging, Ultrasonography methods
- Abstract
Aortic dissection and aneurysm are related to increased vulnerability of the aortic wall due to arteriosclerosis. Echographic findings of aortic sclerosis include irregularity and strong punctate echoes in the intima and meandering of the aorta. Unruptured abdominal aneurysms are often found incidentally by routine echography. The "maximum diameter" and "increase in the size" of aortic aneurysm on echography are important information closely related to the risk of its rupture. In the evaluation of acute aortic dissection, the flap length indicates the range of dissection. The presence or absence of blood flow in the false lumen must be examined simultaneously using color Doppler echography. Some aortic dissections and aneurysms require emergency treatment on detection, and the evaluation of their images on echography, which is often performed for screening of patients with back or abdominal pain, are important for the determination of the therapeutic approach. In patients who are treated conservatively or observed, echography is very useful for the follow-up. Such patients must also be diagnosed or followed up by combining echography with other imaging techniques depending on the condition and necessary information in each patient. more...
- Published
- 2007
28. [Cerebral circulation dynamics following fasudil intravenous infusion: a CT perfusion study].
- Author
-
Ono K, Shirotani T, Yuba K, and Yamana D
- Subjects
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine administration & dosage, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine pharmacology, Adult, Aged, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Perfusion, Subarachnoid Hemorrhage diagnostic imaging, Vasospasm, Intracranial etiology, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine analogs & derivatives, Brain diagnostic imaging, Cerebrovascular Circulation drug effects, Subarachnoid Hemorrhage physiopathology, Tomography, X-Ray Computed
- Abstract
Using CT perfusion studies we evaluated changes in the cerebral circulation before and after the intravenous administration of fasudil 60 mg in 8 patients 7 to 14 days after a subarachnoid hemorrhage. The mean duration to the peak of the time-density curve and the average peak value did not change. In areas with cerebral blood perfusion (CBP) less than 40 ml/100 g/min, the CBP increased from 34.4 +/- 4.7 ml/100 g/min to 41.0 +/- 8.2 ml/100 g/min (p < 0.01) after fasudil infusion, the cerebral blood volume (CBV) rose from 2.41 +/- 0.53 ml/100 g to 2.55 +/- 0.5 ml/100 g (p < 0.05), and the mean transit time (MTT) decreased from 5.09 +/- 1.13 s to 4.82 +/- 0.89 s (p < 0.05). In areas where the CBP was more than 41 ml/100 g/min, the CBP did not change (from 51.8 +/- 7.6 ml/100 g/min to 50.4 +/- 8.4 ml/100 g/min), the CBV decreased (from 2.75 +/- 0.62 ml/100 g to 2.67 +/- 0.55 ml/100 g, p < 0.05), and the MTT did not change (from 3.80 +/- 0.76 s to 3.77 +/- 0.72 s). These results suggest that intravenous infusion of fasudil 60 mg increases cerebral blood flow and cerebral blood volume and shortens MTT in areas with decreased blood flow due to vasospasm. more...
- Published
- 2005
29. [Intra-arterial administration of fasudil hydrochloride: duration of action].
- Author
-
Ono K, Shirotani T, Wada K, Takahara T, Matsushita Y, Yuba K, and Yamana D
- Subjects
- Aged, Carotid Artery, Internal, Cerebral Arteries pathology, Cerebrovascular Circulation, Delayed-Action Preparations, Female, Humans, Injections, Intra-Arterial, Male, Middle Aged, Subarachnoid Hemorrhage complications, Vasospasm, Intracranial physiopathology, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine administration & dosage, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine analogs & derivatives, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine pharmacology, Vasodilator Agents administration & dosage, Vasodilator Agents pharmacology, Vasospasm, Intracranial drug therapy
- Abstract
Intra-arterial infusion (IA) of fasudil hydrochloride for cerebral vasospasm is performed in many institutions and is associated with few side effects. Nonetheless, as optimum dose and duration of action remain unknown, the present study aimed to clarify these variables. We performed intra-arterial injection of fasudil hydrochloride for eight patients with cerebral vasospasm 7-13 days after subarachnoid hemorrhage. Fasudil hydrochloride was administered via the internal carotid artery without selective microcatheterization, at a concentration and speed of 30 mg/20 ml/10-15 min, using a total dose of 30-60 mg. Cerebral angiography was used to measure change in blood vessel diameter at 19 points, and perfusion CT was used to detect changes in cerebral blood perfusion (CBP), cerebral blood volume (CBV), and mean transit time (MTT) at 12 hemispheres. Investigations were performed before IA, immediately after IA (post IA), and 4.5 to 6 hours later. For central vessels, (A1, M1) mean change in diameter (cm) measured pre IA, post IA, and 4.5-6 hours later was 1.2 +/- 0.68, 1.5 +/- 0.72, and 1.2 +/- 0.7, respectively. For peripheral vessels (peripheral to A1, M1, and the ophthalmic artery) change in diameter (cm) was 0.65 +/- 0.16, 0.97 +/- 0.24, and 0.71 +/- 0.24, respectively. Average CBP (m/100g/min) in the infused hemisphere at pre IA, post IA, and 4.5-6 hours later was 41.6 +/- 3.56, 46.4 +/- 5.82, 41.6 +/- 7.42, respectively. Average CBV (ml/100g) was 2.72 +/- 0.21, 2.73 +/- 0.21, 2.91 +/- 0.42, respectively and average MTT (sec) was 5.16 +/- 0.38, 4.57 +/- 0.70, 5.55 +/- 1.0, respectively. Changes in peripheral vessel diameter and in MTT were statistically significant. Therefore, when performing intra-arterial administration of fasudil hydrochloride, clinicians should be aware that vasodilator effect is less than 6 hours. more...
- Published
- 2005
30. Pertussis toxin-sensitive pathway inhibits glucose-stimulated Ca2+ signals of rat islet beta-cells by affecting L-type Ca2+ channels and voltage-dependent K+ channels.
- Author
-
Suga S, Takeo T, Nakano K, Sato T, Igarashi T, Yamana D, and Wakui M
- Subjects
- Animals, Calcium Signaling drug effects, Cells, Cultured, Clonidine pharmacology, Dose-Response Relationship, Drug, Male, Membrane Potentials drug effects, Membrane Potentials physiology, Rats, Rats, Wistar, Calcium Channels, L-Type metabolism, Calcium Signaling physiology, Glucose metabolism, Islets of Langerhans metabolism, Pertussis Toxin pharmacology, Potassium Channels, Voltage-Gated metabolism
- Abstract
A role of pertussis toxin (PTX)-sensitive pathway in regulation of glucose-stimulated Ca2+ signaling in rat islet beta-cells was investigated by using clonidine as a selective agonist to alpha2-adrenoceptors which link to the pathway. An elevation of extracellular glucose concentration from 5.5 to 22.2 mM (glucose stimulation) increased the levels of [Ca2+]i of beta-cells, and clonidine reversibly reduced the elevated levels of [Ca2+]i. This clonidine effect was antagonized by yohimbine, and abolished in beta-cells pre-treated with PTX. Clonidine showed little effect on membrane currents including those through ATP-sensitive K+ channels induced by voltage ramps from -90 to -50 mV. Clonidine showed little effect on the magnitude of whole-cell currents through L-type Ca2+ channels (ICa(L)), but increased the inactivation process of the currents. Clonidine increased the magnitude of the voltage-dependent K+ currents (IVK). These clonidine effects on ICa(L) and IVK were abolished in beta-cells treated with PTX or GDP-betaS. These results suggest that the PTX-sensitive pathway increases IVK activity and decreases ICa(L) activity of islet beta-cells, resulting in a decrease in the levels of [Ca2+]i elevated by depolarization-induced Ca2+ entry. This mechanism seems responsible at least in part for well-known inhibitory action of PTX-sensitive pathway on glucose-stimulated insulin secretion from islet beta-cells. more...
- Published
- 2004
- Full Text
- View/download PDF
31. Transcatheter embolization of arteriovenous malformations in Cowden disease.
- Author
-
Takaya N, Iwase T, Maehara A, Nishiyama S, Nakanishi S, Yamana D, Takei R, Kokubo T, Kohtake H, Furui S, Tomoyasu H, and Seki A
- Subjects
- Adult, Arteriovenous Malformations pathology, Arteriovenous Malformations physiopathology, Humans, Male, Pelvis blood supply, Pelvis pathology, Arteriovenous Malformations therapy, Embolization, Therapeutic, Hamartoma Syndrome, Multiple
- Abstract
A patient with Cowden disease and multiple arteriovenous malformations (AVMs) that resulted in high output heart failure is described. Cowden disease is a familial syndrome characterized by endodermal, mesodermal and ectodermal dysplasia causing benign and malignant tumors of the skin, breast, gastrointestinal tract, and thyroid gland. Our patient had gastrointestinal polyposis, a right renal tumor, a left lung tumor, an adenomatous goiter, and typical dermatologic findings such as facial papules, acral keratosis, gingival papillomatosis and hemangiomas. AVMs were observed in the pelvis, cervical vertebra, liver, and right supraclavicular area. Transcatheter embolization was performed 7 times for the pelvic AVMs, but the effect decreased with repetition and the patient died of heart failure 2 years after the first embolization. The serum levels of tissue plasminogen activator (t-PA), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and transforming growth factor beta1 were high, suggesting that these angiogenic molecules may play a role in the pathogenesis of AVMs in Cowden disease. more...
- Published
- 1999
- Full Text
- View/download PDF
32. Intracaval invasion of left adrenal cortical carcinoma extending into the right atrium.
- Author
-
Yamana D, Yanagi T, Nanbu I, Tanaka K, Hirabayashi S, Tohyama J, Mizutani H, Ohba S, Katoh N, and Ono Y
- Subjects
- Adenocarcinoma complications, Adenocarcinoma surgery, Adrenal Cortex Neoplasms complications, Adrenal Cortex Neoplasms surgery, Adult, Angiography, Humans, Magnetic Resonance Imaging, Male, Neoplasm Invasiveness, Neoplastic Cells, Circulating, Thrombophlebitis diagnosis, Thrombophlebitis etiology, Thrombophlebitis surgery, Tomography, X-Ray Computed, Vena Cava, Inferior diagnostic imaging, Vena Cava, Inferior pathology, Adenocarcinoma diagnosis, Adrenal Cortex Neoplasms diagnosis, Heart Atria diagnostic imaging, Heart Atria pathology, Heart Atria surgery
- Abstract
A case of adrenal carcinoma with advanced inferior vena cava (IVC) involvement is reported. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a large mass over the upper pole of the left kidney, with tumor thrombus from the IVC to the right atrium of the heart. Angiography demonstrated that this mass received its blood supply mainly from the left superior adrenal artery, and, parasitically, the left middle adrenal artery, splenic artery, and lumbar arteries. Venacavography revealed obstruction of the IVC and the collateral, dilated azygos vein. Radical surgery was performed, including resection of the tumor and the tumor thrombus in the IVC and right atrium with the aid of cardiopulmonary bypass. Although renal carcinoma with tumor thrombus invasion of the IVC or atrium is common, adrenal tumor thrombus invasive to the atrium is very rare. more...
- Published
- 1997
33. Germinoma arising in the basal ganglia in early stage: CT and MR findings.
- Author
-
Yamana D, Tohyama J, Mike T, Fukaya N, Okano M, Mimura M, Banno T, and Ohba S
- Subjects
- Basal Ganglia Diseases diagnostic imaging, Brain Edema diagnosis, Brain Neoplasms diagnostic imaging, Cerebral Angiography, Child, Contrast Media, Cysts diagnosis, Gadolinium, Gadolinium DTPA, Germinoma diagnostic imaging, Humans, Image Enhancement, Male, Neoplasm Staging, Organometallic Compounds, Pentetic Acid analogs & derivatives, Radiographic Image Enhancement, Basal Ganglia Diseases diagnosis, Brain Neoplasms diagnosis, Germinoma diagnosis, Magnetic Resonance Imaging, Tomography, X-Ray Computed
- Abstract
We report a patient with a germinoma originating in the left basal ganglia. Unenhanced computed tomography (CT) revealed a relatively well-defined high-density lesion, which was slightly enhanced with contrast medium. No tumor stain was noted on angiography. The mass showed hypointensity on T1-weighted magnetic resonance imaging (MRI), and heterogeneous hyperintensity on T2-weighted imaging. The lesion was homogeneously enhanced after the administration of Gd-DTPA. To our knowledge, the MR findings of basal ganglia germinoma have been retrospectively reviewed in just four reported cases, only two of which were examined with Gd-DTPA enhancement. The two cases revealed relatively large masses with cysts and peritumoral edema, and were slightly enhanced after the intravenous injection of Gd-DTPA. Our case was thought to be in the early stage, and its CT and MR findings were slightly different from those of previously reported cases. more...
- Published
- 1995
34. Three-dimensional image of Bochdalek diaphragmatic hernia; a case report.
- Author
-
Yamana D and Ohba S
- Subjects
- Adipose Tissue diagnostic imaging, Contrast Media, Hernias, Diaphragmatic, Congenital, Humans, Kidney diagnostic imaging, Male, Middle Aged, Spleen diagnostic imaging, Hernia, Diaphragmatic diagnostic imaging, Radiographic Image Enhancement methods, Tomography, X-Ray Computed methods
- Abstract
A 60-year-old man was found to have a mass shadow on the left posterior diaphragm by chest roentgenogram. He was examined by spiral computed tomography (CT) using the Somatom Plus-S. Transaxial, coronal, sagittal, and three-dimensional (3D) imagings were performed. Transaxial, coronal, and sagittal images of CT scans demonstrated not only a large defect of the posteromedial portion of the left diaphragm, but also two small defects on the right side. The spleen was identified through the left-side defect, and subdiaphragmatic fat through the right-side defects. He was diagnosed as having bilateral Bochdalek hernia. 3D Imaging was also useful for stereographic perception of Bochdalek hernia. Although Bochdalek hernia is not rare, to our knowledge, this is the first case of Bochdalek hernia observed by spiral CT 3D imaging. more...
- Published
- 1994
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.