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27 results on '"Yamashita, Midori"'

5. Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade

Author

Nakao, Shinsuke, primary, Arai, Yukinori, additional, Tasaki, Mamoru, additional, Yamashita, Midori, additional, Murakami, Ryuji, additional, Kawase, Tatsuya, additional, Amino, Nobuaki, additional, Nakatake, Motomu, additional, Kurosaki, Hajime, additional, Mori, Masamichi, additional, Takeuchi, Masahiro, additional, and Nakamura, Takafumi, additional

Published
2020
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6. Abstract B019: Effect of oncolytic vaccinia virus-induced IL-7 and IL-12 expression on tumor immune microenvironment in poorly immunogenic murine cancer

Author

Nakao, Shinsuke, primary, Arai, Yukinori, additional, Tasaki, Mamoru, additional, Yamashita, Midori, additional, Amino, Nobuaki, additional, Murakami, Ryuji, additional, Kawase, Tatsuya, additional, Nakatake, Motomu, additional, Kurosaki, Hajime, additional, Mori, Masamichi, additional, Takeuchi, Masahiro, additional, and Nakamura, Takafumi, additional

Published
2019
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8. Identification of ten KB425796-A congeners from Paenibacillus sp. 530603 using an antifungal assay against Aspergillus fumigatus in combination with micafungin

Author

Kai, Hirohito, primary, Yamashita, Midori, additional, Takase, Shigehiro, additional, Hashimoto, Michizane, additional, Muramatsu, Hideyuki, additional, Nakamura, Ikuko, additional, Yoshikawa, Koji, additional, Kanasaki, Ryuichi, additional, Ezaki, Masami, additional, Nitta, Kumiko, additional, Watanabe, Masato, additional, Inamura, Noriaki, additional, and Fujie, Akihiko, additional

Published
2013
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9. KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603

Author

Kai, Hirohito, primary, Yamashita, Midori, additional, Takase, Shigehiro, additional, Hashimoto, Michizane, additional, Muramatsu, Hideyuki, additional, Nakamura, Ikuko, additional, Yoshikawa, Koji, additional, Ezaki, Masami, additional, Nitta, Kumiko, additional, Watanabe, Masato, additional, Inamura, Noriaki, additional, and Fujie, Akihiko, additional

Published
2013
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17. Clinical estimation of Fast 3D-TOF MRA use MTC

Author

TSUKAMOTO, Atsuko, primary, YAMASHITA, Midori, additional, IMAI, Yoshio, additional, FUKUCHI, Tatsuo, additional, YOSHIZAWA, Yasunori, additional, HAMANO, Kouji, additional, OKUAKI, Tomoyuki, additional, and KOBAYASHI, Masatoshi, additional

Published
1995
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18. 191. Multi Slab 3D-TOF MRAngiography of Fast SPGR

Author

Tsukamoto, Atsuko, primary, Yamashita, Midori, additional, Imai, Yoshio, additional, Yoshizawa, Yasunori, additional, Fukuchi, Tatsuo, additional, Hamano, Kouji, additional, Okuaki, Tomoyuki, additional, and Kobayashi, Masatoshi, additional

Published
1994
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20. Purification and Characterization of a Novel Extracellular Lipase Catalyzing Hydrolysis of Oleyl Benzoate from Acinetobacternov. sp. Strain KM109

Author

MITSUHASHI, Kazuya, YAMASHITA, Midori, HWAN, Yeo Soo, IHARA, Fumio, NIHIRA, Takuya, and YAMADA, Yasuhiro

Abstract

A new lipase (OBase) which efficiently hydrolyzes oleyl benzoate (OB) was found in the culture supernatant of Acinetobacternov. sp. strain KM109, a new isolate growing in a minimum medium containing OB as the sole carbon source. OBase was purified to homogeneity with 213-fold purification and 0.8% yield. The molecular weight was estimated to be 62,000±1,000 by SDS-PAGE under denatured-reduced conditions and to be 50,000±1,000 by gel-filtration HPLC under native conditions; these findings indicate that OBase is a monomeric enzyme. The optimum temperature and pH of OBase were about 45°C and pH 8. Temperature and pH stabilities were at or lower than 35°C and in a range of pH 6-8, respectively. Purified OBase preferentially hydrolyzed p-nitrophenyl benzoate (pNPB) over p-nitrophenyl acetate (pNPA) or p-nitrophenyl caproate (pNPC) [pNPB/pNPA=20 and pNPB/pNPC=5.4], indicating that OBase has a high affinity for benzoyl esters. Partial amino-acid sequences of OBase fragments obtained after lysyl endopeptidase treatment showed no similarity with known proteins.

Published
1999
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26. Oncolytic vaccinia virus induces a novel phenotype of CD8 + effector T cells characterized by high ICOS expression.

Author

Yamashita M, Tasaki M, Murakami R, Arai Y, Nakamura T, and Nakao S

Abstract

Characterization of the intratumoral immune status is important for developing immunotherapies and evaluating their antitumor effectiveness. CD8 + T cells are one of the most important cell types that directly and indirectly contribute to antitumor efficacy by releasing cytolytic molecules and inflammatory cytokines in the tumor microenvironment. Previously, we engineered a tumor-selective oncolytic vaccinia virus that encodes interleukin-7 (IL-7) and IL-12 and demonstrated its usefulness as an agent for in situ vaccination against tumors, with data showing that antitumor efficacy was reliant upon CD8 + T cells recruited by viral treatment. Here, we investigated the phenotypic changes in intratumoral CD8 + T cells caused by this oncolytic virus and found increased expression of inducible co-stimulator (ICOS) in PD-1 - CD8 + T cells. Unlike previously reported ICOS + CD8 + T cells, a subset of ICOS + PD-1 - CD8 + T cells showed effector function characterized by granzyme B expression. ICOS expression was induced by the backbone virus, which did not encode any immune transgenes and was independent of upregulation of the type I interferon pathway. Not only did we identify a novel effector cell subset characterized by ICOS expression, but our findings also shed light on a potential unknown aspect of the mechanism of oncolytic vaccinia virotherapy., Competing Interests: M.Y., M.T., R.M., Y.A., and S.N. are employees of Astellas Pharma Inc., Japan. S.N. and T.N. are inventors named on the patent for recombinant oncolytic vaccinia viruses submitted by Astellas Pharma and Tottori University (US patent publication no. US 2017/0340687, published November 20, 2017)., (© 2021 The Author(s).)

Published
2021
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27. [Study of elliptical centric view ordering technique with spectrally selected inversion recovery pulse (spec-IR pulse)].

Author

Okuaki T, Yamashita M, Wakamatsu O, Shirouzu I, Machida T, and Matsuda T

Subjects
Artifacts, Data Collection, Humans, Magnetic Resonance Angiography instrumentation, Magnetic Resonance Angiography methods
Abstract

Among several techniques for contrast-enhanced MRA, the elliptical centric view ordering method, originally developed at the Mayo Clinic, is a promising one. It has been difficult to apply a fat-suppression prepulse, mainly because the conventional fat suppression method requires a longer acquisition time during sampling of the low-frequency domain in k-space, and it causes severe image distortion due to the great change in longitudinal magnetization derived from fat tissue. We developed a novel method to append fat saturation to the elliptical centric view ordering technique, and assessed the feasibility of its use. Our method is to apply fat-saturation pulses only at selected sampling points when any gradient is applied in the slice-encoding direction. In this way, we achieved efficient suppression of fat-derived signal within a relatively short time, comparable to that of the conventional fat-saturation method, and succeeded in minimizing artifacts.

Published
2003
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