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Your search keyword '"Yan, Jizhong"' showing total 478 results
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478 results on '"Yan, Jizhong"'

9. Isolation and identification of unstable components from Caesalpinia sappan by high-speed counter-current chromatography combined with preparative high-performance liquid chromatography

Author

Wu Yameng, Xie Jianhui, Zeng Jielin, Bai Rui, Zhang Hui, and Yan Jizhong

Subjects
unstable components, caesalpinia sappan l., high-speed counter-current chromatography, preparative high-performance liquid chromatography, Chemistry, QD1-999
Abstract

Caesalpinia sappan L. (C. sappan L.), a traditional Chinese medicine, has been widely used to treat bruises and dysmenorrhea, performing pharmacological activities such as anti-inflammatory and anti-tumor. C. sappan L. has been reported to contain compounds such as protosappanins, brazilins, and homoisoflavones. In the pre-experiments, we discovered that there were many unstable components in the characteristic chromatogram of C. sappan L. Here, silica-gel column chromatography, high-speed counter-current chromatography, and preparative high-performance liquid chromatography were combined and applied to isolate the unstable components from alcohol extract of C. sappan L. The results showed that four unstable compounds were collected with the purity higher than 95.0%, characterized as episapponal, brazilin, sapponal, and 4-O-methylsapponal by hydrogen-1 and carbon-13 nuclear magnetic resonance. Based on the above results, the characteristic chromatogram of C. sappan L. was established, and the characteristic peaks were identified. These results provided a theoretical basis for the quality assessment of C. sappan L.

Published
2022
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39. The Functional Fe 3 O 4 @SiO 2 @AuNPs SERS Nanomaterials for Rapid Enrichment and Detection of Mercury Ions in Licorice.

Author

Zhu, Jieqiang, Wang, Baoling, Yang, Ping, Li, Junmei, Xiao, Guyu, Yao, Jiangyu, Gong, Xingchu, Yan, Jizhong, and Zhang, Hui

Subjects
IRON oxides, SERS spectroscopy, MERCURY, CHINESE medicine, METAL ions, HEAVY metals, NANOSTRUCTURED materials
Abstract

There has been an increasing demand for rapid and sensitive techniques for the detection of heavy metal ions that are harmful to the human body in traditional Chinese medicine (TCM). However, the complex chemical composition of TCM makes the quantitative detection of heavy metal ions difficult. In this study, the magnetic Fe3O4@SiO2@AuNPs nanoparticles combined with a probe molecule DMcT were used for the specific enrichment and detection of Hg2+ in the complex system of licorice. The core of Fe3O4 was bonded with SiO2 to increase its stability. A layer of AuNPs was deposited to produce a "core–shell" Raman substrate with high surface-enhanced Raman spectroscopy (SERS) activity, which was surface modified by DMcT probe molecules with sulfhydryl groups. In the presence of Hg2+, Hg2+ binds to N on the amino group of DMcT to form N-Hg2+-N complexes, which induces Fe3O4@SiO2@AuNPs-DMcT clustering to enhance SERS signal. The Raman probe molecule DMcT showed an excellent linear relationship (R2 = 0.9709) between the SERS signal at 1416 cm−1 and the Hg2+ concentration (0.5~100 ng/mL). This method achieved a good recovery (89.10~111.00%) for the practical application of detection of Hg2+ in licorice extracts. The results demonstrated that the functional Fe3O4@SiO2@AuNPs-DMcT performed effective enrichment and showed high sensitivity and accurate detection of heavy metal ions from the analytes. [ABSTRACT FROM AUTHOR]

Published
2022
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42. An intelligent extraction approach of feature information from three-dimensional DAD chromatogram for integrated quality control of traditional Chinese medicines: Gardenia jasminoidesroot as an exampleElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3ay00437f

Author

Zhang, Hui, Liu, Xiaoyi, Chen, Yuan, Bai, Rui, Zhang, Hongxu, Pan, Yixia, Zhu, Jieqiang, and Yan, Jizhong

Abstract

Traditional Chinese medicine (TCM) fingerprinting, which has the characteristics of holism and ambiguity, is a conventional strategy for the holistic quality control of TCMs. However, the fingerprinting of TCMs at the current stage generally adopts a single wavelength or few wavelengths, lacking the effective utilization of diode-array detector (DAD) chromatogram data. This study proposes an intelligent extraction approach of feature information from a three-dimensional DAD chromatogram to establish a novel bar-form-diagram (BFD) for integrated quality control of TCMs. The BFD was automatically established by the chromatographic and spectral information of a complex hybrid system in a DAD chromatogram. This covered the peak areas of target compositions at the optimal absorption wavelength. Taking 27 batches of Gardenia jasminoidesroot as samples, the BFD combined with chemometrics was applied for assessing the quality of samples completely, which improved the accuracy of origin classification using hierarchical cluster analysis, principal component analysis, soft independent modeling of class analogy and orthogonal partial least squares discriminant analysis. Single-wavelength fingerprinting and BFD used 23 and 38 common peaks as variables respectively, and the adjusted rand index results of the single wavelength and BFD were 0.559 and 0.819, respectively. Compared with the ergodic methods of each single wavelength, the peak recognition method in this study improved the operation speed from 180 s to 4 s and the computational complexity. The established BFD approach performed more abundant characteristic information of chemical components of TCMs and more accurate origin classification ability, and it had great advantages in the overall quality control of TCMs.

Published
2023
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