Search

Your search keyword '"Yan, Xianglei"' showing total 33 results
Start Over Author "Yan, Xianglei"
33 results on '"Yan, Xianglei"'

3. Multifunctional photonic integrated circuit for diverse microwave signal generation, transmission and processing

Author

Zou, Xihua, Zou, Fang, Cao, Zizheng, Lu, Bing, Yan, Xianglei, Yu, Ge, Deng, Xiong, Luo, Bin, Yan, Lianshan, Pan, Wei, Yao, Jianping, and Koonen, Antonius M. J.

Subjects
Physics - Applied Physics, Physics - Optics
Abstract

Microwave photonics (MWP) studies the interaction between microwave and optical waves for the generation, transmission and processing of microwave signals (i.e., three key domains), taking advantages of broad bandwidth and low loss offered by modern photonics. Integrated MWP using photonic integrated circuits (PICs) can reach a compact, reliable and green implementation. Most PICs, however, are recently developed to perform one or more functions restricted inside a single domain. In this paper, as highly desired, a multifunctional PIC is proposed to cover the three key domains. The PIC is fabricated on InP platform by monolithically integrating four laser diodes and two modulators. Using the multifunctional PIC, seven fundamental functions across microwave signal generation, transmission and processing are demonstrated experimentally. Outdoor field trials for electromagnetic environment surveillance along an in-service high-speed railway are also performed. The success to such a PIC marks a key step forward for practical and massive MWP implementations., Comment: 17 pages

Published
2019
Full Text
View/download PDF

6. Fcγ-Receptor-Independent Controlled Activation of CD40 Canonical Signaling by Novel Therapeutic Antibodies for Cancer Therapy.

Author

Beckmann, Karsten, Reitinger, Carmen, Yan, Xianglei, Carle, Anna, Blümle, Eva, Jurkschat, Nicole, Paulmann, Claudia, Prassl, Sandra, Kazandjian, Linda V., Loré, Karin, Nimmerjahn, Falk, and Fischer, Stephan

Subjects
IMMUNOGLOBULINS, DENDRITIC cells, CANCER treatment, CYTOKINE receptors, IMMUNE response
Abstract

The activation of CD40-mediated signaling in antigen-presenting cells is a promising therapeutic strategy to promote immune responses against tumors. Most agonistic anti-CD40 antibodies currently in development require the Fcγ-receptor (FcγR)-mediated crosslinking of CD40 molecules for a meaningful activation of CD40 signaling but have limitations due to dose-limiting toxicities. Here we describe the identification of CD40 antibodies which strongly stimulate antigen-presenting cells in an entirely FcγR-independent manner. These Fc-silenced anti-CD40 antibodies induce an efficient upregulation of costimulatory receptors and cytokine release by dendritic cells. Finally, the most active identified anti-CD40 antibody shows activity in humanized mice. More importantly, there are no signs of obvious toxicities. These studies thus demonstrate the potent activation of antigen-presenting cells with anti-CD40 antibodies lacking FcγR-binding activity and open the possibility for an efficacious and safe combination therapy for cancer patients. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Cell targeting and immunostimulatory properties of a novel Fcγ-receptor independent agonistic anti-CD40 antibody in rhesus macaques

Author

Yan, Xianglei, primary, Ols, Sebastian, additional, Cerveira, Rodrigo Arcoverde, additional, Lenart, Klara, additional, Hellgren, Fredrika, additional, Ye, Kewei, additional, Cagigi, Alberto, additional, Buggert, Marcus, additional, Nimmerjahn, Falk, additional, Højen, Jesper Falkesgaard, additional, Parera, Daniel, additional, Pessara, Ulrich, additional, Fischer, Stephan, additional, and Loré, Karin, additional

Published
2023
Full Text
View/download PDF

18. A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma

Author

Luo, Qiuyun, primary, Pan, Wentao, additional, Zhou, Suna, additional, Wang, Guangfeng, additional, Yi, Hanjie, additional, Zhang, Lin, additional, Yan, Xianglei, additional, Yuan, Luping, additional, Liu, Zhenyi, additional, Wang, Jing, additional, Chen, Haibo, additional, Qiu, MiaoZhen, additional, Yang, DaJun, additional, and Sun, Jian, additional

Published
2020
Full Text
View/download PDF

22. Integrated Microwave Photonics: A Multifunctional Photonic Integrated Circuit for Diverse Microwave Signal Generation, Transmission, and Processing (Laser Photonics Rev. 13(6)/2019)

Author

Zou, Xihua, primary, Zou, Fang, additional, Cao, Zizheng, additional, Lu, Bing, additional, Yan, Xianglei, additional, Yu, Ge, additional, Deng, Xiong, additional, Luo, Bin, additional, Yan, Lianshan, additional, Pan, Wei, additional, Yao, Jianping, additional, and Koonen, Antonius M. J., additional

Published
2019
Full Text
View/download PDF

24. A multifunctional photonic integrated circuit for diverse microwave signal generation, transmission and processing

Author

Zou, Xihua, Zou, Fang, Cao, Zizheng, Lu, Bing, Yan, Xianglei, Yu, Ge, Deng, Xiong, Luo, Bin, Yan, Lianshan, Pan, Wei, Yao, Jianping, Koonen, Antonius M.J., Zou, Xihua, Zou, Fang, Cao, Zizheng, Lu, Bing, Yan, Xianglei, Yu, Ge, Deng, Xiong, Luo, Bin, Yan, Lianshan, Pan, Wei, Yao, Jianping, and Koonen, Antonius M.J.

Abstract

Microwave photonics (MWP) studies the interaction between microwaves and optical waves for the generation, transmission, and processing of microwave signals (i.e., three key domains), taking advantage of the broad bandwidth and low loss offered by modern photonics. Integrated MWP using photonic integrated circuits (PICs) can reach a compact, reliable, and green implementation. Most PICs, however, are recently developed to perform one or more functions restricted inside a single domain. Herein, as highly desired, a multifunctional PIC is proposed to cover the three key domains. The PIC is fabricated on an InP platform by monolithically integrating four laser diodes and two modulators. Using the multifunctional PIC, seven fundamental functions across microwave signal generation, transmission, and processing are demonstrated experimentally. Outdoor field trials for electromagnetic environment surveillance along in-service high-speed railways are also performed. The success of such a PIC marks a key step forward for practical and massive MWP implementations.

Published
2019

25. Abstract 2061: A novel small molecule inhibitor of MDM2-p53 (APG-115) has antitumor activity in gastric adenocarcinoma

Author

Mengxian Pan, Xueping Wan, Lin Zhang, Yan Xianglei, Shijuan Mai, Wentao Pan, Yuxing Zhang, Miao Zhen Qiu, Suna Zhou, Luping Yuan, Dajun Yang, and Luo Qiuyun

Subjects
Cancer Research, Cell cycle checkpoint, biology, medicine.diagnostic_test, business.industry, Cancer, medicine.disease, Oncology, In vivo, Apoptosis, Cancer cell, biology.protein, Cancer research, Immunohistochemistry, Medicine, Mdm2, business, Fluorescence in situ hybridization
Abstract

Background: The amplification of Murine Double Minute 2 (MDM2) and mutation of P53 are significant processes in the incidence of gastric cancer. APG-115, a small molecular inhibitor of MDM2-P53, is a novel potential anticancer agent. We aim to investigate the anticancer effect of APG-115 in gastric cancer. Methods: We selected 87 pairs of gastric cancer tissues (primary tumors and metastatic tissues). Using Immunohistochemistry (IHC) and Fluorescence in situ hybridization (FISH), we examined the expression and amplification of MDM2 and P53. Using MTS, we examined the anti-proliferation activity of APG-115 in five gastric cancer cell lines (AGS, MKN-45, BGC-823, NCI-N87, NUGC-3) by CCK-8 assay. We used western blot analysis and siRNA interference for mechanism exploration to examine the anti-cancer activity of APG-115 in p53 wild type gastric cancer cell lines. Gastric cancer cell xenograft nude mice models were used for in vivo efficacy evaluation. Results: We examined 87 pairs of gastric cancer tissues in IHC. The results suggested that the primary tumors and metastatic tissues with high expression of MDM2 and P53 have shortened survival. The proliferation inhibition of APG-115 on p53 wild-type gastric cancer cells of AGS and MKN45 was concentration and time dependent. APG-115 induced apoptosis in gastric cancer cells. APG-115 can induced cell-cycle arrest in G1/G0 phase in the p53 wild-type of gastric cancer cells. APG-115 exhibited potent antitumor activity against established human gastric cancer xenografts. Conclusions: APG-115 can inhibitor tumor growth in p53 wild-type gastric cancer cells by inducing apoptosis and cell cycle arrest both in vitro and vivo. APG-115 can serve as an effective and precise therapeutic strategy for gastric cancer. Citation Format: Lin Zhang, Luo Qiuyun, Yan Xianglei, Xueping Wan, Luping Yuan, Yuxing Zhang, Suna Zhou, Wentao Pan, Mengxian Pan, Miaozhen Qiu, Shijuan Mai, Dajun Yang. A novel small molecule inhibitor of MDM2-p53 (APG-115) has antitumor activity in gastric adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2061.

Published
2019
Full Text
View/download PDF

27. Smac Mimetic APG-1387 Has Synergistic Effect with anti-PD1 Antibody via Increasing NK Cells Recruitment by Inducing Multiple Cytokines from Tumor Cells

Author

Pan, Wentao, primary, Luo, Qiuyun, additional, Fang, Douglas D., additional, Wang, Guangfeng, additional, Shi, Mude, additional, Sun, Jian, additional, Shen, Huimin, additional, Lu, Zhenhai, additional, Zhang, Lin, additional, Yan, Xianglei, additional, Yuan, Luping, additional, Zhou, Suna, additional, Yi, Hanjie, additional, Zhang, Yuxin, additional, Pan, Mengxian, additional, Zhai, Yi-Fan, additional, Qiu, Miao-Zhen, additional, and Yang, Da-Jun, additional

Published
2019
Full Text
View/download PDF

32. Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells

Author

Chen, Haibo, primary, Luo, Dingyuan, additional, Zhang, Lin, additional, Lin, Xiaofeng, additional, Luo, Qiuyun, additional, Yi, Hanjie, additional, Wang, Jing, additional, Yan, Xianglei, additional, Li, Baoxia, additional, Chen, Yuelei, additional, Liu, Xingguang, additional, Zhang, Hong, additional, Liu, Sheng, additional, Qiu, Miaozhen, additional, Yang, Dajun, additional, and Jiang, Ningyi, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results