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Your search keyword '"Yan, Zhen‐Zhen"' showing total 36 results
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36 results on '"Yan, Zhen‐Zhen"'

7. An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury

Author

Zhang, Xiao-Jing, Cheng, Xu, Yan, Zhen-Zhen, Fang, Jing, Wang, Xiaozhan, Wang, Weijun, Liu, Zhen-Yu, Shen, Li-Jun, Zhang, Peng, Wang, Pi-Xiao, Liao, Rufang, Ji, Yan-Xiao, Wang, Jun-Yong, Tian, Song, Zhu, Xue-Yong, Zhang, Yan, Tian, Rui-Feng, Wang, Lin, Ma, Xin-Liang, Huang, Zan, She, Zhi-Gang, and Li, Hongliang

Subjects
Inflammation -- Analysis -- Physiological aspects, Reperfusion injury -- Analysis -- Prevention -- Models, Arachidonic acid -- Analysis -- Physiological aspects, Biological sciences, Health
Abstract

Hepatic ischemia-reperfusion (IR) injury is a common clinical issue lacking effective therapy and validated pharmacological targets. Here, using integrative 'omics' analysis, we identified an arachidonate 12-lipoxygenase (ALOX12)-12-hydroxyeicosatetraenoic acid (12-HETE)-G-protein-coupled receptor 31 (GPR31) signaling axis as a key determinant of the hepatic IR process. We found that ALOX12 was markedly upregulated in hepatocytes during ischemia to promote 12-HETE accumulation and that 12-HETE then directly binds to GPR31, triggering an inflammatory response that exacerbates liver damage. Notably, blocking 12-HETE production inhibits IR-induced liver dysfunction, inflammation and cell death in mice and pigs. Furthermore, we established a nonhuman primate hepatic IR model that closely recapitulates clinical liver dysfunction following liver resection. Most strikingly, blocking 12-HETE accumulation effectively attenuated all pathologies of hepatic IR in this model. Collectively, this study has revealed previously uncharacterized metabolic reprogramming involving an ALOX12-12-HETE-GPR31 axis that functionally determines hepatic IR procession. We have also provided proof of concept that blocking 12-HETE production is a promising strategy for preventing and treating IR-induced liver damage., Author(s): Xiao-Jing Zhang [1, 2, 3, 4]; Xu Cheng [4]; Zhen-Zhen Yan [5]; Jing Fang [6]; Xiaozhan Wang [1, 2]; Weijun Wang [7]; Zhen-Yu Liu [2, 5]; Li-Jun Shen [1, [...]

Published
2018
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9. Trophic interrelationships of bacteria are important for shaping soil protist communities.

Author

Nguyen, Thi Bao Anh, Chen, Qing‐Lin, Yan, Zhen‐Zhen, Li, Chaoyu, He, Ji‐Zheng, and Hu, Hang‐Wei

Subjects
INVERTEBRATE diversity, BIOGEOCHEMICAL cycles, SOIL invertebrates, BACTERIAL diversity, SOILS, ECOSYSTEMS, HABITATS
Abstract

Protists occupy multiple trophic positions in soil food webs and significantly contribute to organic matter decomposition and biogeochemical cycling. Protists can ingest bacteria and fungi as main food sources while being subjected to predation of invertebrates, but our understanding of how bottom‐up and top‐down regulations structure protists in natural soil habitats is limited. Here, we disentangle the effects of trophic regulations to the diversity and structure of soil protists in natural settings across northern and eastern Australia. Bacterial and invertebrate diversity were identified as important drivers of the diversity of functional groups of protists. Moreover, the compositions of protistan taxonomic and functional groups were better predicted by bacteria and fungi, than by soil invertebrates. There were strong trophic interconnections between protists and bacteria in multiple organismic network analysis. Altogether, the study provided new evidence that, bottom‐up control of bacteria played an important role in shaping the soil protist community structure, which can be derived from feeding preferences of protists on microbial prey, and their intimate relationships in soil functioning or environmental adaptation. Our findings advance our knowledge about the impacts of different trophic groups on key soil organismic communities, with implications for ecosystem functions and services. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Wang et al. reply

Author

Wang, Pi-Xiao, Zhao, Guang-Nian, Ji, Yan-Xiao, Zhang, Peng, Zhang, Xiao-Jing, Gong, Jun, Zhao, Ling-Ping, Yan, Zhen-Zhen, Yin, Miao, Jiang, Zhou, Shen, Li-Jun, Yang, Xia, Fang, Jing, Tian, Song, Tong, Jingjing, Wang, Yutao, Zhu, Xue-Yong, Zhang, Xin, Wei, Qiao-Fang, Wang, Yong, Xie, Qingguo, Li, Jing, Wan, Lu, She, Zhi-Gang, Wang, Zhihua, Huang, Zan, and Li, Hongliang

Published
2018
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24. Integrated Omics Reveals Tollip as an Regulator and Therapeutic Target for Hepatic Ischemia‐Reperfusion Injury in Mice

Author

Yan, Zhen‐Zhen, primary, Huang, Yong‐Ping, additional, Wang, Xin, additional, Wang, Hai‐Ping, additional, Ren, Fei, additional, Tian, Rui‐Feng, additional, Cheng, Xu, additional, Cai, Jie, additional, Zhang, Yan, additional, Zhu, Xue‐Yong, additional, She, Zhi‐Gang, additional, Zhang, Xiao‐Jing, additional, Huang, Zan, additional, and Li, Hongliang, additional

Published
2019
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25. Corrigendum: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

Author

Wang, Pi-Xiao, Ji, Yan-Xiao, Zhang, Xiao-Jing, Zhao, Ling-Ping, Yan, Zhen-Zhen, Zhang, Peng, Shen, Li-Jun, Yang, Xia, Fang, Jing, Tian, Song, Zhu, Xue-Yong, Gong, Jun, Zhang, Xin, Wei, Qiao-Fang, Wang, Yong, Li, Jing, Wan, Lu, Xie, Qingguo, She, Zhi-Gang, Wang, Zhihua, Huang, Zan, and Li, Hongliang

Subjects
Biological sciences, Health
Abstract

Author(s): Pi-Xiao Wang; Yan-Xiao Ji; Xiao-Jing Zhang; Ling-Ping Zhao; Zhen-Zhen Yan; Peng Zhang; Li-Jun Shen; Xia Yang; Jing Fang; Song Tian; Xue-Yong Zhu; Jun Gong; Xin Zhang; Qiao-Fang Wei; Yong [...]

Published
2017
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26. Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver

Author

Wang, Siyuan, primary, Yan, Zhen‐Zhen, additional, Yang, Xia, additional, An, Shimin, additional, Zhang, Kuo, additional, Qi, Yu, additional, Zheng, Jilin, additional, Ji, Yan‐Xiao, additional, Wang, Pi‐Xiao, additional, Fang, Chun, additional, Zhu, Xue‐Yong, additional, Shen, Li‐Jun, additional, Yan, Feng‐Juan, additional, Bao, Rong, additional, Tian, Song, additional, She, Zhi‐Gang, additional, and Tang, Yi‐Da, additional

Published
2018
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28. An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury

Author

Zhang, Xiao-Jing, primary, Cheng, Xu, additional, Yan, Zhen-Zhen, additional, Fang, Jing, additional, Wang, Xiaozhan, additional, Wang, Weijun, additional, Liu, Zhen-Yu, additional, Shen, Li-Jun, additional, Zhang, Peng, additional, Wang, Pi-Xiao, additional, Liao, Rufang, additional, Ji, Yan-Xiao, additional, Wang, Jun-Yong, additional, Tian, Song, additional, Zhu, Xue-Yong, additional, Zhang, Yan, additional, Tian, Rui-Feng, additional, Wang, Lin, additional, Ma, Xin-Liang, additional, Huang, Zan, additional, She, Zhi-Gang, additional, and Li, Hongliang, additional

Published
2017
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29. Erratum: Corrigendum: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

Author

Wang, Pi-Xiao, primary, Ji, Yan-Xiao, additional, Zhang, Xiao-Jing, additional, Zhao, Ling-Ping, additional, Yan, Zhen-Zhen, additional, Zhang, Peng, additional, Shen, Li-Jun, additional, Yang, Xia, additional, Fang, Jing, additional, Tian, Song, additional, Zhu, Xue-Yong, additional, Gong, Jun, additional, Zhang, Xin, additional, Wei, Qiao-Fang, additional, Wang, Yong, additional, Li, Jing, additional, Wan, Lu, additional, Xie, Qingguo, additional, She, Zhi-Gang, additional, Wang, Zhihua, additional, Huang, Zan, additional, and Li, Hongliang, additional

Published
2017
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30. Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

Author

Wang, Pi-Xiao, primary, Ji, Yan-Xiao, additional, Zhang, Xiao-Jing, additional, Zhao, Ling-Ping, additional, Yan, Zhen-Zhen, additional, Zhang, Peng, additional, Shen, Li-Jun, additional, Yang, Xia, additional, Fang, Jing, additional, Tian, Song, additional, Zhu, Xue-Yong, additional, Gong, Jun, additional, Zhang, Xin, additional, Wei, Qiao-Fang, additional, Wang, Yong, additional, Li, Jing, additional, Wan, Lu, additional, Xie, Qingguo, additional, She, Zhi-Gang, additional, Wang, Zhihua, additional, Huang, Zan, additional, and Li, Hongliang, additional

Published
2017
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34. The glycosylation of the extracellular loop of β2 subunits diversifies functional phenotypes of BK Channels

Author

Huang, Zhi-Gang, Liu, Hao-Wen, Yan, Zhen-Zhen, Wang, Sheng, Wang, Lu-Yang, and Ding, Jiu-Ping

Abstract

ABSTRACTLarge-conductance Ca2+- and voltage-activated potassium (MaxiK or BK) channels are composed of a pore-forming α subunit (Slo) and 4 types of auxiliary β subunits or just a pore-forming α subunit. Although multiple N-linked glycosylation sites in the extracellular loop of β subunits have been identified, very little is known about how glycosylation influences the structure and function of BK channels. Using a combination of site-directed mutagenesis, western blot and patch-clamp recordings, we demonstrated that 3 sites in the extracellular loop of β2 subunit are N-glycosylated (N-X-T/S at N88, N96 and N119). Glycosylation of these sites strongly and differentially regulate gating kinetics, outward rectification, toxin sensitivity and physical association between the α and β2 subunits. We constructed a model and used molecular dynamics (MD) to simulate how the glycosylation facilitates the association of α/β2 subunits and modulates the dimension of the extracellular cavum above the pore of the channel, ultimately to modify biophysical and pharmacological properties of BK channels. Our results suggest that N-glycosylation of β2 subunits plays crucial roles in imparting functional heterogeneity of BK channels, and is potentially involved in the pathological phenotypes of carbohydrate metabolic diseases.

Published
2017
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35. Agile satellite scheduling based on improved ant colony algorithm.

Author

YAN Zhen-zhen, CHEN Ying-wu, and XING Li-ning

Subjects
*ARTIFICIAL satellites, *MATHEMATICAL models, *SCHEDULING, *ANT algorithms, *MATHEMATICAL optimization, *ALGORITHM research
Abstract

Agile earth observing satellite has two more degrees of freedom combined with the general earth observing satellite. It gives opportunities for a more efficient use of the satellite imaging capabilities, and on the other hand, it greatly expands the search space, which makes the scheduling of agile satellite become significantly difficulty. Ant colony system (ACS) algorithm is one of the efficient method to solve the agile satellite scheduling problem. Considering that the performance of ACS deeply depends on the design of parameter and the modules, uniform design has been proposed to combine the modules optimality. An ACS which can solve the agile satellite effectively is designed. 7 instances are tested to prove that the designed ACS can solve the problem effectively. [ABSTRACT FROM AUTHOR]

Published
2014

36. Cross-biome antibiotic resistance decays after millions of years of soil development

Author

Qing-Lin Chen, Hang-Wei Hu, Zhen-Zhen Yan, Yong-Guan Zhu, Ji-Zheng He, Manuel Delgado-Baquerizo, European Commission, Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Chen, Qinglin, Hu, Hang-Wei, Yan, Zhen-Zhen, Zhu, Yong-Guan, He, Ji-Zheng, Delgado-Baquerizo, Manuel, Chen, Qinglin [0000-0002-5648-277X], Hu, Hang-Wei [0000-0002-3294-102X], Yan, Zhen-Zhen [0000-0002-9410-4753], Zhu, Yong-Guan [0000-0003-3861-8482], He, Ji-Zheng [0000-0002-9169-8058], and Delgado-Baquerizo, Manuel [0000-0002-6499-576X]

Subjects
Soil, Genes, Bacterial, Humans, Drug Resistance, Microbial, Brief Communication, Microbiology, Ecology, Evolution, Behavior and Systematics, Carbon, Ecosystem, Soil Microbiology, Anti-Bacterial Agents
Abstract

4 páginas.- 2 figuras.- 19 referencias.- Supplementary information The online version contains supplementary material available at https://doi.org/10.1038/s41396-022-01225-8, Soils harbor the most diverse naturally evolved antibiotic resistance genes (ARGs) on Earth, with implications for human health and ecosystem functioning. How ARGs evolve as soils develop over centuries, to millennia (i.e., pedogenesis), remains poorly understood, which introduces uncertainty in predictions of the dynamics of ARGs under changing environmental conditions. Here we investigated changes in the soil resistome by analyzing 16 globally distributed soil chronosequences, from centuries to millennia, spanning a wide range of ecosystem types and substrate age ranges. We show that ARG abundance and diversity decline only after millions of years of soil development as observed in very old chronosequences. Moreover, our data show increases in soil organic carbon content and microbial biomass as soil develops that were negatively correlated with the abundance and diversity of soil ARGs. This work reveals natural dynamics of soil ARGs during pedogenesis and suggests that such ecological patterns are predictable, which together advances our understanding of the environmental drivers of ARGs in terrestrial environments., This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 702057. MD-B is supported by a project from the Spanish Ministry of Science and Innovation (PID2020-115813RA-I00), and a project PAIDI 2020 from the Junta de Andalucía (P20_00879).

Published
2022

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