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5. Research Progress of Green Volatile Corrosion Inhibitors

Author

GUO Yipeng, YAN Hongbing, LI Yanling, XU Sen, NING Chunhua, ZHOU Di

Subjects
volatile corrosion inhibitors, environmental protection, green, renewable, Materials of engineering and construction. Mechanics of materials, TA401-492, Technology
Abstract

In recent years， with the continuous improvement of people’s awareness of health， environmental protection， and safety， as well as the implementation of relevant laws and regulations， higher requirements have been put forward in industry for volatile corrosion inhibitors that play a protective role in the production and application of metal products.Consequently， the use of some highly toxic and environmentally impactful volatile corrosion inhibitors has been restricted.Therefore， developing and promoting a new generation of environmentally friendly and safe vapor phase corrosion inhibitors is imperative.Additionally， the development and utilization of renewable resources constitute an important measure for the sustainable development of human society.Renewable resources， derived from natural animal and plant sources， particularly crops， fruits， vegetables and timber processing waste， are rich in natural antioxidants， preservatives and antimicrobial agents.They hold great potential for the development and utilization of vapor phase corrosion inhibitors.Currently， domestic and foreign researchers have conducted focused research on this new generation of green vapor phase corrosion inhibitors.In this paper， the history of volatile corrosion inhibitors was summarized， followed by a discussion on the current research of green volatile corrosion inhibitors， including amino acids， polyaspartate， plant compounds and plant extracts.The future development trend of green volatile corrosion inhibitors was then projected，aiming to provide necessary support for their industrialized application.

Published
2024
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8. Hourly air pollution exposure and the onset of symptomatic arrhythmia: an individual-level case-crossover study in 322 Chinese cities

Author

Xue, Xiaowei, Hu, Jialu, Xiang, Dingcheng, Li, Huichu, Jiang, Yixuan, Fang, Weiyi, Yan, Hongbing, Chen, Jiyan, Wang, Weimin, Su, Xi, Yu, Bo, Wang, Yan, Xu, Yawei, Wang, Lefeng, Li, Chunjie, Chen, Yundai, Zhao, Dong, Kan, Haidong, Ge, Junbo, Huo, Yong, and Chen, Renjie

Subjects
Statistics, Risk factors, Environmental aspects, Health aspects, Arrhythmia -- Statistics -- Risk factors -- Environmental aspects, Air pollution -- Statistics -- Health aspects
Abstract

Arrhythmia is caused by disordered electrical activity in the heart, often occurs abruptly and can lead to severe cardiovascular diseases such as heart failure, acute myocardial infarction, stroke and death. [...], Background: Few studies have explored the relationship between air pollution and arrhythmia onset at the hourly level. We aimed to examine the association of exposure to air pollution with the onset of acute symptomatic arrhythmia at an hourly level. Methods: We conducted a nationwide, time-stratified, case-crossover study in China between 2015 and 2021. We obtained hourly information on the onset of symptomatic arrhythmia (including atrial fibrillation, atrial flutter, atrial and ventricular premature beats and supraventricular tachycardia) from the Chinese Cardiovascular Association Database--Chest Pain Center (including 2025 certified hospitals in 322 cities). We obtained data on hourly concentrations of 6 air pollutants from the nearest monitors, including fine particles (P[M.sub.2.5]), coarse particles (P[M.sub.2.5-10]), nitrogen dioxide (N[O.sub.2]), sulfur dioxide (S[O.sub.2]), carbon monoxide (CO) and ozone. For each patient, we matched the case period to 3 or 4 control periods during the same hour, day of week, month and year. We used conditional logistic regression models to analyze the data. Results: We included a total of 190 115 patients with acute onset of symptomatic arrhythmia. Air pollution was associated with increased risk of onset of symptomatic arrhythmia within the first few hours of exposure; this risk attenuated substantially after 24 hours. An interquartile range increase in P[M.sub.2.5], N[O.sub.2], S[O.sub.2] and CO in the first 24 hours after exposure (i.e., lag period 0-24 h) was associated with significantly higher odds of atrial fibrillation (1.7%-3.4%), atrial flutter (8.1%-11.4%) and supraventricular tachycardia (3.4%-8.9%). Exposure to P[M.sub.2.5-10] was associated with significantly higher odds of atrial flutter (8.7%) and supraventricular tachycardia (5.4%), and exposure to ozone was associated with higher odds of supraventricular tachycardia (3.4%). The exposure-response relationships were approximately linear, without discernible concentration thresholds. Interpretation: Exposure to air pollution was associated with the onset of symptomatic arrhythmia shortly after exposure. This finding highlights the importance of further reducing air pollution and taking prompt protective measures for susceptible populations during periods of elevated levels of air pollutants.

Published
2023
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11. Low temperature and temperature decline increase acute aortic dissection risk and burden: A nationwide case crossover analysis at hourly level among 40,270 patients

Author

Zhang, Qingli, Peng, Li, Hu, Jialu, Li, Huichu, Jiang, Yixuan, Fang, Weiyi, Yan, Hongbing, Chen, Jiyan, Wang, Weimin, Xiang, Dingcheng, Su, Xi, Yu, Bo, Wang, Yan, Xu, Yawei, Wang, Lefeng, Li, Chunjie, Chen, Yundai, Zhao, Dong, Ge, Wenzhen, Bell, Michelle L., Gasparrini, Antonio, Ge, Junbo, Huo, Yong, and Kan, Haidong

Published
2022
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15. Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomization.

Author

Zhao, Xiaoxiao, Li, Jiannan, Yan, Shaodi, Tan, Yu, Chen, Runzhen, Li, Nan, Zhou, Jinying, Liu, Chen, Zhou, Peng, Chen, Yi, Yan, Hongbing, Zhao, Hanjun, and Song, Li

Subjects
ST elevation myocardial infarction, MENDELIAN randomization, TYPE 2 diabetes, MYOCARDIAL infarction, GENOME-wide association studies
Abstract

Aim: Both clonal hematopoiesis of indeterminate potential (CHIP) and type 2 diabetes mellitus (T2DM) are conditions closely associated with advancing age. This study delves into the possible implications and prognostic significance of CHIP and T2DM in patients diagnosed with ST-segment elevation myocardial infarction (STEMI). Methods: Deep-targeted sequencing employing a unique molecular identifier (UMI) for the analysis of 42 CHIP mutations—achieving an impressive mean depth of coverage at 1000 × —was conducted on a cohort of 1430 patients diagnosed with acute myocardial infarction (473 patients with T2DM and 930 non-DM subjects). Variant allele fraction ≥ 2.0% indicated the presence of CHIP mutations. The association between CHIP and T2DM was evaluated by the comparison of (i) the prevalence of CHIP mutations among individuals with diabetes versus those without, (ii) the clinical characteristics delineated by CHIP mutations within the cohort of diabetic patients and (iii) the prognostic significance and correlation of CHIP mutations with mortality rates in T2DM subjects. Furthermore, a two-sample bidirectional Mendelian randomization study was performed using genetic instruments from the genome-wide association study for TET2 mutation CH from the UK Biobank (UKB) (2041 cases,173,918 controls) to investigate the causal relationship with T2DM from the FinnGen consortium (65,085 cases and 335,112 controls), and vice versa. Results: (i) Most commonly CHIP mutations exhibiting a variant allele fraction of ≥ 2.0% were identified in 50/473 (10.6%) patients with T2DM, demonstrating a greater prevalence compared to non-DM subjects [69/930 (7.4%); P < 0.05] across various age groups. (ii) After multivariable adjustment, the mortality of any CHIP mutations were 2.03-fold higher in DM [adjusted hazard ratio (HR) 2.03; 95% confidence interval (CI) 1.07–3.84, P < 0.05]. (iii) In gene-specific analyses, TET2 somatic mutation presented the highest association with mortality among T2DM (adjusted HR 5.24; 95% CI 2.02–13.61, P = 0.001). ASXL1 CHIP mutation which displayed a striking correlation with cardiac death (HR: 3.14; 95% CI 1.24–7.93; P < 0.05) with consistent associations observed among T2DM subgroup (HR: 4.51; 95% CI 1.30–15.6; P < 0.05). (iv) The correlation between PCSK9 and the Tet2-CHIP mutation was observed in both the T2DM cohort (correlation = 0.1215, P = 0.011) and the overall enrolled cohort (correlation = 0.0578, P = 0.0382). (v) Bidirectional Mendelian randomization studies indicated that the development of T2DM increases the propensity for CHIP. However, CHIP does not subsequently accelerate the onset of T2DM. Conclusion: CHIP mutations, particularly TET2, are more prevalent in patients with T2DM compared to individuals without diabetes. The presence of these mutations is associated with adverse clinical outcomes, notably increased mortality rates. Moreover, bidirectional Mendelian randomization analyses provide supporting evidence for a potential causal relationship between TET2-related CHIP and the development of T2DM. Central Illustration: The association between clonal hematopoiesis of indeterminate potential (CHIP) and type 2 diabetes mellitus (T2DM): The prevalence of CHIP is notably higher in individuals with T2DM, as demonstrated in a prospective study within an Asian cohort of acute myocardial infarction (AMI). Furthermore, the predictive value of CHIP as a marker for poor clinical prognosis in T2DM has been assessed in this study. Mendelian randomization studies suggest that the development of T2DM may increase the propensity for CHIP, as indicated by findings from the UK Biobank and FinnGen consortium. T2DM, type 2 diabetes mellitus; CHIP, clonal haematopoiesis of indeterminate potential. [ABSTRACT FROM AUTHOR]

Published
2025
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26. China Tongxinluo Study for myocardial protection in patients with Acute Myocardial Infarction (CTS-AMI): Rationale and design of a randomized, double-blind, placebo-controlled, multicenter clinical trial

Author

Xu, Yi, Li, Xiangdong, Zhang, Haitao, Wu, Yuan, Zhang, Jun, Li, Jia, Dou, Kefei, Yan, Hongbing, You, Shijie, Yang, Yanmin, Liang, Yan, Xu, Lianjun, Gao, Xiaojin, Liu, Chen, Dong, Qiuting, Zhang, Wenjia, Song, Guangyuan, Zhang, Tao, Jiang, Lin, Chen, Guihao, Tang, Ruijie, Jin, Chen, Yang, Jingang, Yao, Chen, Xian, Ying, Peterson, Eric D., Gao, Runlin, and Yang, Yuejin

Published
2020
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28. Quality of primary health care in China: challenges and recommendations

Author

Li, Xi, Krumholz, Harlan M, Yip, Winnie, Cheng, Kar Keung, De Maeseneer, Jan, Meng, Qingyue, Mossialos, Elias, Li, Chuang, Lu, Jiapeng, Su, Meng, Zhang, Qiuli, Xu, Dong Roman, Li, Liming, Normand, Sharon-Lise T, Peto, Richard, Li, Jing, Wang, Zengwu, Yan, Hongbing, Gao, Runlin, Chunharas, Somsak, Gao, Xin, Guerra, Raniero, Ji, Huijie, Ke, Yang, Pan, Zhigang, Wu, Xianping, Xiao, Shuiyuan, Xie, Xinying, Zhang, Yujuan, Zhu, Jun, Zhu, Shanzhu, and Hu, Shengshou

Published
2020
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29. A Combined Measure of the Triglyceride Glucose Index and Trimethylamine N-Oxide in Risk Stratification of ST-Segment Elevation Myocardial Infarction Patients with High-Risk Plaque Features Defined by Optical Coherence Tomography: A Substudy of the OCTAMI Registry Study

Author

Zhao, Xiaoxiao, primary, Zhao, Hanjun, additional, Chen, Runzhen, additional, Li, Jiannan, additional, Zhou, Jinying, additional, Li, Nan, additional, Yan, Shaodi, additional, Liu, Chen, additional, Zhou, Peng, additional, Chen, Yi, additional, Song, Li, additional, and Yan, Hongbing, additional

Published
2024
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30. A Combined Measure of the Triglyceride Glucose Index and Trimethylamine N-Oxide in Risk Stratification of ST-Segment Elevation Myocardial Infarction Patients with High-Risk Plaque Features Defined by Optical Coherence Tomography: A Substudy of the OCTAMI Registry Study

Author

Zhao,Xiaoxiao, Zhao,Hanjun, Chen,Runzhen, Li,Jiannan, Zhou,Jinying, Li,Nan, Yan,Shaodi, Liu,Chen, Zhou,Peng, Chen,Yi, Song,Li, Yan,Hongbing, Zhao,Xiaoxiao, Zhao,Hanjun, Chen,Runzhen, Li,Jiannan, Zhou,Jinying, Li,Nan, Yan,Shaodi, Liu,Chen, Zhou,Peng, Chen,Yi, Song,Li, and Yan,Hongbing

Abstract

Xiaoxiao Zhao,1 Hanjun Zhao,1 Runzhen Chen,1 Jiannan Li,1 Jinying Zhou,1 Nan Li,1 Shaodi Yan,2 Chen Liu,1 Peng Zhou,1 Yi Chen,1 Li Song,1 Hongbing Yan2 1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, BeiJing, People’s Republic of China; 2Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences, ShenZhen, People’s Republic of ChinaCorrespondence: Hanjun Zhao, Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, No. 167, Beijing, 100037, People’s Republic of China, Tel +86-15210020808, Email 15210020808@163.com Hongbing Yan, Fuwai Hospital, Chinese Academy of Medical Sciences, 12 Langshan Road, Shenzhen, 518000, People’s Republic of China, Tel +86-1301339287, Email hbyanfuwai2018@163.comBackground and Aim: An elevated triglyceride-glucose (TyG) level is associated with increased risk of mortality in patients with CAD. Trimethylamine N-oxide (TMAO) has mechanistic links to atherosclerotic coronary artery disease (CAD) pathogenesis and is correlated with adverse outcomes. However, the incremental prognostic value of TMAO and TyG in the cohort of optical coherence tomography (OCT)-defined high-risk ST-segment elevation myocardial infarction (STEMI) patients is unknown.Methods: We studied 274 consecutive aged ≥ 18 years patients with evidence of STEMI and detected on pre-intervention OCT imaging of culprit lesions between March 2017 and March 2019.Outcomes: There were 22 (22.68%), 27 (27.84%), 26 (26.80%), and 22 (22.68%) patients in groups A-D, respectively. The baseline characteristics according to the level of TMAO and TyG showed that patients with higher level in both indicators were more likely to have higher triglycerides (p < 0.001), fasting glucose (p < 0.001) and higher incidence of diabetes (p = 0.008). The group with TMAO > median and TyG ≤ median was associated with higher rates of MA

Published
2024

38. Lipid Content Distribution and its Clinical Implication in Patients with Acute Myocardial Infarction-Plaque Erosion: Results from the Prospective OCTAMI Study

Author

Li, Jiannan, primary, Chen, Runzhen, additional, Zhou, Jinying, additional, Wang, Ying, additional, Zhao, Xiaoxiao, additional, Liu, Chen, additional, Zhou, Peng, additional, Chen, Yi, additional, Song, Li, additional, Yan, Shaodi, additional, Yan, Hongbing, additional, and Zhao, Hanjun, additional

Published
2024
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40. Associations Between Resolvin D1 and Culprit Plaque Morphologies: An Optical Coherence Tomography Study in Patients with ST-Segment Elevation Myocardial Infarction

Author

Chen, Runzhen, primary, Li, Jiannan, additional, Sheng, Zhaoxue, additional, Zhou, Jinying, additional, Wang, Ying, additional, Zhao, Xiaoxiao, additional, Li, Nan, additional, Liu, Weida, additional, Liu, Chen, additional, Zhou, Peng, additional, Chen, Yi, additional, Yan, Shaodi, additional, Song, Li, additional, Yan, Hongbing, additional, and Zhao, Hanjun, additional

Published
2023
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46. Associations Between Resolvin D1 and Culprit Plaque Morphologies: An Optical Coherence Tomography Study in Patients with ST-Segment Elevation Myocardial Infarction

Author

Chen,Runzhen, Li,Jiannan, Sheng,Zhaoxue, Zhou,Jinying, Wang,Ying, Zhao,Xiaoxiao, Li,Nan, Liu,Weida, Liu,Chen, Zhou,Peng, Chen,Yi, Yan,Shaodi, Song,Li, Yan,Hongbing, Zhao,Hanjun, Chen,Runzhen, Li,Jiannan, Sheng,Zhaoxue, Zhou,Jinying, Wang,Ying, Zhao,Xiaoxiao, Li,Nan, Liu,Weida, Liu,Chen, Zhou,Peng, Chen,Yi, Yan,Shaodi, Song,Li, Yan,Hongbing, and Zhao,Hanjun

Abstract

Runzhen Chen,1,2,&ast; Jiannan Li,1,3,&ast; Zhaoxue Sheng,4 Jinying Zhou,1,3 Ying Wang,1 Xiaoxiao Zhao,1,3 Nan Li,1 Weida Liu,5 Chen Liu,1,3 Peng Zhou,1,3 Yi Chen,1,3 Shaodi Yan,2 Li Song,1– 3 Hongbing Yan,2,3 Hanjun Zhao1,3 1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 2Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, People’s Republic of China; 3Coronary Heart Disease Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 4Department of Cardiology, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 5Medical Research Center, Peking Union Medical College Hospital, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hongbing Yan, Fuwai Hospital, Chinese Academy of Medical Sciences, 12 Langshan Road, Nanshan District, Shenzhen, 510000, People’s Republic of China, Email hbyanfuwai2018@163.com; hbyanfuwai@aliyun.com Hanjun Zhao, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, 167 North Lishi Road, Xicheng District, Beijing, 100037, People’s Republic of China, Email 15210020808@163.comBackground: As a specialized pro-resolving lipid mediator, resolvin D1 (RvD1) inhibits atherosclerosis progression in vivo by reducing regional oxidative stress and chronic inflammation. However, it is unclear how RvD1 is involved in human coronary artery disease. This study aims to investigate the association between plasma levels of RvD1 and culprit-plaque characteristics in patients with ST-segment elevation myocardial infarction (STEMI).Methods: A total of 240 STEMI patients undergoing optical coherence tomography (OCT) examination were analyzed. RvD1 levels were measured in patient plasma samples using an enzyme-linked immunosorbent assay.

Published
2023

47. Effect of Triglyceride-Glucose Indices and Circulating PCSK9-Associated Cardiovascular Risk in STEMI Patients with Primary Percutaneous Coronary Artery Disease: A Prospective Cohort Study

Author

Zhao,Xiaoxiao, Song,Li, Li,Jiannan, Zhou,Jinying, Li,Nan, Yan,Shaodi, Chen,Runzhen, Wang,Ying, Liu,Chen, Zhou,Peng, Sheng,Zhaoxue, Chen,Yi, Zhao,Hanjun, Yan,Hongbing, Zhao,Xiaoxiao, Song,Li, Li,Jiannan, Zhou,Jinying, Li,Nan, Yan,Shaodi, Chen,Runzhen, Wang,Ying, Liu,Chen, Zhou,Peng, Sheng,Zhaoxue, Chen,Yi, Zhao,Hanjun, and Yan,Hongbing

Abstract

Xiaoxiao Zhao,1,&ast; Li Song,1,&ast; Jiannan Li,1 Jinying Zhou,1 Nan Li,1 Shaodi Yan,2 Runzhen Chen,1 Ying Wang,1 Chen Liu,1 Peng Zhou,1 Zhaoxue Sheng,1 Yi Chen,1 Hanjun Zhao,1 Hongbing Yan2 1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 2Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hongbing Yan, Fuwai Hospital, Chinese Academy of Medical Sciences, 12 Langshan Road, Shenzhen, 518000, People’s Republic of China, Tel +86-13701339287, Email hbyanfuwai2018@163.com Hanjun Zhao, Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, No. 167, Beijing, 100037, People’s Republic of China, Tel +86-15210020808, Email 15210020808@163.comBackground and Aims: This study aimed to determine whether convertase subtilisin/kexin type 9 (PCSK9)-associated cardiovascular risk is modulated by triglyceride-glucose (TyG) in ST-segment elevation myocardial infarction (STEMI) patients with primary percutaneous coronary disease (PCI).Methods: A total of 1541 patients with STEMI (aged ≥ 18 years) undergoing primary PCI were consecutively enrolled between March 2017 and March 2019.Outcomes: When stratifying the overall population according to TyG indices less than or greater than the median (TyG median = 9.07) as well as according to quartiles of PCSK9 levels, higher TyG index levels were significantly associated with all-cause mortality only when TyG levels were 9.07 or higher (ie, relative to quartile 1 [Q1], the adjusted HR for all-cause mortality was 3.20 [95% CI, 0.54– 18.80] for Q2, p = 0.199; 7.89 [95% CI, 1.56– 40.89] for Q3, p = 0.013; and 5.61 [95% CI, 1.04– 30.30] for Q4, p = 0.045. During a median follow-up period of 1.96 years, the HR for all-cause mortality was higher in th

Published
2023

49. Effect of Triglyceride-Glucose Indices and Circulating PCSK9-Associated Cardiovascular Risk in STEMI Patients with Primary Percutaneous Coronary Artery Disease: A Prospective Cohort Study

Author

Zhao, Xiaoxiao, primary, Song, Li, additional, Li, Jiannan, additional, Zhou, Jinying, additional, Li, Nan, additional, Yan, Shaodi, additional, Chen, Runzhen, additional, Wang, Ying, additional, Liu, Chen, additional, Zhou, Peng, additional, Sheng, Zhaoxue, additional, Chen, Yi, additional, Zhao, Hanjun, additional, and Yan, Hongbing, additional

Published
2023
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50. Prognostic Value of Admission Peak NT-proBNP Combined with Culprit Plaque Types for Predicting Cardiovascular Risk in ST-Segment Elevated Myocardial Infarction: An Optical Coherence Tomography Study

Author

Li, Jiannan, primary, Chen, Runzhen, additional, Zhou, Jinying, additional, Wang, Ying, additional, Zhao, Xiaoxiao, additional, Liu, Chen, additional, Zhou, Peng, additional, Chen, Yi, additional, Song, Li, additional, Yan, Shaodi, additional, Yan, Hongbing, additional, and Zhao, Hanjun, additional

Published
2022
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