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Siltation in coastal river networks is a serious water security issue, and balancing siltation through water diversion is an important measure in ecological water resource dispatching. Taking the Doulong Port in the Lixiahe region of Jiangsu Province as the research subject, this paper redefined the water demand for scouring siltation based on the characteristic of scouring siltation in the area, so as to reflect the water demand for the net change in sediment monitored. By analyzing the in-situ monitoring data for the downstream channel of Doulong Port from 2001 to 2018, the paper extracted key variables such as initial riverbed volume, siltation amount, time duration, rainfall volume, and the frequency of sluice openings. A predictive model of water demand for scouring siltation was constructed, which combined adaptive particle swarm optimization (APSO) algorithm with support vector machine (SVM) and optimized the model parameters of the SVM through the APSO algorithm, enhancing the prediction accuracy of the APSO-SVM model. Furthermore, Sobol sensitivity analysis indicates that siltation amount, initial riverbed volume, and the frequency of sluice openings are the main variables affecting the water demand for scouring siltation, while rainfall volume and time duration show significant interactive effects. This study provides a theoretical basis and practical guidance for water resource management and channel maintenance, contributing to the improvement of water diversion efficiency in sea-entry channels and channel safety.

Abstract Objective To use routine demographic and clinical data to develop an interpretable individual-level machine learning (ML) model to diagnose knee osteoarthritis (KOA) and to identify highly ranked features. Methods In this retrospective, population-based cohort study, anonymized questionnaire data was retrieved from the Wu Chuan KOA Study, Inner Mongolia, China. After feature selections, participants were divided in a 7:3 ratio into training and test sets. Class balancing was applied to the training set for data augmentation. Four ML classifiers were compared by cross-validation within the training set and their performance was further analyzed with an unseen test set. Classifications were evaluated using sensitivity, specificity, positive predictive value, negative predictive value, accuracy, area under the curve(AUC), G-means, and F1 scores. The best model was explained using Shapley values to extract highly ranked features. Results A total of 1188 participants were investigated in this study, among whom 26.3% were diagnosed with KOA. Comparatively, XGBoost with Boruta exhibited the highest classification performance among the four models, with an AUC of 0.758, G-means of 0.800, and F1 scores of 0.703. The SHAP method reveals the top 17 features of KOA according to the importance ranking, and the average of the experience of joint pain was recognized as the most important features. Conclusions Our study highlights the usefulness of machine learning in unveiling important factors that influence the diagnosis of KOA to guide new prevention strategies. Further work is needed to validate this approach.

[Purposes] In order to better understand the permeability changes of coal measure bedded sandy mudstone under stress, the mechanical characteristics and permeability of bedded sandy mudstone were studied by discrete element simulation on the basis of the stress seepage coupling laboratory tests. [Methods] First, the failure mode and the relationship between the full stress-strain loading process and the permeability of sandy mudstone were studied by the stress-seepage coupling laboratory tests in the bedding directions of parallel and perpendicular rock bedding. Second, in the discrete element software PFC2D, a method to characterize the flow field by solving the finite difference method is proposed for the first time, which can well reflect the stress-strain response and permeability changes of sandy mudstone, and the simulated stress-strain and permeability curves obtained are consistent with experimental results, with the fluid flowing intensively along the main fracture. Finally, according to the calibrated parameters, the stress and permeability of rock samples at different bedding angles are simulated, and the relationships between the maximum permeability or peak strength and bedding angles are explored. [Findings] The results show that the strength and permeability of layered sandy mudstone are anisotropic. The flow field direction, flow rate, and contact force chain in the rock sample are closely related to the crack, and the strong contact force chain is concentrated near the shear zone at the joint of the sample. With the increase of the bedding angle α, the peak intensity changes in a“ U” shape, and the maximum permeability decreases linearly. [Conclusions] This numerical simulation method fully takes into account the influence of rock mechanics and seepage characteristics, which provides a theoretical basis for the surrounding rock seepage prevention and reinforcement project, and a new idea for the fluid-structure interaction of discrete element simulation.

Abstract The main goal of image steganalysis, as a technique of confrontation with steganography, is to determine the presence or absence of secret information in conjunction with the specific statistical characteristics of the carrier. With the development of deep learning technology in recent years, the performance of steganography has been gradually enhanced. Especially for the complex reality environment, the image content is mixed and heterogeneous, which brings great challenges to the practical application of image steganalysis technology. In order to solve this problem, we design a forensics aided content selection network (FACSNet) for heterogeneous image steganalysis. Considering the heterogeneous situation of real images, a forensics aided module is introduced to pre-categorise the images to be tested, so that the network is able to detect different categories of images in a more targeted way. The complexity of the images is also further analysed and classified using the content selection module to train a more adapted steganalyser. By doing this, the network is allowed to achieve better performance in recognising and classifying the heterogeneous images for detection. Experimental results show that our designed FACSNet is able to achieve excellent detection performance in heterogeneous environments, improving the detection accuracy by up to 7.14% points, with certain robustness and practicality.

Mesenchymal stem cells (MSCs) have shown significant potential in bone regeneration and regenerative medicine in recent years. With the advancement of tissue engineering, MSCs have been increasingly applied in bone repair and regeneration, and their clinical application potential has grown through interdisciplinary approaches involving biomaterials and genetic engineering. However, there is a lack of systematic reviews summarizing their applications in bone regeneration. To address this gap, we analyzed the latest research on MSCs for bone regeneration published from 2013 to 2023. Using the Web of Science Core Collection, we conducted a literature search in December 2024 and employed bibliometric tools like CiteSpace and VOSviewer for a comprehensive analysis of the key research trends. Our findings focus on the development of cell engineering, highlighting the advantages, limitations, and future prospects of MSC applications in bone regeneration. These insights aim to enhance understanding of MSC-based bone regeneration, inspire new research directions, and facilitate the clinical translation of MSC research.

The separable reversible data hiding in encrypted domain (RDH-ED) algorithm leaves out the embedding space for the information before or after encryption and makes the operation of extracting the information and restoring the image not interfere with each other. The encryption method employed not only affects the embedding space of the information and separability, but is more crucial for ensuring security. However, the commonly used XOR, scram-bling or combination methods fall short in security, especially against known plaintext attack (KPA). Therefore, in order to improve the security of RDH-ED and be widely applicable, this paper proposes a high-security RDH-ED encryption algorithm that can be used to reserve space before encryption (RSBE) and free space after encryption (FSAE). During encryption, the image undergoes block XOR, global intra-block bit-plane scrambling (GIBS) and inter-block scrambling sequentially. The GIBS key is created through chaotic mapping transformation. Subsequently, two RDH-ED algorithms based on this encryption are proposed. Experimental results indicate that the algorithm outlined in this paper maintains consistent key communication traffic post key conversion. Additionally, its computational complexity remains at a constant level, satisfying separability criteria, and is suitable for both RSBE and FSAE methods. Simultaneously, while satisfying the security of a single encryption technique, we have expanded the key space to 28Np×Np!×8!Np, enabling resilience against various existing attack methods. Notably, particularly in KPA testing scenarios, the average decryption success rate is a mere 0.0067% and 0.0045%, highlighting its exceptional security. Overall, this virtually unbreakable system significantly enhances image security while preserving an appropriate embedding capacity.

ObjectiveTo analyze the fertility characteristics of the registered population in a neighborhood in Jing’an District, Shanghai from 2013 to 2022, and to provide a reference for population development planning and allocation of public health resources.MethodsData on newborns and puerperae registered in the neighborhood were collected through the Shanghai Birth Medical Information System and Public Security Department information system. Statistical analysis was conducted using Excel 2010, and the Joinpoint regression model was used to describe the changes.ResultsFrom 2013 to 2022, the crude birth rate, general fertility rate, and total fertility rate showed a declining trend, with average annual percent change (AAPC) values of -7.62%, -6.99%, and -4.54%, respectively. The average age of first childbirth and the age of childbearing among women gradually increased, with AAPC values of 1.24% and 1.28%, respectively. In the past 10 years, the total number of newborns showed a downward trend, with an AAPC value of -6.15%. After the implementation of the two-child policy, the proportion of second children showed an increasing trend, with an AAPC value of 7.37%.ConclusionThe fertility level of the population in the neighborhood is declining. The two-child policy has not significantly improved fertility rates, and the age of childbearing in women continues to rise. Diverse measures are needed to encourage childbirths and promote healthy births.

[Objective] Pipeline network companies need to forecast the short-term natural gas loads of downstream users to ensure a stable gas supply. However, traditional load forecasting methods have various problems such as poor fitting effect and low forecasting accuracy. A combined short-term natural gas load forecasting model based on the Complementary Ensemble of Empirical Mode Decomposition(CEEMD) and the Long Short-Term Memory(LSTM) network is proposed to improve the accuracy of short-term natural gas load forecasting. [Methods] To fully explore the internal hidden feature information of the load series and to avoid the mutual interference between different component features and additional noise, the original load series was decomposed into a finite number of Intrinsic Mode Function(IMF) components through CEEMD. Different IMF components were input into the LSTM model for iterative multi-step forecasting, the hyperparameters of the LSTM model were optimized based on the Bayesian algorithm to improve the learning effect and the forecasting accuracy, and the forecasting results of individual components were superimposed and reconstructed to obtain the final forecasting results. [Results] The comparison of forecasting results obtained by different combined models indicates that the errors in the values forecast by CEEMD-LSTM based on the real values are smaller, proving that the forecasting accuracy is higher. The Bayesian hyperparameter tuning further improves the forecasting accuracy but takes longer forecasting time. [Conclusion] Compared with other forecasting models, the combined CEEMDLSTM forecasting model can effectively extract the time order information of load series, eliminate the influence of nonlinear factors,and reduce reconstruction errors while suppressing modal superposition, thus improving forecasting accuracy. This method can provide a reference for the scheduling management and operation optimization of natural gas pipeline networks.

AIM: To evaluate the effect of symmetrical arc incision correcting corneal astigmatism in femtosecond laser-assisted phacoemulsification (FLACS). METHODS: This study enrolled patients with cataract combined with regular corneal astigmatism of >0.75 D, who underwent FLACS. Symmetrical arc incision was set at 8 mm diameter and 85% depth. The follow-up time was 3-24mo (4.92±3.49mo). Pentacam recorded the corneal astigmatism and higher-order aberration at pre-operation and post-operation. The changes in corneal astigmatism were analyzed by Alpins method. The correlation of astigmatism type, age, corneal horizontal diameter, corneal thickness, arc incision length, and correction index (CI) was analyzed, and the residual corneal astigmatism was compared with the residual whole eye astigmatism. RESULTS: Totally 79 patients (102 eyes) were enrolled, 10 patients had corneal epithelial injury, 1 patient occurred corneal epithelial hyperplasia. The corneal astigmatism was 1.23±0.38 D pre-operation, and decreased to 0.76±0.39 D post-operation (t=10.146, P=0.000). Corneal high-order aberration was 0.17±0.08 μm pre-operation and 0.24±0.11 μm post-operation (t=-5.186, P=0.000). The residual corneal astigmatism and residual whole eye astigmatism were no significant difference (t=-0.347, P=0.729). Using Alpin's method, the following were determined: target-induced astigmatism (TIA) =1.23±0.38 D, surgery-induced astigmatism (SIA) =0.77±0.45 D, difference vector (DV)=0.77±0.39 D, and CI=0.54±0.28. Age, astigmatism size, corneal horizontal diameter, corneal thickness, and arc incision length were not correlated with CI. The CI for against the rule astigmatism (ATR) was better than that for with the rule astigmatism (WTR; P=0.001). CONCLUSION: Femtosecond laser-assisted astigmatic keratotomy has better CI of ATR, but increase higher-order corneal aberration. CI is not ideal, it's not a perfect choice if we pursue ideal correction effect.

Background The incidence of cervical and upper thoracic esophageal cancer is relatively low, with difficulties and controversies of mode in treatment, lack of convenient and accurate prognostic biomarkers, and poor overall prognosis. Objective To investigate the long-term prognosis of patients with cervical and upper thoracic esophageal squamous cell carcinoma under concurrent chemotherapy and radio-therapy (CCRT) . Methods Patients with cervical and thoracic upper esophageal cancer who received CCRT in the Department of Radiotherapy of the Fourth Hospital of Hebei Medical University from January 2013 to December 2017 were selected as the research subjects. General data, Eastern Cooperative Oncology Group (ECOG) score, tumor site, tumor length, TNM stage, radiotherapy dose, irradiation mode, chemotherapy regimen, toxic and side effects were collected by electronic medical record system, and neutrophil to lymphocyte ratio (dNLR) was calculated. The patients were divided into the dNLR

Background The improvement efficacy of consolidation chemotherapy after definitive concurrent chemotherapy and radio-therapy (CCRT) on the prognosis of patients with locally advanced esophageal squamous cell carcinoma (ESCC) remains controversial. In addition, there is a lack of nutritional risk screening tools which can consistently and accurately predict the survival of patients with esophageal cancer. Objective To investigate the effect of consolidation chemotherapy on the prognosis of patients with locally advanced ESCC receiving definitive CCRT. Methods A total of 223 patients with ESCC who received definitive CCRT in the department of radiotherapy, the Fourth Hospital of Hebei Medical University from January 2013 to December 2018 were selected as the research objects and divided into the simple CCRT group (n=87) and combined consolidation chemotherapy group (n=136) according to chemoradiotherapy regimen adopted by the patients. General data, ECOG score, tumor site, tumor length, TNM stage, radiotherapy dose, irradiation mode and chemotherapy regimen of the included patients were collected by electronic medical record system. Nutritional Risk Screening 2002 (NRS 2002) was used to score the nutritional status of the patients before chemoradiotherapy. Efficacy evaluation was performed within 1 month after CCRT, including complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD). Patients were followed up by telephone (completed by the follow-up center) and outpatient review until 2022-09-30, with overall survival (OS), local relapse-free survival (LRRFS) and distant metastasis-free survival (DMFS) collected. Survival curves of OS, LRRFS and DMFS were plotted by Kaplan-Meier method and compared by Log-rank test. Univariate and multivariate Cox risk regression models were used to explore the influencing factors of patient prognosis. Results There was no significant difference in baseline data between the simple CCRT group and combined consolidation chemotherapy group (P>0.05). There was no significant difference in the rates of OS, LRRFS and DMFS between the two groups (χ2=1.942, 0.743, 1.272; P=0.163, 0.389, 0.259). There were significant differences in the rates of OS, LRRFS and DMFS between patients with NRS 2002 score

Maintaining open flowers is critical for successful pollination and depends on long-term water and carbon balance. Yet the relationship between how flower hydraulic traits are coordinated in different habitats is poorly understood. Here, we hypothesize that the coordination and trade-offs between floral hydraulics and economics traits are independent of environmental conditions. To test this hypothesis, we investigated a total of 27 flower economics and hydraulic traits in six aquatic and six terrestrial herbaceous species grown in a tropical botanical garden. We found that although there were a few significant differences, most flower hydraulics and economics traits did not differ significantly between aquatic and terrestrial herbaceous plants. Both flower mass per area and floral longevity were significantly positively correlated with the time required for drying full-hydrated flowers to 70% relative water content. Flower dry matter content was strongly and positively related to drought tolerance of the flowers as indicated by flower water potential at the turgor loss point. In addition, there was a trade-off between hydraulic efficiency and the construction cost of a flower across species. Our results show that flowers of aquatic and terrestrial plants follow the same economics spectrum pattern. These results suggest a convergent flower economics design across terrestrial and aquatic plants, providing new insights into the mechanisms by which floral organs adapt to aquatic and terrestrial habitats.

Identifying how leaf habit subdivisions link to the fast–slow and avoidance–tolerance trait tradeoffs can provide new insight into divergence in ecophysiological strategies among plant functional groups. Here, we tested a hypothesis that the differentiation across deciduous, semi-deciduous and evergreen woody species contributes to physiological trait tradeoffs in a dry-hot valley savanna. We investigated 11 photosynthetic, morphological and hydraulic traits of 24 species including 8 deciduous, 10 semi-deciduous and 6 evergreen species. Deciduous species were grouped in the fast and avoidance side associated with high values of maximum photosynthetic rates, stomatal conductance and leaf size, while evergreen species were grouped in the slow and tolerance side associated with high photosynthetic water use efficiency, leaf mass per area, sapwood density, Huber value, leaf water potential at turgor loss point and water potential causing 50% loss of stem hydraulic conductance. Semi-deciduous species generally had intermediate trait values and represented different physiological characteristics when compared to deciduous and evergreen species. The physiological trait tradeoffs showed a close linkage to the differentiation of these three leaf habits. Our findings clearly reveal trait tradeoffs related to fast–slow and avoidance–tolerance strategies among diverse savanna plants, suggesting a syndrome in multiple ecophysiology strategies across different leaf habits.

IntroductionIn this study, we aimed to identify key genes in endometrial cancer by conducting single-cell analysis of macrophages.MethodsWe sourced clinical data from the TCGA database as well as supplementary datasets GSE201926 and GSE173682. Using bulk-seq data of atypical endometrial hyperplasia and endometrial cancer, we pinpointed key differentially expressed genes. Single-cell RNA sequencing was utilized for further gene expression analysis. Cluster analysis was conducted on TCGA tumor data, identifying two distinct subtypes. Statistical methods employed included LASSO regression for diagnostic modeling and various clustering algorithms for subtype identification.ResultsWe found that subtype B was closely related to cellular metabolism. A diagnostic model was established using LASSO regression and was based on the genes CDH18, H19, PAGE2B, PXDN, and THRB. This model effectively differentiated the prognosis of cervical cancer. We also constructed a prognosis model and a column chart based on these key genes.DiscussionThrough CIBERSORT analysis, CDH18 and PAGE2B were found to be strongly associated with macrophage M0. We propose that these genes influence the transformation from atypical endometrial hyperplasia to endometrial cancer by affecting macrophage M0. In conclusion, these key genes may serve as therapeutic targets for endometrial cancer. A new endometrial cancer risk prognosis model and column chart have been constructed based on these genes, offering a reliable direction for future cervical cancer treatment.

ObjectiveTo introduce an effective approach using the hysteroscopy system for patients with old uterine false passage after a failed conservative treatment.Materials and methodsThis study presents the case of a 34-year-old woman who was treated in the Department of Gynecology of Shenzhen Integrated Traditional Chinese and Western Medicine Hospital in 2018 with the complaint of “menstrual volumereduction for 2 years after abortion.” A hysteroscopy was performed to make a clear diagnosis: (1) uterine cavity adhesion and (2) old uterine false passage. After the separation of adhesions, the patient was treated with estradiol and progesterone in sequence (estradiol valerate 3 mg, b.i.d., oral for 21 days; and dydrogesterone tablets 10 mg, b.i.d., oral for the second half of the cycle) for 3 months. After the review of the hysteroscopy results, it was found that there was no improvement in the old false passage; therefore, a suture and knotting surgery under hysteroscopy was performed to treat the old false passage in the uterus within 10 min, and the intraoperative blood loss was 2 ml. The patient was discharged 24 h postoperatively without any adverse perioperative complications.ResultsTwo months after the operation, the review of the hysteroscopy results showed that the old false passage in the uterus disappeared. After the 6-month follow-up, the menstrual volume increased compared with the previous one, close to the normal menstrual volume, and the patient experienced no pain and menstrual discomfort. The patient was lost to follow-up and was contacted again in 2022. It was found out that in 2019, she was pregnant with a baby boy who is now 3 years old and healthy.ConclusionThe intrauterine suture surgery presents a clear visual field to old uterine false passage after a failed conservative treatment. In patients with old uterine false passage suffering from reduced fertility, the intrauterine suture surgery can be a minimally invasive and effective alternative if the conservative treatment for old uterine false passage failed.

Cancer is a form of inflammation, which is different from common inflammation in that it is uncontrollable and difficult to identify pathogenic microorganisms. Most tumors are related to specific pathogenic microorganisms, especially viral infections. The relationship between gliomas and human cytomegalovirus (HCMV) infection has been debated for decades. This article puts forward the author’s own point of view as an interpretation on the basis of objectively expounding the positive and negative points of view, and put forward a further solution to the dispute, for clinical reference.

Abstract Background Numerous systematic reviews investigating the benefit of the usage of drainage after primary total hip or knee arthroplasty have been published with divergent conclusions. We aim to determine the best available evidence and consider risk of bias of these articles and to provide recommendations. Methods A systematic search of systematic reviews published through to May 2020 was performed in MEDLINE, EMBASE and Cochrane library. Methodological quality, risk of bias and best evidence choice of included articles were evaluated by AMSTAR instrument, ROBIS tool and Jadad decision algorithm, respectively. We selected systematic reviews with high methodological quality and low risk of bias ultimately as best evidence. Results Twelve meta-analyses were included lastly. According to the ROBIS tool, seven of the included systematic reviews were with low risk of bias and five with high risk of bias. The Jadad decision algorithm suggested that two reviews conducted by Zan et al. for hip and Si et al. et al. for knee were selected as the best evidence, with highest AMSTAR score and low risk of bias. Conclusions Ten systematic reviews were included as low-quality with only two high-quality studies. Based on the current available evidence, we have insufficient confidence to draw conclusion that whether to use closed suction drainage for both total knee and hip arthroplasty. To verify the necessity and benefit of using closed suction drainage after primary total knee and hip arthroplasty, and develop exact recommendations, further studies are still required.

Background: Autism spectrum disorder (ASD) is a multifactorial, pervasive, neurodevelopmental disorder, of which intestinal symptoms collectively represent one of the most common comorbidities. Methods: In this study, 1,222 children with ASD and 1,206 typically developing (TD) children aged 2-7 years were enrolled from 13 cities in China. Physical measurement and basic information questionnaires were conducted in ASD and TD children. The Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Autism Behavior Checklist (ABC) were used to evaluate the clinical symptoms of children with ASD. The six-item Gastrointestinal Severity Index (6-GSI) was used to evaluate the prevalence of intestinal symptoms in two groups. Results: The detection rates of constipation, stool odor, and total intestinal symptoms in ASD children were significantly higher than those in TD children (40.098% vs. 25.622%, 17.021% vs. 9.287%, and 53.601% vs. 41.294%, respectively). Autistic children presenting with intestinal comorbidity had significantly higher scores on the ABC, SRS, CARS, and multiple subscales than autistic children without intestinal symptoms, suggesting that intestinal comorbidity may exacerbates the core symptoms of ASD children. Conclusion: Intestinal dysfunction was significantly more common in autistic than in TD children. This dysfunction may aggravate the core symptoms of children with ASD.

Abstract Background Single 6 ml Hylan G-F 20 injection, is indicated for knee osteoarthritis patients who have failed to respond to non-pharmacologic therapy and/or simple analgesics. To obtain more thorough understanding of the clinical efficacy and safety, a randomized clinical trial was conducted comparing intra-articular (IA) administration of single 6 ml Hylan G-F 20 injection versus placebo in knee OA patients of Chinese ethnicity. Methods This was a randomized, multi-center, double-blind, placebo-controlled clinical trial conducted in 21 centers across China. Four hundred forty adults with knee OA received a single 6 ml Hylan G-F 20 or placebo injection and were evaluated for clinical efficacy and safety outcomes over 26 weeks. Western Ontario and McMaster Universities OA (WOMAC) A1 index, treatment-emergent adverse events (TEAEs) and standard safety parameters were measured at pre-injection, and at weeks 1, 4, 8, 12, 16, 20 and 26 post-injection. Results Four hundred forty patients (male: 98 [22.3%]; female: 342 [77.7%]) were randomized. The mean age [standard deviation (SD)] was 61.5 (7.9) years. All patients were of East Asian ethnicity. Mean WOMAC A1 score at baseline was 5.3 (1.2) and 5.2 (1.3) in single 6 ml Hylan G-F 20 injection and placebo groups, respectively. Significant reductions of WOMAC A1 score were observed in both treatment groups when compared to baseline at 26 weeks post-injection, with the mean reduction of [standard error (SE)/percentage] -2.146 (0.108)/− 40.5% and − 2.271 (0.110) /− 43.7% in the single 6 ml Hylan G-F 20 injection and the placebo groups, respectively. Additionally, clinically important reductions in pain at 26 weeks was reported in 67.0 and 68.2% in single 6 ml Hylan G-F 20 injection and placebo groups (p = 0.36). Regarding safety, TEAEs were similar between the two treatment groups (hylan G-F 20 single: 61.5%; placebo: 64.5%). Conclusions While the magnitude of the effect of a single 6 ml Hylan G-F 20 injection in this study is consistent with previously published literature with respect to the efficacy and safety of the drug, the current study shows a strong IA placebo effect and did not established superiority of single 6 ml Hylan G-F 20 injection over IA placebo in Chinese knee OA patients. Trial registration Prospectively registered Jun 16, 2017 at www.clinicaltrials.gov ( NCT03190369 ).

Abstract Background This study aimed to determine whether the accelerometer-based navigation (ABN) could improve the accuracy of restoring mechanical axis (MA), component positioning, and clinical outcomes compared to conventional (CON) total knee arthroplasty (TKA). Methods A total of 301 consecutive patients (ABN: 27, CON: 274) were included. A 1:4 propensity score matching (PSM) was performed between the two groups according to preoperative demographic and clinical parameters. The postoperative MA, femoral coronal angle (FCA), femoral sagittal angle (FSA), tibial coronal angle (TCA) and tibial sagittal angle (TSA) were compared. Absolute deviations of aforementioned angles were calculated as the absolute value of difference between the exact and ideal value and defined as norms if within 3°, otherwise regarded as outliers. Additional clinical parameters, including the Knee Society knee and function scores (KSKS and KSFS) and range of motion (ROM), were assessed at final follow-up (FU) (mean FU was 21.88 and 21.56 months respectively for ABN and CON group). A secondary subgroup analysis and comparison on clinical outcomes were conducted between norms and outliers in different radiological parameters. Results A total of 98 patients/102 knees were analyzed after the PSM (ABN: 21 patients/24 knees, CON: 77 patients/78 knees). In the ABN group, the mean MA, FCA and TSA were significantly improved (p = 0.019, 0.006,

Background: To observe and preliminarily evaluate the efficacy and safety of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in the treatment of non-ampullary duodenal lesions (NADLs). Methods: This retrospective observational study included 84 patients who underwent endoscopic resection (ER) with non-ampullary duodenal lesions, between March 2010 and November 2020, at the Cancer Hospital of the Chinese Academy of Medical Sciences (Beijing, China). Data on patient demographics, therapeutic outcomes, and follow-up results were analyzed. Results: There were 44 patients undergoing EMR, and 40 patients accepting ESD. The overall en bloc resection rate was 98.8% (83/84). For the neoplastic lesions, the overall en bloc resection rate and curative rate were 98.5% (67/68) and 89.7% (61/68), respectively. The procedure-related bleeding and perforation rates were 2.4% and 10.7%, respectively. Univariate analysis results indicated that the main correlation factor of non-curative pathologic resection was tumor size (p = 0.004) and resection size (P < 0.01). There showed a higher curative rate in patients with tumors less than 25 mm in diameter. Multivariate logistic regression analyses determined that the tumor size (OR 0.935; 95% CI 0.878-0.995; P = 0.035) was associated with non-curative resection. No recurrences were observed in patients who had undergone a complete ER during a follow-up period of 42.8 months (range, 3-127 months). Conclusion: Endoscopic resection is an effective, safe, and feasible treatment for non-ampullary duodenal lesions.

NTRU (Number Theory Research Unit) has the characteristics of resistance to quantum computing attacks, fast encryption and decryption, and high security. It is very suitable for wireless confidential data networks and authentication systems. Combined with reversible data hiding technology, a separable reversible data hiding scheme in homomorphic encrypted domain based on NTRU is proposed. The image owner directly divides the cover-image into groups of a reference pixel and T adjacent pixels. Then, the grouped image is encrypted by NTRU. Finally, the encrypted image is uploaded to the data hider. The encrypted image is divided into groups by the same grouping method as the image owner. After that, the data hider calculates T absolute differences of adjacent pixels in each group to obtain histogram of the absolute differences. The additional data can be embedded into the encrypted image by shifting histogram of the absolute differences. After receiving the encrypted image with hidden data, the receiver can either use the data hiding key to directly extract the additional data from encrypted domain to obtain the encrypted image, or use the private key and data hiding key to extract the additional data from plaintext domain to get the cover-image. Experimental results show that our scheme has higher security and better embedding performance comparing with other state-of-the-art works.

In the past few years, the Generative Adversarial Network (GAN), which proposed in 2014, has achieved great success. There have been increasing research achievements based on GAN in the field of computer vision and natural language processing. Image steganography is an information security technique aiming at hiding secret messages in common digital images for covert communication. Recently, research on image steganography has demonstrated great potential by introducing GAN and other neural network techniques. In this paper, we review the art of steganography with GANs according to the different strategies in data hiding, which are cover modification, cover selection, and cover synthesis. We discuss the characteristics of the three strategies of GAN-based steganography and analyze their evaluation metrics. Finally, some existing problems of image steganography with GAN are summarized and discussed. Potential future research topics are also forecasted.

Surfactant dysfunction is a genetically heterogeneous pulmonary disease that causes dyspnea. ATP binding cassette protein transporter subunit A3 (ABCA3) is the main pathogenic gene of pulmonary surfactant dysfunction. In this study, we established an induced pluripotent stem cell line (SMCPGHi001-A) from the peripheral blood cells of a 49-day-old male infant, carrying compound heterozygous variations of the ABCA3 gene (c.3997_3998del, p.R1333fs, and c.3137C > T, p.A1046V). This iPSC line would be a useful tool to study the pathogenesis, disease development, and treatment of pulmonary surfactant dysfunction.

In this paper, a novel data-driven information hiding scheme called “generative steganography by sampling” (GSS) is proposed. Unlike in traditional modification-based steganography, in our method the stego image is directly sampled by a powerful generator: no explicit cover is used. Both parties share a secret key used for message embedding and extraction. The Jensen-Shannon divergence is introduced as a new criterion for evaluating the security of generative steganography. Based on these principles, we propose a simple practical generative steganography method that uses semantic image inpainting. The message is written in advance to an uncorrupted region that needs to be retained in the corrupted image. Then, the corrupted image with the secret message is fed into a Generator trained by a generative adversarial network (GAN) for semantic completion. Message loss and prior loss terms are proposed for penalizing message extraction error and unrealistic stego image. In our design, we first train a generator whose training target is the generation of new data samples from the same distribution as that of existing training data. Next, for the trained generator, backpropagation to the message and prior loss are introduced to optimize the coding of the input noise data for the generator. The presented experiments demonstrate the potential of the proposed framework based on both qualitative and quantitative evaluations of the generated stego images.

Plasmon-induced photocatalysis on noble metal surfaces has attracted broad attention due to its application in sunlight energy conversion, while the selectivity of plasmonic platforms remains unclear. Herein, we present the controlled plasmon-mediated oxidation of para-aminothiophenol (p-ATP) by employing Au@Ag core–shell nanostars with tunable tip plasmons in visible–near-infrared range as reactors. In-situ Raman measurements indicate that Au@Ag core–shell nanostars essentially promote the conversion of p-ATP to 4,4′-dimercaptoazobenzene (DMAB) due to hot carriers excited by localized surface plasmon resonance. Au@Ag nanostars with plasmon modes under resonant light excitation suggested higher catalytic efficiency, as evidenced by the larger intensity ratios between 1440 cm−1 (N=N stretching of DMAB) and 1080 cm−1 shifts (C–S stretching of p-ATP). Importantly, the time-dependent surface-enhanced Raman scattering spectra showed that the conversion efficiency of p-ATP was mainly dictated by the resonance condition between the tip plasmon mode of Au@Ag core–shell nanostars and the excitation light, as well as the choice of excitation wavelength. These results show that plasmon bands of metal nanostructures play an important role in the efficiency of plasmon-driven photocatalysis.