229 results on '"Yan-Yan Hu"'
Search Results
2. Compared with dietary behavior and physical activity risk, sedentary behavior risk is an important factor in overweight and obesity: evidence from a study of children and adolescents aged 13–18 years in Xinjiang, China
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He Liu, Cunjian Bi, Hongniu Lin, Wei Ma, Jie Zhang, Yan-Yan Hu, and Jing-Zhi Liu
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Xinjiang China ,Children and adolescents ,Nutritional status ,Eating behavior ,Physical activity ,Cross-sectional analysis ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Malnutrition or insufficient physical activity (PA) is a risk factor for obesity and chronic disease in children and adolescents. Affected by different economic circumstance, ethnic, dietary behavior, physical activity and other factors, children and adolescents in Xinjiang, China are facing a severe situation of overweight and obesity prevention and control. It is necessary to analyze the dietary behavior and physical activity of children and adolescents with different nutritional status and the relationship between them. Methods Using a stratified cluster sampling method in Xinjiang, China, 4833 middle school students aged 13–18 were selected., and tests for height and weight were conducted. Self-assessment questionnaires were completed for Dietary Behaviors, Physical Activity, and Sedentary Behaviors as well. Chi-square test, Logistic regression analysis and other methods were used to analyze the relationship between Dietary Behaviors, Physical Activity, Sedentary Behaviors and other health behavior risk factors and Weight and BMI. Results Children and adolescents aged 13–18 in Xinjiang, China, girls had a lower BMI compared with boys(19.49 VS. 20.41). The proportions of Underweight, Overweight and Obese among girls were lower (Underweight: 11.8 VS. 14.5; Overweight: 7.6 VS. 12.7; Obese 2.3 VS. 7.0).Boys with higher risk of sedentary had a 1.46-fold higher risk of developing Overweight/Obese than those with lower risk of sedentary (95%CI: 1.07–2.01).Girls with higher risky diet had a 1.56-fold higher risk of developing Underweight than those with lower risky diet (95%CI: 1.11–2.19). For all participants, the risk of Overweight/Obese in children and adolescents with higher risk of sedentary was 1.45 times more than that of children and adolescents with lower Risk sedentary (95%CI: 1.12 ~ 1.88). Overall, Weight had a significant correlation with PA risk (r = 0.076, P
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- 2022
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3. Hemoporfin-mediated photodynamic therapy with general anesthesia showed superior efficacy in the treatment of port-wine stains: a retrospective evaluation
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Yan-Yan Hu, Kai Chen, Lin-Lin Wang, Jia-Fang Wang, Xi Chen, Li-Juan Cao, Qian Jiang, Zhen-Xing Wang, Shan-Shan Qian, Zhi-Jun Chen, Liu-Qing Chen, and Dong-Sheng Li
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photodynamic therapy ,hemoporfin ,general anesthesia ,port-wine stains ,efficacy ,Medicine (General) ,R5-920 - Abstract
BackgroundHemoporfin-mediated photodynamic therapy (PDT) is an effective treatment for port-wine stains (PWS), and pain is the main adverse effect of this therapy. General anesthesia is commonly used for pain management during PDT, but the effect of general anesthetics on the subsequent treatment efficacy of PDT in PWS has not been reported.ObjectivesTo assess the use of general anesthesia combined with PDT compared with PDT alone in 207 PWS patients, and to provide further safety and efficacy data on this combined therapy.MethodsPropensity score matching (PSM) was used at a 2:1 ratio to create a general anesthetic group (n = 138) and a highly comparable nonanesthetic group (n = 69). The clinical outcomes were evaluated, and the treatment reactions and adverse effects were recorded after one treatment with PDT.ResultsAfter matching, there was no significant difference in the demographic data of the patients in the two groups (p > 0.05), while the treatment efficacy was significantly higher in the general anesthetic group than in the nonanesthetic group (76.81 vs. 56.52%, p 0.05). No serious systemic adverse reactions were observed.ConclusionWe recommend this combined therapy, which is associated with painless, as a high efficacy treatment option for PWS patients, especially for patients with a poor response to multiple PDT alone treatments.
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- 2023
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4. Attenuated WNV-poly(A) exerts a broad-spectrum oncolytic effect by selective virus replication and CD8+ T cell-dependent immune response
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Jing Liu, Yan-Yan Hu, Qiu-Yan Zhang, Ya-Nan Zhang, Na Li, Zhe-Rui Zhang, Shun-Li Zhan, Lei Gao, Cheng-Lin Deng, Xiao-Dan Li, Shao-Peng Yuan, Yuan-Qiao He, Han-Qing Ye, and Bo Zhang
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WNV-poly(A) ,Oncolytic virus ,IFN-I-dependent selectivity ,CD8+ T cell ,Immunity therapy ,Broad spectrum ,Therapeutics. Pharmacology ,RM1-950 - Abstract
As an emerging tumor therapy, ideal oncolytic viruses preferentially replicate in malignant cells, reverse the immunosuppressive tumor microenvironment, and eventually can be eliminated by the patient. It is of great significance for cancer treatment to discover new excellent oncolytic viruses. Here, we found that WNV live attenuated vaccine WNV-poly(A) could be developed as a novel ideal oncolytic agent against several types of cancers. Mechanistically, due to its high sensitivity to type Ι interferon (IFN-Ι), WNV-poly(A) could specifically kill tumor cells rather than normal cells. At the same time, WNV-poly(A) could activate Dendritic cells (DCs) and trigger tumor antigen specific response mediated by CD8 + T cell, which contributed to inhibit the propagation of original and distal tumor cells. Like intratumoral injection, intravenous injection with WNV-poly(A) also markedly delays Huh7 hepatic carcinoma (HCC) transplanted tumor progression. Most importantly, in addition to an array of mouse xenograft tumor models, WNV-poly(A) also has a significant inhibitory effect on many different types of patient-derived tumor tissues and HCC patient-derived xenograft (PDX) tumor models. Our studies reveal that WNV-poly(A) is a potent and excellent oncolytic agent against many types of tumors and may have a role in metastatic and recurrent tumors.
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- 2023
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5. Case Report: Improved surgical treatment for breast capsular contracture by the punctiform-incision approach through the nipple
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Yan Zheng, Yan-Yan Hu, Wan-Yi Zhao, Xiao-Feng Wang, Qing-Qing Fang, Xiong Lv, Chun Xiang, Jian-Min Yao, and Wei-Qiang Tan
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capsular contraction release ,breast implants ,punctiform incision ,nipple entry ,innovative double-headed separator ,Surgery ,RD1-811 - Abstract
Capsular contracture is one of the most common complications of breast implants, which often leads to secondary surgery. Patients with unconspicuous breast contracture do not need treatment, while for those with severe symptoms, a capsule revision surgery is of great necessity, including a total periprosthetic capsulectomy and replacement with a new implant. However, if the capsular contracture happens in the submuscular space, it will be very difficult to release it completely, and it may lead to more complications such as damage to surrounding tissue. The new method of pouch can create a new subpectoral plane for the insertion of a new implant instead of a total capsulectomy, but this method is unsuitable for patients who have little breast tissue or thin skin. To solve this thorny clinical problem, we invented a double-headed separating instrument and came up with a novel operation method to release the capsular contracture, which opened from the nipple by the punctiform-incision approach and caused only a mild and undetectable trauma. This operation went off without a hitch, and the postoperative breast shape was good, and the breast felt and moved naturally. In addition, there were no significant complications throughout the one-year follow-up period. This case was an excellent demonstration of the novel breast capsular contracture release surgery using our optimized double-headed capsule contracture separator.
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- 2022
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6. Whole-Genome Sequencing Identified KCNJ12 and SLC25A5 Mutations in Port-Wine Stains
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Kai Chen, Yan-Yan Hu, Lin-Lin Wang, Yun Xia, Qian Jiang, Lan Sun, Shan-Shan Qian, Jin-Zhao Wu, Liu-Qing Chen, and Dong-Sheng Li
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whole genome sequencing (WGS) ,port-wine stains (PWS) ,KCNJ12 ,SLC25A5 ,mutation ,Medicine (General) ,R5-920 - Abstract
Port-wine stains (PWSs) are a congenital capillary malformed disorder and are caused by a number of somatic mutations that disrupt vascular development. However, the underlying genetic mutations in the pathogenesis of PWS have not yet been fully elucidated. To understand PWS genetic variations and investigate novel genetic mutations, we extracted genomic DNA from four sporadic PWS patients and then performed whole-genome sequencing (WGS). Using Sorting Intolerant from Tolerant (SIFT), PolyPhen2, Mutation Assessor, MetaSVM to identify candidate genetic mutations and whole-exome sequencing (WES) to confirm the identified variants. We found a previously reported G protein subunit alpha q (GNAQ) mutation c.548G > A, p.Arg183Gln in one case, whereas no such mutation was found in the other three samples. Moreover, six novel somatic mutations in three genes, including KCNJ12, SLC25A5, POTEE, were found in these four samples. Importantly, WES also verified the KCNJ12 (c.433G > A, p.Gly145Ser) and SLC25A5 (c.413G > A, p.Arg138His) mutations in other five sporadic PWS patients, with the frequency of 60% (3 of 5) and 40% (2 of 5), respectively. Thus, we reveal in this study two novel somatic mutations, KCNJ12 and SLC25A5, in the sporadic PWS patients for the first time. These findings highlight the genetic polymorphism of PWS and provide potential clinical prediction targets for this disease.
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- 2022
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7. Flexible electrical stimulation device with Chitosan-Vaseline® dressing accelerates wound healing in diabetes
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Xiao-Feng Wang, Meng-Lu Li, Qing-Qing Fang, Wan-Yi Zhao, Dong Lou, Yan-Yan Hu, Jun Chen, Xiao-Zhi Wang, and Wei-Qiang Tan
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Diabetic wounds ,Flexible electronic device ,Electrical stimulation ,Chitosan-vaseline® gauze ,Wound healing ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
The healing process of diabetic wounds is typically disordered and prolonged and requires both angiogenesis and epithelialization. Disruptions of the endogenous electric fields (EFs) may lead to disordered cell migration. Electrical stimulation (ES) that mimics endogenous EFs is a promising method in treating diabetic wounds; however, a microenvironment that facilitates cell migration and a convenient means that can be used to apply ES are also required. Chitosan-Vaseline® gauze (CVG) has been identified to facilitate wound healing; it also promotes moisture retention and immune regulation and has antibacterial activity. For this study, we created a wound dressing using CVG together with a flexible ES device and further evaluated its potential as a treatment for diabetic wounds. We found that high voltage monophasic pulsed current (HVMPC) promoted healing of diabetic wounds in vivo. In studies carried out in vitro, we found that HVMPC promoted the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by activating PI3K/Akt and ERK1/2 signaling. Overall, we determined that the flexible ES-chitosan dressing may promoted healing of diabetic wounds by accelerating angiogenesis, enhancing epithelialization, and inhibiting scar formation. These findings provide support for the ongoing development of this multidisciplinary product for the care and treatment of diabetic wounds.
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- 2021
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8. Risk Factors for Carbapenem-Resistant Pseudomonas aeruginosa, Zhejiang Province, China
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Yan-Yan Hu, Jun-Min Cao, Qing Yang, Shi Chen, Huo-Yang Lv, Hong-Wei Zhou, Zuowei Wu, and Rong Zhang
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Carbapenem ,risk factors ,Pseudomonas aeruginosa ,bacteria ,antimicrobial resistance ,surveillance ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a public health concern worldwide, but comprehensive analysis of risk factors for CRPA remains limited in China. We conducted a retrospective observational study of carbapenem resistance in 71,880 P. aeruginosa isolates collected in Zhejiang Province during 2015–2017. We analyzed risk factors for CRPA, including the type of clinical specimen; the year, season, and region in which it was collected; patient information, including age, whether they were an outpatient or inpatient, and whether inpatients were in the intensive care unit or general ward; and the level of hospital submitting isolates. We found CRPA was more prevalent among isolates from patients >60 years of age and in inpatients, especially in intensive care units. In addition, specimen types and seasons in which they were collected were associated with higher rates of CRPA. Our findings can help hospitals reduce the spread of P. aeruginosa and optimize antimicrobial drug use.
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- 2019
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9. Luminescence of Tb3Al5O12 phosphors co-doped with Ce3+/Gd3+ for white light-emitting diodes
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Yu-Guo Yang, Lei Wei, Jian-Hua Xu, Hua-Jian Yu, Yan-Yan Hu, Hua-Di Zhang, Xu-Ping Wang, Bing Liu, Cong Zhang, and Qing-Gang Li
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luminescence ,Tb3Al5O12:Ce3+/Gd3+ ,white light-emitting diodes (WLEDs) ,Technology ,Chemical technology ,TP1-1185 ,Science ,Physics ,QC1-999 - Abstract
Tb2.96−xCe0.04GdxAl5O12 phosphors were synthesized through solid-state reactions. The influence of Gd3+ on the luminescence was investigated. Under the excitation at 460 nm, Tb2.96Ce0.04Al5O12 shows the characteristic emission band of Ce3+ with a peak wavelength at about 554 nm. After co-doping Gd3+ into Tb2.96Ce0.04Al5O12, the peak wavelength of the Ce3+ emission band shifts to longer wavelengths, which is induced by the increasing crystal field splitting. However, the Ce3+ emission intensity also decreases because the substitution of Tb3+ with Gd3+ causes lattice deformation and generates numerous structural and chemical defects. By comparing the light parameters of white light-emitting diodes (WLEDs) containing Y2.96Ce0.04Al5O12, Tb2.96Ce0.04Al5O12 and Tb2.81Ce0.04Gd0.15Al5O12 phosphors, we can find that the WLED containing the Tb2.81Ce0.04Gd0.15Al5O12 phosphor generates warmer light than the WLEDs containing Y2.96Ce0.04Al5O12 and Tb2.96Ce0.04Al5O12 phosphors. Moreover, the WLEDs fabricated by integrating a blue LED chip and Ce3+/Gd3+-co-doped Tb3Al5O12 phosphors show outstanding colour stability when driven under different currents.
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- 2019
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10. Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation
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Tao Zhang, Xiao-Feng Wang, Zheng-Cai Wang, Dong Lou, Qing-Qing Fang, Yan-Yan Hu, Wan-Yi Zhao, Li-Yun Zhang, Li-Hong Wu, and Wei-Qiang Tan
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Hypertrophic scar ,Keloid ,Fibroblast ,TGF-β ,Smad ,Therapeutic strategies ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a pathological disorganized wound healing process with chronic inflammation. The TGF-β/Smad signaling pathway is the most canonical pathway through which the formation of collagen in the fibroblasts and myofibroblasts is regulated. Sustained activation of the TGF-β/Smad signaling pathway results in the long-term overactivation of fibroblasts and myofibroblasts, which is necessary for the excessive collagen formation in aberrant scars. There are two categories of therapeutic strategies that aim to target the TGF-β/Smad signaling pathway in fibroblasts and myofibroblasts to interfere with their cellular functions and reduce cell proliferation. The first therapeutic strategy includes medications, and the second strategy is composed of genetic and cellular therapeutics. Therefore, the focus of this review is to critically evaluate these two main therapeutic strategies that target the TGF-β/Smad pathway to attenuate abnormal skin scar formation.
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- 2020
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11. Co-transfection of hepatocyte growth factor and truncated TGF-β type II receptor inhibit scar formation
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Ji-Hua Xu, Wan-Yi Zhao, Qing-Qing Fang, Xiao-Feng Wang, Ding-Ding Zhang, Yan-Yan Hu, Bin Zheng, and Wei-Qiang Tan
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Wound healing ,Truncated transforming growth factor-β type II receptor ,Hepatocyte growth factor ,Scar ,Rat ,Lentivirus ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Wound scarring remains a major challenge for plastic surgeons. Transforming growth factor (TGF)-β plays a key role in the process of scar formation. Previous studies have demonstrated that truncated TGF-β type II receptor (t-TGF-βRII) is unable to continue signal transduction but is still capable of binding to TGF-β, thereby blocking the TGF-β signaling pathway. Hepatocyte growth factor (HGF) is a multifunctional growth factor that promotes tissue regeneration and wound healing. Theoretically, the combination of HGF and t-TGF-βRII would be expected to exert a synergistic effect on promoting wound healing and reducing collagen formation. In the present study, lentivirus-mediated transfection of the two genes (t-TGF-βRII/HGF) into fibroblasts in vitro and in a rat model in vivo was used. The results demonstrated that the expression of t-TGF-βRII and HGF in NIH-3T3 cells was successfully induced. The expression of both molecules significantly reduced collagen I and III expression, and also inhibited fibroblast proliferation. Furthermore, histological examination and scar quantification revealed less scarring in the experimental wound in a rat model. Moreover, on macroscopic inspection, the experimental wound exhibited less visible scarring compared with the control. Therefore, the present study demonstrated that the combination gene therapy of t-TGF-βRII and HGF promoted wound healing, with less scarring and more epithelial tissue formation, not only by suppressing the overgrowth of collagen due to its antifibrotic effect, but also by promoting tissue regeneration.
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- 2020
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12. The effect of topical ramipril and losartan cream in inhibiting scar formation
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Bin Zheng, Qing-Qing Fang, Xiao-Feng Wang, Bang-Hui Shi, Wan-Yi Zhao, Chun-Ye Chen, Min-Xia Zhang, Li-Yun Zhang, Yan-Yan Hu, Peng Shi, Lie Ma, and Wei-Qiang Tan
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Scar ,Ramipril ,ACEI ,Losartan ,ARB ,Transdermal ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The renin-angiotensin system (RAS) plays an important role in scar formation. We have previously shown that oral administration of ramipril and losartan could inhibit scarring. For easier application, here we developed a series of topical ramipril and losartan creams in different concentrations and formulations to explore the effect on scar formation in a C57BL/6 mouse scar model. The harvested scar tissues were analyzed with H&E staining, Masson staining and immunohistochemical staining. We found the group treated with 0.2% losartan urea cream (Prep. 1) or 0.1% ramipril cream (Prep. 2) had significantly smaller scars compared to the negative control, while the proliferation of fibroblasts was less active and the collagen fibers were more regular; both groups showed similar efficacy with the positive control (triamcinolone acetonide urea). We also found that drug transdermalness couldn’t directly determine the efficacy. Our findings indicate that local application of angiotensin converting enzyme inhibitor drugs (ACEIs) and angiotensin receptor blocker drugs (ARBs) can reduce scarring by reducing the expression of collagen I, collagen III, phosphorylated small mothers against decapentaplegic 3 (p-Smad3) and transforming growth factor-β 1 (TGF-β1). This may provide new insight on scar treatment in clinic.
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- 2019
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13. Characterization of temperature-dependent superlattice in Cu:KTN crystal
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Fei Zhang, Bing Liu, Cheng-Kai Yang, Yan-Yan Hu, Hua-Di Zhang, Qing-Gang Li, Xu-Ping Wang, Yuan-Yuan Zhang, Yu-Guo Yang, and Lei Wei
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KTN ,Superlattice structure ,Domain structure. ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Chemical technology ,TP1-1185 - Abstract
In this study, we grew CuO doped potassium tantalum niobate (Cu:KTN) crystals with a uniform superlattice structure by the off-center top-seeded solution growth (TSSG) method. The process of crystal superlattice structure formation was observed under a polarizing microscope at variable temperatures. It was found that the formation of the superlattice structure in the crystal was closely related to the formation process of the domain structure in the crystal. The 90° domain structure in the crystal promoted the formation of the superlattice structure in the crystal. The purpose of the formation of the superlattice structure is to enable the crystal to reach a more stable state. The clear diffraction effect of the crystal superlattice structure is similar to the x-ray diffraction phenomenon of low-temperature crystals, and it exists in the crystal in a three-dimensional structure.
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- 2020
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14. The protective effect of baicalin against UVB irradiation induced photoaging: an in vitro and in vivo study.
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Jia-an Zhang, Zhi Yin, Li-wen Ma, Zhi-qiang Yin, Yan-yan Hu, Yang Xu, Di Wu, Felicia Permatasari, Dan Luo, and Bing-rong Zhou
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Medicine ,Science - Abstract
OBJECTIVE: This study was aimed to evaluate the anti-photoaging effects of baicalin on Ultraviolet B (UVB)-induced photoaging in the dorsal skin of hairless mice and premature senescence in human dermal fibroblasts. METHODS: We established in vivo and in vitro photoaging models by repeated exposures to UVB irradiation. By HE staining, masson staining, immunohistostaing and real-time RT-PCR, we analyzed epidermal thickness, collagen expression and the mRNA and protein levels of type I collagen, type III collagen, interstitial collagenase (MMP-1 and MMP-3) in UVB exposed dorsal mice skin. The aging condition in human dermal fibroblasts was determined by senescence-associated β-galactosidase (SA-β-gal) staining. Cell viability was determined using the Cell Counting Kit-8 (CCK-8). The G1 phase cell growth arrest was analyzed by flow cytometry. The senescence-related protein levels of p16INK-4a, p21WAF-1, and p53 and protein levels of phosphorylated histone H2AX were estimated by Western blotting. RESULTS: Topically application of baicalin treatment reduced UVB-induced epidermal thickening of mouse skin and also result in an increase in the production of collagen I and III, and a decrease in the expression of MMP-1 and MMP-3. Compared with the UVB-irradiated group, we found that the irradiated fibroblasts additionally treated with baicalin demonstrated a decrease in the expression of SA-β-gal, a increase in the cell viability, a decrease in the G1 phase cell proportion, a downregulation in the level of senescence-associated and γ-H2AX proteins. However, Baicalin had no difference in the normal fibroblasts without UVB irradiation and long-term Baicalin incubation of UVB-SIPS fibroblasts gave no effects on the cell proliferation. CONCLUSIONS: Taken together, these results suggest that baicalin significantly antagonizes photoaging induced by UVB in vivo and in vitro, indicating the potential of baicalin application for anti-photoaging treatment.
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- 2014
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15. Management of vaginal laxity through bilateral wall tightening without mucosal excision
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Qing-Qing Fang, Jian-Min Yao, Ya-Nan Xue, Yong Wang, Wan-Yi Zhao, Zheng-Cai Wang, Hong Wang, Tao Zhang, Yan-Yan Hu, Xiao-Feng Wang, Li-Yun Zhang, and Wei-Qiang Tan
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Surgery - Published
- 2023
16. Unraveling Water and Salt Transport in Polyamide with Nuclear Magnetic Resonance Spectroscopy
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Mahsa Abbaszadeh, Madeline Garell, Ji Il Choi, Yudan Chen, Johannes Leisen, Seung Soon Jang, Yan-Yan Hu, and Marta C. Hatzell
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General Chemical Engineering ,Biomedical Engineering ,General Materials Science - Published
- 2022
17. A combination treatment of drug‐laser‐photon for melasma: A retrospective study of clinical cases
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Ying, Li, Wei-Na, Shao, Qing-Qing, Fang, Wan-Yi, Zhao, Shi-Qin, Wang, Li-Hong, Wu, Yan-Yan, Hu, Xiao-Feng, Wang, Ya-Nan, Xue, Li, Chen, and Wei-Qiang, Tan
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Dermatology - Abstract
Combinational therapy such as taking tranexamic acid while using laser treatment has been proved potential efficacy by many experiments. However, there is few research which contains large samples and consistent observations.We evaluated clinical efficacy and safety of a new systemic treatment of drug-laser-photon therapy.Retrospective and randomized investigator-blinded study of 75 patients with mixed type melasma was analyzed. At each visit, standardized photographs were taken using VISIA. Modified melasma area and severity index (mMASI) scores were marked using photographs by two dermatologists.The mMASI score decreased significantly from 6.92 to 3.84 after the treatment. The VISIA analyze right cheek data shows: Spots (from 49.67 ± 3.43 to 56.09 ± 3.31), UV spots (from 41.39 ± 24.45 to 44.56 ± 25.86), and Brown spots (from 23.97 ± 17.89 to 28.16 ± 21.28) are statistically increased (p = 0.035, p = 0.018, p = 0.07). All patients feel varying degrees of improvement, about 10.17% felt very much improved, 30.51% felt much improved (51%-75%), 45.76% felt moderately improved (26%-50%), and 13.56% felt little improved (1%-25%).This study was no control group.The efficacy and safety profile of the combination of drug-laser-photon therapy systemic treatment in melasma patients has been proved. It has potential possibility to become a new, reliable, widely suitable therapy strategy.
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- 2022
18. Interrupted anion-network enhanced Li+-ion conduction in Li3+yPO4Iy
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Sawankumar V. Patel, Erica Truong, Haoyu Liu, Yongkang Jin, Benjamin L. Chen, Yan Wang, Lincoln Miara, Ryounghee Kim, and Yan-Yan Hu
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Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology ,General Materials Science - Published
- 2022
19. Leveraging local structural disorder for enhanced ion transport
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Michael J. Deck and Yan-Yan Hu
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,Condensed Matter Physics - Published
- 2023
20. Nanoscale Encapsulation of Hybrid Perovskites Using Hybrid Atomic Layer Deposition
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Jue Gong, Moein Adnani, Brendon T. Jones, Yan Xin, Sisi Wang, Sawankumar V. Patel, Eric Lochner, Hedi Mattoussi, Yan-Yan Hu, and Hanwei Gao
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General Materials Science ,Physical and Theoretical Chemistry - Abstract
Organic-inorganic hybrid perovskites have shown tremendous potential for optoelectronic applications. Ion migration within the crystal and across heterointerfaces, however, imposed severe problems with material degradation and performance loss in devices. Encapsulating hybrid perovskite with a thin physical barrier can be essential for suppressing the undesirable interfacial reactions without inhibiting the desirable transport of charge carriers. Here, we demonstrated that nanoscale, pinhole-free Al
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- 2022
21. Solid‐State <scp>NMR</scp> and <scp>EPR</scp> Characterization of Transition‐Metal Oxides for Electrochemical Energy Storage
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Xiang Li, Michael Deck, and Yan‐Yan Hu
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- 2022
22. Fluoride Doping in Crystalline and Amorphous Indium Oxide Semiconductors
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Aritra Sil, Michael J. Deck, Elise A. Goldfine, Chi Zhang, Sawankumar V. Patel, Steven Flynn, Haoyu Liu, Po-Hsiu Chien, Kenneth R. Poeppelmeier, Vinayak P. Dravid, Michael J. Bedzyk, Julia E. Medvedeva, Yan-Yan Hu, Antonio Facchetti, and Tobin J. Marks
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General Chemical Engineering ,Materials Chemistry ,General Chemistry - Published
- 2022
23. Phase Behavior and Superprotonic Conductivity in the System (1–x)CsH2PO4 – xH3PO4: Discovery of Off-Stoichiometric α-[Cs1–xHx]H2PO4
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Louis S. Wang, Sawankumar V. Patel, Erica Truong, Yan-Yan Hu, and Sossina M. Haile
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General Chemical Engineering ,Materials Chemistry ,General Chemistry - Published
- 2022
24. Application of psychological nursing based on narrative therapy in patients with early gastric cancer undergoing radical operation
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Xiao-Li Jiang and Yan-Yan Hu
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- 2021
25. Copper-coordinated cellulose ion conductors for solid-state batteries
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Yimin Mao, Robert M. Briber, Yue Gao, Steven Greenbaum, Yue Qi, Jin Zheng, Martin Winter, Feng Jiao, Pengbo Wang, Alexandra H. Brozena, Chunpeng Yang, Qisheng Wu, Akira Isogai, Madhusudan Tyagi, Liangbing Hu, Mounesha N. Garaga, Xin Zhang, Byung Hee Ko, Chunsheng Wang, Kang Xu, Shuaiming He, Wei-Qi Xie, Paul Albertus, and Yan-Yan Hu
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Battery (electricity) ,Multidisciplinary ,Materials science ,Chemical engineering ,chemistry ,chemistry.chemical_element ,Ionic conductivity ,Lithium ,Conductivity ,Electrical conductor ,Ion transporter ,Ion ,Anode - Abstract
Although solid-state lithium (Li)-metal batteries promise both high energy density and safety, existing solid ion conductors fail to satisfy the rigorous requirements of battery operations. Inorganic ion conductors allow fast ion transport, but their rigid and brittle nature prevents good interfacial contact with electrodes. Conversely, polymer ion conductors that are Li-metal-stable usually provide better interfacial compatibility and mechanical tolerance, but typically suffer from inferior ionic conductivity owing to the coupling of the ion transport with the motion of the polymer chains1–3. Here we report a general strategy for achieving high-performance solid polymer ion conductors by engineering of molecular channels. Through the coordination of copper ions (Cu2+) with one-dimensional cellulose nanofibrils, we show that the opening of molecular channels within the normally ion-insulating cellulose enables rapid transport of Li+ ions along the polymer chains. In addition to high Li+ conductivity (1.5 × 10−3 siemens per centimetre at room temperature along the molecular chain direction), the Cu2+-coordinated cellulose ion conductor also exhibits a high transference number (0.78, compared with 0.2–0.5 in other polymers2) and a wide window of electrochemical stability (0–4.5 volts) that can accommodate both the Li-metal anode and high-voltage cathodes. This one-dimensional ion conductor also allows ion percolation in thick LiFePO4 solid-state cathodes for application in batteries with a high energy density. Furthermore, we have verified the universality of this molecular-channel engineering approach with other polymers and cations, achieving similarly high conductivities, with implications that could go beyond safe, high-performance solid-state batteries. By coordinating copper ions with the oxygen-containing groups of cellulose nanofibrils, the molecular spacing in the nanofibrils is increased, allowing fast transport of lithium ions and offering hopes for solid-state batteries.
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- 2021
26. Location algorithm for Wireless Sensor Networks based on Virtual Plumb Line and Optimized Particle Swarm Optimization
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Yan-Yan Hu, Xiu-Wu Yu, and Yong Liu
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- 2022
27. Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster
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Ya-Nan Zhang, Hong-Qing Zhang, Gui-Feng Wang, Zhe-Rui Zhang, Jia-Qi Li, Xiao-Ling Chen, Yan-Yan Hu, Xiang-Yue Zeng, Yu-Jia Shi, Jing Wang, Ying-Hua Li, Xiao-Dan Li, Chun-He Wang, Bing Zhu, and Bo Zhang
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Pharmacology ,Virology - Abstract
The Omicron variant is sweeping the world, which displays striking immune escape potential through mutations at key antigenic sites on the spike protein, making broad-spectrum SARS-CoV-2 prevention or therapeutical strategies urgently needed. Previously, we have reported a hACE2-targeting neutralizing antibody 3E8, which could efficiently block both prototype SARS-CoV-2 and Delta variant infections in prophylactic mouse models, having the potential of broad-spectrum to prevent SARS-CoV-2. However, preparation of monoclonal neutralizing antibodies is severely limited by the time-consuming process and the relative high cost. Here, we utilized a modified VEEV replicon with two subgenomic (sg) promoters engineered to express the light and heavy chains of the 3E8 mAb. The feasibility and protective efficacy of replicating mRNA encoding 3E8 against Omicron infection in the hamster were demonstrated through the lung targeting delivery with the help of VEEV-VRP. Overall, we developed a safe and cost-effective platform of broad-spectrum to prevent SARS-CoV-2 infection.
- Published
- 2022
28. Real-time monitoring of the lithiation process in organic electrode 7,7,8,8-tetracyanoquinodimethane by in situ EPR
- Author
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Likai Song, Jin Zheng, Yan-Yan Hu, Nhat N. Bui, and Mingxue Tang
- Subjects
Materials science ,Energy Engineering and Power Technology ,02 engineering and technology ,Electron ,Electrolyte ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Tetracyanoquinodimethane ,Redox ,Energy storage ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,Delocalized electron ,Fuel Technology ,chemistry ,law ,Electrode ,Electrochemistry ,0210 nano-technology ,Electron paramagnetic resonance ,Energy (miscellaneous) - Abstract
Organic electrodes are advantageous for rechargeable lithium-ion batteries owing to their high theoretical capacities, diverse functionalities, and environmental compatibility. Understanding the working mechanism of organic electrodes is vital to strategic materials design. However, due to lack of suitable characterization tools, it has been challenging to probe the reaction processes of organic electrodes in real-time. Here, non-destructive in situ electron paramagnetic resonance (EPR) was performed on a model organic electrode, 7,7,8,8-tetracyanoquinodimethane (TCNQ) used in rechargeable lithium-ion batteries, to directly follow the redox reactions in real-time. In order to minimize interfering signals from other parts of the batteries than the TCNQ electrode of interest, two sets of batteries are fabricated and studied with in situ EPR: (1) a LiCoO2//Li4Ti5O12 full-cell battery to determine the EPR signal evolution of additives and electrolytes; (2) a LiCoO2//TCNQ battery, and the difference in the observed EPR signals reflects purely the redox reactions of TCNQ upon lithiation and delithiation. A two-electron reversible redox reaction is delineated for TCNQ. TCNQ dimers form during the first electron injection upon lithiation and followed by the break-down of the dimers and associated electron coupling to produce massive delocalized electrons, resulting in increased EPR signal during the 2nd electron injection. Reversible trends are observed during electron ejection upon delithiation. In situ EPR is very sensitive to electron activities, thus is a powerful tool to follow redox reactions of organic electrodes, allowing for improved fundamental understanding of how organic electrodes work and for informed design of high-performance organic materials for energy storage.
- Published
- 2021
29. Photosynthetic biomaterials: applications of photosynthesis in algae as oxygenerator in biomedical therapies
- Author
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Qing-Qing Fang, Ya-Nan Xue, Dong Lou, Tao Zhang, Mingyuan Jin, Wan-Yi Zhao, Yong Wang, Xiao-Feng Wang, Wei-Qiang Tan, Yan-Yan Hu, and Zheng-Cai Wang
- Subjects
business.industry ,Materials Science (miscellaneous) ,medicine.medical_treatment ,Biomedical Engineering ,Hypoxia (environmental) ,Photodynamic therapy ,Biology ,Photosynthesis ,Bioinformatics ,biology.organism_classification ,Industrial and Manufacturing Engineering ,Transplantation ,Algae ,Light energy ,medicine ,Molecular oxygen ,business ,Biomedicine ,Biotechnology - Abstract
For most organisms, molecular oxygen is indispensable for normal physiological metabolism; in humans, prolonged hypoxia in tissues can induce many diseases, exemplified by cardiovascular disease, chronic wounds, and tissue necrosis. Therefore, the oxygen in our environment is vital for life. As a main source of oxygen in the natural world that transforms light energy into chemical energy and oxygen, photosynthesis has been widely studied in scientific research and used in production of food, fuel, and medicine. In recent years, photosynthesis has become more closely involved in biomedicine and has been widely used in photodynamic therapy, tissue regeneration, transplantation, and in treatment of specific diseases. This review summarizes innovative applications of photosynthesis in biomedical research and highlights the theory and implications of clinical treatment for specific diseases.
- Published
- 2021
30. Lithium Thiostannate Spinels: Air-Stable Cubic Semiconductors
- Author
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Mercouri G. Kanatzidis, Chris Wolverton, Shiqiang Hao, Jin-Ke Bao, Sawankumar Patel, Xiuquan Zhou, Yan-Yan Hu, and Michael A. Quintero
- Subjects
Materials science ,Chalcogenide ,business.industry ,General Chemical Engineering ,Inorganic chemistry ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,Thermal neutron detection ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Alkali metal ,01 natural sciences ,0104 chemical sciences ,Ion ,chemistry.chemical_compound ,Semiconductor ,chemistry ,Materials Chemistry ,Lithium ,0210 nano-technology ,business ,Electrical conductor - Abstract
Lithium chalcogenide materials have been studied less than other alkali metal analogs and are of interest as ion conductors and semiconductors capable of thermal neutron detection. Herein, we descr...
- Published
- 2021
31. Vacancy‐Enabled O3 Phase Stabilization for Manganese‐Rich Layered Sodium Cathodes
- Author
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Yan-Yan Hu, Xin Li, Miao Song, Xiang Li, Fredrick Omenya, Biwei Xiao, David Reed, Yuxin Zhang, Khalil Amine, Sha Tan, Feng Lin, Xiaolin Li, Yichao Wang, Kee Sung Han, Xiao-Qing Yang, Enyuan Hu, and Gui-Liang Xu
- Subjects
Phase transition ,Materials science ,010405 organic chemistry ,Oxide ,chemistry.chemical_element ,General Chemistry ,Manganese ,010402 general chemistry ,Electrochemistry ,01 natural sciences ,Catalysis ,Cathode ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,Transition metal ,chemistry ,Chemical engineering ,law ,Phase (matter) ,Vacancy defect - Abstract
Manganese-rich layered oxide materials hold great potential as low-cost and high-capacity cathodes for Na-ion batteries. However, they usually form a P2 phase and suffer from fast capacity fade. In this work, an O3 phase sodium cathode has been developed out of a Li and Mn-rich layered material by leveraging the creation of transition metal (TM) and oxygen vacancies and the electrochemical exchange of Na and Li. The Mn-rich layered cathode material remains primarily O3 phase during sodiation/desodiation and can have a full sodiation capacity of ca. 220 mAh g-1 . It delivers ca. 160 mAh g-1 specific capacity between 2-3.8 V with >86 % retention over 250 cycles. The TM and oxygen vacancies pre-formed in the sodiated material enables a reversible migration of TMs from the TM layer to the tetrahedral sites in the Na layer upon de-sodiation and sodiation. The migration creates metastable states, leading to increased kinetic barrier that prohibits a complete O3-P3 phase transition.
- Published
- 2021
32. Tunable Lithium-Ion Transport in Mixed-Halide Argyrodites Li6–xPS5–xClBrx: An Unusual Compositional Space
- Author
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Sawankumar Patel, Haoyu Liu, Po-Hsiu Chien, Yan-Yan Hu, Jue Liu, Swastika Banerjee, Shyue Ping Ong, Pengbo Wang, and Xuyong Feng
- Subjects
Materials science ,General Chemical Engineering ,Argyrodite ,Halide ,02 engineering and technology ,General Chemistry ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Space (mathematics) ,Thermal conduction ,01 natural sciences ,0104 chemical sciences ,Lithium ion transport ,Chemical physics ,Materials Chemistry ,engineering ,0210 nano-technology - Abstract
Argyrodites, with fast lithium-ion conduction, are promising for applications in rechargeable solid-state lithium-ion batteries. We report a new compositional space of argyrodite superionic conduct...
- Published
- 2021
33. Polymer-based hybrid battery electrolytes: theoretical insights, recent advances and challenges
- Author
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Yan-Yan Hu, Jelena Popovic, Daniel Brandell, Sanyeuki Ohno, Kelsey B. Hatzell, and Jin Zheng
- Subjects
Battery (electricity) ,chemistry.chemical_classification ,Materials science ,Renewable Energy, Sustainability and the Environment ,Nanotechnology ,02 engineering and technology ,General Chemistry ,Polymer ,Electrolyte ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,0104 chemical sciences ,Characterization (materials science) ,chemistry ,Ionic conductivity ,General Materials Science ,0210 nano-technology - Abstract
Polymer-based hybrid electrolytes are a promissing class of materials for solid-state batteries due to their mechanical, physico-chemical and electrochemical properties. This paper gives an in-depth overview of possible ionic conduction mechanisms essential for good battery performance, and related relevant contemporary materials. The materials' preparation and characterization techniques are given in the light of necessity for deeper understanding of the structure–property relationship in such composites.
- Published
- 2021
34. Structure and Properties of Cs7(H4PO4)(H2PO4)8: A New Superprotonic Solid Acid Featuring the Unusual Polycation (H4PO4)+
- Author
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Yan-Yan Hu, Sawankumar Patel, Sheel Sanghvi, Louis S. Wang, and Sossina M. Haile
- Subjects
Chemistry ,Transition temperature ,General Chemistry ,Conductivity ,010402 general chemistry ,medicine.disease ,01 natural sciences ,Biochemistry ,Catalysis ,0104 chemical sciences ,Crystallography ,Colloid and Surface Chemistry ,Lattice constant ,Chemical Moiety ,Proton transport ,Phase (matter) ,medicine ,Dehydration ,Superstructure (condensed matter) - Abstract
We report the discovery of a new superprotonic compound, Cs7(H4PO4)(H2PO4)8, or CPP, which forms at elevated temperatures from the reaction of CsH2PO4 and CsH5(PO4)2. The structure, solved using high-temperature single-crystal X-ray diffraction and confirmed by high-temperature 31P NMR spectroscopy, crystallizes in space group Pm3n and has a lattice constant of 20.1994(9) A at 130 °C. The unit cell resembles a 4 × 4 × 4 superstructure of superprotonic CsH2PO4, but features an extraordinary chemical moiety, rotationally disordered H4PO4+ cations, which periodically occupy one of every eight cation sites. The influence of this remarkable cation on the structure, thermodynamics, and proton transport properties of the CPP phase is discussed. Notably, CPP forms at a temperature of 90 °C, much lower than the superprotonic transition temperature of 228 °C of CsH2PO4, and the compound does not appear to have an ordered, low-temperature form. Under nominally dry conditions, the material is stable against dehydration to ∼151 °C, and this results in a particularly wide region of stability of a superprotonic material in the absence of active humidification. The conductivity of Cs7(H4PO4)(H2PO4)8 is moderate, 5.8 × 10-4 S cm-1 at 140 °C, but appears nevertheless facilitated by polyanion (H2PO4-) group reorientation.
- Published
- 2020
35. Combustion Synthesis and Polymer Doping of Metal Oxides for High-Performance Electronic Circuitry
- Author
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Binghao Wang, Wei Huang, Michael J. Bedzyk, Vinayak P. Dravid, Yan-Yan Hu, Tobin J. Marks, and Antonio Facchetti
- Subjects
General Medicine ,General Chemistry - Abstract
ConspectusTransparent conducting oxides (TCOs) are inorganic electrical conductors with optical band gaps greater than 3.3 eV. TCOs have been extensively explored in functional windows, touch screen applications, transparent displays, solar cells, and even electronic circuits. Amorphous metal oxide (a-MO) semiconductors are a TCO class that has made impressive progress since the first 2004 demonstration of their utility as the semiconducting layer in thin-film transistors (TFTs). Their excellent counterintuitive electron mobilities in the amorphous state fill the performance gap between amorphous silicon and polysilicon, widening TFT applicability to high-value products such as high-resolution flat panel displays and emerging flexible/wearable electronics. The possibility of solution processing MO "inks" from air-stable precursors, via roll-to-roll and high-throughput printing, further expands their appeal. However, most MO TFTs fabricated using solution-processing require postdeposition film annealing at elevated temperatures (400 °C) to ensure high-quality films and stable charge transport. Thus, MO fabrication on and TFT integration with inexpensive and typically temperature-sensitive flexible polymer substrates remains challenging, as does reducing MO processing times to those acceptable for high-throughput semiconductor circuit manufacture. Consequently, new MO film processing methodologies are being developed to meet these requirements. Among them, science-based combustion synthesis (CS) and polymer doping are promising complementary approaches to optimize materials quality and manufacturing efficiency; they are the topic of this Account.This Account summarizes the progress in CS and MO polymer doping research, made largely at Northwestern University over the past decade, to create high-performance MO TFTs. Regarding CS, we begin with an overview of combustion precursor chemistry that strongly affects the resulting film quality and device performance. Then, single fuel and dual fuel combustion syntheses for diverse MO systems are discussed. Representative examples highlight recent advances, with a focus on the relationship between (co)fuel-oxidizer types/amounts, thermal behavior, film microstructure, and TFT performance. Next, the discussion focuses on polymer doping of several MO matrices as a new approach to achieve semiconducting MO compositions with excellent performance and mechanical flexibility. Thus, the effect of the polymer architecture and content in the MO precursor formulations on the MO film composition, microstructure, electronic structure, and charge transport are discussed. The concluding remarks highlight challenges and emerging opportunities.
- Published
- 2022
36. Enhanced ion conduction by enforcing structural disorder in Li-deficient argyrodites Li6−xPS5−xCl1+x
- Author
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Po-Hsiu Chien, Xuyong Feng, Sawankumar Patel, Yan-Yan Hu, Haoyu Liu, Yan Wang, Marcello Immediato-Scuotto, and Pengbo Wang
- Subjects
Materials science ,Renewable Energy, Sustainability and the Environment ,Analytical chemistry ,Energy Engineering and Power Technology ,Ionic bonding ,02 engineering and technology ,Electrolyte ,Conductivity ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Dielectric spectroscopy ,Ion ,Fast ion conductor ,Ionic conductivity ,General Materials Science ,0210 nano-technology ,Ion transporter - Abstract
Solid electrolytes with high ionic conductivity and good stability are advantageous over the current liquid electrolytes in rechargeable Li-ion batteries. Argyrodites, Li6PS5X (X = Cl, Br, or I), with ionic conductivities on the order of mS/cm have attracted tremendous attention. However, the high potential of argyrodites in fast ion conduction is far from being reached. Significant enhancement in ion conduction relies on the fundamental understanding of the contributing factors for fast ion transport. Here, we have systematically prepared highly conductive Li-deficient Li6−xPS5−xCl1+x and examined the influence of Li-deficiency and Cl substitution of S on ion transport using impedance spectroscopy, solid-state NMR, and first-principles calculations. With increased Cl content, the amount of Cl− at S2− (4d) sites increases, forming a dominant 1S3Cl (4d) configuration. In addition, Li+ redistributes with significantly higher mobility. As a result, the activation energy for Li-ion transport decreases, and the conductivity increases to 17 mS/cm at 25 °C when x equals 0.7 (Li5.3PS4.3Cl1.7). This work not only reports a record ionic conductivity of Cl-containing argyrodites-type fast Li-ion conductors, but also provides new insights into anion disorder-induced ion transport, which has a wide and universal appeal in the development of fast ion conductors and mixed-anion functional materials.
- Published
- 2020
37. Recent Advances in Solid-State Nuclear Magnetic Resonance Techniques for Materials Research
- Author
-
Haoyu Liu, Yan-Yan Hu, Po-Hsiu Chien, Kent J. Griffith, and Zhehong Gan
- Subjects
Physics ,Condensed matter physics ,Observable ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Magnetization ,Solid-state nuclear magnetic resonance ,General Materials Science ,Spectral resolution ,0210 nano-technology ,Spin (physics) - Abstract
Establishing structure–property correlations is of paramount importance to materials research. The ability to selectively detect observable magnetization from transitions between quantized spin states of nuclei makes nuclear magnetic resonance (NMR) spectroscopy a powerful probe to characterize solids at the atomic level. In this article, we review recent advances in NMR techniques in six areas: spectral resolution, sensitivity, atomic correlations, ion dynamics, materials imaging, and hardware innovation. In particular, we focus on the applications of these techniques to materials research. Specific examples are given following the general introduction of each topic and technique to illustrate how they are applied. In conclusion, we suggest future directions for advanced solid-state NMR spectroscopy and imaging in interdisciplinary research.
- Published
- 2020
38. Frequency-Agile Low-Temperature Solution-Processed Alumina Dielectrics for Inorganic and Organic Electronics Enhanced by Fluoride Doping
- Author
-
Yan-Yan Hu, Haoyu Liu, Binghao Wang, Xinming Zhuang, Chi Zhang, Wei Huang, Tobin J. Marks, Junsheng Yu, Sawankumar Patel, Yao Chen, Vinayak P. Dravid, and Antonio Facchetti
- Subjects
Organic electronics ,Doping ,Analytical chemistry ,Oxide ,General Chemistry ,Dielectric ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Capacitance ,Catalysis ,0104 chemical sciences ,Secondary ion mass spectrometry ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,chemistry ,Thin-film transistor ,Fluoride - Abstract
The frequency-dependent capacitance of low-temperature solution-processed metal oxide (MO) dielectrics typically yields unreliable and unstable thin-film transistor (TFT) performance metrics, which hinders the development of next-generation roll-to-roll MO electronics and obscures intercomparisons between processing methodologies. Here, capacitance values stable over a wide frequency range are achieved in low-temperature combustion-synthesized aluminum oxide (AlOx) dielectric films by fluoride doping. For an optimal F incorporation of ∼3.7 atomic % F, the F:AlOx film capacitance of 166 ± 11 nF/cm2 is stable over a 10-1-104 Hz frequency range, far more stable than that of neat AlOx films (capacitance = 336 ± 201 nF/cm2) which falls from 781 ± 85 nF/cm2 to 104 ± 4 nF/cm2 over this frequency range. Importantly, both n-type/inorganic and p-type/organic TFTs exhibit reliable electrical characteristics with minimum hysteresis when employing the F:AlOx dielectric with ∼3.7 atomic % F. Systematic characterization of film microstructural/compositional and electronic/dielectric properties by X-ray photoelectron spectroscopy, time-of-fight secondary ion mass spectrometry, cross-section transmission electron microscopy, solid-state nuclear magnetic resonance, and UV-vis absorption spectroscopy reveal that fluoride doping generates AlOF, which strongly reduces the mobile hydrogen content, suppressing polarization mechanisms at low frequencies. Thus, this work provides a broadly applicable anion doping strategy for the realization of high-performance solution-processed metal oxide dielectrics for both organic and inorganic electronics applications.
- Published
- 2020
39. Microscopic Insights into the Reconstructive Phase Transition of KNaNbOF5 with 19F NMR Spectroscopy
- Author
-
Po-Hsiu Chien, Haoyu Liu, Chen Huang, James M. Rondinelli, Kenneth R. Poeppelmeier, Sawankumar Patel, Yan-Yan Hu, and Jaye K. Harada
- Subjects
Phase transition ,Materials science ,19f nmr spectroscopy ,General Chemical Engineering ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Crystallography ,Vacancy defect ,Phase (matter) ,Materials Chemistry ,0210 nano-technology ,Perovskite (structure) - Abstract
The centrosymmetric polymorph of KNaNbOF5 undergoes a reconstructive transition from a rare A-site vacancy ordered perovskite to a unique nonperovskite high-temperature phase. Previously, the high ...
- Published
- 2020
40. Fast Ion Conduction and Its Origin in Li6–xPS5–xBr1+x
- Author
-
Sawankumar Patel, Haoyu Liu, Pengbo Wang, Yan-Yan Hu, Yan Wang, Po-Hsiu Chien, and Xuyong Feng
- Subjects
Materials science ,General Chemical Engineering ,Argyrodite ,02 engineering and technology ,General Chemistry ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Thermal conduction ,01 natural sciences ,0104 chemical sciences ,Ion ,Chemical physics ,Materials Chemistry ,Fast ion conductor ,engineering ,Ionic conductivity ,0210 nano-technology ,Electrical conductor - Abstract
High ionic conductivity of solid electrolytes is key to achieving high-power all-solid-state rechargeable batteries. The superionic argyrodite family is among the most conductive Li-ion conductors....
- Published
- 2020
41. Enhanced Ion Conduction in Li2.5Zn0.25PS4 via Anion Doping
- Author
-
Sawankumar Patel, Po-Hsiu Chien, Yan Wang, Xuyong Feng, and Yan-Yan Hu
- Subjects
Materials science ,General Chemical Engineering ,Doping ,Analytical chemistry ,Ionic bonding ,02 engineering and technology ,General Chemistry ,Conductivity ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Thermal conduction ,01 natural sciences ,0104 chemical sciences ,Ion ,Materials Chemistry ,0210 nano-technology - Abstract
Li1+2xZn1–xPS4 was computationally predicted to have superionic conductivity of over 50 mS/cm. However, experimental efforts so far have only yielded ionic conductivities on the order of 10–4 S/cm,...
- Published
- 2020
42. Growth hormone therapy for children with KBG syndrome: A case report and review of literature
- Author
-
Yan-Yan Hu, Xiu-Ying Ge, Wen-Wen Hu, Xiao-Ling Li, and Long Ge
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Growth hormone therapy ,General Medicine ,KBG SYNDROME ,Growth hormone ,Short stature ,KBG syndrome ,03 medical and health sciences ,0302 clinical medicine ,ANKRD11 gene ,030220 oncology & carcinogenesis ,Case report ,medicine ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Children - Abstract
BACKGROUND The incidence of short stature in KBG syndrome is relatively high. Data on the therapeutic effects of growth hormone (GH) on children with KBG syndrome accompanied by short stature in the previous literature has not been summarized. CASE SUMMARY Here we studied a girl with KBG syndrome and collected the data of children with KBG syndrome accompanied by short stature from previous studies before and after GH therapy. The girl was referred to our department because of short stature. Physical examination revealed mild dysmorphic features. The peak GH responses to arginine and clonidine were 6.22 and 5.40 ng/mL, respectively. The level of insulin-like growth factor 1 (IGF-1) was 42.0 ng/mL. Genetic analysis showed a c.2635 dupG (p.Glu879fs) mutation in the ANKRD11 gene. She received GH therapy. During the first year of GH therapy, her height increased by 0.92 standard deviation score (SDS). Her height increased from -1.95 SDS to -0.70 SDS after two years of GH therapy. There were ten children with KBG syndrome accompanied by short stature who received GH therapy in reported cases. Height SDS was improved in nine (9/10) of them. The mean height SDS in five children with KBG syndrome accompanied by short stature increased from -2.72 ± 0.44 to -1.95 ± 0.57 after the first year of GH therapy (P = 0.001). There were no adverse reactions reported after GH treatment. CONCLUSION GH treatment is effective in our girl and most children with KBG syndrome accompanied by short stature during the first year of therapy.
- Published
- 2020
43. Enhanced Surface Interactions Enable Fast Li + Conduction in Oxide/Polymer Composite Electrolyte
- Author
-
Nan Wu, Po‐Hsiu Chien, Yumin Qian, Yutao Li, Henghui Xu, Nicholas S. Grundish, Biyi Xu, Haibo Jin, Yan‐Yan Hu, Guihua Yu, and John B. Goodenough
- Subjects
General Medicine - Published
- 2020
44. Enhanced Surface Interactions Enable Fast Li + Conduction in Oxide/Polymer Composite Electrolyte
- Author
-
Guihua Yu, Po-Hsiu Chien, Yan-Yan Hu, John B. Goodenough, Biyi Xu, Yutao Li, Henghui Xu, Haibo Jin, Nicholas S. Grundish, Yumin Qian, and Nan Wu
- Subjects
chemistry.chemical_classification ,Materials science ,Ethylene oxide ,010405 organic chemistry ,Composite number ,Oxide ,General Chemistry ,Polymer ,Electrolyte ,Conductivity ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,visual_art ,visual_art.visual_art_medium ,Ceramic ,Perovskite (structure) - Abstract
Li+ -conducting oxides are considered better ceramic fillers than Li+ -insulating oxides for improving Li+ conductivity in composite polymer electrolytes owing to their ability to conduct Li+ through the ceramic oxide as well as across the oxide/polymer interface. Here we use two Li+ -insulating oxides (fluorite Gd0.1 Ce0.9 O1.95 and perovskite La0.8 Sr0.2 Ga0.8 Mg0.2 O2.55 ) with a high concentration of oxygen vacancies to demonstrate two oxide/poly(ethylene oxide) (PEO)-based polymer composite electrolytes, each with a Li+ conductivity above 10-4 S cm-1 at 30 °C. Li solid-state NMR results show an increase in Li+ ions (>10 %) occupying the more mobile A2 environment in the composite electrolytes. This increase in A2-site occupancy originates from the strong interaction between the O2- of Li-salt anion and the surface oxygen vacancies of each oxide and contributes to the more facile Li+ transport. All-solid-state Li-metal cells with these composite electrolytes demonstrate a small interfacial resistance with good cycling performance at 35 °C.
- Published
- 2020
45. Fast Li+ Conduction Mechanism and Interfacial Chemistry of a NASICON/Polymer Composite Electrolyte
- Author
-
Nicholas S. Grundish, Biyi Xu, Andrei Dolocan, Yan-Yan Hu, Henghui Xu, John B. Goodenough, Nan Wu, Yutao Li, Haibo Jin, and Po-Hsiu Chien
- Subjects
education.field_of_study ,Chemistry ,Composite number ,Population ,General Chemistry ,Activation energy ,Electrolyte ,Conductivity ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Catalysis ,0104 chemical sciences ,Anode ,Colloid and Surface Chemistry ,Chemical engineering ,visual_art ,Fast ion conductor ,visual_art.visual_art_medium ,Ceramic ,education - Abstract
The unclear Li+ local environment and Li+ conduction mechanism in solid polymer electrolytes, especially in a ceramic/polymer composite electrolyte, hinder the design and development of a new composite electrolyte. Moreover, both the low room-temperature Li+ conductivity and large interfacial resistance with a metallic lithium anode of a polymer membrane limit its application below a relatively high temperature. Here we have identified the Li+ distribution and Li+ transport mechanism in a composite polymer electrolyte by investigating a new solid poly(ethylene oxide) (PEO)-based NASICON-LiZr2(PO4)3 composite with 7Li relaxation time and 6Li → 7Li trace-exchange NMR measurements. The Li+ population of the two local environments in the composite electrolytes depends on the Li-salt concentration and the amount of ceramic filler. A composite electrolyte with a [EO]/[Li+] ratio n = 10 and 25 wt % LZP filler has a high Li+ conductivity of 1.2 × 10-4 S cm-1 at 30 °C and a low activation energy owing to the additional Li+ in the mobile A2 environment. Moreover, an in situ formed solid electrolyte interphase layer from the reaction between LiZr2(PO4)3 and a metallic lithium anode stabilized the Li/composite-electrolyte interface and reduced the interfacial resistance, which provided a symmetric Li/Li cell and all-solid-state Li/LiFePO4 and Li/LiNi0.8Co0.1Mn0.1O2 cells a good cycling performance at 40 °C.
- Published
- 2020
46. Potential effect of non-thermal plasma for the inhibition of scar formation: a preliminary report
- Author
-
Zheng-Cai Wang, Xiao-Feng Wang, Qing-Qing Fang, Zhen Liu, Keping Yan, Bing Jia, Shengyong Yin, Wei-Qiang Tan, and Yan-Yan Hu
- Subjects
medicine.medical_specialty ,Multidisciplinary ,business.industry ,Potential effect ,lcsh:R ,Plasma jet ,Urology ,Scars ,lcsh:Medicine ,Nonthermal plasma ,Helium plasma ,Article ,Skin diseases ,Outcomes research ,Preliminary report ,Medicine ,lcsh:Q ,medicine.symptom ,business ,Wound healing ,lcsh:Science ,Type I collagen - Abstract
Non-thermal plasma (NTP) is a promising biomedical tool for application to wound healing. However, there is limited scientific evidence that confirms its efficacy to inhibit scar formation. This study aims to investigate the role of non-thermal plasma in scar formation. Two full-thickness dorsal cutaneous wounds of rats were treated with either a non-thermal helium plasma jet or helium. It was determined that the non-thermal plasma jet accelerated the wound healing process from 5 days after surgery (day 5: 41.27% ± 2.351 vs 54.7% ± 5.314, p
- Published
- 2020
47. Discordant nature of Cd in PbSe: off-centering and core–shell nanoscale CdSe precipitates lead to high thermoelectric performance
- Author
-
Zhong-Zhen Luo, Songting Cai, Yan-Yan Hu, Ctirad Uher, Chris Wolverton, Trevor P. Bailey, Xiaobing Hu, Shiqiang Hao, Xiang Li, Vinayak P. Dravid, Mercouri G. Kanatzidis, and Ido Hadar
- Subjects
Materials science ,Phonon scattering ,Dopant ,Renewable Energy, Sustainability and the Environment ,Analytical chemistry ,Crystal structure ,Atmospheric temperature range ,Microstructure ,Pollution ,Nuclear Energy and Engineering ,Thermoelectric effect ,Environmental Chemistry ,Spectroscopy ,Wurtzite crystal structure - Abstract
We report a novel hierarchical microstructure in the PbSe–CdSe system, which collectively contributes to significant enhancement in thermoelectric performance, with ZTave ∼ 0.83 across the 400–923 K temperature range, the highest reported for p-type, Te-free PbSe systems. We have investigated the local atomic structure as well as the microstructure of a series of PbSe–xCdSe materials, up to x = 10%. We find that the behavior of the Cd atoms in the octahedral rock salt sites is discordant and results in off-center displacement and distortion. Such off-centered Cd in the PbSe matrix creates (1) L–Σ electronic energy band convergence, (2) a flattened L band, both contributing to higher Seebeck coefficients, and (3) enhanced phonon scattering, which leads to lower thermal conductivity. These conclusions are supported by photoemission yield spectroscopy in air (PYSA), solid state 111Cd, 77Se NMR spectroscopy and DFT calculations. Above the solubility limit (>6%CdSe), we also observe endotaxial CdSe nano-precipitates with core–shell architecture formed in PbSe, whose size, distribution and structure gradually change with the Cd content. The nano-precipitates exhibit a zinc blende crystal structure and a tetrahedral shape with significant local strain, but are covered with a thin wurtzite layer along the precipitate/matrix interface, creating a core–shell structure embedded in PbSe. This newly discovered architecture causes a further reduction in lattice thermal conductivity. Moreover, potassium is found to be an effective p-type dopant in the PbSe–CdSe system, leading to an enhanced power factor, a maximum ZT of ∼1.4 at 923 K for Pb0.98K0.02Se–6%CdSe.
- Published
- 2020
48. Synthesis and characterizations of highly conductive and stable electrolyte Li10P3S12I
- Author
-
Sawankumar Patel, Po-Hsiu Chien, Zhehong Gan, Jin Zheng, Yan Xin, Yan-Yan Hu, Marcello Immediato-Scuotto, Xuyong Feng, and Ivan Hung
- Subjects
Materials science ,Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,Electrolyte ,Activation energy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Ion ,law.invention ,Metal ,chemistry ,Chemical engineering ,law ,visual_art ,Phase (matter) ,visual_art.visual_art_medium ,Ionic conductivity ,General Materials Science ,Lithium ,Crystallization ,0210 nano-technology - Abstract
A novel glass-ceramic solid electrolyte Li10P3S12I is synthesized, which delivers a high ionic conductivity of 6.4 mS/cm at 25 °C and a low activation energy of 0.26 eV. Li10P3S12I also exhibits significantly enhanced stability and low interfacial resistance against Li metal compared with thiophosphates. Tracer-exchange Li NMR reveals that lithium ions transport preferably through the glass phase and glass-ceramic interface in Li10P3S12I. Careful control of the synthesis process to avoid complete crystallization helps stabilize the highly Li-conductive phase.
- Published
- 2019
49. Radical Dimerization in a Plastic Organic Crystal Leads to Structural and Magnetic Bistability with Wide Thermal Hysteresis
- Author
-
Stephen Hill, Minyoung Jo, Chongin Pak, Richard T. Oakley, Jeff Lengyel, Ivan Hung, Samuel M. Greer, Yan-Yan Hu, Alexander S. Filatov, Johannes McKay, Michael Shatruk, Elvis Maradzike, Sebastian A. Stoian, Alina Dragulescu-Andrasi, Ashfia Huq, Kristina Lekin, A. Eugene DePrince, and Xiang Li
- Subjects
Phase transition ,Chemistry ,General Chemistry ,Nuclear magnetic resonance spectroscopy ,Crystal structure ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Catalysis ,0104 chemical sciences ,law.invention ,Crystallography ,Paramagnetism ,Colloid and Surface Chemistry ,law ,Phase (matter) ,Plastic crystal ,Electron paramagnetic resonance ,Powder diffraction - Abstract
The nitroxyl radical 1-methyl-2-azaadamantane N-oxyl (Me-AZADO) exhibits magnetic bistability arising from a radical/dimer interconversion. The transition from the rotationally disordered paramagnetic plastic crystal, Me-AZADO, to the ordered diamagnetic crystalline phase, (Me-AZADO)2, has been conclusively demonstrated by crystal structure determination from high-resolution powder diffraction data and by solid-state NMR spectroscopy. The phase change is characterized by a wide thermal hysteresis with high sensitivity to even small applied pressures. The molecular dynamics of the phase transition from the plastic crystal to the conventional crystalline phase has been tracked by solid-state (1H and 13C) NMR and EPR spectroscopies.
- Published
- 2019
50. Phase transitions and potential ferroelectricity in noncentrosymmetric KNaNbOF5
- Author
-
Po-Hsiu Chien, Yan-Yan Hu, Jaye K. Harada, Kenneth R. Poeppelmeier, Haoyu Liu, Sawankumar Patel, Nenian Charles, Ching-Hwa A. Chen, and James M. Rondinelli
- Subjects
Phase transition ,Materials science ,Physics and Astronomy (miscellaneous) ,Condensed matter physics ,0103 physical sciences ,General Materials Science ,02 engineering and technology ,021001 nanoscience & nanotechnology ,010306 general physics ,0210 nano-technology ,01 natural sciences ,Ferroelectricity - Published
- 2021
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