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Hengyu Zhai, Wenhai Li, Kun Jiang, Yanan Zhi, Zhao Yang Department of Thoracic Surgery, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, 710000, People’s Republic of ChinaCorrespondence: Zhao Yang, Department of Thoracic Surgery, Xi’an International Medical Center Hospital, No. 777 Xitai Road, Xi’an, Shaanxi, 710000, People’s Republic of China, Email Zhaoyang_666@aliyun.comBackground: Patients with locally advanced (stage III) non-small cell lung cancer (NSCLC) demonstrate broad anatomic heterogeneity with modest survival benefits. Immune checkpoint inhibitors (ICIs) have shown survival benefit in metastatic NSCLC. We conducted this study to evaluate the efficacy and safety of neoadjuvant nivolumab in combination with chemotherapy in the treatment of this population.Methods: We retrospectively evaluated patients with locally advanced NSCLC receiving neoadjuvant nivolumab and chemotherapy (paclitaxel with carboplatin) followed by surgery at our institution from January 2019 to January 2020.Results: A total of 46 eligible patients, 26 males, and 20 females were diagnosed with NSCLC in a stage IIIA (30 cases) and IIIB (16 cases) to receive neoadjuvant treatment. The treatment was well tolerated with just 7 (15.2%) typical immune-related adverse events (hyperthyroidism, hyperglycemia, and rash) recorded. A total of 45 patients underwent surgical resection, and 43 (95.6%) of them achieved a R0 resection. No major surgical complications were observed. There was a complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) in 2 (4.3%), 26 (56.5%), 17 (37.0%), 6 (26.1%), and 1 (2.2%) patients. Eight patients resulted in a major pathological response (MPR) (17.4%) and 24 patients had a pathological complete response (pCR) (52.2%). At the time of data cutoff (June 1, 2021), the median follow-up period was 15.5 months (IQR 3.9– 29) and 27 (60%) of 45 patients who had tumor resection were progression free. At 24 months, progression-free survival was 45.8% and overall survival was 79.9%.Conclusion: Nivolumab plus paclitaxel and carboplatin could be a potential neoadjuvant regimen for patients with locally advanced NSCLC, rendering a potentially lethal disease to one that is curable.Keywords: non-small cell lung cancer, neoadjuvant therapy, immunotherapy, chemotherapy, DFS, OS

This paper systematically presents the design and performance of an extremely sensitive 1.55-µm free-space monostatic laser Doppler vibrometer (LDV) using optical homodyne detection for real-time acquisition and enhancement of the remote acoustic signals. The phase shifts produced by laser light scattered off a remote target carries the extremely tiny vibration displacement information of the target’ surface motivated by the acoustic source around and is demodulated using the optical in-phase/quadrature demodulator. The real-time acquisitions of the remote acoustic signals, including the sinusoidal signal and the speech signal at the target distance of 100 m, is performed between two buildings. The real-time speech enhancement of remote speech signals is also carried out by the different algorithms based on the short-time spectral magnitude, and the comprehensible speech signals can be reconstructed. The results demonstrate that the designed free-space monostatic homodyne LDV has a low system background noise and can offer high precision for the uncooperative targets in the real-time acquisition of the remote acoustic signal.

Distributed database services are an increasingly important part of cloud computing. They are required to satisfy several key properties, including consensus and fault tolerance. Given the highly concurrent nature of these systems, subtle errors can arise that are difficult to discover through traditional testing methods. Formal verification can help in discovering bugs and ensuring correctness of these systems. In this paper, we apply formal methods to specify and verify an industrial distributed database, Taurus, which uses a combination of several fundamental protocols, including Multi-Version Concurrency Control and Raft-based Cluster Management. TLA\(^{+}\) is used to model an abstraction of the system and specify its properties. The properties are verified using the TLC model checker, as well as by theorem proving using the TLA proof system (TLAPS). We show that model checking is able to reproduce a bug in Taurus that was found during testing. But our most significant result is twofold: we successfully verified an abstract model of Taurus, and convinced our industrial partners of the usefulness of formal methods to industrial systems.

This study proposes two types of metasurfaces to adjust the phase of wavefront based on geometric phases. Specifically, a meta-atom etched by two different elliptic cylinders possesses more adjusted parameters and satisfies some demanding design conditions. Under the illumination of circularly polarized light, one of them, metalens, can focus the light with a focusing efficiency of 60 %. The other can generate vortex beams with an efficiency of ∼55%. Such metasurfaces can be used as planar optical components in biological, medical, and intelligent wearable fields.

Angular spectroscopy of light scattering can be used for quantitative analysis of cellular and subcellular properties, and thus promises a noninvasive methodology for in vivo assessment cellular integrity to complement in vitro histological examination. Spatial information is essential for accurate identification of localized abnormalities. However, conventional angular spectroscopy systems only provide single-channel measurement, which suffers from poor spatial resolution or requires time-consuming scanning over extended area. The purpose of this study was to develop a multi-channel angular spectroscopy for light field imaging in biological tissues.A microlens array (MLA) (8×8) based light field imager for 64-channel angular spectroscopy was developed. A pair of crossed polarizers was employed for polarization-sensitive recording to enable quantitative measurement at high signal specificity and sensitivity. The polarization-sensitive light field imager enables rapid measurement of multiple sampling volumes simultaneously at 18 μm spatial-resolution and 3° angular-resolution. Comparative light field imaging and electrophysiological examination of freshly isolated and physiologically deteriorated lobster leg nerves have been conducted.Two-dimensional (2D) polarization-sensitive scattering patterns of the fresh nerves were highly elliptical, while they gradually lost the ellipticity and became rotationally symmetric (i.e., circular) as the nerves physiologically deteriorated due to repeated electrical stimulations. Characterized parameters, i.e., the ellipticity and the scattering intensity, rendered spatially various characteristics such as different values and deteriorating rates.The polarization-sensitive light field imager is able to provide multi-channel angular spectroscopy of light scattering with both spatial and angular resolutions. The light scattering properties of nerves are highly dependent on the orientation of nerves and their physiological status. Further development of polarization-sensitive multi-channel angular spectroscopy may promise a methodology for rapid and reliable identification of localized abnormalities in biological tissues.

A novel type of electro-optic scanner is presented which can satisfy the requirements for high speed and large-angle. It is a two-stage cascade system which consists of a fine scanning system implemented by using voltage-controlled refraction-based electro-optic deflectors and a coarse scanning using several LiNbO 3 electro-optic switch and polarization beam splitter system. The deflection angle can be enlarged by using the coarse-fine cascaded system. We demonstrate the design scheme of the proposed large-angle optical beam scanner. The system is analyzed and simulated theoretically. It is shown that proper design of the parameters of coarse-fine cascaded two-stage system can lead to an optimal beam scanner with enhanced performance of large angle and high speed. The analysis and observations will be valuable for the accurate design and fabrication of the novel optical scanning devices based on electro-optic effect.

Characteristic of electro-optic modulation of light propagating near the optic axis in a uniaxial crystal is well known but not for the cases of propagating bias the optic axis. In this paper, two pairs of LiNbO 3 crystal plates with the same sizes consist of an optical system in where the sum of geometrically optical length of o-ray and e-ray is equal. And then the characteristics of electro-optic modulation of light propagating bias the optic axis in LiNbO 3 are studied experimentally through a coherent received system. The additional phase shift caused by electro-optic effect is measured. The relation of phase shift varying with applied electric-field is reported when the angle between incident beam and the optic axis is 45o. Based on above experiments, a new 90o optical hybrid will be developed. Key words: LiNbO 3 crystal; electro-optic modulation; phase shift 1. INTRODUCTION The electro-optic effect of crystal is the basic of many electro-optic devices [1-4] . It plays an important role in the fields of optical information processing and optical communication. The properties of electro-optic modulation along optical axis are well known