Search

Your search keyword '"Yang, Chunzheng"' showing total 162 results
Start Over Author "Yang, Chunzheng"
162 results on '"Yang, Chunzheng"'

5. NIR‐Activatable Heterostructured Nanoadjuvant CoP/NiCoP Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy and Photoimmunotherapy

Author

Yang, Chunzheng, primary, Zhang, Jiashi, additional, Chang, Mengyu, additional, Tan, Jia, additional, Yuan, Meng, additional, Bian, Yulong, additional, Liu, Bin, additional, Liu, Zhendong, additional, Wang, Meifang, additional, Ding, Binbin, additional, Ma, Ping'an, additional, and Lin, Jun, additional

Published
2023
Full Text
View/download PDF

20. Heterostructural Nanoadjuvant CuSe/CoSe2for Potentiating Ferroptosis and Photoimmunotherapy through Intratumoral Blocked Lactate Efflux

Author

Yang, Chunzheng, Wang, Man, Chang, Mengyu, Yuan, Meng, Zhang, Wenying, Tan, Jia, Ding, Binbin, Ma, Ping’an, and Lin, Jun

Abstract

The desirable curative effect in clinical immunotherapy has been challenging due to the immunosuppressive tumor microenvironment (TME) with high lactic acid (LA) metabolism in solid tumors. Although targeting metabolic reprogramming of tumor cells can restore the survival and function of immune cells in the TME, it is also plagued by insufficient immunogenicity. Herein, an activatable immunomodulatory nanoadjuvant CuSe/CoSe2@syrosingopine (CSC@Syro) is constructed for simultaneously relieving immunosuppressive TME and boosting tumor immune response. Specifically, CuSe/CoSe2(CSC) exhibits TME-activated glutathione (GSH) depletion and hydroxyl radical (•OH) generation for potential ferroptosis. Meanwhile, the remarkable photothermal conversion efficiency and elevated photocatalytic ROS level both promote CSC heterostructures to induce robust immunogenic cell death (ICD). Besides, the loaded syrosingopine inhibitor achieves LA metabolism blockade in cancer cells by downregulating the expression of monocarboxylate transporter 4 (MCT4), which could sensitize ferroptosis by intracellular milieu acidification and neutralize the acidic TME to alleviate immunosuppression. Hence, advanced metabolic modulation confers the potentiated immune infiltration of ICD-stimulated T lymphocytes and further reinforces antitumor therapy. In brief, CSC@Syro-mediated synergistic therapy could elicit potent immunogenicity and suppress tumor proliferation and metastasis effectually by integrating the tumor metabolic regulation and ferroptosis with immunotherapy.

Published
2023
Full Text
View/download PDF

30. Core–Shell Structured Upconversion/Lead‐Free Perovskite Nanoparticles for Anticounterfeiting Applications.

Author

Xiao, Hui, Liu, Bin, Qiu, Lei, Li, Guogang, Zhang, Guodong, Huang, Dayu, Zhao, Yajie, Yang, Chunzheng, Jiang, Fan, Dang, Peipei, Lian, Hongzhou, Cheng, Ziyong, and Lin, Jun

Subjects
NANOPARTICLES, ULTRAVIOLET lasers, PEROVSKITE, PARAMETRIC downconversion, METAL halides
Abstract

In view of their excellent luminescence properties, nanocrystalline metal halide perovskites have diverse optoelectronic applications, including those related to anticounterfeiting. However, high‐quality optical anticounterfeiting typically requires multiple encryptions relying on several optical modes to ensure information security. Herein, an efficient anticounterfeiting strategy based on dual optical encryption is realized by combining up‐ and downconversion luminescence in a nanocomposite with NaYF4 : Er3+,Yb3+ as core and a CsMnCl3 as shell. The emission color of this nanocomposite depends on the penetration depth of incident radiation and can be changed by varying the excitation source (980 nm laser or UV light) to produce different luminescent patterns. This feature allows one to effectively improve the anticounterfeiting index and fabricate professional anticounterfeiting materials. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

39. Numerical Simulation of Fluid Flow and Thermal Characteristics of Thin Slab in the Funnel-Type Molds of Two Casters

Author

Yang Chunzheng, Qijie Zhai, Gan Yong, Hui Zhang, and Heping Liu

Subjects
Engineering, Caster, business.industry, Mechanical Engineering, Flow (psychology), Metals and Alloys, Mechanical engineering, Mechanics, Electromagnetic brake, Mechanics of Materials, Casting (metalworking), Heat transfer, Materials Chemistry, Slab, Fluid dynamics, Foundry, business
Abstract

A mathematical model of three-dimensional fluid flow, heat transfer and solidification in thin slab casting is developed based on the enthalpy-porosity approach in a single-phase framework and used to analyze and compare the fluid flow and thermal behaviors in the funnel-type molds of Compact Strip Production (CSP®) and Flexible Thin Slab Casting (FTSC®) caster. An Electromagnetic Brake (EMBR) model is also incorporated into this coupled model to see the effects of EMBR on fluid flow and solidification in a CSP caster with EMBR system. The numerical treatments specific to the complex funnel-shaped mold boundaries are discussed. The obtained numerical results are partly validated by those available in literature and theoretical analyses. The fluid flow and thermal features of thin slab in CSP mold and FTSC mold are analyzed and their comparisons between them are made. It is found that the flow pattern, level fluctuation, superheat dissipation, temperature distribution and shell growth in both molds present different features. The structure of SEN strongly affects the flow pattern of the impinging jet from SEN ports, and then the dissipation mode of the melt superheat and the uniform growth of solidification shell. A four-port SEN® with two small upper ports in FTSC mold is helpful to activate the meniscus flow and increase the meniscus temperature, but high level fluctuation may occur. The EMBR in a CSP mold can both suppress the meniscus flow and increase the meniscus temperature. A complete flow-control system including the design of SEN, EMBR and operational conditions is essential for thin slab production considering their individual flow and thermal features in the funnel-type molds of CSP and FTSC casters.

Published
2011

41. Efficient Inhibition of Human B-cell Lymphoma in SCID Mice by Synergistic Antitumor Effect of Human 4-1BB Ligand/Anti-CD20 Fusion Proteins and Anti-CD3/Anti-CD20 Diabodies

Author

Liu, Rong, Jiang, Wenguo, Yang, Ming, Guo, Hongxing, Zhang, Yanjun, Wang, Jinhong, Zhu, Huifang, Shi, Ruizan, Fan, Dongmei, Yang, Chunzheng, Zhu, Zhenping, Xie, Yong, Xiong, Dongsheng, Liu, Rong, Jiang, Wenguo, Yang, Ming, Guo, Hongxing, Zhang, Yanjun, Wang, Jinhong, Zhu, Huifang, Shi, Ruizan, Fan, Dongmei, Yang, Chunzheng, Zhu, Zhenping, Xie, Yong, and Xiong, Dongsheng

Abstract

Here we constructed and produced a recombinant human 4-1BB ligand (4-1BBL)/anti-CD20 fusion protein and examined its antitumor activity, alone and in combination with an anti-CD3/anti-CD20 bispecific diabody. The 4-1BBL/anti-CD20 fusion protein retained both the costimulatory activity of 4-1BBL on T cells and the tumor targeting ability of CD20 antibody on B cells. The fusion protein bound as efficiently to 4-1BB-and CD20-positive cells as its respective parental antibodies, and was capable of cross-linking human T lymphocytes and CD20-positive tumor cells. Combination treatment with 4-1BBL/anti-CD20 fusion protein and anti-CD3/anti-CD20 diabody led to significantly increased T-cell cytotoxicity to human B-lymphoma cells in vitro and drastically more potent tumor inhibitory activity in vivo in xenografted B-cell lymphoma in severe combined immunodeficiency disease mice. Mechanistic studies revealed that the combination treatment remarkably inhibited apoptosis of human peripheral blood lymphocytes, accompanied by upregulation of Bcl-X-L and Bf1-1, perforin and granzyme B mRNA, and increased interleukin-2 production. Taken together, these results suggest that targeted delivery of 4-1BBL to the tumor site, when combined with anti-CD3/anti-CD20 diabody, could strongly potentiate the antitumor activity of the diabody, thus may have significant clinical application in the treatment of human CD20-positive B-cell malignancies.

Published
2010

42. Synthesis of a Dual Functional Anti-MDR Tumor Agent PH II-7 with Elucidations of Anti-Tumor Effects and Mechanisms

Author

Su, Ye, primary, Cheng, Xin, additional, Tan, Yaohong, additional, Hu, Yunhui, additional, Zhou, Yuan, additional, Liu, Juanni, additional, Xu, Yuanfu, additional, Xie, Yinliang, additional, Wang, Caiyun, additional, Gao, Yingdai, additional, Wang, Jianxiang, additional, Cheng, Tao, additional, Yang, Chunzheng, additional, Xiong, Dongsheng, additional, and Miao, Hua, additional

Published
2012
Full Text
View/download PDF

44. Efficient Inhibition of Human B-cell Lymphoma in SCID Mice by Synergistic Antitumor Effect of Human 4-1BB Ligand/Anti-CD20 Fusion Proteins and Anti-CD3/Anti-CD20 Diabodies

Author

Liu, Rong, primary, Jiang, Wenguo, additional, Yang, Ming, additional, Guo, Hongxing, additional, Zhang, Yanjun, additional, Wang, Jinhong, additional, Zhu, Huifang, additional, Shi, Ruizan, additional, Fan, Dongmei, additional, Yang, Chunzheng, additional, Zhu, Zhenping, additional, Xie, Yong, additional, and Xiong, Dongsheng, additional

Published
2010
Full Text
View/download PDF

47. Extracellular domain of 4-1BBL enhanced the antitumoral efficacy of peripheral blood lymphocytes mediated by anti-CD3×anti-Pgp bispecific diabody against human multidrug-resistant leukemia

Author

Guo, Hongxing, primary, Jiang, Wenguo, additional, Liu, Wenge, additional, Gao, Yingdai, additional, Yang, Ming, additional, Zhou, Yuan, additional, Wang, Jinhong, additional, Qi, Jing, additional, Cheng, Xin, additional, Zhu, Zhenping, additional, Yang, Chunzheng, additional, and Xiong, Dongsheng, additional

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results