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The present paper is aimed to investigate the correlation between the fat mass and the bone mass, and to investigate the effect of leptin on bone metabolism in female ovariectomic rats. Forty Wistar female rats, 6-month-old, were randomly divided into the sham surgical (Sham) group and ovariectomic (OVX) group. The body weight, the fat mass inside the abdominal cavity, the bone mineral density (BMD) were determined by DEXA method, and the concentration of leptin was measured by ELISA after operation. The Rats' body mass in ovariectomized group increased significantly (P < 0.05), while the fat mass in abdominal cavity was not increased obviously in ovariectomized group (P = 0.499). The concentration of leptin was no difference between the two groups (P = 0.166). Bone mineral content (BMC)/weight in ovariectomized group was decreased significantly than the sham group (P = 0. 003). The weight at 8th week post-operation was negative correlation with BMC/weight in Sham group and was positive with BMD in OVX group. The fat mass and the leptin concentration were negative correlation with BMC/ weight in Sham group. It was concluded that the fat mass and the leptin were raleted to the BMC/weight.

Objective: To establish an osteoporosis screening tool for Chinese 40-years-old or above women., Methods: The T-score was calculated based on the mean bone mineral density (BMD) of 20-39 years women. Considering the result of dual-energy X-ray absorptiometry(DXA) as the golden criteria, the Bayes discriminant analysis was employed to explore the function., Results: The formula of the screening tool for Chinese 40-years-old or above women as following:osteoporosis screenig tool for Chinese (OSTC):Weight-2 x age+50. OSTC< or =0 was classified into high risk, OSTC>0 was low risk. The hit rate of OSTC was 75.78%. The sensitivity is 76.8%. The specificity is 75.1%, Kappa value was 0.51(P= 0.000). That means the consistency of diagnosis result between OSTC and DXA was relatively good., Conclusion: OSTC is a simple tool. Just based on age and weight, it can evaluate the osteoporosis risk of Chinese 40-years-old or above women. But the effect of OSTC has not been proved by other dataset and should be tested further.

Recently some studies have showed that bone strength may avoid the misdiagnosis and missed diagnosis of osteoporosis(OP) by bone mineral density (BMD) alone. It was found that corrected bone mineral content (cBMC) was well correlated with bone strength. In this study bone strength was replaced by cBMC to compare it with BMD, and evaluate whether BMD has limitations in the diagnosis of OP in obese individuals. one hundred and two healthy subjects in the community with the body mass index (BMI) between 25 and 39 kg/m2 were enrolled. There were 31 males and 71 females with a mean age of 37.2 +/- 9.4 years. Their BMD and BMC of lower limbs, trunk and the whole body were measured with dual energy X-ray absorptiometry (DEXA). cBMC was expressed by BMC divided by weight. Intra abdominal fat area (IAFA) was measured by CT scan at the level between 4th-5th lumbar vertebra. Linear correlation analysis with SPSS 10.0 soft pack was used for statistics. The results showed that there was a positive correlation and tendency between body weight, BMI and BMD values of lower limbs, trunk and the whole body. However, negative correlation and tendency were demonstrated between body weight, BMI and cBMC, between IAFA and BMD of lower limbs, trunk and the whole body and between IAFA and cBMC as well. We found that the tendency of changes of cBMC and bone strength was similar. So we suggest in certain extent that cBMC could replace bone strength in the diagnosis of OP in obese individuals.

Objective: To understand the distribution of prevalence rate of osteoporosis in the middle - aged and elderly in parts of China., Methods: Bone mineral density (BMD) was measured and questionnaires were taken for 5593 people aged above 40 years in five administrative areas in China selected by the stratified - multi - steps - cluster sampling method., Results: The total prevalence rate of osteoporosis was 16.1%. The prevalence rate among males was 11.5% and among females was 19.9% (P < 0.01). There were also osteoporosis prevalence differences among cities, age groups, gender groups and areas., Conclusion: The prevention and treatment of osteoporosis are very important for females but also should not be ignored in males.