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290 results on '"Yang, Hongfang"'

11. Study on high power gyrotron multimode coupling launcher

Author

Zhao Guohui, Xiao Jing, Gao Zhigang, Zhang Heng, and Yang Hongfang

Subjects
Physics, QC1-999
Abstract

In this paper, an improved coupled-mode method is used to design a launcher for a gyrotron quasi-optical mode converter at 170 Ghz with an operating mode of TE32,9. The new method calculates 25 coupled modes, which more accurately simulates the field distribution in the launcher. The diffraction field of the launcher with a spiral cut is calculated by using the scalar diffraction integral method with fast Fourier transform. The radiation power of the launcher is 99.94%, the Gaussian mode content of the radiation beam is 98.40%, the diffraction loss of the launcher is 0.0580%, and the radiation efficiency is 98.34%. The method proposed in this paper is fast in calculation and can be applied to the large-scale high-frequency gyrotron launcher.

Published
2023
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14. A strategy for quality evaluation of complex herbal preparations based on multi-color scale and efficacy-oriented high-performance thin-layer chromatography characteristic fingerprint combined with chemometric method: Sanwujiao Pills as an example

Author

Wenhan, Pei, primary, Huang, Yufeng, additional, Qu, Yuan, additional, Cui, Xiuming, additional, Zhou, Liqin, additional, Yang, Hongfang, additional, Zhao, Mingshun, additional, Zhang, Zhifeng, additional, He, Fan, additional, and Zhou, Hua, additional

Published
2023
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16. Selective Upcycling of Polyethylene Terephthalate towards High‐valued Oxygenated Chemical Methyl p‐Methyl Benzoate using a Cu/ZrO2 Catalyst.

Author

Cheng, Jianian, Xie, Jin, Xi, Yongjie, Wu, Xiaojing, Zhang, Ruihui, Mao, Zhihe, Yang, Hongfang, Li, Zelong, and Li, Can

Subjects
METHYL benzoate, POLYETHYLENE terephthalate, CATALYSTS, ACTIVATION energy, COPPER catalysts, COPPER, SCISSION (Chemistry)
Abstract

Upgrading of polyethylene terephthalate (PET) waste into valuable oxygenated molecules is a fascinating process, yet it remains challenging. Herein, we developed a two‐step strategy involving methanolysis of PET to dimethyl terephthalate (DMT), followed by hydrogenation of DMT to produce the high‐valued chemical methyl p‐methyl benzoate (MMB) using a fixed‐bed reactor and a Cu/ZrO2 catalyst. Interestingly, we discovered the phase structure of ZrO2 significantly regulates the selectivity of products. Cu supported on monoclinic ZrO2 (5 %Cu/m‐ZrO2) exhibits an exceptional selectivity of 86 % for conversion of DMT to MMB, while Cu supported on tetragonal ZrO2 (5 %Cu/t‐ZrO2) predominantly produces p‐xylene (PX) with selectivity of 75 %. The superior selectivity of MMB over Cu/m‐ZrO2 can be attributed to the weaker acid sites present on m‐ZrO2 compared to t‐ZrO2. This weak acidity of m‐ZrO2 leads to a moderate adsorption capability of MMB, and facilitating its desorption. Furthermore, DFT calculations reveal Cu/m‐ZrO2 catalyst shows a higher effective energy barrier for cleavage of second C−O bond compared to Cu/t‐ZrO2 catalyst; this distinction ensures the high selectivity of MMB. This catalyst not only presents an approach for upgrading of PET waste into fine chemicals but also offers a strategy for controlling the primary product in a multistep hydrogenation reaction. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists

Author

Kollmann, Christopher S., Bai, Xiaopeng, Tsai, Ching-Hsuan, Yang, Hongfang, Lind, Kenneth E., Skinner, Steven R., Zhu, Zhengrong, Israel, David I., Cuozzo, John W., Morgan, Barry A., Yuki, Koichi, Xie, Can, Springer, Timothy A., Shimaoka, Motomu, and Evindar, Ghotas

Published
2014
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24. Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis

Author

Wenji Su, Mengyuan Ni, Yulong An, Yanfang Shen, Yang Hongfang, Peng Xuanjia, Xiaodong Shi, Xiaojie Lu, Huanan Wen, Xu Yanfen, Kuai Letian, Weiren Cui, Qu Yi, Li Ke, Alexander L. Satz, and Sixiu Liu

Subjects
Bromides, 0301 basic medicine, Halogenation, Biophysics, chemistry.chemical_element, Conjugated system, Alkylation, Hydrocarbons, Aromatic, Methylation, Biochemistry, Catalysis, Coupling reaction, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Amide, Borates, Combinatorial Chemistry Techniques, Molecular Biology, Amination, Aryl, DNA, Cell Biology, Combinatorial chemistry, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Reagent, Potassium, Palladium
Abstract

A mild reaction for DNA-compatible, palladium promoted Suzuki-Miyaura cross-coupling reaction of potassium Boc-protected aminomethyltrifluoroborate with DNA-conjugated aryl bromides has been developed efficiently. This novel DNA encoded chemistry reaction proceeded well with a wide range of functional group tolerance, including aryl bromides and heteroaryl bromides. Further, the utility our DNA conjugated aminomethylated arene products is demonstrated by reaction with various types of reagents (including amide formation with carboxylic acids, alkylation with aldehydes, and carbamoylation with amines) as would be desired for the production of a DNA encoded library.

Published
2020

28. Copper-Mediated DNA-Compatible One-Pot Click Reactions of Alkynes with Aryl Borates and TMS-N3

Author

Xiaodong Shi, Gao Hong, Alexander L. Satz, Kuai Letian, Yang Hongfang, Jiangong Wang, Weiren Cui, Qu Yi, Huanan Wen, Xu Yanfen, Peng Xuanjia, Rui Ge, and Wenji Su

Subjects
Sanger sequencing, 010405 organic chemistry, DNA damage, Aryl, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Cycloaddition, 0104 chemical sciences, chemistry.chemical_compound, symbols.namesake, chemistry, Intramolecular force, Functional group, Click chemistry, symbols, Molecule, Physical and Theoretical Chemistry
Abstract

We report a DNA-compatible copper-mediated efficient synthesis of 1,2,3-triazoles via a one-pot reaction of aryl borates with TMS-N3 followed by a click cycloaddition reaction. Employing the binuclear macrocyclic nanocatalyst Cu(II)-β-cyclodextrin, the reactions were performed under mild conditions with high conversions and wide functional group tolerance. We also demonstrate the reaction application toward a one-pot DNA-compatible intramolecular macrocyclization. Our optimized reaction protocol results in no significant DNA damage as judged by qPCR analysis and Sanger sequencing data.

Published
2020

29. DNA Compatible Intermolecular Wittig Olefination for the Construction of α, β-Unsaturated Carbonyl Compounds

Author

Lichun Zhou, Disha Wang, Yulong An, Hu Yujing, Chen Linlin, Yanfang Shen, Wenji Su, Li Ke, Hong Zibing, Xiaodong Shi, Liu Shi'en, Kuai Letian, Weiren Cui, Yang Hongfang, and Peng Xuanjia

Subjects
Aldehydes, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Intermolecular force, Stereoisomerism, DNA, Ketones, 010402 general chemistry, 01 natural sciences, Biochemistry, Chloride, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Covalent bond, Wittig reaction, medicine, Molecule, Physical and Theoretical Chemistry, medicine.drug
Abstract

A robust DNA-compatible Wittig reaction mediated by PPh2CH3 has been validated for DNA-conjugated α-chloroacetamides with aldehydes and, alternatively, DNA-conjugated aldehydes with α-halo acetamides or ketones. Further, 2-aminopyridines were acylated with α-chloroacetyl chloride and then reacted with DNA-conjugated aldehydes. Lastly, a pilot library employing our optimized Wittig reaction protocol was synthesized. The ability to generate α,β-unsaturated carbonyl compounds may be particularly useful for the design of DNA-encoded libraries capable of covalently interacting with protein targets.

Published
2020

30. A Strategy for the Synthesis of Sulfonamides on DNA

Author

Deng Wei, Wu Aliang, Li Ke, Liu Wei, Justin Dietrich, Yuan Youlang, Sun Saisai, Peng Xuanjia, Yang Hongfang, Yu Chunyan, Zhonglin Ma, and Xubo Su

Subjects
chemistry.chemical_classification, Sulfonamides, Molecular Structure, Sodium, Organic Chemistry, chemistry.chemical_element, DNA, Sulfinic acid, Sulfinic Acids, Iodine, Biochemistry, Combinatorial chemistry, Sulfonamide, chemistry.chemical_compound, chemistry, Bifunctional reagent, Amines, Physical and Theoretical Chemistry
Abstract

An efficient method is reported to synthesize sulfonamides on DNA from sulfinic acids or sodium sulfinates and amines in the presence of iodine under mild conditions. This method demonstrates a major expansion of scope of sulfonamide formation on DNA through the utilization of a novel sodium carbonate-sodium sulfinate bifunctional reagent class.

Published
2019

35. Synthesis of 1,2-Amino Alcohols by Photoredox-Mediated Decarboxylative Coupling of α-Amino Acids and DNA-Conjugated Carbonyls

Author

Peng Xuanjia, Huanan Wen, Rui Ge, Qi Zhang, Jialin Sun, Wenji Su, Yulong An, Yang Hongfang, Kuai Letian, Weiren Cui, Qu Yi, Hao Yan, Xiaodong Shi, and Alexander L. Satz

Subjects
2019-20 coronavirus outbreak, DNA damage, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Sequencing data, Conjugated system, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, chemistry.chemical_compound, Physical and Theoretical Chemistry, chemistry.chemical_classification, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, DNA, Ketones, Combinatorial chemistry, Amino Alcohols, 0104 chemical sciences, Amino acid, Coupling (electronics), Cyclization, Oxidation-Reduction
Abstract

We report a DNA-compatible photoredox decarboxylative coupling of α-amino acids with carbonyl compounds to access DNA-encoded sp3-rich 1,2-amino alcohols. The reaction proceeds efficiently for a wide range of DNA-conjugated aldehydes and ketones and provides the desired 1,2-amino alcohols with conversions generally >50%. Additional utility of the developed protocol is demonstrated by one-pot cyclization of DNA-conjugated 1,2-amino alcohols into oxazolidiones and morpholinones. Lastly, qPCR and sequencing data analysis indicates no significant DNA damage upon photoredox decarboxylative coupling.

Published
2020

36. DNA-Compatible Copper-Catalyzed Oxidative Amidation of Aldehydes with Non-Nucleophilic Arylamines

Author

Yulong An, Andrew J Little, Peng Xuanjia, Wenji Su, Xiaodong Shi, Eric C. Breinlinger, Yang Hongfang, Duanchen Ding, Weiren Cui, Kuai Letian, Matthew P. Webster, Qu Yi, Jiangong Wang, Huanan Wen, Meng Zhao, Alexander L. Satz, and Li Ke

Subjects
Biomedical Engineering, Pharmaceutical Science, Bioengineering, 02 engineering and technology, Oxidative phosphorylation, 01 natural sciences, Catalysis, chemistry.chemical_compound, Nucleophile, Amines, Pharmacology, Dna integrity, Aldehydes, Aniline Compounds, 010405 organic chemistry, Aryl, Organic Chemistry, DNA, 021001 nanoscience & nanotechnology, Combinatorial chemistry, Amides, 0104 chemical sciences, chemistry, Functional group, Copper catalyzed, 0210 nano-technology, Oxidation-Reduction, Copper, Biotechnology
Abstract

We report a DNA-compatible protocol for synthesizing amides from DNA-bound aldehydes and non-nucleophilic arylamines including aza-substituted anilines, 2-aminobenzimidazoles, and 3-aminopyrazoles. The reactions were carried out at room temperature and provided reasonable conversions and wide functional group compatibility. The reactions were also successful when employing aryl and aliphatic aldehydes. In addition, qPCR and NGS data suggested no negative impact on DNA integrity after the copper-mediated oxidative amidation reaction.

Published
2020

37. Solution Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering

Author

Kuai Letian, Weiren Cui, Mingyue Zheng, Qingxia Sun, Hualiang Jiang, Sixiu Liu, Xiaodong Shi, Yanfang Shen, Zhiqiang Duan, Peng Xuanjia, Wenji Su, Xiaojie Lu, Xiaohong Liu, Yang Hongfang, Kaixian Chen, Yulong An, Alexander L. Satz, and Li Ke

Subjects
Reaction conditions, Pictet–Spengler reaction, business.industry, Computer science, Rational design, Value (computer science), Machine learning, computer.software_genre, Solution phase, chemistry.chemical_compound, chemistry, Artificial intelligence, business, Protocol (object-oriented programming), computer, DNA, Block (data storage)
Abstract

The application of machine learning towards DNA encoded library (DEL) technology is lacking despite obvious synergy between these two advancing technologies. Herein, a machine learning algorithm has been developed that predicts the conversion rate for the DNA compatible reaction of a building block with a model DNA-conjugate. We exemplify the value of this technique with a challenging reaction, the Pictet-Spengler, where acidic conditions are normally required to achieve the desired cyclization between tryptophan and aldehydes to provide tryptolines. To avoid damaging the DNA our reaction conditions must be exceptionally mild, and therefore most building blocks fail to provide acceptable yields of desired product ( 78% pass rate. This is the first demonstration of using a machine learning algorithm to cull potential building blocks prior to their purchase and testing for DNA encoded library synthesis. Importantly, this allows for a challenging reaction, with an otherwise very low building block pass rate in the test reaction, to still be used in DEL synthesis. Furthermore, we discuss herein the rational design of DNA conjugated tryptophan substrates for our Pictet-Spengler reaction, and optimization of the reaction protocols. Lastly, because our protocol is solution-phase it is directly applicable to standard plate-based DEL synthesis.

Published
2020

39. Palladium-mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected aminomethyltrifluoroborate with DNA-Conjugated aryl bromides for DNA-Encoded chemical library synthesis

Author

Qu, Yi, primary, Liu, Sixiu, additional, Wen, Huanan, additional, Xu, Yanfen, additional, An, Yulong, additional, Li, Ke, additional, Ni, Mengyuan, additional, Shen, Yanfang, additional, Shi, Xiaodong, additional, Su, Wenji, additional, Cui, Weiren, additional, Kuai, Letian, additional, Satz, Alexander L., additional, Yang, Hongfang, additional, Lu, Xiaojie, additional, and Peng, Xuanjia, additional

Published
2020
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41. Synthesis of 1,2-Amino Alcohols by Photoredox-Mediated Decarboxylative Coupling of α-Amino Acids and DNA-Conjugated Carbonyls

Author

Wen, Huanan, primary, Ge, Rui, additional, Qu, Yi, additional, Sun, Jialin, additional, Shi, Xiaodong, additional, Cui, Weiren, additional, Yan, Hao, additional, Zhang, Qi, additional, An, Yulong, additional, Su, Wenji, additional, Yang, Hongfang, additional, Kuai, Letian, additional, Satz, Alexander L., additional, and Peng, Xuanjia, additional

Published
2020
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43. Diradical Character and Controllable Magnetic Properties in Chitin Through Radical Modification.

Author

KONG Lingqian, YANG Hongfang, QIAN Zhaohong, ZHOU Lianwen, ZHANG Mei, and XU Jing

Subjects
BIRADICALS, MAGNETIC properties, MAGNETIC materials, MAGNETIC control, FERROMAGNETIC materials
Abstract

The parent and radical-modified chitin units are computationally studied and the parent chitin unit possesses closed-shell singlet (CS) state as its ground state. Two radicals (CH3. and CH3CH2.) are chosen to modify the parent chitin unit. Calculations predict that CH3CH2·-modified chitin unit possesses the open-shell brokensymmetry (BS) singlet diradical ground state, different from that CH3·-modified chitin unit is a triplet diradical. That is to say, the magnetic conversion can occur from nonmagnetic exchange coupling to antiferromagnetic(AFM) or ferromagnetic(FM) exchange coupling by means of the radical modification method. The present work helps to get a basic understanding of structures and electronic properties of chitin and its radical-modified derivatives at the atomistic level. Moreover, it also provides a feasible way to design new chitin-based magnetic materials and organic magnetic switches. [ABSTRACT FROM AUTHOR]

Published
2022
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44. DNA-Compatible Copper-Catalyzed Oxidative Amidation of Aldehydes with Non-Nucleophilic Arylamines

Author

Li, Ke, primary, Qu, Yi, additional, An, Yulong, additional, Breinlinger, Eric, additional, Webster, Matthew P., additional, Wen, Huanan, additional, Ding, Duanchen, additional, Zhao, Meng, additional, Shi, Xiaodong, additional, Wang, Jiangong, additional, Su, Wenji, additional, Cui, Weiren, additional, Satz, Alexander L., additional, Yang, Hongfang, additional, Kuai, Letian, additional, Little, Andrew, additional, and Peng, Xuanjia, additional

Published
2020
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46. DNA Compatible Intermolecular Wittig Olefination for the Construction of α, β-Unsaturated Carbonyl Compounds

Author

An, Yu-Long, primary, Li, Ke, additional, Shen, Yanfang, additional, Hong, Zibing, additional, Chen, Linlin, additional, Hu, Yujing, additional, Zhou, Lichun, additional, Wang, Disha, additional, Shi, Xiaodong, additional, Liu, Shien, additional, Su, Wenji, additional, Cui, Weiren, additional, Kuai, Letian, additional, Yang, Hongfang, additional, and Peng, Xuanjia, additional

Published
2020
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49. Solution Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering

Author

Li, Ke, primary, Liu, Xiaohong, additional, Liu, Sixiu, additional, An, Yulong, additional, Shen, Yanfang, additional, Sun, Qingxia, additional, Shi, Xiaodong, additional, Su, Wenji, additional, Cui, Weiren, additional, Duan, Zhiqiang, additional, Kuai, Letian, additional, Yang, Hongfang, additional, Satz, Alexander L., additional, Chen, Kaixian, additional, Jiang, Hualiang, additional, Zheng, Mingyue, additional, Peng, Xuanjia, additional, and Lu, Xiaojie, additional

Published
2020
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50. A Strategy for the Synthesis of Sulfonamides on DNA

Author

Liu, Wei, primary, Deng, Wei, additional, Sun, Saisai, additional, Yu, Chunyan, additional, Su, Xubo, additional, Wu, Aliang, additional, Yuan, Youlang, additional, Ma, Zhonglin, additional, Li, Ke, additional, Yang, Hongfang, additional, Peng, Xuanjia, additional, and Dietrich, Justin, additional

Published
2019
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