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We aimed to analyze the correlations of the expressions of Toll-like receptor 4 (TLR4) and Janus kinase 3 (JAK3) in peripheral blood mononuclear cells (PBMCs) with T helper 17 cell (Th17)/regulatory T cell (Treg) imbalance in patients with ankylosing spondylitis (AS).

Investigating the constituents of active catalysts is crucial for the advancement of ORR electrocatalysts that are both high in performance and stability, aiming to supplant the expensive platinum-based alternatives, yet this task continues to be a persistent challenge. Firstly, HA nanoplates of hydroxyapatite nanocontainers were decorated with zeolite imidazole salt framework (named as HA-ZIF) by hydrothermal synthesis method, and then Co-based imidazole zeolite framework decorated with Zn group was synthesized by simple self-assembly method, and it was calcined at different temperatures. Finally, the ORR performance obtained samples (named as Co2(PO4)2@NC-800, Co2(PO4)2@NC-900 and Co2(PO4)2@NC-1000) was tested by cyclic voltammetry (CV) and linear scanning voltammetry (LSV), and the morphological and structural characterization of composite catalysts at different temperatures were analyzed by PXRD and SEM. It was found that the Co2(PO4)2@NC-900 had the best catalytic performance. The study presents a flexible approach for creating versatile non-precious catalysts applicable to various energy-related electrocatalytic processes.

The stability of each train, high control accuracy, and minimum safe separation distance are important indexes to measure the performance of the cooperative control system of multiple trains. In this article, aiming at the problem of low accuracy of multiple trains cooperative control with nonlinear running resistance and external disturbance, the distributed cooperative robust adaptive control scheme for multiple trains with RBFNN position output constraints based on train running curve tracking is proposed. Multiple different control techniques are offered for different trains, and that they are based on local knowledge of position, speed, and acceleration. The leading train's speed and position precisely match the planned operation curve, while the following train keeps the tracking interval at the minimum safe distance between two trains. In order to reduce the influence of the uncertainty of basic resistance parameters and external interference on the cooperative control of multiple trains, the parameter uncertainties are compensated by adding a robust adaptive law to the multiple trains control based on position output constraints. The lumped exogenous disturbances (additional resistance, external interference, measurement noise, etc.) are estimated using an RBFNN approximator for the unknown term of the cooperative system. The stability of the cooperative operation of multiple trains is confirmed using the Lyapunov stability theorem. The performance of the proposed scheme was evaluated by the cooperative control system of multiple trains in predecessor following (PF) and bidirectional control (BC) modes. [ABSTRACT FROM AUTHOR]

Background: Chronic obstructive pulmonary disease (COPD) is a widespread inflammatory disease with a high mortality rate. Long noncoding RNAs play important roles in pulmonary diseases and are potential targets for inflammation intervention. Methods: The expression of small nucleolar RNA host gene 6 (SNHG6) in mouse lung epithelial cell line MLE12 with or without cigarette smoke extract (CSE) treatment was first detected using quantitative reverse‐transcription PCR. ELISA was used to evaluate the release of inflammatory cytokines (TNF‐α, IL‐1β, and IL‐6). The binding site of miR‐182‐5p with SNHG6 was predicted by using miRanda, which was verified by double luciferase reporter assay. Results: Here, we revealed that SNHG6 was upregulated in CS‐exposed MLE12 alveolar epithelial cells and lungs from COPD‐model mice. SNHG6 silencing weakened CS‐induced inflammation in MLE12 cells and mouse lungs. Mechanistic investigations revealed that SNHG6 could upregulate IκBα kinase through sponging the microRNA miR‐182‐5p, followed by activated NF‐κB signaling. The suppressive effects of SNHG6 silencing on CS‐induced inflammation were blocked by an miR‐182‐5p inhibitor. Conclusion: Overall, our findings suggested that SNHG6 regulates CS‐induced inflammation in COPD by activating NF‐κB signaling, thereby offering a novel potential target for COPD treatment. [ABSTRACT FROM AUTHOR]

CO2 cycloaddition with epoxides is a key catalytic procedure for CO2 utilization. Several metal-based catalysts with cocatalysts are developed for photo-driven CO2 cycloaddition, while facing difficulties in product purification and continuous reaction. Here, poly(ionic liquid)s are proposed as metal-free catalysts for photo-driven CO2 cycloaddition without cocatalysts. A series of poly(ionic liquid)s with donor-acceptor segments are fabricated and their photo-driven catalytic performance (conversion rate of 83.5% for glycidyl phenyl ether) outstrips (≈4.9 times) their thermal-driven catalytic performance (17.2%) at the same temperature. Mechanism studies confirm that photo-induced charge separation is promoted by the donor-acceptor segments and can accelerate the CO2 cycloaddition reaction. This work paves the way for the further use of poly(ionic liquid)s as catalysts in photo-driven CO2 cycloaddition. [ABSTRACT FROM AUTHOR]