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Metabolism reprogramming within the tumor microenvironment (TME) can have a profound impact on immune cells. Identifying the association between metabolic phenotypes and immune cells in lung adenocarcinoma (LUAD) may reveal mechanisms of resistance to immune checkpoint inhibitors (ICIs). Metabolic phenotypes were classified by expression of metabolic genes. Somatic mutations and transcriptomic features were compared across the different metabolic phenotypes. The metabolic phenotype of LUAD is predominantly determined by reductase-oxidative activity and is divided into two categories: redoxhigh LUAD and redoxlow LUAD. Genetically, redoxhigh LUAD is mainly driven by mutations in KEAP1, STK11, NRF2, or SMARCA4. These mutations are more prevalent in redoxhigh LUAD (72.5%) compared to redoxlow LUAD (17.4%), whereas EGFR mutations are more common in redoxlow LUAD (19.0% vs. 0.7%). Single-cell RNA profiling of pre-treatment and post-treatment samples from patients receiving neoadjuvant chemoimmunotherapy revealed that tissue-resident memory CD8+ T cells are responders to ICIs. However, these cells are significantly reduced in redoxhigh LUAD. The redoxhigh phenotype is primarily attributed to tumor cells and is positively associated with mTORC1 signaling. LUAD with the redoxhigh phenotype demonstrates a lower response rate (39.1% vs. 70.8%, p = 0.001), shorter progression-free survival (3.3 vs. 14.6 months, p = 0.004), and overall survival (12.1 vs. 31.2 months, p = 0.022) when treated with ICIs. The redoxhigh phenotype in LUAD is predominantly driven by mutations in KEAP1, STK11, NRF2, and SMARCA4. This phenotype diminishes the number of tissue-resident memory CD8+ T cells and attenuates the efficacy of ICIs. [ABSTRACT FROM AUTHOR]

The high local electron density and efficient charge carrier separation are two important factors to affect photocatalytic activity, especially for the CO2 photoreduction reaction. However, the systematic studies on the structure‐functional relationship regarding the above two factors based on precisely structure model are rarely reported. Herein, as a proof‐of‐concept, we developed a new strategy on the evaluation of local electron density by controlling the relative electron‐deficient (ED) and electron‐rich (ER) intensity of monomer at a molecular level based on three rational‐designed vinylene‐linked sp2 carbon‐covalent organic frameworks (COFs). As expected, the as‐prepared vinylene‐linked sp2 carbon‐conjugated metal‐covalent organic framework (MCOFs) (VL‐MCOF‐1) with molecular junction exhibited excellent activities for CO2‐to‐HCOOH conversion (283.41 μmol g−1 h−1) and high selectivity of 97.1 %, much higher than the VL‐MCOF‐2 and g‐C34N6‐COF, which is due to the synergistic effect of the multi‐electronic metal clusters (Cu3(PyCA)3) (PyCA=pyrazolate‐4‐carboxaldehyde) as strong ER roles and cyanopyridine units as ED roles and active sites, as well as the boosted photo‐induced charge separation efficiency of vinyl connection and increased light utilization ability. These results not only provide a strategy for regulating the electron‐density distribution of photocatalysts at the molecular level but also offers profound insights for metal clusters‐based COFs to effective CO2 conversion. [ABSTRACT FROM AUTHOR]

An understanding of the relative contributions of sheet and rill erosion to the total soil loss associated with individual events and of changes in their relative importance during an event is important for developing more effective soil erosion prediction models and for predicting the physical and geochemical properties of the eroded sediment in relation to those of the in situ soil. it is difficult to obtain information on variations in the relative importance of sheet and rill erosion during an event using traditional monitoring techniques. The use of environmental radionuclides, particularly beryllium-7 (Be-7) and cesium-137 (Cs-137), as sediment tracers offers an alternative approach to obtaining this information. Because of their contrasting depth distributions, the two radionuclides provide a means of distinguishing sediment eroded from the soil surface by sheet or interrill erosion and that eroded from greater depths by rill erosion. The approach was tested using simulated rainfall experiments undertaken on two small erosion plots located in Yichuan County, Shaanxi Province, China, representative of cultivated land and uncultivated land previously under forest. The results confirmed that the development of rills within the plots was clearly marked by changes in the Be-7 activity of the sediment eroded from the cultivated plot and changes in the Be-7 and Cs-137 activity of the sediment eroded from the uncultivated plot. By relating the changes in the Be-7 and Cs-137 activity of the eroded soil to information on the depth distribution of the two radionuclides in the soils of the two plots and the mass of soil eroded, it was possible to estimate the relative contributions of the two erosion processes to the total soil loss and their changes through an event. This information provided a basis for investigating the influence of temporal variations in the relative contributions of sheet and rill erosion during an event on variations in the physical and geochemical properties of the sediment eroded from the plot during the event.

As hot topics in the chemical conversion of CO2, the photo‐/electrocatalytic reduction of CO2 and use of CO2 as a supporter for energy storage have shown great potential for the utilization of CO2. However, many obstacles still exist on the road to realizing highly efficient chemical CO2 conversion, such as inefficient uptake/activation of CO2 and mass transport in catalysts. Covalent organic frameworks (COFs), as a kind of porous material, have been widely explored as catalysts for the chemical conversion of CO2 owing to their unique features. In particular, COF‐based functional materials containing diverse active sites (such as single metal sites, metal nanoparticles, and metal oxides) offer great potential for realizing CO2 conversion and energy storage. This Minireview discusses recent breakthroughs in the basic knowledge, mechanisms, and pathways of chemical CO2 conversion strategies that use COF‐based functional catalysts. In addition, the challenges and prospects of COF‐based functional catalysts for the efficient utilization of CO2 are also introduced. [ABSTRACT FROM AUTHOR]

To effectively utilize the vegetation on grain-for-green slopes in the wind-water erosion crisscross region, it is necessary to determine the reasonable vegetation utilization intensity. We set up runoff plots on slopes which were not cultivated and were closed for many years in the Liudaogou catchment, a typical catchment in wind-water erosion crisscross region of the Loess Plateau. With artificial simulated rainfall experiments, the characteristics of runoff and sediment yield on slopes (10°, 20° and 30°) under different utilization intensity of vegetation were studied to select the reasonable utilization intensity. The results showed that the runoff rate in the process of rainfall simulation could be divided into two periods; rapidly increasing in the initial period and slow increasing or quasi-steady state in the middle and late periods. The variation of erosion rate during the rainfall was dependent on the slope. The utilization intensity had a significant effect on the runoff yield, which increased with the increasing utilization intensities. The slope gradient had a significant effect on the sediment yield, with the variation of sediment yield with slope gradient being; 20°>30°>10°. Compared with the unused (natural) plots, the relative runoff and sediment increased with increasing utilization intensities. Predicted based on the rainfall data, annual soil erosion amount on the slope would be basically lower than the tolerance level of soil loss when the vegetation cover on the slope surface reached 25% in 15 years after abandoning reclamation. More attention should be paid to the restoration and management of vegetation on the slope of 20° in this area. [ABSTRACT FROM AUTHOR]