Search

Your search keyword '"Yang, Nailin"' showing total 166 results
Start Over Author "Yang, Nailin"
166 results on '"Yang, Nailin"'

17. Liquid metal droplet robot

Author

Li, Fangxia, Shu, Jian, Zhang, Leran, Yang, Nailin, Xie, Jie, Li, Xiangpeng, Cheng, Liang, Kuang, Shaolong, Tang, Shi-Yang, Zhang, Shiwu, Li, Weihua, Sun, Lining, and Sun, Dong

Published
2020
Full Text
View/download PDF

29. Association of Neutrophil Extracellular Traps with Fistula Healing in Patients with Complex Perianal Fistulizing Crohn’s Disease

Author

Cao, Dongxing, primary, Qian, Keyu, additional, Zhao, Ying, additional, Hong, Jie, additional, Chen, Haoyan, additional, Wang, Xiaohui, additional, Yang, Nailin, additional, Zhang, Cheng, additional, Cao, Jingkai, additional, Jia, Keyu, additional, Wu, Guangyu, additional, Zhu, Mingming, additional, Shen, Jun, additional, Zhang, Ye, additional, Cui, Zhe, additional, and Wang, Zheng, additional

Published
2022
Full Text
View/download PDF

34. Association of Neutrophil Extracellular Traps with Fistula Healing in Patients with Complex Perianal Fistulizing Crohn's Disease.

Author

Cao, Dongxing, Qian, Keyu, Zhao, Ying, Hong, Jie, Chen, Haoyan, Wang, Xiaohui, Yang, Nailin, Zhang, Cheng, Cao, Jingkai, Jia, Keyu, Wu, Guangyu, Zhu, Mingming, Shen, Jun, Zhang, Ye, Cui, Zhe, and Wang, Zheng

Abstract

Background and Aims Perianal fistulizing Crohn's disease [pfCD] is a disabling phenotype of Crohn's disease [CD] with suboptimal outcomes. We assessed neutrophil extracellular traps [NETs] in perianal fistulas and implicated their roles in pfCD healing. Methods Patients with complex pfCD who developed preplaced seton drainage were recruited during the verified maintenance of remission in CD. Fistula tracts were sampled during definitive surgery plus seton removal. Patient demographics, CD classification, medication strategy and healing of pfCD were recorded. RNA sequencing was applied for transcriptomic profile analysis. NET components, including myeloperoxidase [MPO], neutrophil elastase [NE] and citrullinated histone H3 [CitH3], were identified using immunofluorescence. Serum infliximab [IFX], anti-IFX antibodies, and tissue levels of IFX, adalimumab [ADA], MPO and CitH3 were determined using enzyme-linked immunosorbent assays. Peptidyl arginine deiminase IV [PAD4], tumour necrosis factor [TNF]-α, and NE were detected using immunohistochemistry. Gene expression levels of PAD family members were assessed with quantitative PCR. Results Twenty-one patients were included, 15 of whom adopted IFX as maintenance treatment. RNA-sequencing revealed differences in neutrophil associated pathways between unhealed and healed fistulas. NET components [MPO/NE/CitH3] were detectable in the fistulas and were parallel with the levels of PAD4. Eleven of 21 [52%] patients experienced complete healing of the pfCD 108 weeks post-operatively. Fistula NETs were significantly increased in patients with unhealed pfCD. Increased NETs were associated with abundant TNF-α production and the absence of IFX in fistulas. Conclusions NETs exist in pfCD fistulas, which are associated with unhealed post-operative fistulas in pfCD, suggesting their prognostic roles in pfCD. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

38. Mechanically active adhesive and immune regulative dressings for wound closure

Author

Hu, Jiaying, primary, Wei, Ting, additional, Zhao, He, additional, Chen, Muchao, additional, Tan, Yanjun, additional, Ji, Zhaoxin, additional, Jin, Qiutong, additional, Shen, Jingjing, additional, Han, Yikai, additional, Yang, Nailin, additional, Chen, Linfu, additional, Xiao, Zhisheng, additional, Zhang, Han, additional, Liu, Zhuang, additional, and Chen, Qian, additional

Published
2021
Full Text
View/download PDF

41. HXV2O5 Nanocatalysts Combined with Ultrasound for Triple Amplification of Oxidative Stress to Enhance Cancer Catalytic Therapy.

Author

Hou, Linqian, Gong, Fei, Han, Zhihui, Wang, Yuanjie, Yang, Yuqi, Cheng, Shuning, Yang, Nailin, Liu, Zhuang, and Cheng, Liang

Subjects
OXIDATIVE stress, CELL death, CANCER treatment, REACTIVE oxygen species, ULTRASONIC imaging, DNA damage
Abstract

Multiple amplification of tumor oxidative stress has been demonstrated as efficient strategy to enhance the reactive oxygen species (ROS)‐mediated cancer therapy. Herein, vanadium‐based nanocatalysts, hydrogen vanadium bronzes (HXV2O5, for short HVO), were constructed and employed as novel biocatalysts for amplifying tumor oxidative stress and enhancing cancer catalytic therapy. Such HVO nanocatalysts harboring multivalent V element possessed multi‐functional catalytic activity in decomposing H2O2 into ⋅OH and depleting endogenous glutathione (GSH) to dually amplify tumor oxidative stress. Meanwhile, HVO nanocatalysts could also be activated by ultrasound to further triply amplify oxidative stress. The massive intracellular ROS caused mitochondrial dysfunction, DNA damage, cell cycle arrest, and cell proliferation inhibition, further realizing cancer cell death and tumor growth inhibition. Collectively, HVO nanocatalysts highlight the remarkable value of ROS‐mediated cancer therapies. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

50. Nano‐Engineered Magnesium Implants for Magnetothermal Enhanced Pyroptosis to Boost Immunotherapy.

Author

Han, Xiao, Sun, Shumin, Yang, Nailin, Han, Zhihui, Pei, Zifan, Yu, Qiao, Nie, Jihu, Wang, Li, Liu, Anhong, Meng, Xiangxue, Wang, Zhanhui, and Cheng, Liang

Abstract

Hepatocellular carcinoma (HCC) is one of the leading contributors to cancer‐related death because the immunosuppressive tumor microenvironment (TME) limits its therapeutic efficacy. Gasdermin (GSDM)‐mediated pyroptosis is a new programmed cell death that can boost antitumor immune responses. However, inducing efficient pyroptosis to reverse the immunosuppressive TME is challenging. Herein, layered double hydroxide‐coated magnesium (Zn‐LDH@Mg) implants are designed and constructed as alternating magnetic field (AMF)‐activated pyroptosis inducers to induce highly effective pyroptosis in cancer cells. The powerful eddy‐thermal effects of Zn‐LDH@Mg implants markedly amplify pyroptosis in malignant cells through the Caspase‐1/GSDMD‐dependent canonical pathway. Moreover, Mg2+ and pyroptosis synergistically activate T cells (especially CD8+ T cells) and enhance the infiltration of immune‐supportive cells. This innovative strategy not only significantly suppresses the proliferation of the primary tumor but also stimulates the immune response to further enhance the efficacy of immune checkpoint inhibitors and impede the progression of distant tumors. This work not only emphasizes the importance of surface engineering strategies for the preparation of novel pyroptosis inducers but also highlights the effectiveness of the strategy in reversing the immunosuppressive TME to enhance immunotherapy, providing a new approach for the rational design of bioactive materials to increase the efficacy of immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results