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948 results on '"Yang, Nian"'

8. Comparison of Jinzhen oral liquid and ambroxol hydrochloride and clenbuterol hydrochloride oral solution in the treatment of acute bronchitis in children: A multicenter, non-inferiority, prospective, randomized controlled trial

Author

Fan, Qinhua, Wu, Chongming, Du, Yawei, Wang, Boyang, Xie, Yanming, Zhang, Zeling, Su, Wenquan, Wang, Zizhuo, Xu, Changchang, Li, Xueke, Ding, Ying, An, Xinjiang, Chen, Jing, Xiao, Yunying, Yu, Rong, Li, Nan, Wang, Juan, Teng, Yiqun, Lv, Hongfen, Yang, Nian, Wen, Yuling, Huang, Xiaoli, Pan, Wei, Liu, Yufeng, Xi, Xueqin, Zhao, Qianye, Liu, Changshan, Xu, Jian, Zhang, Haitao, Zhuo, Lie, Rong, Qiangquan, Xia, Yu, Shen, Qin, Li, Shao, Wang, Junhong, and Wu, Shengxian

Published
2024
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34. Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia

Author

Wang, Fei, Yang, Yu-Jian, Yang, Nian, Chen, Xian-Jun, Huang, Nan-Xin, Zhang, Jun, Wu, Yi, Liu, Zhi, Gao, Xing, Li, Tao, Pan, Guang-Qiang, Liu, Shu-Bao, Li, Hong-Li, Fancy, Stephen PJ, Xiao, Lan, Chan, Jonah R, and Mei, Feng

Subjects
Paediatrics, Biomedical and Clinical Sciences, Preterm, Low Birth Weight and Health of the Newborn, Brain Disorders, Rehabilitation, Pediatric, Infant Mortality, Neurosciences, Perinatal Period - Conditions Originating in Perinatal Period, Neurological, Animals, Animals, Newborn, Chronic Disease, Female, Hypoxia, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Myelin Sheath, Neurogenesis, Oligodendroglia, Receptor, Muscarinic M1, Recovery of Function, Synapses, M1R, Olig2, U-50488, beam-walking test, clemastine, hypomyelination, kappa opioid receptor, synaptogenesis, vGlut1, white matter injury, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

To address the significance of enhancing myelination for functional recovery after white matter injury (WMI) in preterm infants, we characterized hypomyelination associated with chronic hypoxia and identified structural and functional deficits of excitatory cortical synapses with a prolonged motor deficit. We demonstrate that genetically delaying myelination phenocopies the synaptic and functional deficits observed in mice after hypoxia, suggesting that myelination may possibly facilitate excitatory presynaptic innervation. As a gain-of-function experiment, we specifically ablated the muscarinic receptor 1 (M1R), a negative regulator of oligodendrocyte differentiation in oligodendrocyte precursor cells. Genetically enhancing oligodendrocyte differentiation and myelination rescued the synaptic loss after chronic hypoxia and promoted functional recovery. As a proof of concept, drug-based myelination therapies also resulted in accelerated differentiation and myelination with functional recovery after chronic hypoxia. Together, our data indicate that myelination-enhancing strategies in preterm infants may represent a promising therapeutic approach for structural/functional recovery after hypoxic WMI.

Published
2018

47. Do Water Pollutant Reduction Projects Promote or Limit Carbon Reduction? Evidence from Building a Beautiful China.

Author

Cheng, Xi, Zhang, Zhong-Xing, Shi, Ting, Yang, Nian, Yang, Shu-Hao, Chen, Jian-Lin, Mao, Guo-Zhu, Qi, Ze-Feng, Rao, Sheng, Duan, Zhi-Guo, and Jiang, Chun-Lai

Subjects
WATER pollution, WATER quality, GREENHOUSE gas mitigation, CHEMICAL oxygen demand, CARBON emissions
Abstract

The total control of major water pollutants (TCMWP) is a critical strategy for improving water quality in China, with the added benefit of yielding climate-related advantages. This study uses the emission factor method to quantify the reductions in pollutants and carbon emissions resulting from China's implementation of TCMWP. A synergy scale for pollution and carbon reduction was constructed to assess the co-benefits of reducing the Chemical Oxygen Demand (COD) and ammonium nitrogen (NH4+-N) and carbon dioxide (CO2) emissions. Furthermore, to account for regional variations in energy structure regulation strategies, whether aggressive or unified, we developed Pollutant Synergistic Carbon Reduction Pathways at the Regional (R.PSCRP) model framework level to evaluate the carbon emission reduction potential of TCMWP during the "14th Five-Year Plan" period. The study revealed that China's unified TCMWP employs different but highly effective combinations of emission reduction paths across different regions. Notably, new renovations and expansions of wastewater treatment facilities (NRE-WWTFS) and pipeline network construction and renovation (CR-PNK) together accounted for 89.3% of the total emission reduction. The construction of key water pollutant reduction projects plays a significant role in reducing carbon emissions at the district level compared to direct discharge practices. Additionally, indirect emissions resulting from TCMWP implementation account for approximately 50% of the total carbon reduction achieved. By aligning either harmonized or independent energy adjustment targets, regions were able to achieve substantial pollution and carbon reduction benefits, ranging from 7.5 to 8 million tons of CO2-equivalent. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Short-term temperature changes affected the predation ability of Orius similis on Bemisia tabaci nymphs.

Author

Zhang, Bo, Yang, Dan, Zhang, Jinlong, Yang, Nian, Kong, Jiao, Hu, Ying, Liu, Jihuan, Liu, Qing, Chen, Guohua, and Zhang, Xiaoming

Subjects
SWEETPOTATO whitefly, TEMPERATURE, PREDATORY animals, PESTS, EGGS, PREDATION
Abstract

Bemisia tabaci (Gennadius), a major pest that can adversely affect economies and agriculture globally, is particularly sensitive to climate change-induced temperature fluctuations, which can intensify its outbreaks. Orius similis Zheng, a primary natural predator of B. tabaci , also experiences temperature-related effects that influence its biocontrol efficacy. Thus, understanding the response of O. similis to temperature changes is pivotal for optimizing its biocontrol potential. Herein, our investigations showed that the functional response of O. similis to both high- and low-instar nymphs of B. tabaci adheres to the type II model at temperatures of 19, 22, 25, 28, and 31 °C. At 28 °C, O. similis exhibits the highest instantaneous attack rate (high-instar: 1.1580, low-instar: 1.2112), and the shortest handling time per prey (high-instar: 0.0218, low-instar: 0.0191). The efficacy of O. similis in controlling B. tabaci nymphs follows the sequence: 28 °C > 25 °C > 31 °C > 22 °C > 19 °C. Additionally, search efficiency inversely correlates with prey density. Simulations using the Hessell–Varley interference model indicate that increased density of O. similis under any temperature condition leads to reduced predation rates. Moreover, O. similis shows a predation preference for low-instar nymphs of B. tabaci , with higher predation level observed at the same temperature. In conclusion, for effective control of B. tabaci in field releases, O. similis should be optimally released at temperatures between 25 and 28 °C to preferably target the egg or early nymph stages of B. tabaci and determining the appropriate number of O. similis is important to minimize interference among individuals and enhance biocontrol efficacy. [ABSTRACT FROM AUTHOR]

Published
2024
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