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High-performance white light-emitting diodes (WLEDs) used for backlighting display applications require innovative and thermally stable narrow-band emission phosphors, particularly non-rare-earth Bi3+-activated phosphors. In this study, we demonstrate a defect-engineering strategy to create novel anti-thermal quenching phosphors Ca 3 Sc 2 Si 3 O 12 : x Bi3+ (CSSO: x Bi3+). Through structure refinement of CSSO: 0.06Bi3+ phosphor, we found that Bi occupies both Ca and Sc sites in the CSSO lattice. Direct visualization of atomic-resolution TEM and thermoluminescence spectra confirmed the formation of point defects due to the non-equivalent substitution of Ca2+ for Bi3+. Fluorescent-decay analysis revealed that two luminescence sites contribute to the blue-emitting of CSSO:Bi3+ phosphors. CSSO: 0.06Bi3+ phosphor exhibits outstanding thermal stability, with an integrated emission intensity of 103.6% at 423 K compared to that at 298 K. However, the addition of Li or Na as charge compensators reduced cationic defects, leading to a decrease in thermal stability. We believe that V C a ″ defects are primarily responsible for the anti-thermal quenching behavior of CSSO: x Bi3+ phosphors. An optimized CSSO: 0.06Bi3+ phosphor-based WLED displays a high color rendering index (CRI) of 90 and a wide color gamut (90% National Television System Committee (NTSC) standard), indicating its potential for use in industrial applications as a backlighting display. [ABSTRACT FROM AUTHOR]

Objective Rapidly progressive interstitial lung disease (RP-ILD) in DM patients positive for anti-melanoma differentiation-associated gene 5 (anti-MDA5) autoantibody (MDA5-DM) often have a poor prognosis, frequently fatal. As there is a scarcity of data regarding the effect of intravenous immunoglobulin (IVIG) on RP-ILD in MDA5-DM patients (MDA5-RPILD), we conducted this study to determine the efficacy of a IVIG add-on initial treatment. Methods Patients with newly-onset MDA5-RPILD from September 2018 to June 2020 were retrospectively reviewed for 6 months in the First Affiliated Hospital of Zhengzhou University. They were divided into two groups: IVIG and non-IVIG groups. The major measurement of treatment outcome was the difference in the mortality in 3-month and 6-month between two group patients. Other relevant indicators were also recorded, including the incidence of infection, the dosages of GCs, the remission rate and the variables in laboratory data. Results The IVIG group (n  = 31) showed significantly lower 6-month mortality rate than the non-IVIG group (n  = 17) (22.6% vs 52.9%; P  =0.033). The IVIG group patients had a higher remission rate at 3 months (71.0% vs 41.2%; P  =0.044). Gradual reduction was observed in the first 3 months with regard to the titre of anti-MDA5 autoantibody, the serum level of ferritin and the ground glass opacification GGO scores. Conclusion IVIG adjunct therapy is a very effective first-line treatment for patients with MDA5-RPILD. IVIG may increase the survival and remission rate by lowering ferritin concentration, anti-MDA5 titre and GGO score. [ABSTRACT FROM AUTHOR]

The synthesis and characterization of six novel naphthol derivatives (1–6) were realized by means of IR, 1H NMR, HRMS and single crystal X-ray crystallography. The anticancer activities of these compounds were investigated against three human gastric cancer cells (MGC-803, SGC-790, MKN45) by MTT assay. In addition, the relationship between anticancer activity and structure of compounds (1–3) was further investigated through molecular docking study. [ABSTRACT FROM AUTHOR]

Eu3+-activated luminous materials play important roles in WLEDs and optical temperature sensors, etc. While most Eu3+-activated phosphors have suffered from notable problems including low thermal quenching (TQ) temperature and quantum efficiency (QE). Here, we report a serial of Ba 3 Eu 2 (BO 3) 4 : xF (BEB: xF) (x = 0–0.7) phosphors covering high QE (97.3%) and excellent thermal stability (83.6%@423 K). Structural and spectral analysis indicate that Eu3+ in the 8 d lattice site dominantly attributes to the red emission. F- ions substitution induces more distorted inversion asymmetry for Eu3+ and results in stronger luminescence. Comparing serials of reported red phosphors under ∼393 nm excitation, these newly developed red phosphors present outstanding QE. Using the new excellent BEB: xF phosphors, two representative WLEDs have been fabricated with a satisfactory color-rendering index and luminous efficacy, demonstrating their potential performance for WLEDs. Meanwhile, a highly sensitive non-contacted optical thermometer has also been designed with the maximum relative sensor sensitivities of about 2.23% and 2.42% K−1 for BEB: xF (x = 0, 0.5) phosphors, respectively. This kind of single-activator doped phosphors provides a new and effective way for realizing dual-functional applications. In addition, the strategy of anion substitution can be adopted to develop optimal phosphors. [Display omitted] • Crystal structure for BEB: F has been determined, with the efficient luminous center Eu3+ located in a 8 d site • F- ions enhanced UV light absorption, leading to the enhanced luminescence intensity of Eu3+ in BEB. • BEB: xF phosphors exhibit intense red emission, high QE and good thermal stability, using for WLED. • 5D 0 and 5D 1 of Eu3+ exhibit different TQ behavior, making BEB: xF phosphors as the promising optical temperature sensor. [ABSTRACT FROM AUTHOR]

Modulating the active sites in atomic level is very meaningful to optimize catalyst performance but still very challenge. Herein, Pt catalysts loaded on different supports (ZSM-5, Al 2 O 3 , ZrO 2 , CeO 2) were sulfate modified by in situ pyrolysis of (NH 4) 2 SO 4 mixed with Pt catalyst. Sulfate remarkably improves these catalyst activities for propane combustion, particularly for the sulfate modified Pt/ZSM-5 catalyst with the highest activity among them. Through controlling the amount of (NH 4) 2 SO 4 used and the loading of Pt, Pt/S atomic ratio in the sulfate modified Pt/ZSM-5 catalyst was successfully regulated. Pt/S atomic ratio significantly affects the electron transfer from Pt species to sulfate and also their interaction strength, which is decisive to the synergetic catalysis of sulfate and Pt species. The 5S-2Pt/ZSM-5 with Pt/S atomic ratio of 0.5 shows a moderate strength of sulfate and Pt species interaction, which is responsible for its highest reaction rate of 86.5 μmol·g Pt −1·s−1 at 200 °C. [Display omitted] • Pt based catalysts were modified with sulfate species by in situ pyrolysis of (NH 4) 2 SO 4. • Pt/S atomic ratio was successfully regulated to optimize catalytic activity for propane oxidation. • The synergy catalysis of sulfate and Pt species for propane oxidation is affected by their interaction strength. • Moderately strong interaction between sulfate and Pt species achieves the highest activity. [ABSTRACT FROM AUTHOR]

H 2 O poisoning of platinum-based catalysts for VOCs oxidation is a long-standing problem due to H 2 O strongly competitive adsorption on active sites. In this work, it is found that the H 2 O competitive adsorption on Pt active sites is effectively weakened by enhancing strong metal-support interaction (SMSI) in Pt-based catalyst. SMSI between WO 3 and Pt species occurs in the WO 3 supported Pt catalyst (Pt/WO 3) but disappears in Pt-3W/ZrO 2 due to monolayer dispersed WO 3 on ZrO 2. The formation of aggregated WO 3 species in Pt-3W/SO 4 2--ZrO 2 leads to the SMSI which is further enhanced by SO 4 2--ZrO 2. The enhanced SMSI plays critical role on weakening water vapor adsorption on active sites, thus Pt-3W/SO 4 2--ZrO 2 exhibits both highest activity (T 90 = 200 °C) and water tolerance which is much superior than Pt/ZrO 2 , Pt/WO 3 , Pt-3W/ZrO 2 and Pt/SO 4 2--ZrO 2 under wet condition (5% H 2 O). Our primary results provide a promising strategy for designing superior platinum catalysts for VOCs complete oxidation. [Display omitted] • Pt-based catalyst with high water tolerance was designed by modulating strong metal-support interaction (SMSI). • WO 3 is monolayer dispersed in Pt-3 W/ZrO 2 but aggregates in Pt-3 W/SO 4 2--ZrO 2. • SMSI disappears in Pt-3 W/ZrO 2 catalyst due to monolayer dispersed WO 3. • Aggregated WO 3 leads to SMSI which is further enhanced by SO 4 2--ZrO 2 in Pt-3 W/SO 4 2--ZrO 2. • Enhanced SMSI weakens the adsorption of water steam on active sites thus improves water tolerance of catalyst. [ABSTRACT FROM AUTHOR]

Antibody targeted delivery is an effective strategy to improve the diagnostic imaging outcome of nanoscale imaging agents in the focal areas. Dual targeting micelles encapsulating superparamagnetic iron oxide were prepared from the amphiphilic block copolymer poly(ethylene glycol)-poly( ɛ-caprolactone) (PEG- b-PCL) with different targeting ligands cRGD and scFv-ErbB single chain antibody conjugated to the distal ends of PEG block. The breast cancer animal model was established by subcutaneous injecting the BT474 cells into the BALB/c-nu female nude mice and then employed to assess the potential of the dual ligand targeted magnetic micelles as a novel MRI contrast agent on a 1.5 T clinical MRI scanner. The T signal intensity of the tumor in animals receiving the dual ligand targeted magnetic micelles via tail vein decreased more significantly than the single ligand targeted and nontargeted magnetic micelles. These results indicate that the dual ligand targeted magnetic micelles, cRGD/scFv-ErbB-PEG-PCL-SPION, have great potential to act as a new type of effective nanoscale MRI contrast agent for early diagnosis of breast cancer. [ABSTRACT FROM AUTHOR]

Immobilization of the chiral salen-metal complex [MnIII(salen)(H2O)2ClO4] on the Keggin-type polyoxometalate (POM) skeletons leads to the isolation of POM derivatives functionalized with chiral salen-metal complexes, which represent the first examples of introducing chiral salen-metal complexes into the POM systems. [ABSTRACT FROM AUTHOR]