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Honeysuckle, as an important medicinal and edible plant, contains a variety of chemical active components, mainly including volatile oils, flavonoids, organic acids and iridoid glycosides, etc., which have antibacterial, antiinflammatory, antiviral, antioxidant, antipyretic, and immunomodulatory effects. Honeysuckle and its extract can improve the digestion, absorption and utilization rate of feed, promote the growth and development of livestock and poultry and meat quality, regulate the metabolism of energy, protein, lipids and sugar of livestock and poultry, and improve the immune function and antioxidant capacity of livestock and poultry. In the paper, the main active components, physiological functions, and application status of honeysuckle and its extracts in livestock and poultry production were summarized, in order to provide a reference for honeysuckle and its extracts to improve the production efficiency and product quality of livestock and poultry, and to replace antibiotics in livestock and poultry production. [ABSTRACT FROM AUTHOR]

Cynanotophyllosides E-F, two new minor pregnane glycosides were isolated from the antidepressant active fraction of cultivated Cynanchum otophyllum, and their structures were determined as 12-O-vanilloyl-deacetylmetaplexigenin 3-O- β -D-glucopyranosyl-(1→4)- β -D-glucopyranosyl-(1→4)- β -D-cymaropyranosyl-(1→4)- β -D-oleandropyranosyl-(1→4)- β -D-digitoxopyranoside, and 12-O-nicotinoyl-deacetylmetaplexigenin 3-O- β -D-glucopyranosyl-(1→4)- β -D-glucopyranosyl-(1→4)- β -D-cymaropyranosyl-(1→4)- β -D-oleandropyranosyl-(1→4)- β -D-cymaropyranoside respectively, with the combination of spectroscopic and chemical analysis. [ABSTRACT FROM AUTHOR]

Two new secolignans, 3,4-trans-3-hydroxymethyl-4-[bis(4-hydroxy-3- methoxyphenyl)methyl]butyrolactone (1) and 3,4-trans-3-hydroxymethyl-4- [bis(3,4-dimethoxyphenyl)methyl]butyrolactone (2) have been isolated from the roots of Urtica fissa E.Pritz. Their structures were determined on the basis of spectroscopic methods, especially 1H NMR, 13C NMR, 2D NMR, and HR-ESI-MS. The inhibitory effects on N1 and N2, two subtypes of neuraminidases (NAs), of these two compounds were assayed. [ABSTRACT FROM AUTHOR]

Context: Antidepressant effects of various plants are generally attributed to their anti-inflammation and antioxidant activities. Cynanchum auriculatum Royle ex Wight (Asclepiadaceae) is a traditional medicinal plant in China and India used for immunological regulation, anti-inflammation, and antioxidant purposes. However knowledge about its antidepressant activity has been poorly investigated. Objective:To investigate the antidepressant activities of the total glycosides of C. auriculatum (TGC) and its CHCl3/MeOH (10:1) fractions (TGC-D and TGC-E) in mice. Materials and methods: TGC, TGC-D and TGC-E (20, 40 and 80 mg/kg) were intragastrically administered to mice twice a day for 5 days. The tail suspension test, forced swimming test, and locomotor activity test in mice were used to evaluate the effect of C. auriculatum. The inhibition of [3H]-serotonin reuptake in rat brain synaptosomes was detected to investigate their mechanism. Results:TGC, TGC-D and TGC-E (80 mg/kg) decreased the immobility time by 61.7, 64.5, and 61.9% in tail suspension test. TGC (80 mg/kg), TGC-D (80 mg/kg) and TGC-E (20 mg/kg) decreased the immobility time by 32.6, 47.3, and 48.7% in forced swimming test. TGC (80 mg/kg) and TGC-E (20 and 40 mg/kg) decreased the crossing distances by 28.8, 29.5, and 36.2% in locomotor activity test. TGC, TGC-D and TGC-E (10 mg/L) inhibited serotonin reuptake by 7.4, 4.5, and 71.1% in rat brain synaptosomes, and IC50 value of TGC-E was 5.2 mg/L. Discussion and Conclusion:TGC, TGC-D and TGC-E have potential antidepressant activities. The antidepressive effect of TGC-E maybe attributed partly by the inhibiting effect on serotonin reuptake. [ABSTRACT FROM AUTHOR]