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18. A Serological Survey of Measles and Rubella Antibodies among Different Age Groups in Eastern China.

Author

Yan, Rui, He, Hanqing, Deng, Xuan, Zhou, Yang, Tang, Xuewen, Zhu, Yao, Liang, Hui, Chen, Yaping, Yang, Mengya, Du, Yuxia, Chen, Can, Chen, Jiaxin, and Yang, Shigui

Subjects
RUBELLA, RUBELLA virus, HERD immunity, MEASLES virus, MEASLES
Abstract

Background: Measles and rubella are vaccine-preventable diseases targeted for elimination in most World Health Organization regions, and China is considered to have momentum towards measles elimination. Therefore, this study aimed to assess the population immunity levels against measles and rubella in Zhejiang Province in China in order to provide valuable insights for informing future public health measures and contributing to the ongoing global campaign against these diseases. Materials and methods: A cross-sectional serological survey was conducted in 2022. A total of 2740 blood samples were collected from healthy individuals spanning the age range of 0–59 years, representing diverse demographic strata across 11 prefectures in Zhejiang Province in China. The sera were tested for measles and rubella IgG antibodies to determine positivity rates and geometric mean concentrations (GMCs). Results: The overall positivity rate for the measles IgG antibody was 85.3%, with a GMC of 588.30 mIU/mL. The positivity rate for the rubella IgG antibody was 70.9%, and the GMC was 35.30 IU/mL. Measles IgG antibody positivity rates across the 0–11 months, 12–23 months, 24–35 months, 3–5 years, 6–9 years, 10–14 years, 15–19 years, 20–29 years, and 30–59 years age groups were 63.1%, 92.5%, 97.0%, 94.0%, 85.8%, 77.3%, 86.9%, 84.9%, and 88.7%, respectively (trend χ2 = 118.34, p < 0.001). Correspondingly, rubella antibody positivity rates for these same age brackets were 55.9%, 87.9%, 94.7%, 88.2%, 69.9%, 54.2%, 72.6%, 67.5%, and 74.3% (trend χ2 = 199.18, p < 0.001). Both univariate and multivariate analyses consistently demonstrated that age, immunization history, and differing economic levels were significant factors contributing to variations in antibody levels. Conclusions: The seroprevalence of measles and rubella was lower than that required for herd immunity. Periodic vaccination campaigns should be launched to increase immunity. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Evaluating Socioeconomic Disparities in Comorbid Chronic Kidney Disease and Hepatitis B or Hepatitis C Infections: A NHANES Analysis

Author

Chen, Juping, primary, Chen, Can, additional, Mi, Fenfang, additional, Yuan, Zhenglin, additional, Qu, Rongrong, additional, Chen, Mengsha, additional, Cao, Kexin, additional, Wu, Xiaoyue, additional, Zhou, Wenkai, additional, Qi, Jiaxing, additional, Yan, Dong, additional, Zhu, Changtai, additional, and Yang, Shigui, additional

Published
2024
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23. Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients

Author

Huang, Fengming, Guo, Jing, Zou, Zhen, Liu, Jun, Cao, Bin, Zhang, Shuyang, Li, Hui, Wang, Wei, Sheng, Miaomiao, Liu, Song, Pan, Jingcao, Bao, Changjun, Zeng, Mei, Xiao, Haixia, Qian, Guirong, Hu, Xinjun, Chen, Yuanting, Chen, Yu, Zhao, Yan, Liu, Qiang, Zhou, Huandi, Zhu, Jindong, Gao, Hainv, Yang, Shigui, Liu, Xiaoli, Zheng, Shufa, Yang, Jiezuan, Diao, Hongyan, Cao, Hongcui, Wu, Ying, Zhao, Min, Tan, Shuguang, Guo, Dan, Zhao, Xiliang, Ye, Yicong, Wu, Wei, Xu, Yingchun, Penninger, Josef M, Li, Dangsheng, Gao, George F, Jiang, Chengyu, and Li, Lanjuan

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Influenza, Infectious Diseases, Pneumonia & Influenza, Hypertension, Cardiovascular, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Angiotensin II, Biomarkers, C-Reactive Protein, Disease Progression, Female, Humans, Influenza A Virus, H7N9 Subtype, Influenza, Human, Male, Middle Aged, Prognosis, Viral Load
Abstract

A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the spring of 2013. This virus causes severe disease in humans, including acute and often lethal respiratory failure. As of January 2014, 275 cases of H7N9-infected patients had been reported, highlighting the urgency of identifying biomarkers for predicting disease severity and fatal outcomes. Here, we show that plasma levels of angiotensin II, a major regulatory peptide of the renin-angiotensin system, are markedly elevated in H7N9 patients and are associated with disease progression. Moreover, the sustained high levels of angiotensin II in these patients are strongly correlated with mortality. The predictive value of angiotensin II is higher than that of C-reactive protein and some clinical parameters such as the PaO2/FiO2 ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen). Our findings indicate that angiotensin II is a biomarker for lethality in flu infections.

Published
2014

32. Acceptance of the Human Papillomavirus Vaccine among General Men and Men with a Same-Sex Orientation and Its Influencing Factors: A Systematic Review and Meta-Analysis.

Author

Shen, Fang, Du, Yuxia, Cao, Kexin, Chen, Can, Yang, Mengya, Yan, Rui, and Yang, Shigui

Subjects
HUMAN papillomavirus vaccines, RANDOM effects model, HUMAN papillomavirus, GENITAL warts, VACCINATION
Abstract

The human papillomavirus (HPV) vaccine reduces the prevalence of genital warts and the cancers they are associated with in males. However, the vaccination of males has always been neglected. Here, we performed a meta-analysis to comprehend the acceptability of the HPV vaccine in men and the factors impacting vaccination intentions. We searched PubMed, Web of Science, Embase, Ovid, CNKI, and Wan Fang up to 5 July 2023 for studies that reported HPV vaccine acceptance among men. A random effects model was used to obtain the pooled acceptance rate, and subgroup analysis was performed. Then, the influencing factors of HPV vaccination in males were analyzed. A total of 57 studies with 32,962 samples were included in the analysis. The overall acceptance rate of the HPV vaccine in general men was 47.04% (95% confidence interval [95%CI]: 39.23–54.93%), and 62.23% (95% CI: 52.93–71.10%) among those whose sexual orientation contained men. HPV vaccine acceptance rates differed significantly between the two populations (p = 0.01). The population with a medical background (46.23%, 95% CI: 40.28–52.24%) was more willing to be vaccinated. In comparison to the employed population (66.93%, 95% CI: 48.79–82.81%) and the unemployed (68.44%, 95% CI: 52.82–82.23%), vaccination acceptance rates were lower among students (47.35%, 95% CI: 37.00–57.81%) (p = 0.04). The most significant barriers to vaccination were perceived low risk of infection for themselves (45.91%, 95% CI: 31.73–60.43%), followed by vaccine cost (43.46%, 95% CI: 31.20–56.13%). Moreover, the recommendations from medical professionals (60.90%, 95%CI: 44.23–76.37%) and sexual partners (60.09%, 95%CI: 27.11–88.67%) were significant factors in promoting vaccination. Overall, acceptance of the HPV vaccine among general men was at a lower level, despite being slightly higher among men with a same-sex orientation. Popularizing knowledge about diseases and vaccines, encouraging medical professionals to recommend vaccines to men, or reducing the cost of vaccines may promote HPV vaccination. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Establishment and development of national community-based collaborative innovation demonstration areas to achieve the control target of hepatitis B in China

Author

Ruan, Bing, Yu, Zhixin, Yang, Shigui, Xu, Kaijin, Ren, Jingjing, Yao, Jun, Wu, Nanping, Yu, Chengbo, Deng, Min, Xie, Tiansheng, Chen, Ping, Wang, Chencheng, Li, Yiping, Zhao, Yanhong, Sheng, Jifang, Hou, Yunde, Wu, Zunyou, Jin, Shuigao, Chen, Yude, Li, Mengfeng, Zhu, Fengcai, Tang, Hong, Hao, Yuantao, Pang, Xinghuo, Lu, Lin, Yang, Wen, Yuan, Zhengan, Xu, Aiqiang, Li, Zizhao, Ni, Mingjian, Yan, Yongping, Zhong, Qiu, Zhou, Lin, Li, Guojian, Meng, Qun, Hu, Jianping, Zhou, Hong, Zhang, Guangyu, Li, Dexin, Jiang, Wei, Li, Qing, Wu, Peixin, Xing, Ruoqi, Gu, Jinhui, Gao, Di, and Li, Lanjuan

Published
2019
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42. Comparison of Patients Hospitalized With Influenza A Subtypes H7N9, H5N1, and 2009 Pandemic H1N1

Author

Wang, Chen, Yu, Hongjie, Horby, Peter W., Cao, Bin, Wu, Peng, Yang, Shigui, Gao, Hainv, Li, Hui, Tsang, Tim K., Liao, Qiaohong, Gao, Zhancheng, Ip, Dennis K. M., Jia, Hongyu, Jiang, Hui, Liu, Bo, Ni, Michael Y., Dai, Xiahong, Liu, Fengfeng, Van Kinh, Nguyen, Liem, Nguyen Thanh, Hien, Tran Tinh, Li, Yu, Yang, Juan, Wu, Joseph T., Zheng, Yaming, Leung, Gabriel M., Farrar, Jeremy J., Cowling, Benjamin J., Uyeki, Timothy M., and Li, Lanjuan

Published
2014
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48. Psychological stress; knowledge, attitude and practice and acceptance of antiviral therapy in pregnant women with hepatitis B in Zhejiang, China: a case comparison study

Author

Liu, Xiaoxiao, primary, Chen, Can, additional, Jiang, Daixi, additional, Yan, Danying, additional, Zhou, Yuqing, additional, Ding, Cheng, additional, Lan, Lei, additional, Huang, Chenyang, additional, Zhang, Xiaobao, additional, Li, Lanjuan, additional, and Yang, Shigui, additional

Published
2022
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49. Additional file 1 of Exhausted phenotype of circulating CD8+ T cell subsets in hepatitis B virus carriers

Author

Jiang, Daixi, Chen, Can, Yan, Danying, Zhang, Xiaobao, Liu, Xiaoxiao, Yan, Dong, Cui, Dawei, and Yang, Shigui

Abstract

Additional file 1. Table S1. List of antibodies used in the study. Table S2. List of primer sequences used for RT–PCR. Table S3. Correlations between the subsets of exhausted Tfc/Tc17 cells and the serum level of HbsAg. Figure S1. Gating strategy in CD8+ T cell subsets. A: gating strategy to detect inhibitory receptors expressed in CD8+ T cell subsets; B: gating strategy to detect effector cytokines expressed in CD8+ T cell subsets. Figure S2. Additional data of CD8+ T cells in HCs and HBV carriers. A: multiple inhibitory receptor expression on CD8+ T cells in HCs and HBV carriers; B: correlations between the frequencies of PD+ or TIM3+ Tfc/Tc17 cells and the serum level of TNF-α; C: correlations between the frequencies of PD+ or TIM3+ Tfc/Tc17 cells and the serum level of IFN-γ; D-E: the production of effector cytokines in Tc/Tfc subsets in HCs (n = 15) and HBV carriers (n = 15); E: the production of cytokines in the Tc subset in HBV carriers. HCs: healthy controls, HBV: hepatitis B virus, Tfc: follicular cytotoxic T cells (CXCR5+FOXP3-), Tc: cytotoxic T cells (CXCR5-FOXP3-); data are presented as the means ± SEs; *P < 0.01, **P < 0.01.

Published
2022
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