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186 results on '"Yang, Shixiong"'

13. Predictive value of plasma long non-coding RNA H19 in neoadjuvant therapy for breast cancer

Author

CHEN Anli, SHEN Haoyuan, YANG Shixiong, DENG Chunyan, HU Chaohua, LIU Hanzhong, WANG Shu, QIAN Fang

Subjects
breast cancer, neoadjuvant therapy, long non-coding rna, lncrna h19, pathological complete response, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background and purpose: Long noncoding RNA (LncRNA) plays an important role in the development of distant metastasis and drug resistance of tumors, and it is highly expressed in breast cancer tissues and plasma of breast cancer patients. However, the dynamic changes of its expression level in neoadjuvant therapy (NAT) for breast cancer and its relationship with relevant clinicopathological features have not been reported. This study aimed to investigate the predictive value of dynamic changes of plasma long lncRNA H19 in NAT for different molecular types of breast cancer. Methods: Forty-five breast cancer patients undergoing NAT were prospectively selected from January 2021 to December 2021 in the Department of Gynecology, Xiaogan Central Hospital, Wuhan University of Science and Technology. The corresponding treatment plan and cycle were selected for all cases according to their pathological types and general conditions. Real-time fluorescence quantitative polymerase chain reaction (RTFQ-PCR) was used to dynamically detect the expression levels and changes of lncRNA H19 in peripheral blood before NAT, after treatment with NAT for 2, 4 and 6 cycles, and after surgery. The differences and dynamic changes of lncRNA H19 expression levels in different periods of NAT and different molecular types of breast cancer were compared and analyzed, and the efficacy of NAT was evaluated according to pathological features after surgery. Results: LncRNA H19 expression was detected in peripheral blood plasma of 45 breast cancer patients treated with NAT. Among them, 20 patients (44.4%) achieved pathological complete response (pCR), 25 patients (55.6%) did not achieve pCR, and the level of H19 before NAT in patients who achieved pCR was significantly higher compared with non-pCR patients (P0.05), while H19 expression level in TNBC patients was significantly lower compared with patients with hormone receptor-positive type (P0.05), and there were significant differences in tumor residual load and lncRNA H19 expression after NAT (P

Published
2022
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19. Characteristics and Sources of Heavy Metals Pollution in Surface Sediments: An Integrated Land–Sea Comparative Analysis in Dingzi Bay, South Yellow Sea.

Author

Gu, Xiaoyuan, Liu, Yang, Yang, Shixiong, Sun, Jianwei, Wang, Qingtong, Wang, Haigen, Chen, Yuhai, and Wang, Wei

Subjects
HEAVY metal toxicology, METALLIC surfaces, COASTAL sediments, MARINE pollution, COASTAL zone management, AGRICULTURAL pollution, ECOLOGICAL risk assessment, ATMOSPHERIC mercury, HEAVY elements
Abstract

Systematic and scientific assessments on heavy metal pollution are greatly important to protecting the coastal eco-environment. In this paper, the spatial distribution, pollution degree, ecological toxicity and possible sources of eight heavy metal elements collected from the 126 marine and 715 terrestrial surface sediments surrounding Dingzi Bay were analyzed by obtaining concentration measurements. The results revealed that the concentrations of heavy metals followed a pattern: inner bay > terrestrial areas > outer bay. Cr, Ni, Cu, Zn, Cd, Pb, and Hg were found to accumulate in fine particles (<0.063 mm), while As showed an association with specific particles (>0.25 mm and <0.016 mm). Spatial pollution patterns varied from non-polluted to low pollution levels overall, with localized contamination by individual elements. In addition to natural sources, four types of anthropogenic pollution were identified in the marine and terrestrial settings. Agricultural pollution, characterized by As predominance, exerted profound effects on both terrestrial and marine environments. Industrial pollution, featuring Hg dominance, was widespread in land environment and predominantly linked to atmospheric deposition. Traffic pollution, marked by elevated Pb and Cd, was concentrated around factories and densely populated areas. Maritime pollution, comprising Hg, Cr, Cd, and Zn, primarily occurred in the nearshore areas outside the bay. The findings of this study provide scientific data to the authorities in charge of sustainable coastal zone management in the South Yellow Sea. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Effect of nanoprocessing on the physicochemical properties of bovine, porcine, chicken, and rabbit bone powders

Author

Zhang Ling, Gao Feihu, Zhifei He, Yang Shixiong, Li Xue, Hongjun Li, Dong Zhang, Liang Yexing, Zefu Wang, and Xu Jingbing

Subjects
Bone particle, Nutrition. Foods and food supply, characteristics, rabbit, animal bone, chemistry.chemical_element, Rabbit (nuclear engineering), Calcium, Bovine bone, chemistry, Porcine bone, TX341-641, Food science, nanoprocessing, Animal bone, Chicken bone, Original Research, Food Science
Abstract

The chemical composition and hardness of bovine bone, porcine bone, chicken bone, and rabbit bone were compared, as well as the influence of nanoprocessing on the physicochemical characteristics of these bone powders. A series of nanofabrication processes led to an increase in bone minerals and the loss of protein and fat. The hardness of softened bovine bone was still the largest, whereas chicken and rabbit bones were relatively soft. There were no significant differences in the functional groups between nanoscale bone powders. Overall, nanomachining significantly reduced and homogenized the bone particle size and improved the color and release rate of calcium ions of bone powders at the same time; these effects were different for several bones. Nanoscale rabbit bone had higher comminution efficiency, as well as satisfactory nutritional value, color, and product yield, which supports its strong development potential., This study mainly described the application of nanoprocessing in common mammalian bones (bovine and porcine), common poultry bone (chicken), and new material rabbit bone. The effects of nanoprocessing on the physicochemical properties of rabbit bone and other three common bones were compared. The excellent properties of nanoscaled rabbit bone (NRB), which support its great development potential.

Published
2021

47. Holocene vegetation history and responses to climate and sea-level change in the Liaohe Delta, northeast China

Author

Marine palynology and palaeoceanography, Marine Palynology, Yang, Shixiong, Gu, Fang, Song, Bing, Ye, Siyuan, Yuan, Yongming, He, Lei, Li, Jie, Zhao, Guangming, Ding, Xigui, Pei, Shaofeng, Laws, Edward A., Sangiorgi, Francesca, Marine palynology and palaeoceanography, Marine Palynology, Yang, Shixiong, Gu, Fang, Song, Bing, Ye, Siyuan, Yuan, Yongming, He, Lei, Li, Jie, Zhao, Guangming, Ding, Xigui, Pei, Shaofeng, Laws, Edward A., and Sangiorgi, Francesca

Published
2022

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