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127 results on '"Yang, Sujuan"'

6. KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

Author

Mahadevan, Krishnan K., McAndrews, Kathleen M., LeBleu, Valerie S., Yang, Sujuan, Lyu, Hengyu, Li, Bingrui, Sockwell, Amari M., Kirtley, Michelle L., Morse, Sami J., Moreno Diaz, Barbara A., Kim, Michael P., Feng, Ningping, Lopez, Anastasia M., Guerrero, Paola A., Paradiso, Francesca, Sugimoto, Hikaru, Arian, Kent A., Ying, Haoqiang, Barekatain, Yasaman, Sthanam, Lakshmi Kavitha, Kelly, Patience J., Maitra, Anirban, Heffernan, Timothy P., and Kalluri, Raghu

Published
2023
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11. Improved Efficient Dictionary Learning with Cross-Label and Group Regularization

Author

Zhou, Tian, Yang, Sujuan, Xiong, Jian, Yang, Jie, Gui, Guan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Liu, Xin, editor, Na, Zhenyu, editor, Wang, Wei, editor, Mu, Jiasong, editor, and Zhang, Baoju, editor

Published
2020
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17. Data from Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer

Author

McAndrews, Kathleen M., primary, Chen, Yang, primary, Darpolor, J. Kebbeh, primary, Zheng, Xiaofeng, primary, Yang, Sujuan, primary, Carstens, Julienne L., primary, Li, Bingrui, primary, Wang, Huamin, primary, Miyake, Toru, primary, Correa de Sampaio, Pedro, primary, Kirtley, Michelle L., primary, Natale, Mariangela, primary, Wu, Chia-Chin, primary, Sugimoto, Hikaru, primary, LeBleu, Valerie S., primary, and Kalluri, Raghu, primary

Published
2023
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18. Supplementary Data from Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer

Author

McAndrews, Kathleen M., primary, Chen, Yang, primary, Darpolor, J. Kebbeh, primary, Zheng, Xiaofeng, primary, Yang, Sujuan, primary, Carstens, Julienne L., primary, Li, Bingrui, primary, Wang, Huamin, primary, Miyake, Toru, primary, Correa de Sampaio, Pedro, primary, Kirtley, Michelle L., primary, Natale, Mariangela, primary, Wu, Chia-Chin, primary, Sugimoto, Hikaru, primary, LeBleu, Valerie S., primary, and Kalluri, Raghu, primary

Published
2023
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19. Oncogenic KrasG12Dspecific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+T cells dependent manner

Author

Mahadevan, Krishnan K., primary, McAndrews, Kathleen M., additional, LeBleu, Valerie S., additional, Yang, Sujuan, additional, Lyu, Hengyu, additional, Li, Bingrui, additional, Sockwell, Amari M., additional, Kirtley, Michelle L., additional, Morse, Sami J., additional, Moreno Diaz, Barbara A., additional, Kim, Michael P., additional, Feng, Ningping, additional, Lopez, Anastasia M., additional, Guerrero, Paola A., additional, Sugimoto, Hikaru, additional, Arian, Kent A., additional, Ying, Haoqiang, additional, Barekatain, Yasaman, additional, Kelly, Patience J., additional, Maitra, Anirban, additional, Heffernan, Timothy P., additional, and Kalluri, Raghu, additional

Published
2023
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20. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Author

Kamerkar, Sushrut, LeBleu, Valerie S., Sugimoto, Hikaru, Yang, Sujuan, Ruivo, Carolina F., Melo, Sonia A., Lee, J. Jack, and Kalluri, Raghu

Subjects
Cell organelles -- Health aspects, Cancer -- Care and treatment, Oncogenes -- Health aspects, Pancreatic cancer -- Care and treatment, Guanosine triphosphatase -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes are extracellular vesicles generated by all cells, and are naturally present in the blood. Here we show that enhanced retention of exosomes, compared to liposomes, in the circulation of mice is likely due to CD47-mediated protection of exosomes from phagocytosis by monocytes and macrophages. Exosomes derived from normal fibroblast-like mesenchymal cells were engineered to carry short interfering RNA or short hairpin RNA specific to oncogenic Kras.sup.G12D, a common mutation in pancreatic cancer. Compared to liposomes, the engineered exosomes (known as iExosomes) target oncogenic KRAS with an enhanced efficacy that is dependent on CD47, and is facilitated by macropinocytosis. Treatment with iExosomes suppressed cancer in multiple mouse models of pancreatic cancer and significantly increased overall survival. Our results demonstrate an approach for direct and specific targeting of oncogenic KRAS in tumours using iExosomes. Exosomes improve the delivery of siRNA to mutant KRAS in the pancreatic tumours and bypass immune clearance better than artificial liposomes, probably owing to enhanced macropinocytocis and presence of CD47 on exosomes, respectively. Exosomes target KRAS in the pancreas Mutant KRAS is a common driver of pancreatic cancer, and decreasing its expression with siRNA is a potential strategy to forestall pancreatic tumour growth. To improve delivery of short interfering RNA to the pancreas, Raghu Kalluri and colleagues harness exosomes and show that these endogenous vesicles can bypass immune clearance better than artificial liposomes, probably owing to expression of CD47 in their membrane. The iExosomes are uptaken preferentially by pancreatic tumour cells. The authors suggest that this uptake is facilitated by increased macropinocytosis. iExosomes are able to reduce KRAS oncogenic signalling and reduce tumour growth in mouse models of pancreatic cancer., Author(s): Sushrut Kamerkar [sup.1] , Valerie S. LeBleu [sup.1] , Hikaru Sugimoto [sup.1] , Sujuan Yang [sup.1] , Carolina F. Ruivo [sup.2] [sup.4] , Sonia A. Melo [sup.1] [sup.2] [sup.4] [...]

Published
2017
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22. Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer

Author

McAndrews, Kathleen M., primary, Chen, Yang, additional, Darpolor, J. Kebbeh, additional, Zheng, Xiaofeng, additional, Yang, Sujuan, additional, Carstens, Julienne L., additional, Li, Bingrui, additional, Wang, Huamin, additional, Miyake, Toru, additional, Correa de Sampaio, Pedro, additional, Kirtley, Michelle L., additional, Natale, Mariangela, additional, Wu, Chia-Chin, additional, Sugimoto, Hikaru, additional, LeBleu, Valerie S., additional, and Kalluri, Raghu, additional

Published
2022
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23. Phase I study of mesenchymal stem cell (MSC)-derived exosomes with KRASG12D siRNA in patients with metastatic pancreatic cancer harboring a KRASG12D mutation.

Author

Surana, Rishi, primary, LeBleu, Valerie S., additional, Lee, J. Jack, additional, Smaglo, Brandon George, additional, Zhao, Dan, additional, Lee, Michael Sangmin, additional, Wolff, Robert A., additional, Overman, Michael J., additional, Mendt, Mayela C., additional, McAndrews, Kathleen M., additional, Yang, Sujuan, additional, Rezvani, Katy, additional, Kalluri, Raghu, additional, Maitra, Anirban, additional, Shpall, Elizabeth J., additional, and Pant, Shubham, additional

Published
2022
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30. Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts

Author

Yang, Sujuan, primary, Zhang, Ximei, additional, Chen, Jingrong, additional, Dang, Junlong, additional, Liang, Rongzhen, additional, Zeng, Donglan, additional, Zhang, Huan, additional, Xue, Youqiu, additional, Liu, Yan, additional, Wu, Wenbin, additional, Zhao, Jun, additional, Wang, Julie, additional, Pan, Yunfeng, additional, Xu, Hanshi, additional, Sun, Bing, additional, Huang, Feng, additional, Lu, Yan, additional, Hsueh, Willa, additional, Olsen, Nancy, additional, and Zheng, Song Guo, additional

Published
2020
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32. Abstract A108: Identification of distinct fibroblast populations with unique roles in PDAC progression and tumor immunity

Author

Darpolor, J. Kebbeh, primary, Zheng, Xiaofeng, additional, Yang, Sujuan, additional, McAndrews, Kathleen M., additional, Carstens, Julienne L., additional, Phillips, Patricia E., additional, Sugimoto, Hikaru, additional, De Sampaio, Pedro Correa, additional, Wu, Chia-Chin, additional, LeBleu, Valerie S., additional, and Kalluri, Raghu, additional

Published
2020
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34. Comparison and optimization of the method for Cry1Ac protoxin preparation in HD73 strain

Author

Yang Sujuan, Chang-long Shu, Zishan Zhou, Fuping Song, Xueping Zhou, and Jie Zhang

Subjects
endocrine system, Ecology, biology, Strain (chemistry), Cry1Ac protoxin, Chemistry, Agriculture (General), fungi, Bacillus thuringiensis, toxicity, Plant Science, biology.organism_classification, Biochemistry, S1-972, total yield, Food Animals, Cry1Ac, Solubilization, crystal solubilization, Animal Science and Zoology, Food science, Agronomy and Crop Science, Food Science
Abstract

Bacillus thuringiensis is one of the most widely used bioinsecticides, and cry gene is the major insecticidal gene. Because Cry1Ac protein shows strong toxicity against many lepidopteran species, it has been applied widely in spraying products and transgenic Bt-crops. The preparation of Cry protoxin is the first step in the very important processes of understanding the insecticidal mechanism, resistance screening, and biosafety assessments. The media for crystal production and the method for Cry protoxin preparation were varied, however, it was not clear which was better for preparing a larger amount of Cry protoxin. In this paper, three media for crystal production and the method for Cry1Ac protoxin preparation from HD73 strain were compared to find an efficacious way to prepare a large number of Cry1Ac protoxin. The results showed that the ½ LB (Luria-Bertani) medium was the ideal medium for crystal production, because the total yield of Cry1Ac protoxin in 300 mL ½ LB medium was (112.38±5.64) mg, the highest one among three media; the repeated crystal solubilization method was better for the preparation of the Cry protoxin comparing with the continuous crystal solubilization method. It will be a reference for other Cry protoxin preparation, especially for larger number.

Published
2015

36. Generation and testing of clinical-grade exosomes for pancreatic cancer

Author

Mendt, Mayela, primary, Kamerkar, Sushrut, additional, Sugimoto, Hikaru, additional, McAndrews, Kathleen M., additional, Wu, Chia-Chin, additional, Gagea, Mihai, additional, Yang, Sujuan, additional, Blanko, Elena V. Rodriges, additional, Peng, Qian, additional, Ma, Xiaoyan, additional, Marszalek, Joseph R., additional, Maitra, Anirban, additional, Yee, Cassian, additional, Rezvani, Katayoun, additional, Shpall, Elizabeth, additional, LeBleu, Valerie S., additional, and Kalluri, Raghu, additional

Published
2018
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38. Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer

Author

Yang, Sujuan, primary, Che, Sara P. Y., additional, Kurywchak, Paul, additional, Tavormina, Jena L., additional, Gansmo, Liv B., additional, Correa de Sampaio, Pedro, additional, Tachezy, Michael, additional, Bockhorn, Maximilian, additional, Gebauer, Florian, additional, Haltom, Amanda R., additional, Melo, Sonia A., additional, LeBleu, Valerie S., additional, and Kalluri, Raghu, additional

Published
2017
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46. 99mTc-Labeled Dimeric Octreotide Peptide: A Radiotracer with High Tumor Uptake for Single-Photon Emission Computed Tomography Imaging of Somatostatin Receptor Subtype 2-Positive Tumors

Author

Dong, Chengyan, primary, Zhao, Huiyun, additional, Yang, Sujuan, additional, Shi, Jiyun, additional, Huang, Jinming, additional, Cui, Liyang, additional, Zhong, Lijun, additional, Jin, Xiaona, additional, Li, Fang, additional, Liu, Zhaofei, additional, Jia, Bing, additional, and Wang, Fan, additional

Published
2013
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50. Oligomerization of Cry9Aa in solution without receptor binding, is not related with insecticidal activity

Author

Changlong Shu, Longfa Fang, Mario Soberón, Zishan Zhou, Bo Wang, Alejandra Bravo, Yang Sujuan, Jie Zhang, and Fuping Song

Subjects
0106 biological sciences, 0301 basic medicine, lcsh:Biotechnology, Mutant, medicine.disease_cause, Insecticidal activity, 01 natural sciences, Applied Microbiology and Biotechnology, 03 medical and health sciences, Bacillus thuringiensis, lcsh:TP248.13-248.65, medicine, Oligomerization, Disulfide bonds, lcsh:QH301-705.5, Alanine, biology, Toxin, Chemistry, Cry9Aa655, Midgut, Trypsin, biology.organism_classification, 030104 developmental biology, Biochemistry, lcsh:Biology (General), Toxicity, 010606 plant biology & botany, Cysteine, medicine.drug, Biotechnology
Abstract

Background: Bacillus thuringiensis Cry toxins bind with different insect midgut proteins leading to toxin oligomerization, membrane insertion and pore formation. However, different Cry toxins had been shown to readily form high molecular weight oligomers or aggregates in solution in the absence of receptor interaction. The role of Cry oligomers formed in solution remains uncertain. The Cry9A proteins show high toxicity against different Lepidoptera, and no-cross resistance with Cry1A. Results: Cry9Aa655 protein formed oligomers easily in solution mediated by disulfide bonds, according to SDS-PAGE analysis under non-reducing and reducing conditions. However, oligomerization is not observed if Cry9Aa655 is activated with trypsin, suggesting that cysteine residues, C14 and C16, located in the N-terminal end that is processed during activation participate in this oligomerization. To determine the role of these residues on oligomerization and in toxicity single and double alanine substitution were constructed. In contrast to single C14A and C16A mutants, the double C14A-C16A mutant did not formed oligomers in solution. Toxicity assays against Plutella xylostella showed that the C14A-C16A mutant had a similar insecticidal activity as the Cry9Aa655 protein indicating the oligomers of Cry9Aa formed in solution in the absence of receptor binding are not related with toxicity. Conclusions: The aggregation of Cry9Aa655 polypeptides was mediated by disulfide bonds. Cry9Aa655 C14 and C16C are involved in oligomerization in solution. These aggregate forms are not related to the mode of action of Cry9Aa leading to toxicity.

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