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To investigate the efficacy and safety of Dermalax in the correction of moderate to severe nasolabial folds (NLFs) compared to Restylane. A total of 324 subjects with moderate to severe NLFs were enrolled in this multicenter, randomized, double-blind, active-controlled clinical study. Eligible subjects were randomly assigned to the test group received Dermalax injection (n = 162) or control group received Restylane injection (n = 162). Clinical efficacy and safety were assessed based on the Wrinkle Severity Rating Scale (WSRS) and the Global Esthetic Improvement Scale(GAIS) at weeks 2, 8, 16, 24, 36 and 48 weeks after injection. At week 24, similar improvements of effective rate were obtained on the Dermalax group (93.75%) and Restylane group (89.44%). Significances were found at 36 weeks and 48 weeks after injection, Dermalax seemed be better than Restylane in maintaining the effect in the later period. The improvement of mean WSRS score for test group was superior to that of control group with significance. GAIS scores rated at week 24 were 1.65 VS 1.94 (p <.001) and 2.10 VS 2.27 (p =.060), seperately. Dermalax was no inferior to or better than that of the control filler Restylane in correcting of moderate to severe NLFs in Chinese subjects. [ABSTRACT FROM AUTHOR]

Two series of inorganic melamine salts containing a tungstate or molybdate were synthesized as a flame retardant and smoke suppressant for flexible PVC, and their flame retardancy and smoke suppression were studied by limiting oxygen index (LOI), smoke density rating (SDR) test, cone calorimeter, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). It can be found that the presence of melamine tungstate or melamine molybdate causes an obvious increase in LOI and a decrease in SDR. The cone calorimeter results reveal that melamine tungstate or melamine molybdate can clearly change the decomposition behavior of PVC and form a char layer on the surface of the composites, consequently resulting in efficient reduction of the flammability parameters, such as heat release rate, smoke production rate, total smoke production, and so on. The TGA and SEM results demonstrate that melamine tungstate can delay the degradation of PVC and improve the stability of the char residue. Moreover, melamine molybdate and the PVC matrix form a novel intumescent flame retardant and smoke suppression system, in which the PVC matrix acts as the carbonization agent and molybdate as the acid source (Lewis acid). Molybdate can catalyze the dehydrochlorination reaction and promote the crosslinking reaction of PVC effectively. Melamine (MA) and the released hydrogen chloride can act as the blowing agent, which enhance the intumescence of the char. POLYM. COMPOS., 39:529–536, 2018. © 2016 Society of Plastics Engineers [ABSTRACT FROM AUTHOR]

Background: To investigate the efficacy and safety of Dermalax in the correction of moderate to severe nasolabial folds (NLFs) compared to Restylane., Methods: A total of 324 subjects with moderate to severe NLFs were enrolled in this multicenter, randomized, double-blind, active-controlled clinical study. Eligible subjects were randomly assigned to the test group received Dermalax injection ( n  = 162) or control group received Restylane injection ( n  = 162). Clinical efficacy and safety were assessed based on the Wrinkle Severity Rating Scale (WSRS) and the Global Esthetic Improvement Scale(GAIS) at weeks 2, 8, 16, 24, 36 and 48 weeks after injection., Results: At week 24, similar improvements of effective rate were obtained on the Dermalax group (93.75%) and Restylane group (89.44%). Significances were found at 36 weeks and 48 weeks after injection, Dermalax seemed be better than Restylane in maintaining the effect in the later period. The improvement of mean WSRS score for test group was superior to that of control group with significance. GAIS scores rated at week 24 were 1.65 VS 1.94 ( p  < .001) and 2.10 VS 2.27 ( p  = .060), seperately., Conclusions: Dermalax was no inferior to or better than that of the control filler Restylane in correcting of moderate to severe NLFs in Chinese subjects.

A method for the determination of metolcarb and diethofencarb in apples and apple juice is developed using solid-phase microextraction (SPME) coupled with high-performance liquid chromatography (HPLC). The experimental conditions of SPME, such as the kind of extraction fiber, extraction time, stirring rate, pH of the extracting solution, and desorption conditions are optimized. The SPME is performed on a 60 microm polydimethylsiloxane/divinylbenzene fiber for 40 min at room temperature with the solution being stirred at 1100 rpm. The extracted pesticides on the SPME fiber are desorbed in the mobile phase into SPME-HPLC interface for HPLC analysis. Separations are carried out on a Baseline C18 column (4.6 i.d. x 250 mm, 5.0 microm) with acetonitrile-water (55/45, v/v) as the mobile phase at a flow rate of 1.0 mL/min, and photodiode-array detection at 210 nm. For apple samples, the method is linear for both metolcarb and diethofencarb in the range of 0.05-1.0 mg/kg (r > 0.99), with a detection limit (S/N = 3 ) of 15 and 5 microg/kg, respectively. For apple juice, the method is linear for both metholcarb and diethofencarb over the range of 0.05-1.0 mg/L (r > 0.99) with the detection limit (S/N = 3 ) of 15 and 3 microg/L, respectively. Excellent recovery and reproducibility values are achieved. The proposed method is shown to be simple, sensitive, and organic solvent-free, and is suitable for the determination of the two pesticides in apples and apple juice.

Aim: To study the interaction between strychnine and bovine serum albumin., Methods: Fluorescence spectroscopy and ultraviolet spectroscopy were used., Results: The static quenching and the non-radiation energy transfer are the two main reasons to leading the fluorescence quenching of BSA. The apparent combining constants (K(A)) between strychnine and BSA are 3.72 x 10(3) at 27 degrees C, 4.27 x 10(3) at 37 degrees C, 4.47 x 10(3) at 47 degrees C and the combining sites are 1.01 +/- 0.03. The combining distance (r = 3.795 nm) and energy transfer efficiency (E = 0.0338) are obtained by Förster's non-radiation energy transfer mechanism., Conclusion: The interaction between strychnine and BSA was driven mainly by hydrophobic force.