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121 results on '"Yang, Yanlei"'

4. Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

Author

Zhu, Rongjia, Yan, Tingdong, Feng, Yingmei, Liu, Yan, Cao, Hongcui, Peng, Gongxin, Yang, Yanlei, Xu, Zhen, Liu, Jingqi, Hou, Wei, Wang, Xiaoyue, Li, Zhe, Deng, Luchan, Wang, Shihua, Li, Jing, Han, Qin, Li, Hongling, Shan, Guangliang, Cao, Yinghao, An, Xingyan, Yan, Jianshe, Zhang, Zhonghui, Li, Huafei, Qu, Xuebin, Zhu, Jiaqi, Zhou, Shumin, Wang, Jiao, Zhang, Fengchun, Gao, Jinming, Jin, Ronghua, Xu, Dayong, Ma, Yan-Qing, Huang, Tao, Peng, Shuang, Zheng, Zhi, Stambler, Ilia, Gilson, Eric, Lim, Lee Wei, Moskalev, Alexey, Cano, Antonio, Chakrabarti, Sasanka, Ulfhake, Brun, Su, Huanxing, Xu, Haoying, Xu, Sihuan, Wei, Feng, Brown-Borg, Holly M., Min, Kyung-Jin, Ellison-Hughes, Georgina, Caruso, Calogero, Jin, Kunlin, and Zhao, Robert Chunhua

Published
2021
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8. Changing cancer survival in China during 2003–15: a pooled analysis of 17 population-based cancer registries

Author

Zeng, Hongmei, Chen, Wanqing, Zheng, Rongshou, Zhang, Siwei, Ji, John S, Zou, Xiaonong, Xia, Changfa, Sun, Kexin, Yang, Zhixun, Li, He, Wang, Ning, Han, Renqiang, Liu, Shuzheng, Li, Huizhang, Mu, Huijuan, He, Yutong, Xu, Yanjun, Fu, Zhentao, Zhou, Yan, Jiang, Jie, Yang, Yanlei, Chen, Jianguo, Wei, Kuangrong, Fan, Dongmei, Wang, Jian, Fu, Fangxian, Zhao, Deli, Song, Guohui, Chen, Jianshun, Jiang, Chunxiao, Zhou, Xin, Gu, Xiaoping, Jin, Feng, Li, Qilong, Li, Yanhua, Wu, Tonghao, Yan, Chunhua, Dong, Jianmei, Hua, Zhaolai, Baade, Peter, Bray, Freddie, Jemal, Ahmedin, Yu, Xue Qin, and He, Jie

Published
2018
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23. TOX promotes follicular helper T cell differentiation in patients with primary Sjögren's syndrome.

Author

Liu, Suying, Yang, Yanlei, Zeng, Liuting, Wang, Li, He, Chengmei, Chen, Zhilei, Sun, Jinlei, Lyu, Taibiao, Wang, Mu, Chen, Hua, and Zhang, Fengchun

Subjects
*CELL differentiation, *HIGH throughput screening (Drug development), *CYTOKINES, *BIOCHEMISTRY, *SEQUENCE analysis, *PHENOMENOLOGICAL biology, *RNA, *GENE expression, *CELLULAR signal transduction, *JANUS kinases, *DNA-binding proteins, *CELL proliferation, *DESCRIPTIVE statistics, *RESEARCH funding, *SJOGREN'S syndrome, *T cells, *NEUROTRANSMITTER uptake inhibitors, *T helper cells
Abstract

Objectives Whether naive CD4+ T cells are dysregulated and associated with the overactivation of CD4+ T cells in primary SS (pSS) remains unclear. We aimed to explore the role and underlying mechanism of naive CD4+ T cells in pSS. Methods We examined the activation, proliferation and differentiation of naive CD4+ T cells from pSS patients and healthy controls. Differentially expressed genes were identified using RNA sequencing, and were overexpressed or silenced to determine the gene regulating follicular helper T (Tfh) cells. Assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) with chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq) was performed to explore the epigenetic mechanism. Naive CD4+ T cells were treated with pSS-related cytokines to explore the upstream signalling pathway. Results pSS naive CD4+ T cells had higher potentials of activation, proliferation and differentiation towards Tfh cells. Thymocyte selection-associated high mobility group box protein (TOX) was upregulated in pSS naive CD4+ T cells and promoted T cell activation and Tfh cell polarization. TOX silencing in pSS naive CD4+ T cells downregulated B cell lymphoma 6 (BCL6) expression and altered levels of multiple Tfh-associated genes. ChIP-seq analysis implied that TOX bound to the BCL6 locus, where there were accessible regions found by ATAC-seq. IFN-α induced TOX overexpression, which was attenuated by Janus kinase (JAK) and signal transducer and activator of transcription 1 (STAT1) inhibitors. Conclusion Our data suggest that TOX in pSS naive CD4+ T cells is upregulated, which facilitates Tfh cell differentiation. Mechanistically, IFN-α induces TOX overexpression in naive CD4+ T cells through JAK–STAT1 signalling and TOX regulates BCL6 expression. Therefore, IFN-α-JAK–STAT1 signalling and TOX might be potential therapeutic targets in pSS. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Ten-year survival analysis of patients with primary Sjögren’s syndrome in China: a national prospective cohort study

Author

Qian, Junyan, primary, He, Chengmei, additional, Li, Ya, additional, Peng, Linyi, additional, Yang, Yunjiao, additional, Xu, Dong, additional, Fei, Yunyun, additional, Zhang, Wen, additional, Zhao, Yan, additional, Dong, Yi, additional, Li, Yongzhe, additional, Zhang, Xuan, additional, Chen, Hua, additional, Yang, Yanlei, additional, Chen, Zhilei, additional, Liu, Suying, additional, Wang, Li, additional, and Zhang, Fengchun, additional

Published
2021
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33. Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

Author

Leng, Zikuan, primary, Zhu, Rongjia, primary, Hou, Wei, primary, Feng, Yingmei, primary, Yang, Yanlei, primary, Han, Qin, primary, Shan, Guangliang, primary, Meng, Fanyan, primary, Du, Dongshu, primary, Wang, Shihua, primary, Fan, Junfen, primary, Wang, Wenjing, primary, Deng, Luchan, primary, Shi, Hongbo, primary, Li, Hongjun, primary, Hu, Zhongjie, primary, Zhang, Fengchun, primary, Gao, Jinming, primary, Liu, Hongjian, primary, Li, Xiaoxia, primary, Zhao, Yangyang, primary, Yin, Kan, primary, He, Xijing, primary, Gao, Zhengchao, primary, Wang, Yibin, primary, Yang, Bo, primary, Jin, Ronghua, primary, Stambler, Ilia, primary, Lim, Lee Wei, primary, Su, Huanxing, primary, Moskalev, Alexey, primary, Cano, Antonio, primary, Chakrabarti, Sasanka, primary, Min, Kyung-Jin, primary, Ellison-Hughes, Georgina, primary, Caruso, Calogero, primary, Jin, Kunlin, primary, and Zhao, Robert Chunhua, primary

Published
2020
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43. Species-specificity in the interaction of IgE with FcεRI between humans and rats

Author

Li, Fei, Wang, Nannan, Yang, Yanlei, Zhang, Su, Cui, Zhe, Zhang, Yanfen, and Liu, Zhongcheng

Abstract

The interaction of immunoglobulin E (IgE) to its high-affinity receptor (FcεRI) plays a key role in triggering allergic reactions. However, it is still controversial whether species specificity influences the binding ability between humans and rodents. Recombinant hFcεRIα / RBL-2H3 and hFcεRIα / MGC-803 cells were prepared and sensitized with hIgE/anti-hIgE antibody or DNP-IgE/DNP-BSA, respectively. Species-specificity was investigated using immuno-fluorescent analysis, β-hexosaminidase release rate assay, intracellular calcium concentration assay and apoptosis assay, and the results showed that there is species-specificity in IgE/FcεRI in humans and rats, and no cross-recognition between IgE and FcεRI in two species. These results should provide the experimental evidence for further research on the pathogenesis and the drug development of allergic diseases.

Published
2019
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50. TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy

Author

Wang, Chengyan, primary, Tang, Xuming, additional, Sun, Xiaomeng, additional, Miao, Zhenchuan, additional, Lv, Yaxin, additional, Yang, Yanlei, additional, Zhang, Huidan, additional, Zhang, Pengbo, additional, Liu, Yang, additional, Du, Liying, additional, Gao, Yang, additional, Yin, Ming, additional, Ding, Mingxiao, additional, and Deng, Hongkui, additional

Published
2011
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