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Recent advancements in deep learning have shifted the development of brain imaging analysis. However, several challenges remain, such as heterogeneity, individual variations, and the contradiction between the high dimensionality and small size of brain imaging datasets. These issues complicate the learning process, preventing models from capturing intrinsic, meaningful patterns and potentially leading to suboptimal performance due to biases and overfitting. Curriculum learning (CL) presents a promising solution by organizing training examples from simple to complex, mimicking the human learning process, and potentially fostering the development of more robust and accurate models. Despite its potential, the inherent limitations posed by small initial training datasets present significant challenges, including overfitting and poor generalization. In this paper, we introduce the Progressive Self-Paced Distillation (PSPD) framework, employing an adaptive and progressive pacing and distillation mechanism. This allows for dynamic curriculum adjustments based on the states of both past and present models. The past model serves as a teacher, guiding the current model with gradually refined curriculum knowledge and helping prevent the loss of previously acquired knowledge. We validate PSPD's efficacy and adaptability across various convolutional neural networks using the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, underscoring its superiority in enhancing model performance and generalization capabilities. The source code for this approach will be released at https://github.com/Hrychen7/PSPD., Comment: miccai-2024

Vascular segmentation in medical imaging plays a crucial role in analysing morphological and functional assessments. Traditional methods, like the centerline Dice (clDice) loss, ensure topology preservation but falter in capturing geometric details, especially under translation and deformation. The combination of clDice with traditional Dice loss can lead to diameter imbalance, favoring larger vessels. Addressing these challenges, we introduce the centerline boundary Dice (cbDice) loss function, which harmonizes topological integrity and geometric nuances, ensuring consistent segmentation across various vessel sizes. cbDice enriches the clDice approach by including boundary-aware aspects, thereby improving geometric detail recognition. It matches the performance of the boundary difference over union (B-DoU) loss through a mask-distance-based approach, enhancing traslation sensitivity. Crucially, cbDice incorporates radius information from vascular skeletons, enabling uniform adaptation to vascular diameter changes and maintaining balance in branch growth and fracture impacts. Furthermore, we conducted a theoretical analysis of clDice variants (cl-X-Dice). We validated cbDice's efficacy on three diverse vascular segmentation datasets, encompassing both 2D and 3D, and binary and multi-class segmentation. Particularly, the method integrated with cbDice demonstrated outstanding performance on the MICCAI 2023 TopCoW Challenge dataset. Our code is made publicly available at: https://github.com/PengchengShi1220/cbDice., Comment: accepted by MICCAI 2024

Foundation models pretrained on large-scale datasets via self-supervised learning demonstrate exceptional versatility across various tasks. Due to the heterogeneity and hard-to-collect medical data, this approach is especially beneficial for medical image analysis and neuroscience research, as it streamlines broad downstream tasks without the need for numerous costly annotations. However, there has been limited investigation into brain network foundation models, limiting their adaptability and generalizability for broad neuroscience studies. In this study, we aim to bridge this gap. In particular, (1) we curated a comprehensive dataset by collating images from 30 datasets, which comprises 70,781 samples of 46,686 participants. Moreover, we introduce pseudo-functional connectivity (pFC) to further generates millions of augmented brain networks by randomly dropping certain timepoints of the BOLD signal. (2) We propose the BrainMass framework for brain network self-supervised learning via mask modeling and feature alignment. BrainMass employs Mask-ROI Modeling (MRM) to bolster intra-network dependencies and regional specificity. Furthermore, Latent Representation Alignment (LRA) module is utilized to regularize augmented brain networks of the same participant with similar topological properties to yield similar latent representations by aligning their latent embeddings. Extensive experiments on eight internal tasks and seven external brain disorder diagnosis tasks show BrainMass's superior performance, highlighting its significant generalizability and adaptability. Nonetheless, BrainMass demonstrates powerful few/zero-shot learning abilities and exhibits meaningful interpretation to various diseases, showcasing its potential use for clinical applications.

Large language models (LLMs) have demonstrated remarkable potential in natural language understanding and generation, making them valuable tools for enhancing conversational interactions. However, LLMs encounter challenges such as lacking multi-step reasoning capabilities, and heavy reliance on prompts. In this regard, we introduce a prompt-refinement system named PromptMind, also known as "Prompt Your Mind", to provide an automated solution for generating contextually relevant prompts during conversations. PromptMind enhances the overall interaction between humans and chatbots through an automatic prompt suggestion and an automatic prompt refinement. To assess the effectiveness of PromptMind, we designed three interaction tasks to evaluate emotional support, advice acquisition, and task-oriented interactions during human-chatbot interactions. The results demonstrated that PromptMind reduced mental demands during interactions and fostered enhanced performance and social connections between users and chatbots. In summary, our findings indicate that PromptMind acts as a bridge, facilitating smoother information exchange and enhancing the usability of chatbot interactions.

In recent years, audio-driven 3D facial animation has gained significant attention, particularly in applications such as virtual reality, gaming, and video conferencing. However, accurately modeling the intricate and subtle dynamics of facial expressions remains a challenge. Most existing studies approach the facial animation task as a single regression problem, which often fail to capture the intrinsic inter-modal relationship between speech signals and 3D facial animation and overlook their inherent consistency. Moreover, due to the limited availability of 3D-audio-visual datasets, approaches learning with small-size samples have poor generalizability that decreases the performance. To address these issues, in this study, we propose a cross-modal dual-learning framework, termed DualTalker, aiming at improving data usage efficiency as well as relating cross-modal dependencies. The framework is trained jointly with the primary task (audio-driven facial animation) and its dual task (lip reading) and shares common audio/motion encoder components. Our joint training framework facilitates more efficient data usage by leveraging information from both tasks and explicitly capitalizing on the complementary relationship between facial motion and audio to improve performance. Furthermore, we introduce an auxiliary cross-modal consistency loss to mitigate the potential over-smoothing underlying the cross-modal complementary representations, enhancing the mapping of subtle facial expression dynamics. Through extensive experiments and a perceptual user study conducted on the VOCA and BIWI datasets, we demonstrate that our approach outperforms current state-of-the-art methods both qualitatively and quantitatively. We have made our code and video demonstrations available at https://github.com/sabrina-su/iadf.git.

Source-free domain adaptation (SFDA) aims to adapt models trained on a labeled source domain to an unlabeled target domain without the access to source data. In medical imaging scenarios, the practical significance of SFDA methods has been emphasized due to privacy concerns. Recent State-of-the-art SFDA methods primarily rely on self-training based on pseudo-labels (PLs). Unfortunately, PLs suffer from accuracy deterioration caused by domain shift, and thus limit the effectiveness of the adaptation process. To address this issue, we propose a Chebyshev confidence guided SFDA framework to accurately assess the reliability of PLs and generate self-improving PLs for self-training. The Chebyshev confidence is estimated by calculating probability lower bound of the PL confidence, given the prediction and the corresponding uncertainty. Leveraging the Chebyshev confidence, we introduce two confidence-guided denoising methods: direct denoising and prototypical denoising. Additionally, we propose a novel teacher-student joint training scheme (TJTS) that incorporates a confidence weighting module to improve PLs iteratively. The TJTS, in collaboration with the denoising methods, effectively prevents the propagation of noise and enhances the accuracy of PLs. Extensive experiments in diverse domain scenarios validate the effectiveness of our proposed framework and establish its superiority over state-of-the-art SFDA methods. Our paper contributes to the field of SFDA by providing a novel approach for precisely estimating the reliability of pseudo-labels and a framework for obtaining high-quality PLs, resulting in improved adaptation performance.

Convolutional neural networks (CNN) and Transformer variants have emerged as the leading medical image segmentation backbones. Nonetheless, due to their limitations in either preserving global image context or efficiently processing irregular shapes in visual objects, these backbones struggle to effectively integrate information from diverse anatomical regions and reduce inter-individual variability, particularly for the vasculature. Motivated by the successful breakthroughs of graph neural networks (GNN) in capturing topological properties and non-Euclidean relationships across various fields, we propose NexToU, a novel hybrid architecture for medical image segmentation. NexToU comprises improved Pool GNN and Swin GNN modules from Vision GNN (ViG) for learning both global and local topological representations while minimizing computational costs. To address the containment and exclusion relationships among various anatomical structures, we reformulate the topological interaction (TI) module based on the nature of binary trees, rapidly encoding the topological constraints into NexToU. Extensive experiments conducted on three datasets (including distinct imaging dimensions, disease types, and imaging modalities) demonstrate that our method consistently outperforms other state-of-the-art (SOTA) architectures. All the code is publicly available at https://github.com/PengchengShi1220/NexToU., Comment: 13 pages, 6 figures

International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multi-center study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and postprocessing (66%). The "typical" lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work., Comment: accepted to CVPR 2023

Since 2019, coronavirus Disease 2019 (COVID-19) has been widely spread and posed a serious threat to public health. Chest Computed Tomography (CT) holds great potential for screening and diagnosis of this disease. The segmentation of COVID-19 CT imaging can achieves quantitative evaluation of infections and tracks disease progression. COVID-19 infections are characterized by high heterogeneity and unclear boundaries, so capturing low-level features such as texture and intensity is critical for segmentation. However, segmentation networks that emphasize low-level features are still lacking. In this work, we propose a DECOR-Net capable of capturing more decorrelated low-level features. The channel re-weighting strategy is applied to obtain plenty of low-level features and the dependencies between channels are reduced by proposed decorrelation loss. Experiments show that DECOR-Net outperforms other cutting-edge methods and surpasses the baseline by 5.1% and 4.9% in terms of Dice coefficient and intersection over union. Moreover, the proposed decorrelation loss can improve the performance constantly under different settings. The Code is available at https://github.com/jiesihu/DECOR-Net.git.

In sponsored search advertising (SSA), keywords serve as the basic unit of business model, linking three stakeholders: consumers, advertisers and search engines. This paper presents an overarching framework for keyword decisions that highlights the touchpoints in search advertising management, including four levels of keyword decisions, i.e., domain-specific keyword pool generation, keyword targeting, keyword assignment and grouping, and keyword adjustment. Using this framework, we review the state-of-the-art research literature on keyword decisions with respect to techniques, input features and evaluation metrics. Finally, we discuss evolving issues and identify potential gaps that exist in the literature and outline novel research perspectives for future exploration., Comment: 88 pages, 3 figures, 15 tables

As a prevalent problem in online advertising, CTR prediction has attracted plentiful attention from both academia and industry. Recent studies have been reported to establish CTR prediction models in the graph neural networks (GNNs) framework. However, most of GNNs-based models handle feature interactions in a complete graph, while ignoring causal relationships among features, which results in a huge drop in the performance on out-of-distribution data. This paper is dedicated to developing a causality-based CTR prediction model in the GNNs framework (Causal-GNN) integrating representations of feature graph, user graph and ad graph in the context of online advertising. In our model, a structured representation learning method (GraphFwFM) is designed to capture high-order representations on feature graph based on causal discovery among field features in gated graph neural networks (GGNNs), and GraphSAGE is employed to obtain graph representations of users and ads. Experiments conducted on three public datasets demonstrate the superiority of Causal-GNN in AUC and Logloss and the effectiveness of GraphFwFM in capturing high-order representations on causal feature graph., Comment: 40 pages, 6 figures, 5 tables

Based on the Denoising Diffusion Probabilistic Model (DDPM), medical image segmentation can be described as a conditional image generation task, which allows to compute pixel-wise uncertainty maps of the segmentation and allows an implicit ensemble of segmentations to boost the segmentation performance. However, DDPM requires many iterative denoising steps to generate segmentations from Gaussian noise, resulting in extremely inefficient inference. To mitigate the issue, we propose a principled acceleration strategy, called pre-segmentation diffusion sampling DDPM (PD-DDPM), which is specially used for medical image segmentation. The key idea is to obtain pre-segmentation results based on a separately trained segmentation network, and construct noise predictions (non-Gaussian distribution) according to the forward diffusion rule. We can then start with noisy predictions and use fewer reverse steps to generate segmentation results. Experiments show that PD-DDPM yields better segmentation results over representative baseline methods even if the number of reverse steps is significantly reduced. Moreover, PD-DDPM is orthogonal to existing advanced segmentation models, which can be combined to further improve the segmentation performance.

Multi-modal neuroimaging technology has greatlly facilitated the efficiency and diagnosis accuracy, which provides complementary information in discovering objective disease biomarkers. Conventional deep learning methods, e.g. convolutional neural networks, overlook relationships between nodes and fail to capture topological properties in graphs. Graph neural networks have been proven to be of great importance in modeling brain connectome networks and relating disease-specific patterns. However, most existing graph methods explicitly require known graph structures, which are not available in the sophisticated brain system. Especially in heterogeneous multi-modal brain networks, there exists a great challenge to model interactions among brain regions in consideration of inter-modal dependencies. In this study, we propose a Multi-modal Dynamic Graph Convolution Network (MDGCN) for structural and functional brain network learning. Our method benefits from modeling inter-modal representations and relating attentive multi-model associations into dynamic graphs with a compositional correspondence matrix. Moreover, a bilateral graph convolution layer is proposed to aggregate multi-modal representations in terms of multi-modal associations. Extensive experiments on three datasets demonstrate the superiority of our proposed method in terms of disease classification, with the accuracy of 90.4%, 85.9% and 98.3% in predicting Mild Cognitive Impairment (MCI), Parkinson's disease (PD), and schizophrenia (SCHZ) respectively. Furthermore, our statistical evaluations on the correspondence matrix exhibit a high correspondence with previous evidence of biomarkers.

In sponsored search advertising (SSA), advertisers need to select keywords and determine matching types for selected keywords simultaneously, i.e., keyword targeting. An optimal keyword targeting strategy guarantees reaching the right population effectively. This paper aims to address the keyword targeting problem, which is a challenging task because of the incomplete information of historical advertising performance indices and the high uncertainty in SSA environments. First, we construct a data distribution estimation model and apply a Markov Chain Monte Carlo method to make inference about unobserved indices (i.e., impression and click-through rate) over three keyword matching types (i.e., broad, phrase and exact). Second, we formulate a stochastic keyword targeting model (BB-KSM) combining operations of keyword selection and keyword matching to maximize the expected profit under the chance constraint of the budget, and develop a branch-and-bound algorithm incorporating a stochastic simulation process for our keyword targeting model. Finally, based on a realworld dataset collected from field reports and logs of past SSA campaigns, computational experiments are conducted to evaluate the performance of our keyword targeting strategy. Experimental results show that, (a) BB-KSM outperforms seven baselines in terms of profit; (b) BB-KSM shows its superiority as the budget increases, especially in situations with more keywords and keyword combinations; (c) the proposed data distribution estimation approach can effectively address the problem of incomplete performance indices over the three matching types and in turn significantly promotes the performance of keyword targeting decisions. This research makes important contributions to the SSA literature and the results offer critical insights into keyword management for SSA advertisers., Comment: 38 pages, 4 figures, 5 tables

The brain age has been proven to be a phenotype of relevance to cognitive performance and brain disease. Achieving accurate brain age prediction is an essential prerequisite for optimizing the predicted brain-age difference as a biomarker. As a comprehensive biological characteristic, the brain age is hard to be exploited accurately with models using feature engineering and local processing such as local convolution and recurrent operations that process one local neighborhood at a time. Instead, Vision Transformers learn global attentive interaction of patch tokens, introducing less inductive bias and modeling long-range dependencies. In terms of this, we proposed a novel network for learning brain age interpreting with global and local dependencies, where the corresponding representations are captured by Successive Permuted Transformer (SPT) and convolution blocks. The SPT brings computation efficiency and locates the 3D spatial information indirectly via continuously encoding 2D slices from different views. Finally, we collect a large cohort of 22645 subjects with ages ranging from 14 to 97 and our network performed the best among a series of deep learning methods, yielding a mean absolute error (MAE) of 2.855 in validation set, and 2.911 in an independent test set.

Purpose: We model group advertising decisions, which are the collective decisions of every single advertiser within the set of advertisers who are competing in the same auction or vertical industry, and examine resulting market outcomes, via a proposed simulation framework named EXP-SEA (Experimental Platform for Search Engine Advertising) supporting experimental studies of collective behaviors in the context of search engine advertising. Design: We implement the EXP-SEA to validate the proposed simulation framework, also conduct three experimental studies on the aggregate impact of electronic word-of-mouth, the competition level, and strategic bidding behaviors. EXP-SEA supports heterogeneous participants, various auction mechanisms, and also ranking and pricing algorithms. Findings: Findings from our three experiments show that (a) both the market profit and advertising indexes such as number of impressions and number of clicks are larger when the eWOM effect presents, meaning social media certainly has some effect on search engine advertising outcomes, (b) the competition level has a monotonic increasing effect on the market performance, thus search engines have an incentive to encourage both the eWOM among search users and competition among advertisers, and (c) given the market-level effect of the percentage of advertisers employing a dynamic greedy bidding strategy, there is a cut-off point for strategic bidding behaviors. Originality: This is one of the first research works to explore collective group decisions and resulting phenomena in the complex context of search engine advertising via developing and validating a simulation framework that supports assessments of various advertising strategies and estimations of the impact of mechanisms on the search market., Comment: 26 pages, 7 figures, 5 tables

In sponsored search advertising, advertisers need to make a series of keyword decisions. Among them, how to group these keywords to form several adgroups within a campaign is a challenging task, due to the highly uncertain environment of search advertising. This paper proposes a stochastic programming model for keywords grouping, taking click-through rate and conversion rate as random variables, with consideration of budget constraints and advertisers' risk-tolerance. A branch-and-bound algorithm is developed to solve our model. Furthermore, we conduct computational experiments to evaluate the effectiveness of our model and solution, with two real-world datasets collected from reports and logs of search advertising campaigns. Experimental results illustrated that our keywords grouping approach outperforms five baselines, and it can approximately approach the optimum in a steady way. This research generates several interesting findings that illuminate critical managerial insights for advertisers in sponsored search advertising. First, keywords grouping does matter for advertisers, especially in the situation with a large number of keywords. Second, in keyword grouping decisions, the marginal profit does not necessarily show the marginal diminishing phenomenon as the budget increases. Such that, it's a worthy try for advertisers to increase their budget in keywords grouping decisions, in order to obtain additional profit. Third, the optimal keywords grouping solution is a result of multifaceted trade-off among various advertising factors. In particular, assigning more keywords into adgroups or having more budget won't certainly lead to higher profits. This suggests a warning for advertisers that it's not wise to take the number of keywords as the criterion for keywords grouping decisions., Comment: 36 pages, 6 figures, 5 tables

In this research, we investigate a generalized form of Vidale-Wolfe (GVW) model. One key element of our modeling work is that the GVW model contains two useful indexes representing advertiser's elasticity and the word-of-mouth (WoM) effect, respectively. Moreover, we discuss some desirable properties of the GVW model, and present a deep neural network (DNN)-based estimation method to learn its parameters. Furthermore, based on three realworld datasets, we conduct computational experiments to validate the GVW model and identified properties. In addition, we also discuss potential advantages of the GVW model over econometric models. The research outcome shows that both the ad elasticity index and the WoM index have significant influences on advertising responses, and the GVW model has potential advantages over econometric models of advertising, in terms of several interesting phenomena drawn from practical advertising situations. The GVW model and its deep learning-based estimation method provide a basis to support big data-driven advertising analytics and decision makings; in the meanwhile, identified properties and experimental findings of this research illuminate critical managerial insights for advertisers in various advertising forms., Comment: 20 pages, 8 figures, 1 table

In sponsored search advertising, keywords serve as an essential bridge linking advertisers, search users and search engines. Advertisers have to deal with a series of keyword decisions throughout the entire lifecycle of search advertising campaigns. This paper proposes a multi-level and closed-form computational framework for keyword optimization (MKOF) to support various keyword decisions. Based on this framework, we develop corresponding optimization strategies for keyword targeting, keyword assignment and keyword grouping at different levels (e.g., market, campaign and adgroup). With two real-world datasets obtained from past search advertising campaigns, we conduct computational experiments to evaluate our keyword optimization framework and instantiated strategies. Experimental results show that our method can approach the optimal solution in a steady way, and it outperforms two baseline keyword strategies commonly used in practice. The proposed MKOF framework also provides a valid experimental environment to implement and assess various keyword strategies in sponsored search advertising., Comment: 21 pages, 3 figures,1 table

Predicting the probability that a user will click on a specific advertisement has been a prevalent issue in online advertising, attracting much research attention in the past decades. As a hot research frontier driven by industrial needs, recent years have witnessed more and more novel learning models employed to improve advertising CTR prediction. Although extant research provides necessary details on algorithmic design for addressing a variety of specific problems in advertising CTR prediction, the methodological evolution and connections between modeling frameworks are precluded. However, to the best of our knowledge, there are few comprehensive surveys on this topic. We make a systematic literature review on state-of-the-art and latest CTR prediction research, with a special focus on modeling frameworks. Specifically, we give a classification of state-of-the-art CTR prediction models in the extant literature, within which basic modeling frameworks and their extensions, advantages and disadvantages, and performance assessment for CTR prediction are presented. Moreover, we summarize CTR prediction models with respect to the complexity and the order of feature interactions, and performance comparisons on various datasets. Furthermore, we identify current research trends, main challenges and potential future directions worthy of further explorations. This review is expected to provide fundamental knowledge and efficient entry points for IS and marketing scholars who want to engage in this area., Comment: 85 pages, 12 figures, 9 tables

Accurate medical image segmentation is crucial for diagnosis and analysis. However, the models without calibrated uncertainty estimates might lead to errors in downstream analysis and exhibit low levels of robustness. Estimating the uncertainty in the measurement is vital to making definite, informed conclusions. Especially, it is difficult to make accurate predictions on ambiguous areas and focus boundaries for both models and radiologists, even harder to reach a consensus with multiple annotations. In this work, the uncertainty under these areas is studied, which introduces significant information with anatomical structure and is as important as segmentation performance. We exploit the medical image segmentation uncertainty quantification by measuring segmentation performance with multiple annotations in a supervised learning manner and propose a U-Net based architecture with multiple decoders, where the image representation is encoded with the same encoder, and segmentation referring to each annotation is estimated with multiple decoders. Nevertheless, a cross-loss function is proposed for bridging the gap between different branches. The proposed architecture is trained in an end-to-end manner and able to improve predictive uncertainty estimates. The model achieves comparable performance with fewer parameters to the integrated training model that ranked the runner-up in the MICCAI-QUBIQ 2020 challenge., Comment: MICCAI_QUBIQ challenge, conference, Uncertainty qualification

As a mainstream marketing channel on the Internet, Search Engine Advertising (SEA) has a huge business impact and attracts a plethora of attention from both academia and industry. One important goal of advertising is to increase sales. Nevertheless, while previous research has studied multiple factors that are potentially related to the outcome of SEA campaigns, effects of these factors on actual sales generated by SEA remain understudied. It is also unclear whether and how such effects change over time in highly dynamic SEA campaigns. As the first empirical investigation of the dynamic advertisement-sales relationship in SEA, this study builds an advertising response model within a time-varying coefficient (TVC) modeling framework, and estimates the model using a unique dataset from a large E-Commerce retailer in the United States. Results reveal the effects of the advertising expenditure, consumer behaviors and advertisement characteristics on realized sales, and demonstrate that such effects on sales do change over time in non-linear ways. More importantly, we find that carryover has a stronger effect in generating sales than direct response does, conversion rate is much more important than click-through rate, and ad position does not have significant effects on sales. These findings have direct implications for advertisers to launch more effective SEA campaigns.