Search

Your search keyword '"Yang, Yinhua"' showing total 178 results
Start Over Author "Yang, Yinhua"
178 results on '"Yang, Yinhua"'

4. 1,3,5–2,4,6‐Functionalized Benzene Molecular Cage: An Environmentally Responsive Scaffold that Supports Hierarchical Superstructures.

Author

Pang, Xin‐Yu, Zhou, Hang, Xie, Xiaojiang, Jiang, Wei, Yang, Yinhua, Sessler, Jonathan L., and Gong, Han‐Yuan

Subjects
SOLID solutions, BENZENE, ISOMERIZATION, MOIETIES (Chemistry), MOLECULES
Abstract

New stimulus‐responsive scaffolds are of interest as constituents of hierarchical supramolecular ensembles. 1,3,5–2,4,6‐Functionalized, facially segregated benzene moieties have a time‐honored role as building blocks for host molecules. However, their user as switchable motifs in the construction of multi‐component supramolecular structures remains poorly explored. Here, we report a molecular cage 1, which consists of a bent anthracene dimer 3 paired with 1,3,5‐tris(aminomethyl)‐2,4,6‐triethylbenzene 2. As the result of the pH‐induced ababab↔bababa isomerization of the constituent‐functionalized benzene units derived from 2, this cage can reversibly convert between an open state and a closed form, both in solution and in the solid state. Cage 1 was used to create stimuli‐responsive hierarchical superstructures, namely Russian doll‐like complexes with [K⊂18‐crown‐6⊂1]+ and [K⊂cryptand‐222⊂1]+. The reversible assembly and disassembly of these superstructures could be induced by switching cage 1 from its open to closed form. The present study thus provides an unusual example where pH‐triggered conformation motion within a cage‐like scaffold is used to control the formation and disassociation of hierarchical ensembles. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Data from Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer

Author

Moore, Paul A., primary, Shah, Kalpana, primary, Yang, Yinhua, primary, Alderson, Ralph, primary, Roberts, Penny, primary, Long, Vatana, primary, Liu, Daorong, primary, Li, Jonathan C., primary, Burke, Steve, primary, Ciccarone, Valentina, primary, Li, Hua, primary, Fieger, Claudia B., primary, Hooley, Jeff, primary, Easton, Ann, primary, Licea, Monica, primary, Gorlatov, Sergey, primary, King, Kathy L., primary, Young, Peter, primary, Adami, Arash, primary, Loo, Deryk, primary, Chichili, Gurunadh R., primary, Liu, Liqin, primary, Smith, Douglas H., primary, Brown, Jennifer G., primary, Chen, Francine Z., primary, Koenig, Scott, primary, Mather, Jennie, primary, Bonvini, Ezio, primary, and Johnson, Syd, primary

Published
2023
Full Text
View/download PDF

12. Tables S1-S5; Figures S1-S5 from Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer

Author

Moore, Paul A., primary, Shah, Kalpana, primary, Yang, Yinhua, primary, Alderson, Ralph, primary, Roberts, Penny, primary, Long, Vatana, primary, Liu, Daorong, primary, Li, Jonathan C., primary, Burke, Steve, primary, Ciccarone, Valentina, primary, Li, Hua, primary, Fieger, Claudia B., primary, Hooley, Jeff, primary, Easton, Ann, primary, Licea, Monica, primary, Gorlatov, Sergey, primary, King, Kathy L., primary, Young, Peter, primary, Adami, Arash, primary, Loo, Deryk, primary, Chichili, Gurunadh R., primary, Liu, Liqin, primary, Smith, Douglas H., primary, Brown, Jennifer G., primary, Chen, Francine Z., primary, Koenig, Scott, primary, Mather, Jennie, primary, Bonvini, Ezio, primary, and Johnson, Syd, primary

Published
2023
Full Text
View/download PDF

13. Supplemental Figure S5 from MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies

Author

Liu, Liqin, primary, Lam, Chia-Ying K., primary, Long, Vatana, primary, Widjaja, Lusiana, primary, Yang, Yinhua, primary, Li, Hua, primary, Jin, Linda, primary, Burke, Steve, primary, Gorlatov, Sergey, primary, Brown, Jennifer, primary, Alderson, Ralph, primary, Lewis, Margaret D., primary, Nordstrom, Jeffrey L., primary, Koenig, Scott, primary, Moore, Paul A., primary, Johnson, Syd, primary, and Bonvini, Ezio, primary

Published
2023
Full Text
View/download PDF

14. Supplementary Table 1 from Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity

Author

Loo, Deryk, primary, Alderson, Ralph F., primary, Chen, Francine Z., primary, Huang, Ling, primary, Zhang, Wenjun, primary, Gorlatov, Sergey, primary, Burke, Steve, primary, Ciccarone, Valentina, primary, Li, Hua, primary, Yang, Yinhua, primary, Son, Tom, primary, Chen, Yan, primary, Easton, Ann N., primary, Li, Jonathan C., primary, Rillema, Jill R., primary, Licea, Monica, primary, Fieger, Claudia, primary, Liang, Tony W., primary, Mather, Jennie P., primary, Koenig, Scott, primary, Stewart, Stanford J., primary, Johnson, Syd, primary, Bonvini, Ezio, primary, and Moore, Paul A., primary

Published
2023
Full Text
View/download PDF

15. Supplementary Figure 3 from Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity

Author

Loo, Deryk, primary, Alderson, Ralph F., primary, Chen, Francine Z., primary, Huang, Ling, primary, Zhang, Wenjun, primary, Gorlatov, Sergey, primary, Burke, Steve, primary, Ciccarone, Valentina, primary, Li, Hua, primary, Yang, Yinhua, primary, Son, Tom, primary, Chen, Yan, primary, Easton, Ann N., primary, Li, Jonathan C., primary, Rillema, Jill R., primary, Licea, Monica, primary, Fieger, Claudia, primary, Liang, Tony W., primary, Mather, Jennie P., primary, Koenig, Scott, primary, Stewart, Stanford J., primary, Johnson, Syd, primary, Bonvini, Ezio, primary, and Moore, Paul A., primary

Published
2023
Full Text
View/download PDF

16. Supplementary Figure 2 from Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity

Author

Loo, Deryk, primary, Alderson, Ralph F., primary, Chen, Francine Z., primary, Huang, Ling, primary, Zhang, Wenjun, primary, Gorlatov, Sergey, primary, Burke, Steve, primary, Ciccarone, Valentina, primary, Li, Hua, primary, Yang, Yinhua, primary, Son, Tom, primary, Chen, Yan, primary, Easton, Ann N., primary, Li, Jonathan C., primary, Rillema, Jill R., primary, Licea, Monica, primary, Fieger, Claudia, primary, Liang, Tony W., primary, Mather, Jennie P., primary, Koenig, Scott, primary, Stewart, Stanford J., primary, Johnson, Syd, primary, Bonvini, Ezio, primary, and Moore, Paul A., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Figure Legend from Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity

Author

Loo, Deryk, primary, Alderson, Ralph F., primary, Chen, Francine Z., primary, Huang, Ling, primary, Zhang, Wenjun, primary, Gorlatov, Sergey, primary, Burke, Steve, primary, Ciccarone, Valentina, primary, Li, Hua, primary, Yang, Yinhua, primary, Son, Tom, primary, Chen, Yan, primary, Easton, Ann N., primary, Li, Jonathan C., primary, Rillema, Jill R., primary, Licea, Monica, primary, Fieger, Claudia, primary, Liang, Tony W., primary, Mather, Jennie P., primary, Koenig, Scott, primary, Stewart, Stanford J., primary, Johnson, Syd, primary, Bonvini, Ezio, primary, and Moore, Paul A., primary

Published
2023
Full Text
View/download PDF

18. Supplemental Figure Legends from MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies

Author

Liu, Liqin, primary, Lam, Chia-Ying K., primary, Long, Vatana, primary, Widjaja, Lusiana, primary, Yang, Yinhua, primary, Li, Hua, primary, Jin, Linda, primary, Burke, Steve, primary, Gorlatov, Sergey, primary, Brown, Jennifer, primary, Alderson, Ralph, primary, Lewis, Margaret D., primary, Nordstrom, Jeffrey L., primary, Koenig, Scott, primary, Moore, Paul A., primary, Johnson, Syd, primary, and Bonvini, Ezio, primary

Published
2023
Full Text
View/download PDF

19. Supplementary Table 2 from Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity

Author

Loo, Deryk, primary, Alderson, Ralph F., primary, Chen, Francine Z., primary, Huang, Ling, primary, Zhang, Wenjun, primary, Gorlatov, Sergey, primary, Burke, Steve, primary, Ciccarone, Valentina, primary, Li, Hua, primary, Yang, Yinhua, primary, Son, Tom, primary, Chen, Yan, primary, Easton, Ann N., primary, Li, Jonathan C., primary, Rillema, Jill R., primary, Licea, Monica, primary, Fieger, Claudia, primary, Liang, Tony W., primary, Mather, Jennie P., primary, Koenig, Scott, primary, Stewart, Stanford J., primary, Johnson, Syd, primary, Bonvini, Ezio, primary, and Moore, Paul A., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure 4 from Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity

Author

Loo, Deryk, primary, Alderson, Ralph F., primary, Chen, Francine Z., primary, Huang, Ling, primary, Zhang, Wenjun, primary, Gorlatov, Sergey, primary, Burke, Steve, primary, Ciccarone, Valentina, primary, Li, Hua, primary, Yang, Yinhua, primary, Son, Tom, primary, Chen, Yan, primary, Easton, Ann N., primary, Li, Jonathan C., primary, Rillema, Jill R., primary, Licea, Monica, primary, Fieger, Claudia, primary, Liang, Tony W., primary, Mather, Jennie P., primary, Koenig, Scott, primary, Stewart, Stanford J., primary, Johnson, Syd, primary, Bonvini, Ezio, primary, and Moore, Paul A., primary

Published
2023
Full Text
View/download PDF

21. Supplemental Tables S1 and S2 from MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies

Author

Liu, Liqin, primary, Lam, Chia-Ying K., primary, Long, Vatana, primary, Widjaja, Lusiana, primary, Yang, Yinhua, primary, Li, Hua, primary, Jin, Linda, primary, Burke, Steve, primary, Gorlatov, Sergey, primary, Brown, Jennifer, primary, Alderson, Ralph, primary, Lewis, Margaret D., primary, Nordstrom, Jeffrey L., primary, Koenig, Scott, primary, Moore, Paul A., primary, Johnson, Syd, primary, and Bonvini, Ezio, primary

Published
2023
Full Text
View/download PDF

22. Supplementary Figure 1 from Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity

Author

Loo, Deryk, primary, Alderson, Ralph F., primary, Chen, Francine Z., primary, Huang, Ling, primary, Zhang, Wenjun, primary, Gorlatov, Sergey, primary, Burke, Steve, primary, Ciccarone, Valentina, primary, Li, Hua, primary, Yang, Yinhua, primary, Son, Tom, primary, Chen, Yan, primary, Easton, Ann N., primary, Li, Jonathan C., primary, Rillema, Jill R., primary, Licea, Monica, primary, Fieger, Claudia, primary, Liang, Tony W., primary, Mather, Jennie P., primary, Koenig, Scott, primary, Stewart, Stanford J., primary, Johnson, Syd, primary, Bonvini, Ezio, primary, and Moore, Paul A., primary

Published
2023
Full Text
View/download PDF

24. Dual-affinity re-targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells

Author

Sung, Julia A.M., Pickeral, Joy, Liu, Liqin, Stanfield-Oakley, Sherry A., Lam, Chia-Ying Kao, Garrido, Carolina, Pollara, Justin, LaBranche, Celia, Bonsignori, Mattia, Moody, M. Anthony, Yang, Yinhua, Parks, Robert, Archin, Nancie, Allard, Brigitte, Kirchherr, Jennifer, Kuruc, JoAnn D., Gay, Cynthia L., Cohen, Myron S., Ochsenbauer, Christina, Soderberg, Kelly, Liao, Hua-Xin, Montefiori, David, Moore, Paul, Johnson, Syd, Koenig, Scott, Haynes, Barton F., Nordstrom, Jeffrey L., Margolis, David M., and Ferrari, Guido

Subjects
T cells -- Genetic aspects, Viral proteins -- Properties, Immune response -- Regulation, HIV infection -- Genetic aspects -- Development and progression, Health care industry
Abstract

Enhancement of HIV-specific Immunity Is likely required to eliminate latent HIV Infection. Here, we have developed an Immunotherapeutic modality aimed to improve T cell-mediated clearance of HIV-1-infected cells. Specifically, we employed Dual-Affinity Re-Targeting (DART) proteins, which are bispecific, antibody-based molecules that can bind 2 distinct cell-surface molecules simultaneously. We designed DARTs with a monovalent HIV-1 envelope-binding (Env-binding) arm that was derived from broadly binding, antibody-dependent cellular cytotoxicity-mediating antibodies known to bind to HIV- infected target cells coupled to a monovalent CD3 binding arm designed to engage cytolytic effector T cells (referred to as HIVxCD3 DARTs). Thus, these DARTs redirected polyclonal T cells to specifically engage with and kill Env-expressing cells, including [CD4.sup.+] T cells infected with different HIV-1 subtypes, thereby obviating the requirement for HIV- specific immunity. Using lymphocytes from patients on suppressive antiretroviral therapy (ART), we demonstrated that DARTs mediate [CD8.sup.+] T cell clearance of [CD4.sup.+] T cells that are superinfected with the HIV-1 strain JR-CSF or infected with autologous reservoir viruses isolated from HIV-infected-patient resting [CD4.sup.+] T cells. Moreover, DARTs mediated [CD8.sup.+] T cell clearance of HIV from resting [CD4.sup.+] T cell cultures following induction of latent virus expression. Combined with HIV latency reversing agents, HIVxCD3 DARTs have the potential to be effective immunotherapeutic agents to clear latent HIV-1 reservoirs in HIV-infected individuals., Introduction The inability of antiretroviral therapy (ART) to eradicate HIV was first suggested by the demonstration of latent infection of resting [CD4.sup.+] T cells (1) and then by the recovery [...]

Published
2015
Full Text
View/download PDF

33. Gibberellins modulate shade-induced soybean hypocotyl elongation downstream of the mutual promotion of auxin and brassinosteroids

Author

Jiang, Hengke, primary, Shui, Zhaowei, additional, Xu, Li, additional, Yang, Yinhua, additional, Li, Yan, additional, Yuan, Xiaoqin, additional, Shang, Jing, additional, Asghar, Muhammad Ahsan, additional, Wu, Xiaoling, additional, Yu, Liang, additional, Liu, Chunyan, additional, Yang, Wenyu, additional, Sun, Xin, additional, and Du, Junbo, additional

Published
2020
Full Text
View/download PDF

39. Backbone Coplanarity Tuning of 1,4-Di(3-alkoxy-2-thienyl)-2,5-difluorophenylene-Based Wide Bandgap Polymers for Efficient Organic Solar Cells Processed from Nonhalogenated Solvent

Author

Liao, Qiaogan, primary, Yang, Kun, additional, Chen, Jianhua, additional, Koh, Chang Woo, additional, Tang, Yumin, additional, Su, Mengyao, additional, Wang, Yang, additional, Yang, Yinhua, additional, Feng, Xiyuan, additional, He, Zhubing, additional, Woo, Han Young, additional, and Guo, Xugang, additional

Published
2019
Full Text
View/download PDF

41. Abstract 554: Tumor-antigen 5T4-dependent activation of the CD137 costimulatory pathway by bispecific 5T4 x CD137 x CD137 TRIDENT™ molecules

Author

Liu, Liqin, primary, Huang, Ling, additional, Long, Vatana, additional, Yang, Yinhua, additional, Burns, Robert, additional, Li, Jonathan, additional, DiChiara, Jennifer, additional, Xu, Qihong, additional, Whiddon, Arin, additional, Lam, Chia-Ying K, additional, Tamura, Jim, additional, Ciccarone, Valentina, additional, Johnson, Syd, additional, Bonvini, Ezio, additional, and Moore, Paul, additional

Published
2019
Full Text
View/download PDF

42. Abstract 1560: Selection of a bispecific trivalent HER2 x CD137 TRIDENT format providing optimal tumor-anchored immune co-stimulation

Author

Liu, Liqin, primary, Lam, Chia-Ying K., additional, Alderson, Ralph, additional, Long, Vatana, additional, Yang, Yinhua, additional, Burns, Robert, additional, Widjaja, Lusiana, additional, Li, Jonathan, additional, Wolf, Christina, additional, Ciccarone, Valentina, additional, Tamura, James, additional, Diedrich, Gundo, additional, Bonvini, Ezio, additional, Johnson, Syd, additional, and Moore, Paul A., additional

Published
2019
Full Text
View/download PDF

44. Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer

Author

Moore, Paul A., primary, Shah, Kalpana, additional, Yang, Yinhua, additional, Alderson, Ralph, additional, Roberts, Penny, additional, Long, Vatana, additional, Liu, Daorong, additional, Li, Jonathan C., additional, Burke, Steve, additional, Ciccarone, Valentina, additional, Li, Hua, additional, Fieger, Claudia B., additional, Hooley, Jeff, additional, Easton, Ann, additional, Licea, Monica, additional, Gorlatov, Sergey, additional, King, Kathy L., additional, Young, Peter, additional, Adami, Arash, additional, Loo, Deryk, additional, Chichili, Gurunadh R., additional, Liu, Liqin, additional, Smith, Douglas H., additional, Brown, Jennifer G., additional, Chen, Francine Z., additional, Koenig, Scott, additional, Mather, Jennie, additional, Bonvini, Ezio, additional, and Johnson, Syd, additional

Published
2018
Full Text
View/download PDF

48. MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies

Author

Liu, Liqin, primary, Lam, Chia-Ying K., additional, Long, Vatana, additional, Widjaja, Lusiana, additional, Yang, Yinhua, additional, Li, Hua, additional, Jin, Linda, additional, Burke, Steve, additional, Gorlatov, Sergey, additional, Brown, Jennifer, additional, Alderson, Ralph, additional, Lewis, Margaret D., additional, Nordstrom, Jeffrey L., additional, Koenig, Scott, additional, Moore, Paul A., additional, Johnson, Syd, additional, and Bonvini, Ezio, additional

Published
2017
Full Text
View/download PDF

49. Abstract 1498: Development of an IL13Ralpha2 x CD3 bispecific DART® protein for redirected T-cell killing of solid tumors

Author

Rillema, Jill, primary, Licea, Monica, additional, Saini-Lal, Shereen, additional, Smith, Doug, additional, Chen, Francine, additional, Lam, Annie, additional, Yang, Yinhua, additional, Liu, Liqin, additional, Tamura, James, additional, Alderson, Ralph, additional, Bonvini, Ezio, additional, Johnson, Syd, additional, and Moore, Paul, additional

Published
2016
Full Text
View/download PDF

50. Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer

Author

Root, Adam, primary, Cao, Wei, additional, Li, Bilian, additional, LaPan, Peter, additional, Meade, Caryl, additional, Sanford, Jocelyn, additional, Jin, Macy, additional, O’Sullivan, Cliona, additional, Cummins, Emma, additional, Lambert, Matthew, additional, Sheehan, Alfredo, additional, Ma, Weijun, additional, Gatto, Scott, additional, Kerns, Kelvin, additional, Lam, Khetemenee, additional, D’Antona, Aaron, additional, Zhu, Lily, additional, Brady, William, additional, Benard, Susan, additional, King, Amy, additional, He, Tao, additional, Racie, Lisa, additional, Arai, Maya, additional, Barrett, Dianah, additional, Stochaj, Wayne, additional, LaVallie, Edward, additional, Apgar, James, additional, Svenson, Kristine, additional, Mosyak, Lidia, additional, Yang, Yinhua, additional, Chichili, Gurunadh, additional, Liu, Liqin, additional, Li, Hua, additional, Burke, Steve, additional, Johnson, Syd, additional, Alderson, Ralph, additional, Finlay, William, additional, Lin, Laura, additional, Olland, Stéphane, additional, Somers, William, additional, Bonvini, Ezio, additional, Gerber, Hans-Peter, additional, May, Chad, additional, Moore, Paul, additional, Tchistiakova, Lioudmila, additional, and Bloom, Laird, additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results