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181 results on '"Yang, Zhen Kun"'

6. Ethanol extract of Evodia lepta Merr. ameliorates cognitive impairment through inhibiting NLRP3 inflammasome in scopolamine-treated mice

Author

Hu, Rui-Dan, primary, Zhu, Wen-Li, additional, Lin, Wei-Yao, additional, Qiu, Yu-Hui, additional, Wu, Guang-Liang, additional, Ding, Xiao-Ying, additional, Yang, Zhen-Kun, additional, Feng, Qian, additional, Zhang, Rong-Rong, additional, Qiao, Li-Jun, additional, Cai, Ye-Feng, additional, and Zhang, Shi-Jie, additional

Published
2024
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10. The rice LATE ELONGATED HYPOCOTYL enhances salt tolerance by regulating Na+/K+ homeostasis and ABA signalling.

Author

Li, Chao, He, Yi‐Qin, Yu, Jie, Kong, Jia‐Rui, Ruan, Cheng‐Cheng, Yang, Zhen‐Kun, Zhuang, Jun‐Jie, Wang, Yu‐Xiao, and Xu, Jian‐Hong

Subjects
CIRCADIAN rhythms, CLOCK genes, ABSCISIC acid, MOLECULAR clock, GENE expression, RICE, SALT
Abstract

The circadian clock plays multiple functions in the regulation of plant growth, development and response to various abiotic stress. Here, we showed that the core oscillator component late elongated hypocotyl (LHY) was involved in rice response to salt stress. The mutations of OsLHY gene led to reduced salt tolerance in rice. Transcriptomic analyses revealed that the OsLHY gene regulates the expression of genes related to ion homeostasis and the abscisic acid (ABA) signalling pathway, including genes encoded High‐affinity K+ transporters (OsHKTs) and the stress‐activated protein kinases (OsSAPKs). We demonstrated that OsLHY directly binds the promoters of OsHKT1;1, OsHKT1;4 and OsSAPK9 to regulate their expression. Moreover, the ossapk9 mutants exhibited salt tolerance under salt stress. Taken together, our findings revealed that OsLHY integrates ion homeostasis and the ABA pathway to regulate salt tolerance in rice, providing insights into our understanding of how the circadian clock controls rice response to salt stress. Summary statement: The expression of rice core component circadian clock gene LATE ELONGATED HYPOCOTYL can be induced under salt stress, which alters the expression of Na+ and K+ transporter related genes and genes in the ABA signalling pathway to positively regulate salt stress tolerance in rice. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Circulating Chromogranin B Is Associated With Left Ventricular Functional Recovery After Successful Recanalization of Chronic Total Occlusion

Author

Shen, Ying, primary, Aihemaiti, Muladili, additional, Shu, Xin Yi, additional, Yang, Chen Die, additional, Chen, Jia Wei, additional, Dai, Yang, additional, Ding, Feng Hua, additional, Yang, Zhen Kun, additional, Hu, Jian, additional, Zhang, Rui Yan, additional, Lu, Lin, additional, Wang, Xiao Qun, additional, and Shen, Wei Feng, additional

Published
2021
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32. new demethylase gene, OsDML4, is involved in high temperature-increased grain chalkiness in rice.

Author

Yan, Yan, Li, Chao, Liu, Zhen, Zhuang, Jun-Jie, Kong, Jia-Rui, Yang, Zhen-Kun, Yu, Jie, Alam, Mohammad Shah, Ruan, Cheng-Cheng, Zhang, Heng-Mu, and Xu, Jian-Hong

Subjects
SEED proteins, DEMETHYLASE, GLUTELINS, DNA methylation, TRANSCRIPTION factors, SEED storage
Abstract

High temperature (HT) can affect the accumulation of seed storage materials and cause adverse effects on the yield and quality of rice. DNA methylation plays an important role in plant growth and development. Here, we identified a new demethylase gene OsDML4 and discovered its function in cytosine demethylation to affect endosperm formation. Loss of function of OsDML4 induced chalky endosperm only under HT and dramatically reduced the transcription and accumulation of glutelins and 16 kDa prolamin. The expression of two transcription factor genes RISBZ1 and RPBF was significantly decreased in the osdml4 mutants, which caused adverse effects on the formation of protein bodies (PBs) with greatly decreased PB-II number, and incomplete and abnormally shaped PB-IIs. Whole-genome bisulfite sequencing analysis of seeds at 15 d after pollination revealed much higher global methylation levels of CG, CHG, and CHH contexts in the osdml4 mutants compared with the wild type. Moreover, the RISBZ1 promoter was hypermethylated but the RPBF promoter was almost unchanged under HT. No significant difference was detected between the wild type and osdml4 mutants under normal temperature. Our study demonstrated a novel OsDML4 -mediated DNA methylation involved in the formation of chalky endosperm only under HT and provided a new perspective in regulating endosperm development and the accumulation of seed storage proteins in rice. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Additional file 1 of Visit-to-visit HbA1c variability is associated with in-stent restenosis in patients with type 2 diabetes after percutaneous coronary intervention

Author

Yang, Chen Die, Shen, Ying, Lu, Lin, Yang, Zhen Kun, Hu, Jian, Zhang, Rui Yan, Shen, Wei Feng, Ding, Feng Hua, and Wang, Xiao Qun

Abstract

Additional file 1: Figure S1 Cumulative frequency curves for diameter stenosis (DS, A), net luminal gain (B) and net luminal loss (C) at follow-up angiography in subjects with different tertiles of SD of HbA1c. Figure S2 Cumulative frequency curves for diameter stenosis (DS, A), net luminal gain (B) and net luminal loss (C) at follow-up angiography in subjects with different tertiles of VIM of HbA1c. Figure S3 Comparison of different measures of intraindividual variability of HbA1c between patients with and without ISR. Figure S4 Subgroup analysis of diameter stenosis (DS) at follow-up angiography based on tertiles of SD of HbA1c. Data are expressed as mean ± confidence interval (CI). T1 the lowest tertile; T2 intermediate tertile; T3 the highest tertile. *P

Published
2020
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49. Predictive value of SYNTAX score II for clinical outcomes in octogenarian undergoing percutaneous coronary intervention

Author

Kurniawan, Evan, Ding, Feng-Hua, Zhang, Qi, Yang, Zhen-Kun, Hu, Jian, Shen, Wei-Feng, and Zhang, Rui-Yan

Subjects
Elderly, cardiovascular diseases, Risk stratification, Research Article, Clinical research
Abstract

Objective To evaluate the predictive value of SYNTAX Score II (SS-II) for percutaneous coronary intervention (PCI) in octogenarian (≥ 80 years old) undergoing PCI. Methods & Results Data from three consecutive years of octogenarian undergoing PCI from Ruijin Hospital (Shanghai, China) was retrospectively collected (n = 308). Follow up clinical data at one year including all cause mortality, cardiac mortality and main adverse cardiovascular and cerebrovascular events (MACCE) were collected. Patients were stratified according to tertiles of SS-II for PCI: SS-II ≤ 26 (n = 104), SS-II: 27–31 (n = 102), SS-II > 31 (n = 102). After adjustment for confounding factors, SS-II for PCI was an independent risk factors for all cause mortality (odds ratio: 2.77, 95% CI: 1.13–8.06; P = 0.04). Kaplan-Meier curves showed higher event rates for all cause mortality and cardiac mortality in higher tertile of SS-II for PCI (Log-Rank test P = 0.002 and P = 0.001, respectively). SS-II for PCI predicted one year mortality in octogenarian population undergoing PCI. Conclusions In octogenarian, SS-II which incorporated clinical variables with angiographic anatomy variable was suitable in risk stratifying and predicting clinical outcomes at one year.

Published
2016

50. [Studies on resistance of

Author

Qian, Ke, Liang, You-Sheng, Wang, Wei, Qu, Guo-Li, Li, Hong-Jun, Yang, Zhen-Kun, Zhao, Zheng-Yang, Xing, Yuntian, and Dai, Jian-Rong

Subjects
Anthelmintics, Male, Mice, Schistosomiasis japonica, Snails, Drug Resistance, Animals, Female, Cercaria, Parasite Egg Count, Praziquantel, Schistosoma japonicum
Abstract

To investigate the biological characteristics of the praziquantel-resistant isolate ofMice were infected with the cercariae released from two praziquantel-resistant isolates and two praziquantel-susceptible isolates ofThe prepatent period of parasite eggs, egg counts in mouse feces, adult worms recovered from each mouse, egg counts in mouse tissues, egg counts in the mouse liver, and egg counts in intestine tissues were 36.1 d and 36.8 d (The praziquantel-resistant isolate of

Published
2018

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