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265 results on '"Yang Jian-yu"'

1. CP asymmetries corresponding to the imaginary parts of the interference terms in cascade decays of heavy hadrons

Author

Qi, Jing-Juan, Yang, Jian-Yu, and Zhang, Zhen-Hua

Subjects
High Energy Physics - Phenomenology
Abstract

A mechanism of generating CP violation through the imaginary part of the interference of two amplitudes is proposed. This mechanism has shown clear evidence in decays such as $B^\pm\to \pi^\pm\pi^+\pi^-$. The proposed mechanism is helpful in searching for CP violation in bottom and charmed baryon decay processes., Comment: 12 pages,1 figure

Published
2024

3. An Optimal DEM Reconstruction Method for Linear Array Synthetic Aperture Radar Based on Variational Model

Author

Shi Jun, Zhang Xiao-ling, Wei Shun-jun, Xiang Gao, and Yang Jian-yu

Subjects
Linear Array Synthetic Aperture Radar (LASAR), Variational model, Optimal DEM reconstruction, Least mean squares criterion, Electricity and magnetism, QC501-766
Abstract

Downward-looking Linear Array Synthetic Aperture Radar (LASAR) has many potential applications in the topographic mapping, disaster monitoring and reconnaissance applications, especially in the mountainous area. However, limited by the sizes of platforms, its resolution in the linear array direction is always far lower than those in the range and azimuth directions. This disadvantage leads to the blurring of Three-Dimensional (3D) images in the linear array direction, and restricts the application of LASAR. To date, the research on 3D SAR image enhancement has focused on the sparse recovery technique. In this case, the one-to-one mapping of Digital Elevation Model (DEM) brakes down. To overcome this, an optimal DEM reconstruction method for LASAR based on the variational model is discussed in an effort to optimize the DEM and the associated scattering coefficient map, and to minimize the Mean Square Error (MSE). Using simulation experiments, it is found that the variational model is more suitable for DEM enhancement applications to all kinds of terrains compared with the Orthogonal Matching Pursuit (OMP)and Least Absolute Shrinkage and Selection Operator (LASSO) methods.

Published
2015
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4. Development Laws and Macro Trends Analysis of Radar Technology

Author

Yang Jian-yu

Subjects
Radar technology, Developing motivation, Developing law, Macro trends, Electricity and magnetism, QC501-766
Abstract

Viewing from the interaction between external and internal causes on the time scale of history, present and future, this paper analyzes and demonstrates the developing motivation and stage characteristics of radar technology. The external causes are interpreted as target, environment and mission, and the internal causes as information acquisition pattern, realization ability and resource utilization. The fundamental law of radar development is revealed as evolving stepwise from lower into higher dimension of detection through the aromorphosis of channel configuration, viewing angle and signal dimensionality, while the main innovation strategies of radar technology are summarized as modifying information acquisition pattern, enhancing realization ability and increasing utilized resources. Furthermore, the developing trends and main characteristics of future radar technology are deduced, and proposals for promoting future innovation and development are also presented.

Published
2012

10. Construction and validation of immunogenic cell death-related molecular clusters, signature, and immune landscape in pancreatic cancer.

Author

Hu, Cheng-Yu, Yin, Yi-Fan, Xu, Da-Peng, Xu, Yu, Yang, Jian-Yu, Xu, Yan-Nan, and Hua, Rong

Subjects
GENE expression, MEDICAL sciences, LIFE sciences, CANCER genetics, PANCREATIC cancer
Abstract

Pancreatic cancer (PC) is a malignancy of the gastrointestinal tract that is characterized by a poor prognosis. This study investigates the roles of immunogenic cell death (ICD) genes in the prognosis and progression of PC. Expression data for PC patients were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets, while ICD genes were sourced from published literature. We explored the expression patterns and identified two distinct clusters based on ICD genes. Kaplan–Meier analysis, differential expression analysis, tumor mutational burden analysis, and immune cell infiltration analysis were performed on these clusters. An ICD gene-based risk model was developed, categorizing samples from the TCGA and GEO datasets into low- and high-risk groups. Additionally, we investigated the expression levels of the genes included in the risk model within the TCGA cohort and our own samples. Finally, a loss-of-function assay was conducted to assess the role of MYD88 in PC. Two clusters of PC samples were identified, patients in the ICD-low cluster exhibited a higher degree of immune cell enrichment. The survival time of patients in the low-risk group was longer than that of those in the high-risk group. The genes included in the risk model (CASP1, MYD88, and PIK3CA) showed upregulated expression levels in tumor samples. Furthermore, the predictive accuracy of our risk model was validated using our own samples. Genetic inhibition of MYD88 led to significantly decreased proliferation and migration of PC cells in the loss-of-function assay. There were disparities in survival time and tumor immune microenvironment (TIME) between two ICD gene clusters. Additionally, we developed an ICD-related risk model that was validated as an independent prognostic indicator for patients with PC. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma.

Author

Liu, Wei, primary, Jia, Qinyuan, additional, Zhu, Yuheng, additional, Yao, Hong-fei, additional, Yin, Yifan, additional, Duan, Zonghao, additional, Zheng, Jia-hao, additional, Ma, Ding, additional, Yang, Min-Wei, additional, Yang, Jian-yu, additional, Zhang, Junfeng, additional, Liu, De-jun, additional, Hua, Rong, additional, Huo, Yan-Miao, additional, Xue-Liang, Fu, additional, and Sun, Yong-Wei, additional

Published
2023
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18. The lncRNA LINC01605 promotes the progression of pancreatic ductal adenocarcinoma by activating the mTOR signaling pathway

Author

Zhu, Yu-Heng, primary, Jia, Qin-Yuan, additional, Yao, Hong-Fei, additional, Duan, Zong-Hao, additional, Ma, Xue-Shi-Yu, additional, Zheng, Jia-Hao, additional, Yin, Yi-Fan, additional, Liu, Wei, additional, Zhang, Jun-Feng, additional, Hua, Rong, additional, Ma, Ding, additional, Sun, Yong-Wei, additional, Yang, Jian-Yu, additional, Liu, De-Jun, additional, and Huo, Yan-Miao, additional

Published
2023
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19. Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

Author

Jiang, Shu-Heng, Li, Jun, Dong, Fang-Yuan, Yang, Jian-Yu, Liu, De-Jun, Yang, Xiao-Mei, Wang, Ya-Hui, Yang, Min-Wei, Fu, Xue-Liang, Zhang, Xiao-Xin, Li, Qing, Pang, Xiu-Feng, Huo, Yan-Miao, Li, Jiao, Zhang, Jun-Feng, Lee, Ho-Young, Lee, Su-Jae, Qin, Wen-Xin, Gu, Jian-Ren, Sun, Yong-Wei, and Zhang, Zhi-Gang

Published
2017
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21. Exploitation and Verification of a Stroma- and Metastasis-Associated Risk Prognostic Signature in Pancreatic Adenocarcinoma

Author

Zheng, Jia-Hao, primary, Yao, Hong-Fei, additional, Duan, Zong-Hao, additional, Ji, Pei-Xuan, additional, Yang, Jian, additional, Zhu, Yu-Heng, additional, Jia, Qin-Yuan, additional, Yang, Jian-Yu, additional, Liu, De-Jun, additional, Sun, Yong-Wei, additional, Chen, Peng-Cheng, additional, Shi, Pei-Dong, additional, and Chen, Li, additional

Published
2022
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27. SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A–c‐Myc axis

Author

Yang, Jian‐Yu, primary, Huo, Yan‐Miao, additional, Yang, Min‐Wei, additional, Shen, Yang, additional, Liu, De‐Jun, additional, Fu, Xue‐Liang, additional, Tao, Ling‐Ye, additional, He, Rui‐Zhe, additional, Zhang, Jun‐Feng, additional, Hua, Rong, additional, Jiang, Shu‐Heng, additional, Sun, Yong‐Wei, additional, and Liu, Wei, additional

Published
2021
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30. Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma

Author

Yang, Min-Wei, primary, Tao, Ling-Ye, additional, Jiang, Yong-Sheng, additional, Yang, Jian-Yu, additional, Huo, Yan-Miao, additional, Liu, De-Jun, additional, Li, Jiao, additional, Fu, Xue-Liang, additional, He, Ruizhe, additional, Lin, Chaoyi, additional, Liu, Wei, additional, Zhang, Jun-Feng, additional, Hua, Rong, additional, Li, Qing, additional, Jiang, Shu-Heng, additional, Hu, Li-Peng, additional, Tian, Guang-Ang, additional, Zhang, Xiao-Xin, additional, Niu, Ningning, additional, Lu, Ping, additional, Shi, Juanjuan, additional, Xiao, Gary G., additional, Wang, Li-Wei, additional, Xue, Jing, additional, Zhang, Zhi-Gang, additional, and Sun, Yong-Wei, additional

Published
2020
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34. SFRP4 is a prognostic marker and correlated with Treg cell infiltration in pancreatic ductal adenocarcinoma

Author

Yang, Min-Wei, Tao, Ling-Ye, Yang, Jian-Yu, Jiang, Yong-Sheng, Fu, Xue-Liang, Liu, Wei, Huo, Yan-Miao, Li, Jiao, Zhang, Jun-Feng, Hua, Rong, Qin, Xiao-Ran, Sun, Yong-Wei, and Liu, De-Jun

Subjects
Original Article
Abstract

Secreted Frizzled-Related Protein 4 (SFRP4), a member of secreted frizzled-related protein family, has been found as a vital modulator in cell proliferation, cell self-renew and apoptosis through Wnt signaling transduction pathway. In the present study, we re-analyzed the expression pattern of SFRPs in Gene Expression Omnibus (GEO) datasets and evaluated the expression of SFRP4 at protein level in both Kras(G12D/+); Trp53(R172H/+); Pdx1-Cre; (KPC) mice and human pancreatic ductal adenocarcinoma (PDAC) tissue. We found that the expression of SFRP4 increased gradually in PanINs and PDAC lesions in KPC mice and high expression of SFRP4 was much more common in tumor lesions compared to the adjacent non-tumor tissues. Then we performed Kaplan-Meier survival and Cox regression analysis and found that high expression of SFRP4 in the serum and tumor lesions predicted poor prognosis for pancreatic cancer patients. Furthermore, we demonstrated that SFRP4 positively correlated with FOXP3+ Treg cells infiltration while the down-regulation of SFRP4 in tumor cells impaired the production of cytokines and the recruitments of T cells. This study suggested that SFRP4 can be a novel prognostic biomarker and potential therapeutic target for pancreatic cancer.

Published
2019

38. Clinical significance of programmed death 1/programmed death ligand 1 pathway in gastric neuroendocrine carcinomas

Author

Yang, Min-Wei, primary, Fu, Xue-Liang, additional, Jiang, Yong-Sheng, additional, Chen, Xiao-Jing, additional, Tao, Ling-Ye, additional, Yang, Jian-Yu, additional, Huo, Yan-Miao, additional, Liu, Wei, additional, Zhang, Jun-Feng, additional, Liu, Pei-Feng, additional, Liu, Qiang, additional, Hua, Rong, additional, Zhang, Zhi-Gang, additional, Sun, Yong-Wei, additional, and Liu, De-Jun, additional

Published
2019
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40. GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner

Author

Jiang, Shu-Heng, primary, Zhu, Li-Li, additional, Zhang, Man, additional, Li, Rong-Kun, additional, Yang, Qin, additional, Yan, Jiang-Yu, additional, Zhang, Ce, additional, Yang, Jian-Yu, additional, Dong, Fang-Yuan, additional, Dai, Miao, additional, Hu, Li-Peng, additional, Li, Jun, additional, Li, Qing, additional, Wang, Ya-Hui, additional, Yang, Xiao-Mei, additional, Zhang, Yan-Li, additional, Nie, Hui-Zhen, additional, Zhu, Lei, additional, Zhang, Xue-Li, additional, Tian, Guang-Ang, additional, Zhang, Xiao-Xin, additional, Cao, Xiao-Yan, additional, Tao, Ling-Ye, additional, Huang, Shan, additional, Jiang, Yong-Sheng, additional, Hua, Rong, additional, Qian Luo, Kathy, additional, Gu, Jian-Ren, additional, Sun, Yong-Wei, additional, Hou, Shangwei, additional, and Zhang, Zhi-Gang, additional

Published
2019
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41. Chord angle representation for shape matching under occlusion

Author

黄伟国 Huang Wei-guo, 朱忠奎 Zhu Zhong-kui, 胡大盟 Hu Da-Meng, and 杨剑宇 Yang Jian-Yu

Subjects
Chord (geometry), business.industry, Computer science, Occlusion, Shape matching, Computer vision, Artificial intelligence, business, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Published
2015
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43. Efficacy of Neo-Adjuvant Chemoradiotherapy for Resectable Pancreatic Adenocarcinoma

Author

Liu, Wei, Fu, Xue-Liang, Yang, Jian-Yu, Liu, De-Jun, Li, Jiao, Zhang, Jun-Feng, Huo, Yan-Miao, Yang, Min-Wei, Hua, Rong, and Sun, Yong-Wei

Subjects
Pancreatic Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Humans, Chemoradiotherapy, Adjuvant, Hospital Mortality, Adenocarcinoma, Survival Analysis, Systematic Reviewand Meta-Analysis, Research Article, Pancreaticoduodenectomy
Abstract

We have conducted a meta-analysis and systematic review to determine the overall survival, mortality rate, and complete resection rate of neo-adjuvant chemoradiotherapy (CRT) compared with pancreaticoduodenectomy alone in patients with pancreatic adenocarcinoma. Whether neo-adjuvant CRT is beneficial in the treatment of resectable pancreatic cancer or not, it is still a controversial issue. Medline and Cochrane were searched with relevant terms. Eight studies with a total of 833 participants were selected. The meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The analysis revealed neo-adjuvant group may have a benefit in the overall survival, as compared with the resection group, although it did not reach statistical significance (pooled hazard ratio = 0.87, 95% confidence interval [CI] = 0.75–1.00, P = 0.051). We found no difference in the in-hospital mortality rate (pooled odds ratio [OR] = 1.27, 95% CI = 0.35–4.58, P = 0.710). The complete resection rate was significantly higher in the neo-adjuvant group than in the resection group (pooled OR = 2.39, 95% CI = 1.21–4.74, P = 0.012). This meta-analysis found that there was no significant difference in the overall survival between patients treated with neo-adjuvant CRT or pancreaticduodenectomy.

Published
2016

45. Corrigendum: Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma

Author

Yang, Jian-Yu, Jiang, Shu-Heng, Liu, De-Jun, Yang, Xiao-Mei, Huo, Yan-Miao, Li, Jiao, Hua, Rong, Zhang, Zhi-Gang, and Sun, Yong-Wei

Subjects
Male, Down-Regulation, Kaplan-Meier Estimate, Middle Aged, Protein Serine-Threonine Kinases, Prognosis, Real-Time Polymerase Chain Reaction, Corrigenda, Pancreatic Neoplasms, AMP-Activated Protein Kinase Kinases, Cell Line, Tumor, Multivariate Analysis, Humans, Female, RNA, Messenger, Pancreas, Aged, Carcinoma, Pancreatic Ductal, Demography, Proportional Hazards Models
Abstract

Liver kinase B1 (LKB1) has been identified as a critical modulator involved in cell proliferation and polarity. The purpose of the current study was to characterize the expression pattern of LKB1 and assess the clinical significance of LKB1 expression in pancreatic ductal adenocarcinoma (PDAC) patients. LKB1 mRNA expression which was analyzed in 32 PDAC lesions and matched non-tumor tissues, was downregulated in 50% (16/32) of PDAC lesions. Similar results were also obtained by analyzing three independent datasets from Oncomine. Protein expression of LKB1 was significantly reduced in 6 PDAC cell lines and downregulated in 31.3% (10/32) of PDAC lesions compared to matched non-tumorous tissues, as determined by Western blot analysis. Additionally, tissue microarray containing 205 PDAC specimens was evaluated for LKB1 expression by IHC and demonstrated that reduced expression of LKB1 in 17.6% (36/205) of PDAC tissues was significantly correlated with clinical stage, T classification, N classification, liver metastasis and vascular invasion. Importantly, Kaplan-Meier survival and Cox regression analyses were executed to evaluate the prognosis of PDAC and found that LKB1 protein expression was one of the independent prognostic factors for overall survival of PDAC patients.

Published
2015

46. High Expression of FAM83B Predicts Poor Prognosis in Patients with Pancreatic Ductal Adenocarcinoma and Correlates with Cell Cycle and Cell Proliferation

Author

Shen, Chao-qin, primary, Yan, Ting-Ting, additional, Liu, Wei, additional, Zhu, Xiao-qiang, additional, Tian, Xiang-long, additional, Fu, Xue-liang, additional, Hua, Rong, additional, Zhang, Jun-feng, additional, Huo, Yan-miao, additional, Liu, De-jun, additional, Yang, Jian-yu, additional, Sun, Yong-Wei, additional, Fang, Jing-Yuan, additional, Chen, Hao-Yan, additional, and Hong, Jie, additional

Published
2017
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49. Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer

Author

Jiang, Shu-Heng, primary, Wang, Yang, additional, Yang, Jian-Yu, additional, Li, Jun, additional, Feng, Ming-Xuan, additional, Wang, Ya-Hui, additional, Yang, Xiao-Mei, additional, He, Ping, additional, Tian, Guang-Ang, additional, Zhang, Xiao-Xin, additional, Li, Qing, additional, Cao, Xiao-Yan, additional, Huo, Yan-Miao, additional, Yang, Min-Wei, additional, Fu, Xue-Liang, additional, Li, Jiao, additional, Liu, De-Jun, additional, Dai, Miao, additional, Wen, Shan-Yun, additional, Gu, Jian-Ren, additional, Hong, Jie, additional, Hua, Rong, additional, Zhang, Zhi-Gang, additional, and Sun, Yong-Wei, additional

Published
2015
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