1. Effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-a and coagulation factors in peripheral blood of elderly patients after hip arthroplasty
- Author
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Huang Zhi, Cai Yan, Yang Yunfei, Shi Jin, Zhao Xuya, Mo Haise, and Zeng Qingfan
- Subjects
lumbar slave-sciatic nerve block ,epidural anesthesia ,inflammatory factor ,coagulation factor ,Biochemistry ,QD415-436 - Abstract
Background: To investigate the effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of inflammatory factors such as Interleukin-6 (IL6), Interleukin-8 (IL-8), Tumor necrosis factor-a (TNF-a) and coagulation factors in peripheral blood of elderly patients after hip arthroplasty to provides reference value for the choice of intraoperative anesthesia. Methods: 96 elderly patients underwent hip arthroplasty in our hospital from March 2018 to December 2019 were selected and divided into ultrasound-guided lumbar-sciatic nerve block group (group A) and epidural anesthesia group (group B) randomly , there were 48 cases in each group. The onset time of intraoperative anesthesia, postoperative hemodynamic indexes, pain score, inflammatory factors and blood coagulation factor levels were compared between group A and group B. Results: It was proved that: (1) The onset time of sensory block and motor block in group B were shorter compared with group A, and the maintenance time of anesthesia was prolonged (P0.05); (3) Compared with group A, the levels of TNF- , IL-8and IL-6 in peripheral blood of group B decreased after T2, T3 and T4 (P0.05). Conclusions: Compared with epidural anesthesia, lumbarsciatic nerve block is showed significantly lower values in concentration of peripheral blood coagulation factors and inflammatory factors after surgery, thereby alleviating postoperative hypercoagulability and inflammation.
- Published
- 2022
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