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In the quest for bioactive compounds from Ganoderma, artificially cultivated fruiting bodies of Ganoderma cf. mastoporum, strain TBRC-BCC 47851 were chemically investigated. The study led to the isolation of three undescribed lanostane triterpenoids (1–3) together with twelve known compounds. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The new compounds were inactive in the antimalarial and antitubercular activity assays. [ABSTRACT FROM AUTHOR]

Seven undescribed lanostane triterpenoids (1 – 7) were isolated from artificially cultivated fruiting bodies of Ganoderma wiiroense , strain TBRC-BCC 60613. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The C-23 absolute configuration of 1 was determined to be 23 S using the modified Mosher's method. The isolated compounds were evaluated for their antitubercular and antimalarial activities. Compound 7 showed activity against Mycobacterium tuberculosis H37Ra (MIC 50 μg/ml). [Display omitted] • Seven undescribed lanostanes were isolated from Ganoderma wiiroense. • The structures were elucidated by spectroscopic methods and chemical correlations. • One of the undescribed lanostanes showed antitubercular activity. [ABSTRACT FROM AUTHOR]

A new acetylenic sesquiterpenoid, stereyne A (1), and its acetonide derivative, stereyne B (2), were isolated from cultures of the basidiomycete Stereum cf. hirsutum BCC 26597. The structures were elucidated by spectroscopic analysis and a chemical correlation. Their absolute configurations were determined by application of the modified Mosher's method. They represent new structural type of sesquiterpenoids from Stereum. [ABSTRACT FROM AUTHOR]