1. Evaluation of the immunogenicity and protective efficacy of an inactivated vaccine candidate for sheep infected with ovine parainfluenza virus type 3
- Author
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Yanhua Ma, Jialei Wang, Youzhi Wu, Xiaohui Zan, Yan Wang, Yanyan Zhou, Tao Wang, Caifeng Gong, Kai Meng, Rui Niu, Qiang Shang, Hao Wang, Jiali Wang, Ying He, and Wei Wang
- Subjects
Ovine parainfluenza virus type 3 ,inactivated OPIV3 vaccine ,pathogenicity ,respiratory disease ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Respiratory diseases constitute a major health problem for ruminants, resulting in considerable economic losses throughout the world. Parainfluenza type 3 virus (PIV3) is one of the most important respiratory pathogens of ruminants. The pathogenicity and phylogenetic analyses of PIV3 virus have been reported in sheep and goats. However, there are no recent studies of the vaccination of sheep or goats against PIV3. Here, we developed a purified inactivated ovine parainfluenza virus type 3 (OPIV3) vaccine candidate. In addition, we immunized sheep with the inactivated OPIV3 vaccine and evaluated the immune response and pathological outcomes associated with OPIV3 TX01 infection. The vaccinated sheep demonstrated no obvious symptoms of respiratory tract infection, and there were no gross lesions or pathological changes in the lungs. The average body weight gain significantly differed between the vaccinated group and the control group (P
- Published
- 2024
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