9 results on '"Yanzhao Bi"'
Search Results
2. Are adaptable employees more likely to stay? Boundaryless careers and career ecosystem perspectives on career adaptability and turnover
- Author
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Zhimei Wang, Anguo Fu, Yanjun Guan, Yanzhao Bi, Zhuolin She, Fuxi Wang, Xinyi Zhou, and Ying Xu
- Subjects
Arts and Humanities (miscellaneous) ,media_common.quotation_subject ,Developmental and Educational Psychology ,Ecosystem ,Business ,Marketing ,Applied Psychology ,Adaptability ,media_common - Abstract
Employees with higher career adaptability (CA) have been shown in previous research to be more likely to build high-quality social exchange relations with current employers, thereby displaying a lower intention to leave. Based on boundaryless careers and career ecosystem perspectives, this study aimed to challenge and enrich the extant understanding of this important question by examining the mixed effects of CA on turnover behavior. Results from a three-wave survey study with 179 Chinese employees show that after controlling the baseline turnover intention (Time 1), CA (Time 1) predicted both affective commitment and relative deprivation at Time 2 (6 months after Time 1), which in turn produced opposite effects on voluntary turnover behavior at Time 3 (12 months after Time 1). Moreover, the boundaryless career mindset positively moderated the relationship between CA and relative deprivation and strengthened the indirect positive effect of CA on turnover behavior via relative deprivation. These results offer a more comprehensive and balanced view of the mixed role of CA in employees' turnover behavior and carry important implications for human resource management
- Published
- 2021
3. Do adaptable employees always display high performance? Dual roles of proactive behavior and self-construal
- Author
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Yanzhao Bi, Qi Nie, Jie Zhang, and Miaomiao Wang
- Subjects
Self construal ,ComputingMilieux_THECOMPUTINGPROFESSION ,Social Psychology ,media_common.quotation_subject ,Applied psychology ,Proactivity ,Organizational performance ,Adaptability ,Dual (category theory) ,Interdependence ,Job performance ,Organizational behavior ,Psychology ,media_common - Abstract
We examined a dual-path model to explain the opposite roles of career adaptability and organizational performance. We used a time-lagged survey of 53 supervisors and 327 employees in China to collect data. Results show that career-oriented proactive behavior mediated the negative effect of career adaptability on performance, and work unitoriented proactive behavior mediated the positive effect of career adaptability on performance. Moreover, the effects of career adaptability and career-oriented proactive behavior on performance were significant only for employees with high independent selfconstrual, and the effects of career adaptability and work unit-oriented proactive behavior on performance were significant only for employees with high interdependent self-construal. This study extends career construction theory in the organizational behavior field and has practical significance for the effective guiding of adaptable employees' contribution to organizational performance.
- Published
- 2021
4. Investigation and improvement of the Mini-Max Polynomial Approximation method for solving burnup equations
- Author
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Cong Zhang, Binhang Zhang, Yanzhao Bi, Xianbao Yuan, Yonghong Zhang, and Haibo Tang
- Subjects
Nuclear Energy and Engineering - Published
- 2023
5. Damage identification of wind turbine blades based on acoustic emission.
- Author
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Zihan Wang, Kaidi Xu, Zhichun Luo, Jia Zhang, and Yanzhao Bi
- Subjects
WIND turbine blades ,ACOUSTIC emission ,WIND damage ,GLASS fibers ,ACOUSTIC signal processing ,LAMINATED materials ,EPOXY resins - Abstract
Wind turbine blades are subjected to alternating fatigue load caused by wind and, as a result, are prone to damage. It is hard to investigate the damage mechanism of the blades due to their complex structure and large size. In this paper, damage to wind turbine blade composites is identified based on acoustic emission (AE). Samples of singlecomponent glass fibre/epoxy resin composite laminate [90°] and [45°] were prepared and put through a tensile process and the acoustic emission signals during this process were analysed using cluster methodology and wavelet packet transformation. The results show that there are four damage modes: matrix damage, fibre break, interface damage and delamination, with the characteristic frequency bands of 0-0.06 MHz, 0.06-0.12 MHz, 0.25-0.32 MHz and 0.37-0.45 MHz, respectively. The damage process of laminate [45°] is analysed using the damage evolution diagram. The tensile process can be divided into four stages: matrix damage and interface damage appear first, then the fibre starts to break, after which follows the stationary expansion stage, resulting in interlaminar damage until fracture. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
6. Functionalized graphene oxide for anti-VEGF siRNA delivery: preparation, characterization and evaluation in vitro and in vivo
- Author
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Yanzhao Bi, Chunying Cui, Lulu Ren, Xu Ge, and Yifan Zhang
- Subjects
Chemistry ,General Chemical Engineering ,RNA ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Molecular biology ,In vitro ,0104 chemical sciences ,In vivo ,RNA interference ,Gene silencing ,Electrophoretic mobility shift assay ,MTT assay ,0210 nano-technology ,Cytotoxicity - Abstract
RNA interference (RNAi) treatment is a promising and effective method for gene therapy in cancer treatments. Small interference RNA (siRNA) plays an indispensable role in the process of RNAi, resulting in gene silencing. However, naked siRNA has difficulty in crossing the cell membrane and can easily be deactivated by enzymolysis. An ideal carrier is required for siRNA delivery to overcome these disadvantages. In this study, GO–PLL–SDGR (poly-L-lysine and Arg-Gly-Asp-Ser functionalized graphene oxide), a graphene oxide (GO)-based carrier that can actively target tumors, was prepared and characterized. Results of an agarose gel retardation assay indicated that 10 μg of GO–PLL–SDGR could load 1 μg of VEGF-siRNA. It was found that the release of VEGF-siRNA from GO–PLL–SDGR/VEGF-siRNA was slow and sustained. The efficiency of gene silencing and the tumor growth inhibitory activity of GO–PLL–SDGR/VEGF-siRNA were investigated both in vitro and in vivo by RT-qPCR, ELISA and an S180 tumor-bearing mice model. RT-qPCR and ELISA assays revealed that the expressions of VEGF-mRNA and VEGF protein were down-regulated by 40.86% and 51.71%, respectively, in vitro. In vivo, the Cy-3 labeled VEGF-siRNA was observed to assemble in tumor tissues, and the tumor inhibitory rate of GO–PLL–SDGR/VEGF-siRNA was 51.74%. What's more, GO–PLL–SDGR exhibited low cytotoxicity in the MTT assay. As all the evidence shows above, GO–PLL–SDGR could be used in siRNA delivery systems as a non-viral tumor targeting carrier.
- Published
- 2017
7. Gene-silencing effects of anti-survivin siRNA delivered by RGDV-functionalized nanodiamond carrier in the breast carcinoma cell line MCF-7
- Author
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Yanzhao Bi, Chunying Cui, Lulu Ren, Xueyun Jiang, and Yifan Zhang
- Subjects
Male ,0301 basic medicine ,Small interfering RNA ,Materials science ,Survivin ,Biophysics ,Down-Regulation ,Pharmaceutical Science ,Apoptosis ,Bioengineering ,02 engineering and technology ,Inhibitor of Apoptosis Proteins ,Nanodiamonds ,Flow cytometry ,Biomaterials ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,International Journal of Nanomedicine ,In vivo ,Drug Discovery ,medicine ,Animals ,Humans ,MTT assay ,Electrophoretic mobility shift assay ,Gene Silencing ,Propidium iodide ,RNA, Small Interfering ,Cytotoxicity ,Original Research ,Cell Proliferation ,Drug Carriers ,medicine.diagnostic_test ,Organic Chemistry ,General Medicine ,021001 nanoscience & nanotechnology ,NDCONH(CH2)2NH-VDGR ,Molecular biology ,Nanomedicine ,030104 developmental biology ,chemistry ,RNAi ,siRNA carrier ,MCF-7 Cells ,0210 nano-technology ,Oligopeptides - Abstract
Yanzhao Bi, Yifan Zhang, Chunying Cui, Lulu Ren, Xueyun Jiang School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, People’s Republic of China Abstract: Nanodiamond (ND) is a renowned material in nonviral small interfering RNA (siRNA) carrier field due to its unique physical, chemical, and biological properties. In our previous work, it was proven that ND could deliver siRNA into cells efficiently and downregulate the expression of desired protein. However, synthesizing a high-efficient tumor-targeting carrier using ND is still a challenge. In this study, a novel carrier, NDCONH(CH2)2NH-VDGR, was synthesized for siRNA delivery, and its properties were characterized with methods including Fourier transform infrared spectrometry, transmission electron microscopy, scanning electron microscopy, gel retardation assay, differential scanning calorimetry, confocal microscopy, releasing test, real-time polymerase chain reaction (PCR) assay, enzyme-linked immunosorbent assay (ELISA), flow cytometry, cytotoxicity assay, and gene-silencing efficacy assay in vitro and in vivo. The mechanism of NDCONH(CH2)2NH-VDGR/survivin-siRNA-induced tumor apoptosis was evaluated via flow cytometer assay using Annexin V–fluorescein isothiocyanate/propidium iodide staining method. The NDCONH(CH2)2NH-VDGR/survivin-siRNA nanoparticle with 60–110nm diameter and 35.65±3.90mV zeta potential was prepared. For real-time PCR assay, the results showed that the expression of survivin mRNA was reduced to 46.77%±6.3%. The expression of survivin protein was downregulated to 48.49%±2.25%, as evaluated by ELISA assay. MTT assay showed that NDCONH(CH2)2NH-VDGR/survivin-siRNA had an inhibitory effect on MCF-7 cell proliferation. According to these results, the survivin-siRNA could be delivered, transported, and released stably, which benefits in increasing the gene-silencing effect. Therefore, as an siRNA carrier, NDCONH(CH2)2NH-VDGR was suggested to be used in siRNA delivery system and in cancer treatments. Keywords: NDCONH(CH2)2NH-VDGR, siRNA carrier, RNAi, survivin
- Published
- 2016
8. The Mixed Role of Career Adaptability in Turnover Intention: A Multi-Path Moderated Mediation Model
- Author
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Zhuolin She, Yanjun Guan, Yanzhao Bi, Zhimei Wang, Fuxi Wang, Xinyi Zhou, and Ying Xu
- Subjects
Focus (computing) ,Moderated mediation ,Empirical research ,Extant taxon ,Social exchange theory ,media_common.quotation_subject ,Turnover intention ,General Medicine ,Multi path ,Psychology ,Social psychology ,Adaptability ,media_common - Abstract
Extant empirical research tends to focus on the negative effect of career adaptability on turnover intention, which is often explained by career construction and social exchange theories. This stud...
- Published
- 2020
9. The Mixed Role of Career Adaptability in Turnover Intention: A Multi-Path Moderated Mediation Model.
- Author
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Yanjun Guan, Ying Xu, Fuxi Wang, Xinyi Zhou, Zhuolin She, Zhimei Wang, and Yanzhao Bi
- Abstract
Extant empirical research tends to focus on the negative effect of career adaptability on turnover intention, which is often explained by career construction and social exchange theories. This study aims to enrich and challenge existing understanding of this important relationship based on job embeddedness and boundaryless careers perspectives. A multi-path mediation model (career satisfaction, affective commitment, job embeddedness, internal employability and external employability as mediators) integrating the above perspectives was tested using a sample of 202 Chinese employees in a three-wave survey study. The results show that when these mediators are put together, affective commitment serves as a significant mediator for the negative indirect effect from career adaptability to turnover intention, yielding support for the social exchange perspective. Importantly, this study reveals a novel positive indirect effect from career adaptability to turnover intention through the mediation of external employability, which is more salient when employees perceive more external opportunities. In addition, the mediation role of job embeddedness is only significant when employees perceive few external opportunities. These findings reveal a more comprehensive and dynamic view for the mixed role of career adaptability in employee turnover intention, which carries important implications for career adaptability and career mobility research. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
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