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4. Early use of intravitreal triamcinolone to inhibit traumatic proliferative vitreoretinopathy: a randomised clinical trial

Author

Guo, Haixia, primary, Yu, Jinguo, additional, He, Tiangeng, additional, Chen, Song, additional, Sun, Zhuoyu, additional, Zhang, Jingkai, additional, Sun, Zhiyong, additional, Yang, Wenhui, additional, Yao, Baoqun, additional, Yang, Xueli, additional, Liu, Yuanyuan, additional, Zhang, Mingxue, additional, Meng, Yu, additional, Yang, Likun, additional, and Yan, Hua, additional

Published
2023
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6. Ocular Perforating Injury

Author

Yan, Hua, primary, Yao, Baoqun, additional, Mao, Chunjie, additional, Zhao, Pingting, additional, Zheng, Fang, additional, and Zhang, Wei, additional

Published
2018
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8. Early use of intravitreal triamcinolone to inhibit traumatic proliferative vitreoretinopathy: a randomised clinical trial

Author

Guo, Haixia, Yu, Jinguo, He, Tiangeng, Chen, Song, Sun, Zhuoyu, Zhang, Jingkai, Sun, Zhiyong, Yang, Wenhui, Yao, Baoqun, Yang, Xueli, Liu, Yuanyuan, Zhang, Mingxue, Meng, Yu, Yang, Likun, and Yan, Hua

Abstract

AimsTo evaluate the efficacy and safety of intravitreal triamcinolone acetonide (TA) injection at the end of emergency surgery for open globe injury (OGI) to suppress traumatic proliferative vitreoretinopathy (TPVR).MethodsA single-centre, participant-masked, prospective, randomised controlled clinical trial. A total of 68 globe rupture patients with zone III were randomised to the control group (n=34) or the TA group (n=34) in 1:1 allocation ratio. Patients were treated with 0.1 mL TA in the TA group and 0.1 mL balanced salt solution in the control group at the end of emergency surgery. The primary outcome was the assessment of TPVR during vitrectomy 10±3 days later. Secondary outcomes included visual acuity (VA), retinal attachment rate, macular attachment rate, proliferative vitreoretinopathy (PVR) recurrent rate, side effects 6 months after vitrectomy.ResultsDuring vitrectomy, the TPVR grade of the control group was significantly more severe than the TA group (p=0.028). The TPVR score was significantly better in the TA group (9.30±0.82) than in the control group (6.44±1.06) (p=0.036). The final VA improved in 23 eyes (92%) in the TA group and in 14 eyes (63.64%) in the control group (p=0.008). The retinal attachment rates were 88% and 63.64% in the TA and control group, respectively (p=0.049). The two groups showed no significant difference in macular repositioning and PVR recurrent rate (p=0.215, 0.191). Temporary intraocular pressure elevation occurred in one eye in the TA group after emergency surgery.ConclusionsEarly intravitreal TA injection for OGI effectively reduces TPVR, increases surgical success and improves visual prognosis.

Published
2024
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9. Joint effects of meteorological factors and PM2.5 on age-related macular degeneration: a national cross-sectional study in China

Author

He, Jiayu, primary, Liu, Yuanyuan, additional, Zhang, Ai, additional, Liu, Qianfeng, additional, Yang, Xueli, additional, Sun, Naixiu, additional, Yao, Baoqun, additional, Liang, Fengchao, additional, Yan, Xiaochang, additional, Liu, Yang, additional, Mao, Hongjun, additional, Chen, Xi, additional, Tang, Nai-jun, additional, and Yan, Hua, additional

Published
2023
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10. Glaucoma in rural China (the Rural Epidemiology for Glaucoma in China (REG-China)): a national cross-sectional study

Author

Liu, Yuanyuan, primary, Yao, Baoqun, additional, Chen, Xi, additional, Yang, Xueli, additional, Liu, Yong, additional, Xie, Zhenggao, additional, Chen, Xiaofeng, additional, Yuan, Zhigang, additional, Wang, Xingrong, additional, Hu, Dan, additional, Ma, Xiang, additional, Gao, Weiqi, additional, Wang, Ruifeng, additional, Yang, Yuzhong, additional, Chen, Song, additional, Zhang, Jingkai, additional, Song, Zuoqing, additional, Wang, Junsu, additional, Wang, Jing, additional, Pei, Jinyun, additional, Wang, Weijuan, additional, Wang, Meiyan, additional, Gao, Jun, additional, Zhang, Hongwen, additional, Tan, Lian, additional, Du, Wei, additional, Pan, Xuehui, additional, Liu, Gang, additional, Du, Xiujuan, additional, Hou, Xu, additional, Gao, Xin, additional, Zhang, Zhen, additional, Shen, Zhansheng, additional, Wu, Changfu, additional, Yan, Xiaochang, additional, Bo, Shaoye, additional, Sun, Xinghuai, additional, Tang, Nai-jun, additional, Zhang, Chun, additional, and Yan, Hua, additional

Published
2022
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11. Association between long-term exposure to fine particulate matter and diabetic retinopathy among diabetic patients: A national cross-sectional study in China

Author

Shan, Anqi, primary, Chen, Xi, additional, Yang, Xueli, additional, Yao, Baoqun, additional, Liang, Fengchao, additional, Yang, Ze, additional, Liu, Fangchao, additional, Chen, Song, additional, Yan, Xiaochang, additional, Huang, Jianfeng, additional, Bo, Shaoye, additional, Tang, Nai-Jun, additional, Gu, Dongfeng, additional, and Yan, Hua, additional

Published
2021
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12. The association between long-term exposure to ambient fine particulate matter and glaucoma: A nation-wide epidemiological study among Chinese adults

Author

Yang, Xueli, primary, Yang, Ze, additional, Liu, Yuanyuan, additional, Chen, Xi, additional, Yao, Baoqun, additional, Liang, Fengchao, additional, Shan, Anqi, additional, Liu, Fangchao, additional, Chen, Song, additional, Yan, Xiaochang, additional, Huang, Jianfeng, additional, Bo, Shaoye, additional, Liu, Yang, additional, Tang, Naijun, additional, Gu, Dongfeng, additional, and Yan, Hua, additional

Published
2021
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14. Glaucoma in rural China (the Rural Epidemiology for Glaucoma in China (REG-China)): a national cross-sectional study

Author

Liu, Yuanyuan, Yao, Baoqun, Chen, Xi, Yang, Xueli, Liu, Yong, Xie, Zhenggao, Chen, Xiaofeng, Yuan, Zhigang, Wang, Xingrong, Hu, Dan, Ma, Xiang, Gao, Weiqi, Wang, Ruifeng, Yang, Yuzhong, Chen, Song, Zhang, Jingkai, Song, Zuoqing, Wang, Junsu, Wang, Jing, Pei, Jinyun, Wang, Weijuan, Wang, Meiyan, Gao, Jun, Zhang, Hongwen, Tan, Lian, Du, Wei, Pan, Xuehui, Liu, Gang, Du, Xiujuan, Hou, Xu, Gao, Xin, Zhang, Zhen, Shen, Zhansheng, Wu, Changfu, Yan, Xiaochang, Bo, Shaoye, Sun, Xinghuai, Tang, Nai-jun, Zhang, Chun, and Yan, Hua

Abstract

ObjectiveThis study aimed to investigate the prevalence of glaucoma with associated factors in the rural populations of 10 provinces in China.DesignA population-based cross-sectional study.MethodsAll participants aged 6 years or older from 10 provinces completed visual acuity testing, slit-lamp examination, ophthalmoscopy and non-contact tonometry. Glaucoma suspects underwent fundus photography, Goldmann applanation tonometry, visual field testing and gonioscopy. Glaucoma was determined according to the International Society of Geographical and Epidemiological Ophthalmology classification scheme. Associations of demographics and medical factors with glaucoma were assessed using multiple logistic regression models.ResultsFrom June 2017 to October 2018, 48 398 of 52 041 participants were included in the final analyses. The age-standardised prevalence of glaucoma was 1.7% (95% CI 1.55% to 1.78%) among the participants older than 6 years, which was 2.1% (95% CI 1.93% to 2.23%) in participants aged over 40 years. The constituent ratios of glaucoma were: 44.4% primary angle-closure glaucoma (PACG), 34.7% primary open-angle glaucoma, 2.6% congenital glaucoma and 18.3% other types of glaucoma. Increasing age, smoking, cerebral stroke, type 2 diabetes, higher education (college or more) and higher personal income were significant risk factors for PACG. The unilateral and bilateral blindness rates in the entire study population were 4.692% and 1.068%, respectively. A family history of glaucoma was a significant risk factor for the prevalence of glaucoma and blindness in at least one eye.ConclusionsRural populations have a high prevalence of glaucoma, which should be included in chronic disease management programmes in China for long-term care.

Published
2023
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15. Prevalence and Risk Factors of Glaucoma in Rural China (the Rural Epidemiology for Glaucoma in China [REG-China]): A National Cross-Sectional Study

Author

Yao, Baoqun, primary, Chen, Xi, additional, Yang, Xueli, additional, Liu, Yong, additional, Xie, Zhenggao, additional, Chen, Xiaofeng, additional, Yuan, Zhigang, additional, Wang, Xingrong, additional, Hu, Dan, additional, Ma, Xiang, additional, Gao, Weiqi, additional, Wang, Ruifeng, additional, Yang, Yuzhong, additional, Chen, Song, additional, Zhang, Jingkai, additional, Song, Zuoqing, additional, Wang, Junsu, additional, Wang, Jing, additional, Pei, Jinyun, additional, Wang, Weijuan, additional, Wang, Meiyan, additional, Gao, Jun, additional, Zhang, Hongwen, additional, Tan, Lian, additional, Du, Wei, additional, Pan, Xuehui, additional, Liu, Gang, additional, Du, Xiujuan, additional, Hou, Xu, additional, Gao, Xin, additional, Zhang, Zhen, additional, Shen, Zhansheng, additional, Wu, Changfu, additional, Yan, Xiaochang, additional, Bo, Shaoye, additional, Zhang, Chun, additional, Sun, Xinghuai, additional, Tang, Nai-Jun, additional, and Yan, Hua, additional

Published
2020
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16. Rural Glaucoma in China: Present Status and Future Directions

Author

Yao, Baoqun, primary, Chen, Xi, additional, Liu, Yong, additional, Xie, Zhenggao, additional, Chen, Xiaofeng, additional, Yuan, Zhigang, additional, Wang, Xingrong, additional, Hu, Dan, additional, Ma, Xiang, additional, Gao, Weiqi, additional, Wang, Ruifeng, additional, Yang, Yuzhong, additional, Chen, Song, additional, Zhang, Jingkai, additional, Song, Zuoqing, additional, Wang, Junsu, additional, Wang, Jing, additional, Pei, Jinyun, additional, Wang, Weijuan, additional, Wang, Meiyan, additional, Gao, Jun, additional, Zhang, Hongwen, additional, Tan, Lian, additional, Du, Wei, additional, Pan, Xuehui, additional, Liu, Gang, additional, Du, Xiujuan, additional, Hou, Xu, additional, Gao, Xin, additional, Zhang, Zhen, additional, Shen, Zhansheng, additional, Wu, Changfu, additional, Yan, Xiaochang, additional, Bo, Shaoye, additional, Zhang, Chun, additional, Sun, Xinghuai, additional, Tang, Nai-Jun, additional, and Yan, Hua, additional

Published
2020
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18. Correlation between the Reduced Circulating Endothelial Progenitor Cell Counts and Elevated Intraocular Pressure-Induced Retinal Ganglion Cell Apoptosis.

Author

Yao, Baoqun, Zhao, Qing, Yan, Hua, Chen, Fanglian, and Liu, Li

Subjects
*INTRAOCULAR pressure, *PROGENITOR cells, *OPEN-angle glaucoma, *RETINAL ganglion cells, *APOPTOSIS, *CONTROL groups, *LABORATORY rats
Abstract

Purpose: To investigate the correlations between intraocular pressure (IOP) and circulating endothelial progenitor cells (EPCs), retinal ganglion cells (RGC) apoptosis and EPCs, and explore the possible role of EPCs in the elevated IOP-induced RGC apoptosis. Materials and methods: A rat model of IOP elevation was induced by photocoagulation of the limbus vein and episcleral veins using a 532-nm green laser. Twenty rats were randomly assigned to normal control (NC) group, 30 rats were randomly assigned to sham-treated control (STC) group and 50 rats were randomly assigned to laser-treated (LT) group. The IOPs were measured with a Tono-pen XL tonometer. Hematoxylin-eosin staining was performed to observe the effects of IOP elevation on the structure of retina. Retinal apoptotic cells were determined by in situ TUNEL staining, and peripheral blood EPCs (CD34+/CD133+) were detected by flow cytometry. Results: Compared with the NC group (9.9 ± 1.2 mmHg), the IOPs in the LT group were 37.4 ± 1.5, 31.8 ± 4.1, 25.9 ± 2.2, 23.1 ± 3.6 and 22.4 ± 3.0 mmHg on the third day, seventh day, third week, second month and third month, respectively, after the laser photocoagulation. There were significant differences in IOPs between the groups at the different time points ( F = 110.02, p < 0.001). TUNEL analysis showed that only few apoptotic RGCs were found on the third and the seventh day after the laser treatment, and then many more apoptotic RGCs were found beginning on the third week after the laser treatment. The EPC counts were 121.3 ± 22.4, 81.3 ± 23.7, 46.1 ± 15.8, 54.4 ± 19.1 and 54.7 ± 15.9 /2 × 105 mononuclear cells (MNCs) on the third day, seventh day, third week, second month and third month, respectively, after the laser photocoagulation, compared with the NC group (62.1 ± 13.1)/2 × 105 MNCs. There were significant differences in EPC counts between the groups at the different time points ( F = 22.09, p < 0.001). Conclusions: Elevated IOP-induced RGC apoptosis is associated with the reduced circulating EPC counts. [ABSTRACT FROM AUTHOR]

Published
2015
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19. Retinal Detachment after Intraocular Foreign Body Removal with Vitrectomy

Author

Yan Hua, Yao Baoqun, He Tiangeng, Xu Yinghai, and Zhang Jingkai

Subjects
Intraocular foreign body, Retina, medicine.medical_specialty, business.industry, medicine.medical_treatment, Retinal detachment, Vitrectomy, Emergency Nursing, medicine.disease, medicine.anatomical_structure, Ophthalmology, Emergency Medicine, medicine, business, Foreign Bodies
Abstract

目的 报告并分析眼内异物摘出术后视网膜脱离发生率及有关病因.方法 眼内异物20例(20眼),用玻璃体切除术摘出眼内异物.结果 20眼中术后视网膜脱离4眼(22%).术后视力提高14眼(70%),视力不变3眼(15%),视力下降3眼(15%).结论 眼内异物摘出术后视网膜脱离发生原因:(1)残留玻璃体形成牵拉;(2)激光封闭裂孔不确切;(3)术中未发现的小裂孔;(4)术前玻璃体积血浑浊未能及时激光治疗;(5)异物较大,从玻璃体切除的切口摘异物时对周边部视网膜划伤.

Published
2001

20. Joint effects of meteorological factors and PM 2.5 on age-related macular degeneration: a national cross-sectional study in China.

Author

He J, Liu Y, Zhang A, Liu Q, Yang X, Sun N, Yao B, Liang F, Yan X, Liu Y, Mao H, Chen X, Tang NJ, and Yan H

Subjects
Humans, Adult, Middle Aged, Cross-Sectional Studies, Particulate Matter analysis, China epidemiology, Meteorological Concepts, Air Pollutants analysis, Macular Degeneration epidemiology, Macular Degeneration etiology
Abstract

Background: Weather conditions are a possible contributing factor to age-related macular degeneration (AMD), a leading cause of irreversible loss of vision. The present study evaluated the joint effects of meteorological factors and fine particulate matter (PM 2.5 ) on AMD., Methods: Data was extracted from a national cross-sectional survey conducted across 10 provinces in rural China. A total of 36,081 participants aged 40 and older were recruited. AMD was diagnosed clinically by slit-lamp ophthalmoscopy, fundus photography, and spectral domain optical coherence tomography (OCT). Meteorological data were calculated by European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis and were matched to participants' home addresses by latitude and longitude. Participants' individual PM 2.5 exposure concentrations were calculated by a satellite-based model at a 1-km resolution level. Multivariable-adjusted logistic regression models paired with interaction analysis were performed to investigate the joint effects of meteorological factors and PM 2.5 on AMD., Results: The prevalence of AMD in the study population was 2.6% (95% CI 2.42-2.76%). The average annual PM 2.5 level during the study period was 63.1 ± 15.3 µg/m 3 . A significant positive association was detected between AMD and PM 2.5 level, temperature (T), and relative humidity (RH), in both the independent and the combined effect models. For PM 2.5 , compared with the lowest quartile, the odds ratios (ORs) with 95% confidence intervals (CIs) across increasing quartiles were 0.828 (0.674,1.018), 1.105 (0.799,1.528), and 2.602 (1.516,4.468). Positive associations were observed between AMD and temperature, with ORs (95% CI) of 1.625 (1.059,2.494), 1.619 (1.026,2.553), and 3.276 (1.841,5.830), across increasing quartiles. In the interaction analysis, the estimated relative excess risk due to interaction (RERI) and the attributable proportion (AP) for combined atmospheric pressure and PM 2.5 was 0.864 (0.586,1.141) and 1.180 (0.768,1.592), respectively, indicating a synergistic effect between PM 2.5 and atmospheric pressure., Conclusions: This study is among the first to characterize the coordinated effects of meteorological factors and PM 2.5 on AMD. The findings warrant further investigation to elucidate the relationship between ambient environment and AMD.

Published
2023
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