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This study aimed to explore the influence of temperature on the growth and isoprene metabolism pathways of Eucommia ulmoides seedlings. Growth indices and levels of rubber and total triterpenoids in leaves were assessed under three temperature treatments: low (15 °C/10 °C), control (25 °C/20 °C), and high (35 °C/30 °C). High-throughput sequencing identified 2309 differentially expressed genes, of which 1608 were upregulated and 701 were downregulated. After 40 days, leaf length, leaf width, and plant height were significantly lower in low- and high-temperature treatments compared with the control. Specific leaf weight was higher in LT-treated leaves. Chlorophyll a and b contents were 1.372 mg.g−1 and 0.594 mg.g−1, respectively, in control leaves, followed by low- and high-temperature treatments. Carotenoid content was the highest in LT treatment. The rubber content of LT and HT groups significantly decreased by 16.5% and 38%, respectively, compared with that of the control group. Total triterpene content was the lowest in control leaves at 1.02%, which was 30% and 20% less than that in low- and high-temperature treatments, respectively. This study provides insights into the efficient cultivation of E. ulmoides and the regulatory network of secondary metabolic pathways. [ABSTRACT FROM AUTHOR]

A novel reaction-based fluorescent probe 1 for Hg2+ was designed and synthesized. 1 was almost nonfluoresent due to inhibition of the ESIPT process between hydroxy group and imid carbonyl oxygen by diphenylphosphinothioate group. After reacting with Hg2+, the fluorescence intensity of 1 exhibited significant enhancement owing to recovery of the ESIPT process via Hg2+-promoted desulfurization-hydrolysis of the diphenylphosphinothioate moiety and cleavage of the P-O bond. 1 not only showed rapid response, high sensitivity, excellent selectivity for Hg2+ over other metal ions, but also could detect Hg2+ with large Stokes shift (165 nm), which was attributed to the ESIPT process. Moreover, the reaction mechanism was fully validated by absorption spectra, fluorescence spectra, fluorescence color as well as ESI–MS analysis.1 is the reaction-based ESIPT fluorescent probe for the detection of Hg2+ with large Stokes shift, rapid response, high sensitivity and selectivity.Graphical Abstract: A novel reaction-based fluorescent probe 1 for Hg2+ was designed and synthesized. 1 was almost nonfluoresent due to inhibition of the ESIPT process between hydroxy group and imid carbonyl oxygen by diphenylphosphinothioate group. After reacting with Hg2+, the fluorescence intensity of 1 exhibited significant enhancement owing to recovery of the ESIPT process via Hg2+-promoted desulfurization-hydrolysis of the diphenylphosphinothioate moiety and cleavage of the P-O bond. 1 not only showed rapid response, high sensitivity, excellent selectivity for Hg2+ over other metal ions, but also could detect Hg2+ with large Stokes shift (165 nm), which was attributed to the ESIPT process. Moreover, the reaction mechanism was fully validated by absorption spectra, fluorescence spectra, fluorescence color as well as ESI–MS analysis.1 is the reaction-based ESIPT fluorescent probe for the detection of Hg2+ with large Stokes shift, rapid response, high sensitivity and selectivity. [ABSTRACT FROM AUTHOR]

Transition metal sulfides derived from metal‐organic frameworks (MOFs) have received increasing attention as a potential energy storage electrode material. Here, a series of NiS2/CoS2/NC‐T (T=temperature) have been successfully constructed by carbonizing and sulfuring the precursor of Ni/Co‐MOF. It is worth emphasizing that N‐doped carbon materials improve the conductivity of the electrode material. Moreover, NiS2/CoS2/NC‐500 maintains the rod‐like structure of the precursor and exhibits a high specific capacitance of 1325 F g−1 at a current density of 1 A g−1. Apart from high capacitance, the NiS2/CoS2/NC‐500 also demonstrated excellent cycling stability with retention rate of 75 % after 5000 cycles at a current density of 5 A g−1. The good performance could be attributed to the unique rod‐like structure and pore‐size distribution of NiS2/CoS2/NC‐500. Moreover, an assembled asymmetric supercapacitor NiS2/CoS2/NC‐500//AC displays a high energy density of 53.93 Wh kg−1 at a power density of 800 W kg−1 and good cycle stability with capacitance retention of 85.71 % after 20,000 cycles at 5 A g−1. In particular, a red LED can be illuminated by the assembled ASC, indicating that as‐synthesized NiS2/CoS2/NC‐500 hold great potential for practical applications. [ABSTRACT FROM AUTHOR]

A novel mitochondrion-targeted Hg 2+ -specific fluorescent probe 1 based on ESIPT phthalimide was designed and synthesized for the first time. Owing to the blockage of the ESIPT process between the hydroxy group and the carbonyl oxygen of the imide by the diphenylphosphinothioate group, 1 was almost nonfluorescent. After reacting with Hg 2+ , 1 exhibited a dramatic fluorescence enhancement due to the recovery of the ESIPT process through Hg 2+ -induced desulfurization-hydrolysis of the diphenylphosphinothioate moiety and the cleavage of the P-O bond. 1 showed a large Stokes shift, rapid response and high sensitivity and selectivity for Hg 2+ over other metal ions. Moreover, 1 was successfully employed to image Hg 2+ in the mitochondria of living cells.

Objective: Current evidence on the relationship between decreased handgrip strength and depression risk is controversial, and there is limited study focus on the potential bidirectional associations between them. We aim to explore their bidirectional relationships., Methods: This study used panel data from the Health and Retirement Study involving 17,713 aging Americans (≥50 years old) who participated in at least 2 waves. Smedley spring-type hand-held dynamometer was used to assess the handgrip strength. Depression was evaluated by the 8-item Center for Epidemiologic Studies-Depression (CESD) scale. Time-lagged general estimating equations (GEE) were used to assess the bidirectional association between handgrip strength and the depression risk., Results: In the fully adjusted model, every 5 kg decreased handgrip strength was associated with a 6% (95%CI: 3%-9%) increased risk of depression. Compared with non-weakness participants, those with weakness had a higher depression risk (OR = 1.22, 95%CI: 1.09-1.36). Conversely, depression might associate with a 0.33 kg (95% CI: 0.09-0.56) decrease in handgrip strength and increased the risk of weakness by 18% (95% CI: 6%-33%). In addition, the results remained stable in the stratified analyses by gender and sex. Interestingly, the above-mentioned associations were also observed in overweight and obese participants., Conclusions: The present study found bidirectional associations between handgrip strength and depression risk. Our results indicated early interventions for depression and handgrip strength might achieve reciprocal benefits over time., (Copyright © 2021 Elsevier Inc. All rights reserved.)