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41 results on '"Yao, Xiuzhong"'

5. Efficacy of nab‑paclitaxel vs. Gemcitabine in combination with S‑1 for advanced pancreatic cancer: A multicenter phase II randomized trial

Author

Guo, Xi, primary, Lou, Wenhui, additional, Xu, Yaolin, additional, Zhuang, Rongyuan, additional, Yao, Lie, additional, Wu, Junwei, additional, Fu, Deliang, additional, Zhang, Jun, additional, Liu, Jing, additional, Rong, Yefei, additional, Jin, Dayong, additional, Wu, Wenchuan, additional, Xu, Xuefeng, additional, Ji, Yuan, additional, Wu, Lili, additional, Lv, Minzhi, additional, Yao, Xiuzhong, additional, Liu, Xiaowei, additional, Wang, Dansong, additional, Kuang, Tiantao, additional, Liu, Liang, additional, Wang, Wenquan, additional, Liu, Tianshu, additional, and Zhou, Yuhong, additional

Published
2024
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9. Insulin Glargine is More Suitable Than Exenatide in Preventing Muscle Loss in Non-Obese Type 2 Diabetic Patients with NAFLD

Author

Liu, Lin, primary, Wang, Ruwen, primary, Gao, Jian, primary, Yan, Jianhua, additional, Zhang, Jingtian, additional, Zhang, Zhitian, additional, Liu, Jiaojiao, additional, Lin, Huandong, additional, Rao, Shengxiang, additional, Yao, Xiuzhong, additional, Wu, Weiyun, additional, Bian, Hua, additional, Wang, Xiangyu, additional, Guo, Shanshan, additional, Gao, Xin, additional, and Yan, Hongmei, additional

Published
2023
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15. A novel model for detecting advanced fibrosis in patients with nonalcoholic fatty liver disease

Author

Yang, Xinyu, primary, Xia, Mingfeng, additional, Chang, Xinxia, additional, Zhu, Xiaopeng, additional, Sun, Xiaoyang, additional, Yang, Yinqiu, additional, Wang, Liu, additional, Liu, Qiling, additional, Zhang, Yuying, additional, Xu, Yanlan, additional, Lin, Huandong, additional, Liu, Lin, additional, Yao, Xiuzhong, additional, Hu, Xiqi, additional, Gao, Jian, additional, Yan, Hongmei, additional, Gao, Xin, additional, and Bian, Hua, additional

Published
2022
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17. Differentiating Cytokeratin 19 expression of hepatocellular carcinoma by using multi-b-value diffusion-weighted MR imaging with mono-exponential, stretched exponential, intravoxel incoherent motion, diffusion kurtosis imaging and fractional order calculus models

Author

Guo, Yixian, primary, Chen, Jiejun, additional, Zhang, Yunfei, additional, Guo, Yinglong, additional, Jiang, Mengmeng, additional, Dai, Yongming, additional, and Yao, Xiuzhong, additional

Published
2022
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20. Dextran-based Nanomicelle System with Directly Ester-bound Gadolinium Chelates as a Magnetic Resonance Imaging Contrast Agent for Tumor Detection

Author

Ma, Lirong, Yang, Weiyu, Wu, Dingmei, Jiang, Mengmeng, Yao, Xiuzhong, and Weng, Weiyu

Subjects
endocrine system, Biocleavable gadolinium chelates, Tumor imaging, Elimination, polycyclic compounds, Original Article, Dextran, hormones, hormone substitutes, and hormone antagonists, Nanomicelle system
Abstract

There is a strong need to develop MRI contrast agents (CAs) with lower in-vivo retention, stronger signal enhancement, and more specific imaging. Here, we report a novel dextran (DEX)-based nanomicelle system as an MRI CA with superior tumor imaging and relatively short intravascular persistence. Gadolinium (Gd)-chelate (DTPA-Gd) was conjugated directly to DEX hydroxyl via a degradable ester bond. DEX-DTPA-Gd was then modified with dodecylsuccinic anhydride to obtain the amphiphilic derivative, 2-dodecylsuccinic acid (DSA)-grafted DEX-DTPA-Gd. Nanomicelles were prepared by dissolving DSA-DEX-DTPA-Gd in water using ultrasonication. The physicochemical properties, cytotoxicity, and MRI efficiency of the synthesized CA were evaluated. The synthesized DSA-DEX-DTPA-Gd self-assembled into nanomicelles with an average diameter of 67.80 ± 5.21 nm. Within the given Gd concentration range, DSA-DEX-DTPA-Gd and Magnevist® exhibited similar cytotoxicity. DEX-based CAs resulted in a greater contrast enhancement of T1-weighted signal intensity in the tumor region than Magnevist®, and the tumors were clearly defined for at least 3 h. Simultaneously, the ester bond in DSA-DEX-DTPA-Gd facilitated the elimination of Gd chelates, compared with the relatively more stable amide linker. The DEX-based nanomicelle system with directly ester-bound DTPA-Gd may serve as an MRI CA with superior tumor imaging and relatively rapid elimination.

Published
2020

21. Performance of Liver Stiffness Measurement from FibroScan was Affected by Glucose Metabolism in Patients with Nonalcoholic Fatty Liver Disease

Author

Xinyu Yang, Xinxia Chang, Shengdi Wu, Xiaoyang Sun, Xiaopeng Zhu, Sheng-Xiang Rao, Hongmei Yan, Yushan Xu, Mingfeng Xia, Liu Wang, Hua Bian, Gao Xin, Xiqi Hu, and Yao Xiuzhong

Subjects
medicine.medical_specialty, Liver stiffness, business.industry, Internal medicine, Nonalcoholic fatty liver disease, medicine, In patient, Carbohydrate metabolism, medicine.disease, business, Gastroenterology
Abstract

Background: The performance of liver stiffness measurement (LSM) obtained using FibroScan can be affected by several factors and cut-off values were different for fibrosis caused by various etiologies. The aim of this study was to evaluate the diagnostic performance of LSM in nonalcoholic fatty liver disease (NAFLD) patients with abnormal glucose metabolism and investigate whether LSM value would be affected by metabolic indicators. Methods: The study involved 91 NAFLD patients with abnormal glucose metabolism who underwent liver biopsy. The receiver operator characteristic (ROC) curves were used to evaluate the diagnostic accuracy, with the biopsy results taken as the gold standard. Multivariate linear regression and subgroup analysis were used to determine the correlated indicators.Results: The areas under ROC curves (AUROCs) of LSM values in diagnosing fibrosis stage≥1, 2, 3 and 4 were 0.793 (95% confidence interval [CI]: 0.695-0.871), 0.764 (95% CI: 0.663-0.846), 0.837 (95% CI: 0.744-0.906) and 0.902 (95% CI: 0.822-0.955), with cut-off values of 6.3, 7.6, 8.3 and 13.8 kPa, respectively. Multivariate linear regression demonstrated that HbA1c (β=0.200, p=0.038) and AST (β=0.200, p=0.044) were independently associated with LSM value after adjustment for fibrosis stage from liver biopsy. Subgroup analysis revealed that LSM values were slightly higher in patients with HbA1c ≥7% than those HbA1c 2 than those BMI 2.Conclusions: FibroScan was valuable for the evaluation of liver fibrosis in NAFLD patients with abnormal glucose metabolism. It was recommended for evaluating severe fibrosis, especially for excluding advanced fibrosis. Glucose metabolism state may affect LSM value.

Published
2021

22. Performance of liver stiffness measurements obtained with FibroScan is affected by glucose metabolism in patients with nonalcoholic fatty liver disease

Author

Yang, Xinyu, primary, Chang, Xinxia, additional, Wu, Shengdi, additional, Sun, Xiaoyang, additional, Zhu, Xiaopeng, additional, Wang, Liu, additional, Xu, Yushan, additional, Yao, Xiuzhong, additional, Rao, Shengxiang, additional, Hu, Xiqi, additional, Xia, Mingfeng, additional, Bian, Hua, additional, Yan, Hong-Mei, additional, and Gao, Xin, additional

Published
2021
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23. Performance of Liver Stiffness Measurement from FibroScan was Affected by Glucose Metabolism in Patients with Nonalcoholic Fatty Liver Disease

Author

Yang, Xinyu, primary, Chang, Xinxia, additional, Wu, Shengdi, additional, Sun, Xiaoyang, additional, Zhu, Xiaopeng, additional, Wang, Liu, additional, Xu, Yushan, additional, Yao, Xiuzhong, additional, Rao, Shengxiang, additional, Hu, Xiqi, additional, Xia, Mingfeng, additional, Bian, Hua, additional, Yan, Hong-Mei, additional, and Gao, Xin, additional

Published
2021
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37. Multifunctional gadolinium-labeled silica-coated Fe3O4 and CuInS2 nanoparticles as a platform for in vivo tri-modality magnetic resonance and fluorescence imaging.

Author

Shen, Jianhua, Zhu, Yihua, Yang, Xiaoling, Li, Chunzhong, Li, Yunfeng, Yao, Xiuzhong, Li, Jun, and Huang, Guangjian

Abstract

The facile fabrication of Gd-labeled superparamagnetic Fe3O4 nanoparticles (NPs) and fluorescent CuInS2 (CIS) quantum dots conjugated with arginine-glycine-aspartic acid (RGD) peptides has been demonstrated, for tri-mode targeted T1-, T2-weighted magnetic resonance (MR) and fluorescence imaging of pancreatic cancer. The core–shell nanocomposites formed are water-dispersible, stable and biocompatible, as confirmed by MTT assay on BXPC-3 cells. Relaxivity measurements show a T1 relaxivity (r1) of 1.56 mM−1 s−1 and a T2 relaxivity (r2) of 23.22 mM−1 s−1, which enable T1- and T2-weighted MR imaging of cancer cells in vitro and in vivo. The MR imaging data clearly indicate that the multifunctional NPs can specifically target cancer cells with αvβ3 integrin over-expression on the cell surface, through a receptor-mediated delivery pathway. The T1-weighted positive and T2-weighted negative enhancement in the MR imaging significantly improves the diagnosis accuracy, and fluorescence imaging of tumor tissue can assist in clinical surgery. These findings suggest that these multifunctional NPs could be used as a platform for bimodal imaging (both MR and fluorescence) in various biological systems. [ABSTRACT FROM AUTHOR]

Published
2015
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38. Stearic Acid-Grafted Chitooligosaccharide Nanomicelle System with Biocleavable Gadolinium Chelates as a Multifunctional Agent for Tumor Imaging and Drug Delivery.

Author

Xin, Chuhua, Yao, Xiuzhong, Du, Bin, Yang, Weiyu, Wang, Liuguo, Ma, Lirong, and Weng, Weiyu

Subjects
*EARLY detection of cancer, *STEARIC acid, *OLIGOSACCHARIDES, *GADOLINIUM chelates, *DRUG delivery systems
Abstract

Purpose: Theranostic nanoplatforms are promising approaches for diagnosis and treatment. Here, we report a drug-loaded nanomicelle system with biocleavable gadolinium (Gd) chelates as a multifunctional biodegradable agent for simultaneous magnetic resonance imaging (MRI) and drug delivery.Methods: Self-assembled nanomicelles based on stearic acid-grafted chitooligosaccharide were utilized as vehicles. Gd chelates, DTPA-Gds, were linked to the nanomicelles via redox-responsive disulfide bonds, and hydrophobic drugs were encapsulated in the micelle cores. MRI and cargo delivery were investigated in orthotopic pancreatic tumor-bearing mice.Results: In vivo MRI demonstrated that the biodegradable agent was cleaved by endogenous thiols after intravenous injection, and the released DTPA-Gds were eliminated rapidly. At the same time, the agent resulted in a greater contrast enhancement of T1-weighted MR signal intensity at the tumor region than Magnevist®, and the tumor boundaries were clearly defined for at least 2 h. In addition, the agent possessed high drug-loading and tumor-targeting capacities. Loading content and encapsulation efficiency of docetaxel were 3.2% and 99.4%, respectively. Compared with Taxotere®, the commercially available docetaxel injection, the docetaxel-loaded agent significantly increased the drug concentration in tumor tissue in vivo.Conclusion: The fabricated multifunctional agent may serve as a biodegradable nanoscale MRI contrast agent and as a drug delivery system for tumor diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Published
2019
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41. Multifunctional gadolinium-labeled silica-coated Fe 3 O 4 and CuInS 2 nanoparticles as a platform for in vivo tri-modality magnetic resonance and fluorescence imaging.

Author

Shen J, Li Y, Zhu Y, Yang X, Yao X, Li J, Huang G, and Li C

Abstract

The facile fabrication of Gd-labeled superparamagnetic Fe 3 O 4 nanoparticles (NPs) and fluorescent CuInS 2 (CIS) quantum dots conjugated with arginine-glycine-aspartic acid (RGD) peptides has been demonstrated, for tri-mode targeted T 1 -, T 2 -weighted magnetic resonance (MR) and fluorescence imaging of pancreatic cancer. The core-shell nanocomposites formed are water-dispersible, stable and biocompatible, as confirmed by MTT assay on BXPC-3 cells. Relaxivity measurements show a T 1 relaxivity (r 1 ) of 1.56 mM -1 s -1 and a T 2 relaxivity (r 2 ) of 23.22 mM -1 s -1 , which enable T 1 - and T 2 -weighted MR imaging of cancer cells in vitro and in vivo. The MR imaging data clearly indicate that the multifunctional NPs can specifically target cancer cells with α v β 3 integrin over-expression on the cell surface, through a receptor-mediated delivery pathway. The T 1 -weighted positive and T 2 -weighted negative enhancement in the MR imaging significantly improves the diagnosis accuracy, and fluorescence imaging of tumor tissue can assist in clinical surgery. These findings suggest that these multifunctional NPs could be used as a platform for bimodal imaging (both MR and fluorescence) in various biological systems.

Published
2015
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