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12 results on '"Yap, Kah Hui"'

2. Randomized Double-Blind Placebo-Controlled Trial of the Effects of Oral Trehalose in Spinocerebellar Ataxia Type 3: An Interim Analysis

Author

Yap, Kah Hui, primary, Azmin, Shahrul, additional, Manan, Hanani Abdul, additional, Yahya, Noorazrul, additional, Ahmad, Norfazilah, additional, Tajurudin, Farah Waheeda, additional, Mat Desa, Siti Hajar, additional, van de Warrenburg, Bart, additional, Mohamed Mukari, Shahizon Azura, additional, Achok, Hamdi Najman, additional, Ahmad Damanhuri, Hanafi, additional, Rani, Rufaidah, additional, and Mohamed Ibrahim, Norlinah, additional

Published
2024
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5. Movement Disorders Resulting From Bilateral Basal Ganglia Lesions in End-Stage Kidney Disease: A Systematic Review

Author

Yap, Kah Hui, primary, Baharudin, Nurul Husna, additional, Gafor, Abdul Halim Abdul, additional, Remli, Rabani, additional, Lim, Shen-Yang, additional, Zaidi, Wan Asyraf Wan, additional, Azmin, Shahrul, additional, Mukari, Shahizon Azura Mohamed, additional, Khalid, Raihanah Abdul, additional, and Ibrahim, Norlinah Mohamed, additional

Published
2022
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11. Visualizing Hyperactivation in Neurodegeneration Based on Prefrontal Oxygenation: A Comparative Study of Mild Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls

Author

Yap, Kah Hui, primary, Ung, Wei Chun, additional, Ebenezer, Esther G. M., additional, Nordin, Nadira, additional, Chin, Pui See, additional, Sugathan, Sandheep, additional, Chan, Sook Ching, additional, Yip, Hung Loong, additional, Kiguchi, Masashi, additional, and Tang, Tong Boon, additional

Published
2017
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12. Profiling neuroprotective potential of trehalose in animal models of neurodegenerative diseases: a systematic review.

Author

Yap KH, Azmin S, Makpol S, Damanhuri HA, Mustapha M, Hamzah JC, and Ibrahim NM

Abstract

Trehalose, a unique nonreducing crystalline disaccharide, is a potential disease-modifying treatment for neurodegenerative diseases associated with protein misfolding and aggregation due to aging, intrinsic mutations, or autophagy dysregulation. This systematic review summarizes the effects of trehalose on its underlying mechanisms in animal models of selected neurodegenerative disorders (tau pathology, synucleinopathy, polyglutamine tract, and motor neuron diseases). All animal studies on neurodegenerative diseases treated with trehalose published in Medline (accessed via EBSCOhost) and Scopus were considered. Of the 2259 studies screened, 29 met the eligibility criteria. According to the SYstematic Review Center for Laboratory Animal Experiment (SYRCLE) risk of bias tool, we reported 22 out of 29 studies with a high risk of bias. The present findings support the purported role of trehalose in autophagic flux and protein refolding. This review identified several other lesser-known pathways, including modifying amyloid precursor protein processing, inhibition of reactive gliosis, the integrity of the blood-brain barrier, activation of growth factors, upregulation of the downstream antioxidant signaling pathway, and protection against mitochondrial defects. The absence of adverse events and improvements in the outcome parameters were observed in some studies, which supports the transition to human clinical trials. It is possible to conclude that trehalose exerts its neuroprotective effects through both direct and indirect pathways. However, heterogeneous methodologies and outcome measures across the studies rendered it impossible to derive a definitive conclusion. Translational studies on trehalose would need to clarify three important questions: 1) bioavailability with oral administration, 2) optimal time window to confer neuroprotective benefits, and 3) optimal dosage to confer neuroprotection., Competing Interests: None

Published
2023
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