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The consumption of fruit juices remains controversial due to their potentially negative impact on postprandial glycemic response. The aim of this study was to determine the glycemic index and glycemic load of four fruit juices in apparently healthy adult subjects. This study included 16 healthy adults. Each subject consumed the reference food twice and the fruit juices once. The fruit juices studied were orange, papaya, apple, and mango, all freshly pressed with no added sugar. All juices were made from very ripe fruit. Blood glucose levels were measured using a calibrated glucometer (On Call Plus). The glycemic index (GI) and glycemic load (GL) were determined using standard methods. The results showed that mango juice had a moderate GI (56.41 ± 3.52) and a high GL (7.46 ± 0.47). Papaya, orange, and apple juices all had low GI (49.67 ± 5.05, 42.97 ± 2.93, and 31.50 ± 3.32, respectively) and low GL (4.23 ± 0.43, 3.91 ± 0.27, and 2.56 ± 0.38, respectively). This study indicates that although the GL of the fruit juices studied was low, particularly mango juice, should be consumed in moderation by diabetic subjects.

In 2018, the Ministry of Health and Social Services (MoHSS) introduced acetic acid visual inspection (AAVI) screening program and treatment of cervical precancers with cryotherapy in replacement of Pap smear intervention in Namibia. The study examines the effective use of AAVI-and-cryotherapy treatment on HPV-diagnosed women. Female patients of the reproductive age (20-49 years) group visiting 2 Namibian healthcare facilities for AAVI and cryotherapy treatment were investigated using a cross-sectional approach. The SPSS and coding themes were used to analyze data received through questionnaires and face-to-face interviews from a total of 265 participants. Written informed consent was obtained from participants for treatment and for publication. Among the women that participated in the study, 151 (62%) tested HPV positive, of which 132 (53%) were referred for cryotherapy and 19 (8%) for colposcopy treatments due to Cervical Intraepithelial Neoplasia (CIN I-III) detected. Regardless of the age groups, there was significant evidence of an association between para gravida and HPV positive (χ 2 (6) = 24.518; P

Yam holds the top position in food crop production, and Kponan yam is highly prized by Ivorians. However, storage deterioration poses economic challenges for wholesalers and producers. This study assesses Kponan yam quality in warehouse storage, considering its geographical origin. To achieve this, yams from the Bondoukou, Bouna, and Kouassi-Kouassikro regions were kept at a warehouse in Abidjan, allowing an assessment of alterations, cooking properties, and organoleptic characteristics over a 3-month storage period. Kponan yam tubers were placed on boards at the warehouse's temperature (27.98 °C) and relative humidity (85.61 %). Temperature and humidity levels were recorded three times per week and four times daily at 08:00, 12:00, 16:00, and 20:00. Physical, cooking, and sensory characteristics were checked at harvest and during each month. The results showed that the main damage observed during storage at the warehouse was rotting and dehydration of the tubers. Rot rates were 47.53 % for yams grown in Bondoukou, 51.96 % for those grown in Bouna and 60.65 % for those grown in Kouassi-Kouassikro. Dehydrated tubers rates were 17.88 %, 25.04 % and 29.20 % for yams from Bondoukou, Bouna and Kouassi-Kouassikro, respectively. The browning indices of Kponan yams decrease (P

Abstract Background Decreased efficacy of artemisinin-based combination therapy (ACT) for Plasmodium falciparum malaria has been previously reported in patients with sickle cell disease (SCD). The main purpose of this study was to investigate the in vitro susceptibility of isolates to dihydro-artemisinin (DHA) to provide a hypothesis to explain this treatment failure. Methods Isolates were collected from patients attending health centres in Abidjan with uncomplicated P . falciparum malaria. The haemoglobin type has been identified and in vitro drug sensitivity tests were conducted with the ring stage assay and maturation inhibition assay. Results 134 isolates were obtained. Parasitaemia and haemoglobin levels at inclusion were lower in patients with haemoglobin HbSS and HbSC than in patients with normal HbAA. After ex vivo RSA and drug inhibition assays, the lowest rate of parasitic growth was found with isolates from HbAS red cells. Conversely, a significantly higher survival rate of parasites ranging from 15 to 34% were observed in isolates from HbSS. Isolates with in vitro reduced DHA sensitivity correlate with lower RBC count and haematocrit and higher parasitaemia at inclusion compared to those with isolates with normal DHA sensitivity. However, this decrease of in vitro sensitivity to DHA was not associated with Kelch 13-Propeller gene polymorphism. Conclusion This study highlights an in vitro decreased sensitivity to DHA, for isolates collected from HbSS patients, not related to the Pfkelch13 gene mutations. These results are in line with recent studies pointing out the role of the redox context in the efficacy of the drug. Indeed, SCD red cells harbour a highly different ionic and redox context in comparison with normal red cells. This study offers new insights into the understanding of artemisinin selective pressure on the malaria parasite in the context of haemoglobinopathies in Africa.

The objective of this study was to investigate the effects on laying performance, egg quality traits, color, and composition of supplementing a white corn-based diet with Desmodium tortuosum leaf flour. Three hundred 32-week-old hens were distributed to 30 pens of 10 hens each and allocated to six dietary treatments (five replicates per treatment) for 13 weeks. Two control groups of 50 hens received one of either diet Y, based on yellow corn, or diet W, based on white corn. The other groups received a diet based on white corn supplemented with Desmodium tortuosum leaf flour at 2.5%, 5%, 7.5%, or 10% (diet D). Diet D improved laying performance and yolk color at a reduced feed cost per egg but had no effect on cholesterol content. In conclusion, the inclusion of Desmodium tortuosum leaf flour, in a white corn-based diet, is effective in lowering feed cost, increasing egg production, and improving yolk color.

Few standardized language assessments are adapted to different cultural and linguistic contexts to assess children's first language (L1) abilities. We introduce the Ivorian Children's Language Assessment Toolkit for measuring phonological awareness, vocabulary, oral comprehension, and tone awareness in the Abidji, Attié, and Baoulé languages of Côte d'Ivoire. Six hundred and three primary-school children (age 4-14) completed language assessments in their L1 and French. The toolkit provided a reliable and comprehensive assessment of children's language abilities. We observed age- and grade-related increases in all subtest scores. Still, children scored higher in their L1 compared to French, highlighting the need for language assessments in a bilingual's two languages to achieve an accurate measure of children's language abilities. The ability to benchmark children's scores relative to age- and grade-norms are discussed in the context of language of instruction education policies as well as the potential use of age- and grade-norms in identifying children with language impairment and/or children who are at risk for reading difficulties due to poor language skills.

Abstract Background The aim of this work is to share the authors’ experience and assist therapeutic decision-making in the management of Lemierre syndrome (LS). This is a retrospective descriptive study carried out in the stomatology, maxillofacial surgery, and ENT departments of the teaching hospital of Treichville (Abidjan, Côte d’Ivoire). LS cases managed from 2013 to 2023 were included in the study. Results Eight patients were enrolled (six men and two women). Internal jugular vein thrombosis was unilateral in 7 cases and bilateral in one. No germs were found in four patients. In one patient, a bacterial co-infection was responsible for the thrombosis. Surgical debridement was systematically performed in cases of necrosis. Anticoagulation was justified in three patients. No deaths were observed. Conclusion This work describes the epidemiological, clinical, therapeutic, and evolutionary aspects of LS. The management of LS should not be improvised. The choice of surgical debridement and anticoagulation depends on specific situations.

Background: The lives of individuals affected by sickle cell disease are marked by painful crises sometimes accompanied by complications. Curative treatments such as bone marrow transplantation or gene therapy exist, but are not currently performed in Côte d'Ivoire. Treatment with hydroxyurea remains an effective alternative. The aim of our study is to contribute to improving the management of children with sickle cell disease. Methods: We conducted a prospective observational study from November 2017 to April 2019 at the at the Yopougon University Hospital. Children aged 5 to 15 years experiencing at least 3 vaso-occlusive crises (VOC) per year were included in the study after obtaining informed and written consent from their parents. Each patient received a daily dose of 15mg/kg of hydroxyurea. Results: The mean age of the children was 9 years. More than 75% of patients were homozygous SSFA2 major sickle cell individuals. After 6 months on hydroxyurea, our study observed rates of 84.4%, 100%, and 97.8%, respectively, for the absence of vaso-occlusive crises, hospitalization, and transfusion. Biologically, from M0 to M12 the mean hemoglobin level increased significantly, from 7.24 to 8.55 g/dL; white blood cell (WBC) and platelet counts decreased; Fetal hemoglobin (Hb F) increased significantly from 10.3% to 19.7%. Biochemical parameters within normal ranges, except for a moderate treatment-related increase in transaminases. Conclusion: The induction of fetal hemoglobin (Hb F) production through hydroxyurea intake is the primary mechanism by which hydroxyurea modifies the pathogenesis of sickle cell disease

Introduction: Maxillofacial trauma in children is uncommon, accounting for between 1 % and 14 % of all facial trauma in the general population. Objective: To describe the epidemiological and anatomical-clinical aspects of mandibular fractures in children. Material and method: This was a retrospective descriptive cross-sectional study with non-probabilistic accidental sampling. It took place in the maxillofacial surgery and stomatology department of Cocody University Hospital in the Republic of Côte d'Ivoire, over a 20-year period (2000–2019). The study population consisted of patients aged 0–16 years admitted to our department for a mandibular fracture. At the end of this study, we identified 58 patients. Data was entered using Excel 2016. Tables and graphs were processed using Excel version 2016. Results: we have identified 58 patients. The mean age of patients was 9.35 ± 2.1 years, with extremes of 1 and 16 years, and a sex ratio of 2,22 in favouring men. The 6–12 age group was the most affected (n: 34 cases or 60.35 %). Soft tissue wounds were present in all our patients, followed by peri-mandibular swelling (n: 37 cases or 63.79 %) and disorders of the dental articulation (n: 28 cases or 48.2 %). Condylar fractures were the most frequent (46.87 %).Mandibular fracture lines were uni-focal in 75 % of cases. These fractures were associated with other facial lesions in 48.28 % of cases and with extra-facial lesions in 34.48 % of cases. Conclusion: Mandibular fractures are common in maxillofacial trauma in children. Condylar fractures are the most common, almost always associated with chin injuries. Hence the importance of a systematic examination of the mandibular condyles.

In Côte d'Ivoire, there is a high intensity of pyrethroid resistance in malaria vectors which may threaten successful vector control. Molecular studies of the target site mutation in the voltage-gated sodium channel (VGSC) 1014F show that the gene frequencies of these mutations are high, widely spread across Côte d’Ivoire, and even fixed in some areas. To further characterize insecticide resistance in Côte d’Ivoire beyond target site mutations, the metabolic resistance mechanism was explored. Overexpression of the metabolic enzyme cytochrome CYP6M2, CYP6P3, CYP6P4, and CYP6P5 was investigated in Anopheles gambiae (s.s.) and An. coluzzii collected from 30 insecticide resistance monitoring sites across the country in 2021 and 2022. Quantitative real-time polymerase chain reaction (qRT-PCR) assay was carried out using RNA-later preserved 60 surviving mosquitoes from each site after phenotypic susceptibility tests. Additionally, a subsample of about 100 mosquitoes from each site was identified to species by PCR, and the frequency of the VGSC 1014F and 1014S was determined. All four CYPs were found to be overexpressed in Côte d’Ivoire with at least one CYP statistically significantly overexpressed in 27 of the 30 sites investigated compared to the susceptible An. gambiae (s.s.) Kisumu (P

Diphallia, or penile duplication, is a rare congenital urological malformation. It may be associated with other congenital malformations. The objective of present paper is to report the case of a two-year boy with ventral duplication of the penis associated with proximal hypospadias. The ventral penis was amputated, and Duckett urethroplasty was done. There were no reported postoperative complications in the follow-up.

Abstract Background A better understanding of vector distribution and malaria transmission dynamics at a local scale is essential for implementing and evaluating effectiveness of vector control strategies. Through the data gathered in the framework of a cluster randomized controlled trial (CRT) evaluating the In2Care (Wageningen, Netherlands) Eave Tubes strategy, the distribution of the Anopheles vector, their biting behaviour and malaria transmission dynamics were investigated in Gbêkê region, central Côte d’Ivoire. Methods From May 2017 to April 2019, adult mosquitoes were collected monthly using human landing catches (HLC) in twenty villages in Gbêkê region. Mosquito species wereidentified morphologically. Monthly entomological inoculation rates (EIR) were estimated by combining the HLC data with mosquito sporozoite infection rates measured in a subset of Anopheles vectors using PCR. Finally, biting rate and EIR fluctuations were fit to local rainfall data to investigate the seasonal determinants of mosquito abundance and malaria transmission in this region. Results Overall, Anopheles gambiae, Anopheles funestus, and Anopheles nili were the three vector complexes found infected in the Gbêkê region, but there was a variation in Anopheles vector composition between villages. Anopheles gambiae was the predominant malaria vector responsible for 84.8% of Plasmodium parasite transmission in the area. An unprotected individual living in Gbêkê region received an average of 260 [222–298], 43.5 [35.8–51.29] and 3.02 [1.96–4] infected bites per year from An. gambiae, An. funestus and An. nili, respectively. Vector abundance and malaria transmission dynamics varied significantly between seasons and the highest biting rate and EIRs occurred in the months of heavy rainfall. However, mosquitoes infected with malaria parasites remained present in the dry season, despite the low density of mosquito populations. Conclusion These results demonstrate that the intensity of malaria transmission is extremely high in Gbêkê region, especially during the rainy season. The study highlights the risk factors of transmission that could negatively impact current interventions that target indoor control, as well as the urgent need for additional vector control tools to target the population of malaria vectors in Gbêkê region and reduce the burden of the disease.

Abstract Background Entomological surveillance provides critical information on vectors for appropriate malaria vector control and strategic decision-making. The widely documented insecticide resistance of malaria vectors in Côte d’Ivoire requires that any vector control intervention deployment be driven by entomological data to optimize its effectiveness and appropriate resource allocations. To achieve this goal, this study documents the results of monthly vector surveillance and insecticide susceptibility tests conducted in 2019 and a review of all previous entomological monitoring data used to guide vector control decision making. Furthermore, susceptibility to pirimiphos-methyl and clothianidin was assessed in addition to chlorfenapyr and pyrethroids (intensity and piperonyl butoxide (PBO) synergism) tests previously reported. Vector bionomic data were conducted monthly in four sites (Sakassou, Béoumi, Dabakala and Nassian) that were selected based on their reported high malaria incidence. Adult mosquitoes were collected using human landing catches (HLCs), pyrethrum spray catches (PSCs), and human-baited CDC light traps to assess vector density, behaviour, species composition and sporozoite infectivity. Results Pirimiphos-methyl and clothianidin susceptibility was observed in 8 and 10 sites, respectively, while previous data reported chlorfenapyr (200 µg/bottle) susceptibility in 13 of the sites, high pyrethroid resistance intensity and increased mortality with PBO pre-exposure at all 17 tested sites. Anopheles gambiae sensu lato was the predominant malaria vector collected in all four bionomic sites. Vector density was relatively higher in Sakassou throughout the year with mean biting rates of 278.2 bites per person per night (b/p/n) compared to Béoumi, Dabakala and Nassian (mean of 48.5, 81.4 and 26.6 b/p/n, respectively). The mean entomological inoculation rate (EIR) was 4.44 infective bites per person per night (ib/p/n) in Sakassou, 0.34 ib/p/n in Beoumi, 1.17 ib/p/n in Dabakala and 1.02 ib/p/n in Nassian. The highest EIRs were recorded in October in Béoumi (1.71 ib/p/n) and Nassian (3.22 ib/p/n), in July in Dabakala (4.46 ib/p/n) and in May in Sakassou (15.6 ib/p/n). Conclusion Based on all results and data review, the National Malaria Control Programme developed and implemented a stratified insecticide-treated net (ITN) mass distribution in 2021 considering new generation ITNs. These results also supported the selection of clothianidin-based products and an optimal spraying time for the first indoor residual spraying (IRS) campaign in Sakassou and Nassian in 2020.

Introduction: Maxillofacial and oral trauma in children are a frequent reason for consultation in stomatology and maxillofacial surgery. Patients and methods: Retrospective study with a descriptive aim, carried out on the basis of an analysis of the physical medical files of cases of maxillofacial and oral trauma admitted to the stomatological emergencies of the university hospital center of cocody over a period of 04 years (January 2016 to December 2019). Results: The average age of the patients was 7.56±2.1 years with extremes of 05 days of life and 15 years. The sex ratio was 1.56. The age group between 05 and 09 years old was the most affected with 43.12% (n = 113/262). Road accidents were the main cause of these injuries with a prevalence of 65.65% (n = 172/262). In 68.32% of the cases (n = 179/262), the soft tissues were affected, while the bones and dental injuries represented respectively 18.32% (n = 48/262) and13.36% (n = 35/262). Conclusion: Know and master the specificities of maxillofacial and oral trauma in children anatomy helps to avoid a preventable delay to the diagnostic, and to reduce long-term complications.

Background: Diabetes mellitus (DM) is considered as one of the deadly disorders of current times. Diabetes is associated with abnormalities in blood lipids and lipoprotein levels commonly referred to as dyslipidaemia. The aim of this study was to assess the prevalence of dyslipidaemia in diabetic patients in Windhoek, Namibia. The inherent danger and attendant paucity of information concerning the condition in the community motivated the study. Methods: This was a retrospective study using state diabetic patient records at the Namibia Institute of Pathology (NIP) for the period between January 2016 and December 2018. Only patients with available records of Glycosylated hemoglobin (HbA1c) and lipid profiles and aged above 18 years were considered. A total of 4,332 (1800 diabetic and 2532 non-diabetic control) cases were eventually reviewed and data was reported under 8 different age groups namely; 18–25, 26–30, 31–35, 36–40, 41–55, 56–60, 61–65 and above 65 years. 58.7% of participants were female while male participants constitute 41.3%. Results: The study revealed a prevalence of dyslipidaemia among diabetic patients with the older patients and females patients being more prone to the anomaly. Additionally, there is a strong correlation between abnormalities in lipid profile components and blood levels of glycosylated hemoglobin of diabetic patients in Windhoek. The age, gender and diabetes status of participants were statistically significant predictors for dyslipidaemia (P-values ˂ 0.05) and the odds for dyslipidaemia in diabetic patients is 1.51 times higher than the odds in non-diabetic control participant. Conclusions: It was concluded from the findings of this study that diabetic patients in Windhoek, especially the female and elderly ones have a high risk of developing dyslipidaemia. Improved awareness of this finding among health providers may be instrumental in improving the management of diabetes mellitus.

Abidjan, the economic capital of Côte d'Ivoire, has several coconut water sale points in the streets. This natural beverage was very appreciated by people. Coconut waters from several varieties of coconut trees were proposed to consumers. Thus, the biochemical, nutritional, and microbiological properties of coconut water could be influenced by the variety of coconut tree. The purpose of this study was to provide the social and scientific data of coconut water sold in Abidjan streets. The study has been carried in two steps. The first step aimed to determine the knowledge level of coconut water and the reasons for consumption and the second phase regarded to analyse physicochemical, biochemical and functional properties of coconut water samples from different varieties of coconut trees. The survey through questionnaire revealed that coconut water was well known by consumers (100%) and it was consumed for its strengthen (33.33%), digestive (29.33%) and refreshing (28.34%) properties. Physicochemical, biochemical and functional properties were influenced by the variety of coconut tree. Microbiological quality of all samples in this study was not acceptable. Microbial load requires Aerobic Mesophilic Germs (AMG) to have a count of less than 5.103 UFC/mL, fewer than 10 total coliforms, and no faecal coliforms. Coconut water samples from coconut tree dwarf (CWD) were characterized by contents of fat (0.335%), titratable acidity (0.202%), total flavonoids (0.381 µg/mL QE), total phenols (0.177 µg/mL GAE), proteins (0.291%), phosphorus (0.05 mg/L) and energy value (20.21 Kcal/100 mL). The coconut water samples from coconut tree tall (CWT) were characterized by calcium (1.14 mg/L), pH (5.59), ash (0.470%), total soluble solids (5.06 °Brix), moisture (94.96%) and Calcium phosphorus ratio contents (Ca:P) (57). The coconut water samples from the streets (CWS) were characterized by contents of fiber (0.0355%), carbohydrate (4.38%), dry matter (5.09%), (total coliforms ((1.4 ± 0.4)108)CFU/mL, aerobic mesophilic germs ((4.7 ± 1.2)109)CFU/mL, antiradical activity (DPPH) (65.14±0.005%), condensed tannins (0.260±0.05 µg/mL CE) and of phosphorus (0.05 mg/L). Overall, statistical analyses showed a significant difference (P

This study evaluates the performance of two planetary boundary parameterizations in simulating the mean climate of West Africa using the Regional Climate Model version 5 (RegCM5). These planetary boundary parameterizations are the Holtslag scheme and the University of Washington scheme. Two sets of three one-year simulations were carried out at 25 km horizontal resolution with three different initial conditions. The first set of simulations used the Holtslag scheme (hereafter referred to as Hol), while the second used the University of Washington (UW) scheme (hereafter referred to as UW). The results displayed in this study are an average of the three simulations. During the JJAS rainy season, with respect to GPCP, both models overestimated total rainfall in the orographic regions. The UW experiment represented total rainfall fairly well compared to its counterpart, Hol. Both models reproduced convective rainfall well, with a relatively weak dry bias over the Guinean coast subregion. Globally, UW performed better than Hol in simulating precipitation. The pattern of near-surface temperature in both models was well reproduced with a higher bias with Hol than with UW. Indeed, the UW scheme led to a cooling effect owing to the reduction in eddy heat diffusivity in the lower troposphere contributing to reduce the bias. As a consequence, the height of the planetary boundary layer (PBL) was best simulated using the UW scheme but was underestimated compared to ERA5, while using the Hol scheme failed to capture the height of the PBL. This is coherent with the distribution of total cloud cover, which was better simulated with the UW scheme compared to the Hol scheme. This study shows that use of both planetary boundary parameterizations leads to a good simulation of most of the climatological characteristics of the West African region. Nevertheless, use of the UW scheme contributes to a better performance than use of the Hol scheme, and the differentiation between the two schemes is significant along the Guinea Coast and in orographic regions. In these topographically complex regions, UW appears to be more appropriate than Hol. This study emphasizes the importance of planetary boundary parameterizations for accurately simulating climate variables and for improving climate forecasts and projections in West Africa.

Abstract Background The use of long-lasting insecticide-treated nets (LLINs) is one of the main malaria prevention method promoted by the World Health Organization (WHO) in Côte d'Ivoire. LLIN-coverage has reached 95% since 2015 and nearly 16 million LLINs were distributed in 2017. Despite these efforts, malaria incidence at the national level remains high (120‰ in 2012 to 164‰ in 2017) although this could be partly explained by increased screening efforts. This study aimed at determining what preventative measures were used against mosquito bites, as well as LLIN maintenance practices used by the inhabitants of the city of Bouaké, capital city of the Gbêkê region with a malaria incidence of 257‰ in 2017. Methods A descriptive qualitative investigation took place in Bouaké, in four neighbourhoods that were selected through purposive sampling based on their social composition. Data were collected using an interview guide based on convenience sampling. Results The results of the study reveal that LLINs are the most reported used malaria prevention measure (66.4%). Environmental health (28.8%) came second in their declarations, smoke coils (23.5%) third and aerosol cans (18.8%) last. The percentage of respondents who answered that they had slept under an LLIN the previous night was 53%. 57.7% reported that they wash their LLINs, 12.1% that they do not wash them, and 4% that they replace dirty LLINs with new ones. The LLINs washing methods described by the respondents did not comply with the WHO recommendations and there was no mention of LLINs repairs. Conclusion Despite mass distributions of LLINs in Côte d'Ivoire, this key malaria control tool remains under-used by the population. Regarding LLIN maintenance, more than half of the population reports that they wash their nets while not complying with recommended practices or repairing them.

Abstract Aim The study examines limiting factors associated with cervical cancer Pap smear screening among participants of reproductive age attending a healthcare facility in Namibia. Design A cross‐sectional descriptive and exploratory study was conducted. Methods The data were collected using a face‐to‐face interview (qualitative) and a structured questionnaire (quantitative). A total of 49 participants (10 qualitative and 39 quantitative) aged 17–45 years participated in the study. Results The study revealed that 80% of participants have limited knowledge of cervical cancer, while 49% have never done the test before and 8% were not informed of the screening and risk of the disease. Furthermore, 49% of participants responded that the screening fees are not affordable. Meanwhile, all participants (100%) complained of the long waiting period. Other main barriers for not screening were missed announcements and unsuitable time allocation. Knowledge on cervical cancer and turn‐up for Pap smear screening test was low among participants of reproductive age.

Abstract Background Cervical cancer is one of the leading malignancies globally and has taken third place in Namibia amongst women aged 15–44 years. Infection with the Human Immunodeficiency Virus (HIV) has been proven to increase women’s susceptibility to developing cervical carcinoma. Sadly, Namibia carries a twin burden of HIV and cervical cancer. Namibians are aware of HIV/AIDS, but remain poorly informed about cervical cancer. Furthermore, among those who are aware of the disease, low utilisation of screening tests have been reported. Objective The purpose was to explore perceptions and attitudes held by women about cervical cancer, reasons for low uptake of Pap smear testing amongst those who are aware of the malignancy as well as unearth motivation factors that has fuelled women to go for screening. Methodology A descriptive, cross-sectional study was conducted using convenience sampling as a sampling technique. The survey instrument used was a self-administered questionnaire. It consisted of both closed and open ended questions. A total of 136 women were surveyed. Results and conclusion The level of awareness for cervical cancer (92.6%) and Pap smear (93.4%) were high. Most were able to identify that Pap smear test is used for screening for pre-cancerous lesions. However, knowledge about the impact of a HIV positive status along with co infection with HPV as the leading causes for progression of invasive cervical carcinoma was not well known. Knowledge about the other risk factors such as multiple sexual partners (39.7%), early sex debut (34.9%) and smoking was poorly demonstrated. This suggests that a high awareness level does not necessarily translate into having a good perception or understanding of a disease. A good attitude towards screening was observed although less than half of the study population reported ever having a test done.

CO2, CH4, and CO are the most critical atmospheric gases in terms of their impact on the radiative system, air quality, and health. This work provides information on the direction of source areas and potential sources of emissions and shows many aspects of these gases by a statistical analysis using bivariate polar diagrams and local weather conditions (e.g., temperature, wind speed, and wind direction), recorded at the Lamto station (LTO, 6°31′ N and 5°2′ W) in Côte d’Ivoire over the 2014–2018 period. The results show that the main regions contributing to the high concentrations of CH4 (>1925 ppb) and CO2 (>420 ppm) in the great dry season (GDS), great wet season (GWS), short dry season (SDS), and short wet season (SWS) are the north and north-west sectors of Lamto. In these directions, CH4 and CO2 concentrations are associated with wind speeds less than 6 m.s−1, due to the influences of local sources as emissions resulting from the degradation of organic matter submerged during the impoundment of the Taabo dam, and/or human activities linked to the practice of intensive agriculture. In addition, the high concentrations of CO (>350 ppb) are observed in GDS in the north, north-west, north-east, and east sectors for wind speeds less than or equal to 9 m.s−1, due to the influences of both local and distant sources. The correlation coefficients between CH4 and CO and between CH4 and CO2 are positive and significant in all sectors. However, those calculated between CO2 and CO have showed both low and high values in all seasons.

This study analyzes the potential response of the seasonal cycle of heatwaves (HWDI) and dry (CDD) and wet (CWD) spell indices over West Africa for the near- (2031–2060) and the far-future periods (2071–2100) under RCP4.5 and RCP8.5 scenarios using Coordinated Regional Climate Downscaling Experiment (CORDEX) simulations. Despite the fact that some relative biases (an underestimation of 30% for CDD, an overestimation of about 60% for CWD, and an overestimation of about 50% for HWDI) exist, during the historical period (1976–2005) in general, the CORDEX simulations and their ensemble mean outperform the seasonal variability in the above-mentioned indices over three defined subregions of West Africa (i.e., the Gulf of Guinea and Western and Eastern Sahel). They show high correlation coefficients (0.9 in general) and less RMSE. They project an increase (about 10 and 20 days) in heatwave days for both the near- and far-future periods over the whole West African region under both RCP scenarios. In addition, projections indicate that the Sahel regions will experience a decrease (about 5 days) in wet spell days from March to November, while in the Gulf of Guinea, a decrease (about 3 days) is projected throughout the year, except in the CCCLM simulation, which indicates an increase (about 5 days) during the retreat phase of the monsoon (October to December). Our results also highlight an increase (about 80%) in dry spells over the Sahel regions that are more pronounced during the March–November period, while over the Gulf of Guinea, an increase (about 40%) is projected over the entire year. Moreover, the months of increasing dry spells and decreasing wet spells coincide, suggesting that countries in these regions could be simultaneously exposed to dry seasons associated with a high risk of drought and heatwaves under future climate conditions.

Introduction: Scoliosis is the most frequent spine deformity in children. Epidemiological data are available in Western countries due to the systematic screening policies implemented at school. Unfortunately, in our country, there are neither national data nor screening policy for scoliosis. Are the epidemiological and diagnostic characteristics of scoliosis in our practice similar to the data in the literature? Patients and Methods: We retrospectively reviewed 106 medical records of patients under 19 years old between 2010 and 2019 at the 'Vivre Debout' Centre for structural scoliosis confirmed by spine X-ray with a Cobb angle ≥10°. The epidemiological and diagnostic characteristics were noted. The data were treated with Excel 2010. Results: The mean frequency of scoliosis was 10 cases/year. The male-to-female sex ratio was 1:1.3. The mean age at diagnosis was 11.2 ± 2.13 years. There was a family history of scoliosis in two cases (1.8%). Twenty-four girls (39.3%) out of 61 had had menarche at the time of diagnosis. The mean time from noticing deformity to consultation was 17.9 ± 21.9 months. Lateral deviation of the spine (n = 77; 72.6%), hump (n = 12; 11.3%) and pain (n = 3; 2.8%) were the main complaints for consultation. In 14 cases (13.2%), the discovery was fortuitous during a medical examination for another complaint. The curvature was single in 88 cases (83%) and double in 18 (17%). The convexity was right in 69 cases (65.1%) and left in 37 (34.9%). Curvatures were thoracic (n = 57; 53.8%), lumbar (n = 10; 9.4%) and thoracolumbar (n = 39; 36.8%). The average Cobb angle was 35.2° ±10.71° (range: 11°–90°). Curvatures were moderate (20°–40°) in 49 cases (46.2) and severe (>40°) in 18 (17%). The aetiologies were predominated by idiopathic causes (n = 79; 74.5%), followed by congenital (n = 16; 15.1%) and neuromuscular (n = 11; 10.4%) causes. Conclusion: Scoliosis is uncommon in our practice. It is characterised by single curvature. The predominance of moderate and severe curvatures was due to delayed consultation.

Introduction: Bladder exstrophy is a major malformation in paediatric urology. The treatment results are not still completely satisfactory, and their management is an enormous problem in Sub-Saharan Africa. While outlining our challenges, we report our management experience to improve our results. Subjects and Methods: We retrospectively reviewed the records of patients undergoing surgical repair of classic bladder exstrophy at our department between January 2010 and December 2019 (10 years). Epidemiological, clinical, therapeutic and evolution data were analysed. Results: Twenty-five children with classic bladder exstrophy were treated. Our series included 16 boys and 9 girls with a sex ratio of 1.7. Age ranged from 0 day to 6 years. Twenty-five bladder closures were performed, associated to pelvic osteotomy in 11 cases. Epispadias repair was performed on nine boys. Eight cases of bladder neck reconstruction and three cases of bladder enlargement were performed. We observed six bladder fistulas, four wound dehiscence, of which three partial, two parietal suppurations and six cases of urinary tract infection. Eight children had a continence of 1–2 h. Conclusion: The treatment of bladder exstrophy in our context is still limited because of financial difficulties encountered by the population and the insufficient technical platform in our country.

Abstract Background There is evidence that the knockdown resistance gene (Kdr) L1014F and acetylcholinesterase-1 gene (Ace-1 R ) G119S mutations involved in pyrethroid and carbamate resistance in Anopheles gambiae influence malaria transmission in sub-Saharan Africa. This is likely due to changes in the behaviour, life history and vector competence and capacity of An. gambiae. In the present study, performed as part of a two-arm cluster randomized controlled trial evaluating the impact of household screening plus a novel insecticide delivery system (In2Care Eave Tubes), we investigated the distribution of insecticide target site mutations and their association with infection status in wild An. gambiae sensu lato (s.l.) populations. Methods Mosquitoes were captured in 40 villages around Bouaké by human landing catch from May 2017 to April 2019. Randomly selected samples of An. gambiae s.l. that were infected or not infected with Plasmodium sp. were identified to species and then genotyped for Kdr L1014F and Ace-1 R G119S mutations using quantitative polymerase chain reaction assays. The frequencies of the two alleles were compared between Anopheles coluzzii and Anopheles gambiae and then between infected and uninfected groups for each species. Results The presence of An. gambiae (49%) and An. coluzzii (51%) was confirmed in Bouaké. Individuals of both species infected with Plasmodium parasites were found. Over the study period, the average frequency of the Kdr L1014F and Ace-1 R G119S mutations did not vary significantly between study arms. However, the frequencies of the Kdr L1014F and Ace-1 R G119S resistance alleles were significantly higher in An. gambiae than in An. coluzzii [odds ratio (95% confidence interval): 59.64 (30.81–131.63) for Kdr, and 2.79 (2.17–3.60) for Ace-1 R ]. For both species, there were no significant differences in Kdr L1014F or Ace-1 R G119S genotypic and allelic frequency distributions between infected and uninfected specimens (P > 0.05). Conclusions Either alone or in combination, Kdr L1014F and Ace-1 R G119S showed no significant association with Plasmodium infection in wild An. gambiae and An. coluzzii, demonstrating the similar competence of these species for Plasmodium transmission in Bouaké. Additional factors including behavioural and environmental ones that influence vector competence in natural populations, and those other than allele measurements (metabolic resistance factors) that contribute to resistance, should be considered when establishing the existence of a link between insecticide resistance and vector competence. Graphical Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). This virus has become a global pandemic with unprecedented mortality and morbidity along with attendant financial and economic crises. Furthermore, COVID-19 can easily be transmitted regardless of religion, race, sex, or status. Globally, high hospitalization rates of COVID-19 patients have been reported, and billions of dollars have been spent to contain the pandemic. Angiotensin-converting enzyme (ACE) 2 is a receptor of SARS-CoV-2, which has a significant role in the entry of the virus into the host cell. ACE2 is highly expressed in the type II alveolar cells of the lungs, upper esophagus, stratified epithelial cells, and other tissues in the body. The diminished expressions of ACE2 have been associated with hypertension, arteriosclerosis, heart failure, chronic kidney disease, and immune system dysregulation. Overall, the potential drug candidates that could serve as ACE2 activators or enhance the expression of ACE2 in a disease state, such as COVID-19, hold considerable promise in mitigating the COVID-19 pandemic. This study reviews the therapeutic potential and pharmacological benefits of the novel ACE2 in the management of COVID-19 using search engines, such as Google, Scopus, PubMed, and PubMed Central.

Corbula trigona shell powder (CTSP) was modified by a hydrothermal method using phosphoric acid to remove fluoride ions from groundwater. This method was performed by keeping the Ca/P molar ratio constant at 1.67. Fourier Transform Infrared Spectroscopy (FT-IR), X-Ray Diffraction (XRD) and scanning electronic microscopy (SEM) analysis confirmed the formation of hydroxyapatite (HAP) after CTSP pre-treatment. Batch adsorption experiments were conducted in beakers containing modified-CTSP. Moreover, the modified-CTSP dose variated from 0.1 to 0.8 g, in the presence of 100 mL of groundwater. This groundwater was contaminated by 2.20 mg/L of fluoride. Adsorption kinetics indicated that the adsorption process was governed by pseudo-second-order kinetics. Furthermore, the reaction rate constant for fluoride removal was 0.161 g mg−1 min−1. Also, adsorption isotherms showed that fluoride removal was mainly controlled by physical adsorption with 4.517 mg g−1 maximum adsorption capacity. But the relatively low enthalpy value (∆adH0

The surgical treatment of long bone defects in septic environments remains a challenge for any orthopedic surgeon. The two-stage reconstruction technique described by Masquelet AC is a better alternative in our regions where expertise in microsurgical techniques is rare. We report our first experience with this technique through the reconstruction of the humeral diaphyseal bone defect. We presented a 12-year-old boy diagnosed with chronic osteomyelitis of the left humerus with sequestrum, a pathologic fracture with overly joint involvement. The first stage consisted of a sequestrectomy removing the entire humerus shaft (25 cm) with conservation of the humerus paddle followed by the implantation of cement spacer into the bone defect and stabilization with 2 Kirschner wires (22/10th) and a thoraco-brachial cast. Eleven months later, we performed a cancellous autograft associated with a free non-vascularised fibula graft (12 cm). The bone corticalisation was obtained after 11 months. At the 43-month follow-up, despite joint stiffness and unequal length of brachial segments, the patient and his parents were satisfied.

Background: Elastic stable intramedullary nailing has become the treatment of choice for femur shaft fractures in school-age children in developed world. However, in the sub-Saharan Africa, this management is still challenging because of the lack of fluoroscopy in more hospitals. We performed either primary open reduction and intramedullary K-wire fixation (PORIKF) or conservative treatment. The aim of this study was to compare the clinical and functional outcomes of these two procedures employed. Patients and Methods: This retrospective study included 62 children with 64 fractures (10 years on an average; range: 6–15 years) treating for femoral shaft fractures either by PORIKF (n = 21; 23 fractures) or skin traction followed by spica cast (n = 41) between 2008 and 2017. Outcomes were assessed using Flynn criteria. Comparisons were made by Fisher and Student's t-test with a significant P < 5%. Results: Outcomes were satisfactory in 21 cases (91%) in the PORIKF group compared with 32 (78%) in the conservative group (P = 0.3012). The average hospital stay was 18.6 days in the PORIKF group, whereas it was 20 in the conservative group (P = 0.0601). The mean time for bone union was 13.9 weeks in the PORIKF group and 13.2 weeks in the conservative group, (P = 0.4346). There was a statistically significant difference between the two groups in terms of major complications (P = 0.0177). One patient had osteomyelitis in the PORIKF group. Unacceptable shortening >2 cm was observed only in the conservative group. The average time to return to daily activities was 30 days shorter in the PORIKF group when compared to conservative group (P < 0.05). Conclusion: PORIKF provides better results than conservative treatment. Open reduction did not increase the rate of infectious complication.

Since its independence in 1960, Cфte d’Ivoire has opted for an industrial policy that has given rise to two major types of agrofood industry. The first is small-scale units owned by nationals and the second is agro-food industries owned by large international firms that mainly export their products. This strategy has led to commodity specialisation that deteriorates the terms of trade. Thus, despite a significant industrial sector, the country suffers from deteriorating trade terms due to an overly extroverted economy, the corollary of which is over-indebtedness. This paper compares the performance of domestic and international markets of Cфte d’Ivoire to identify the type of agro-food industry that should be promoted for development. The ripple effects in domestic and international markets are estimated and compared using the Leontief model and data from the Cфte d’Ivoire Input-Output Table of 2018. We show that the cocoa and coffee processing branch of the agro-food industry is commercially outward-oriented, the oilseed industry is commercially mixed or dual-oriented, and the other branches are commercially inward-oriented. The ripple effects of the domestic market are almost four times higher than those of the external market. The high rate of population growth, galloping urbanization and the social nature of food are key determinants of the findings. We conclude that the domestic market better stimulates the development of the agro-food industry. We therefore recommend a strategy of orienting products towards domestic and West African markets, which could lead the country to sustainable economic development more rapidly.

Traumatic vulvar hematomas are rare in children. they are most often due to perineal blunt trauma in non obstetric population. Management was not establishing and conservative treatment alone is sufficient in most cases. The time to surgery and their indications must be precise to avoid complication. This is a report of a teenager who presented with a large right vulva hematoma after pubic blunt trauma. Surgical intervention was done faced to the failure of initial conservative treatment. The outcome was uneventfull.