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Transplantation-associated thrombotic microangiopathy (TA-TMA) is a severe complication of haematopoietic stem cell transplantation (HSCT). Complement activation is involved in the development of TA-TMA. However, the underlying mechanism is unclear. Therefore, 21 samples of TA-TMA and 1:1 matched controls were measured for hypoxia-inducible factor-1α (HIF-1α) and complement protein. The mechanism was investigated both in vitro and in vivo. In this study, we found that levels of HIF-1α were significantly higher in TA-TMA patients than that in non-TA-TMA controls. Upregulation of HIF-1α induced an increase in membrane-bound complement C3 and dysfunction of human umbilical vein endothelial cells (HUVECs) in vitro. Increasing HIF-1α in vivo led to C3 and C5b-9 deposition in the glomerular endothelial capillary complex, thrombocytopenia, anaemia, and increased serum lactate dehydrogenase (LDH) levels in wild-type (WT) but not in C3

Thrombocytopenia is a tough complication after hematopoietic stem cell transplantation (HSCT) with elusive pathogenesis and lack of well-established therapies. Thrombopoietin receptor agonists (TPO-RAs) have been used for thrombocytopenia post HSCT in recent years, but the outcomes remain debatable. We conducted this meta-analysis and systematic-review to evaluate the efficacy and safety of TPO-RAs for platelet recovery after HSCT. We searched PubMed, EMBASE, and Cochrane databases for studies on the application of TPO-RAs (eltrombopag and romiplostim) in the settings of primary or secondary thrombocytopenia after HSCT by 17 March 2021. Efficacy outcomes included response rate and survival rate, and adverse events were also evaluated. A total of 19 studies involving 378 patients were included. The pooled response rate was 73% (95%CI: 68-78%), which was significantly higher than recombinant human thrombopoietin (rhTPO) (27.8%). The pooled survival rate was 66% (95%CI: 54-77%), and infection was found to be the main cause of death. In addition, the pooled rate of adverse events was 3% (95%CI: 1-7%), with no severe adverse events reported. TPO-RAs could effectively and safely promote the recovery of platelets in patients after HSCT.

The liver has recently been identified as a major organ for destruction of desialylated platelets. However, the underlying mechanism remains unclear. Kupffer cells, which are professional phagocytic cells in the liver, comprise the largest population of resident tissue macrophages in the body. Kupffer cells express a C-type lectin receptor, CLEC4F, that recognizes desialylated glycans with an unclear in vivo role in mediating platelet destruction. In this study, we generated a CLEC4F-deficient mouse model (Clec4f−/−) and found that CLEC4F was specifically expressed by Kupffer cells. Using the Clec4f−/− mice and a newly generated platelet-specific reporter mouse line, we revealed a critical role for CLEC4F on Kupffer cells in mediating destruction of desialylated platelets in the liver in vivo. Platelet clearance experiments and ultrastructural analysis revealed that desialylated platelets were phagocytized predominantly by Kupffer cells in a CLEC4F-dependent manner in mice. Collectively, these findings identify CLEC4F as a Kupffer cell receptor important for the destruction of desialylated platelets induced by bacteria-derived neuraminidases, which provide new insights into the pathogenesis of thrombocytopenia in disease conditions such as sepsis.

Genetic changes have prognostic significance in cytogenetically normal acute myeloid leukemia (CN-AML). We set out to evaluate the prognostic of 6 gene mutations in CN-AML. We performed a mutational analysis and evaluated prognostic findings of six genes (NPM1, CEBPA, DNMT3A, FLT3-ITD, FLT3-TKD, and C-KIT) in 428 CN-AML patients at our center over 10 years. A total of 282 patients (65.9%) had at least one gene mutation, and the mutation frequencies were as follows: 29.7% (NPM1), 24.1% (CEBPA), 20.1% (FLT3-ITD), 4.0% (FLT3-TKD), 11.9% (DNMT3A), and 4.7% (C-KIT). Multivariate analysis indicated that FLT3-ITDmut and CEBPAwt were independent risk factors correlated with poor overall survival (OS) and disease-free survival (DFS) of CN-AML. Compared with patients who received chemotherapy as consolidation, hematopoietic stem cell transplantation (HSCT) significantly improved OS of CN-AML patients. For standard/high risk patients, HSCT improved both OS and DFS. Combined analysis showed that patients with CEBPAmut/FLT3-ITDwt had the best prognosis, and patients with CEBPAwt/FLT3-ITDmut had the worst OS, with 3-year OS of only 44%. In 212 patients who received HSCT, FLT3-ITD/CEBPA mutations and minimal residual disease (MRD) were correlated with OS and DFS in univariate analysis. We found that HSCT significantly improves the prognosis of standard/high risk CN-AML patients with superior OS and DFS. Molecular marker analyses, especially combined analysis of the FLT3-ITD and CEBPA status revealed a correlation with the prognosis of CN-AML. For patients who have received HSCT, MRD before transplantation was a strong prognostic marker predicting patient outcome.

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication for patients undergoing hematopoietic stem cell transplantation (HSCT). N-acetylcysteine (NAC) has recently been considered as a potential treatment for patients with thrombotic thrombocytopenic purpura. To assess the value of NAC for the prevention of TA-TMA, we conducted a prospective study at the First Affiliated Hospital of Soochow University. This open-label, randomized placebo-controlled trial included 160 patients who were scheduled for allogeneic HSCT. Participants were assigned at random 1:1 to either oral NAC (50 mg/kg/day from 9 days before HSCT to 30 days after HSCT) or placebo treatment. The primary outcome was the incidence of TA-TMA. Overall survival (OS) and event-free survival (EFS) were assessed in the NAC and placebo control groups. The incidence of TA-TMA was 9.1% (95% confidence interval [CI], 2% to 16.2%) in the NAC group, compared with 23% (95% CI, 13.2% to 32.8%) in the control group, with a rate ratio of .34 (95% CI, .123 to .911; P = .039). The median time to the onset of TA-TMA was 60 days (interquartile range [IQR], 42 to 129 days) in the NAC group and 36 days (IQR, 30.5 to 51 days) in the control group (P = .063). The 2-year OS rate was 75.4% (95% CI, 28.65% to 73.53%) in the NAC group and 63.0% (95% CI, 50.8% to 73.5%) in the control group, with a hazard ratio (HR) of .622 (95% CI, .334-1.155; P = .132). The EFS rate was 25.8% in the NAC patients and 8.1% in controls (HR, .254; 95% CI, .094 to .692; P = .024). The median time of EFS was 60 days in the NAC group and 38 days in controls. Our findings suggest that NAC may be a potential treatment to reduce the incidence of TA-TMA.

Chimeric antigen receptor (CAR) T-cell therapy has shown excellent clinical efficacy in patients with hematologic malignancies. However, severe bleeding after this treatment is a life-threatening complication for most patients. This study evaluated the risk factors associated with bleeding in CAR T treatment and developed a predictive model for this complication. Analysis performed in the First Affiliated Hospital of Suzhou University and external validation launched in Suzhou Hongci Hematology Hospital (Jiangsu, China). We conducted a real-world study incorporating data from 400 patients with hematologic malignancies treated with CAR T between 1 November 2015 and 1 September 2019. Also, 39 patients from another hospital were selected for external validation. Patients with severe bleeding (hazard ratio [HR] 13.04, 95% confidence interval 5.82-29.18; p < 0.001) had a higher risk of death after CAR T. Stage III and IV cytokine release syndrome (CRS) (odds ratio [OR] 6.07, 95% CI 2.35-16.76; p < 0.001) and higher tumor necrosis factor-α (TNF-α) levels (OR 4.00, 95% CI 1.53-11.35; p < 0.001) were independent factors of bleeding in patients after CAR-T treatment. The predictive model developed by Lasso regression, which selected factors such as CRS period, transfusion volume, platelet percentage, platelet count, thrombinogen time, interleukin 6, and TNF-α levels, and showed Nomogram, yielded excellent agreement (C-statistics = 0.905) with the calibration curve, which improved clinical benefit with respect to established bleeding scores such as outpatient bleeding risk index (MOBRI). External validation was performed using 39 patients from another hospital with an AUC of 0.700. Patients with severe bleeding after Car-T therapy had increased the risk of death. A cross-validated bleeding risk score based on CRS stages and TNF-α level show significant prognostic value in patients undergoing CAR-T treatment.

Transplant-associated thrombotic microangiopathy (TA-TMA) has a high mortality rate and lacks effective treatments. We searched the GEO database and analyzed RNA-seq data and whole-genome sequencing data from patients' blood samples. We identified N-acetyl-L-cysteine (NAC) as a possible therapeutic target for TA-TMA. In vitro experiments showed that NAC reduced complement activation and VWF multimerization in HUVECs. We also treated a 36-year-old female TA-TMA patient with NAC. Hemoglobin, platelet counts, lactate dehydrogenase levels, and sC5b-9 levels and schistocytes were normalized after using NAC. It shows that NAC may be an effective drug to improve TA-TMA symptoms by inhibiting complement activation.

During assembly of a cable-net reflector, surface adjustments must be made to meet the stick accuracy requirement of a space mission by changing the lengths of adjustable cables. It is desirable to...

In this paper, single material beams as the basic structural members in the traditional periodic frame structure were extended to the ones of multi-material composite beam with locally resonant (LR) unit. Based on the spectral element method and the topological characteristics of structure, an assembly method of the stiffness matrix for virtual full component model is presented. This method can be applied not only to the periodic structures, but also to the aperiodic structures, because the whole stiffness matrix of the structure is assembled by its topological information. The effects of the rest design parameters on the band gap behavior of two-dimension (2D) periodic frame structure were studied when the lattice constant was fixed. The results show that the Bragg band gaps can be adjusted by changing the lengths of structural members and the length ratio of the subunit A to the structural members. The results also show that the LR band gaps can be adjusted by adding LR units with different parameters into different members. The results in this work enrich and expand the modulatory pathway of the band gaps of periodic frame structure, and provide a modified approach to the design and correction of the passive vibration suppression system.

Due to the time-dependent load-elongation characteristic of cables, the cable-net reflector antenna shows a creep and recovery behaviour which has limited the development of the cable-net reflector antenna with high frequency and high stability. Therefore, this study is dedicated to investigating a time-dependent radiation pattern analysis method for cable-net reflector antennas. Based on the physical optics (PO) method, formulas are firstly established for the time-dependent far-field radiated pattern analysis. To avoid the repetitive computation of PO radiation integrals and improve the calculation efficiency, the exponential error terms are expanded by the Taylor series at the mean values of phase errors in each small region and the time factor is separated from the integral for some special case. Eventually, an axis-symmetric reflector antenna is taken as a numerical example to verify the practicability, validity and robustness of the proposed method.

Cytogenetic and genetic changes have prognostic significance in acute myelogenous leukemia (AML). In our study, we compared the cytogenetic changes and gene mutations (NPM1, CEBPA, DNMT3A, FLT3-ITD, FLT3-TKD, and C-KIT) with clinical outcomes in 1132 patients with AML enrolled at our center over a 10-year period. A total of 977 patients provided gene mutation data. There were subsets of patients who exhibited mutations in NPM1 (17.9%), CEBPA (16.4%), FLT3-ITD (18.5%), FLT3-TKD (3.9%), DNMT3A (8.6%), and C-KIT (8.8%). A total of 557 patients (49.2%) underwent hematopoietic stem cell transplantation (HSCT) as consolidation therapy. Multivariate analysis identified an adverse karyotype (hazard ratio [HR], 1.48; P = .001), the presence of FLT3-ITD (HR, 1.90; P.001), and receipt of nonstandard first-line induction chemotherapy (HR, 1.45; P = .003) as significant risk factors for poor overall survival (OS), and the presence of CEBPA

When working in space environment, cable net structures suffer multisource errors including dimension errors, material parameter errors and external excitation errors. Thus, an interval force densi...

SF3B1 gene mutations are the most frequent mutations found in myelodysplastic syndromes (MDS), and the prognostic implication of these mutations remains controversial. We conducted a meta-analysis of studies assessing the prognostic impact and clinical feature of SF3B1 mutations in MDS patients. The overall hazard ratio for overall survival (OS) was 0.90 (95% confidence interval 0.60–1.35, P = 0.61) in MDS patients with SF3B1 mutations compared to those without. Lower leukemia-free survival was associated with SF3B1 mutations. Subgroup analyses showed that Asian cohorts and Illumina HiSeq 2000 methods were significantly associated with OS. Furthermore, SF3B1 mutations were significantly correlated with a lower level of blast cells and a high level of platelet counts and bone marrow ring sideroblasts. Thus, the current meta-analysis suggests that SF3B1 mutations have no significant impact on the OS of MDS patients, and the hematologic parameters of SF3B1 mutations identify a distinct subset of MDS patients with homogeneous features.

Backgroud: Chimeric antigen receptor (CAR) T-cell therapy has shown excellent clinical efficacy in patients with hematologic malignancies. However, severe bleeding after this treatment is a life-threatening complication for most patients. Objectives: This study evaluated the risk factors associated with bleeding in CAR-T treatment and developed a predictive model for this complication. Methods: We conducted a real-world study incorporating data from 400 patients with hematologic malignancies treated with CAR-T between November 1, 2015 and September 1, 2019. Also 39 patients from another hospital were selected for external validation. Results: Patients with severe bleeding (hazard ratio [HR] 13.04, 95% confidence interval [CI] 5.82-29.18; pConclusions: Patients with severe bleeding after Car-T therapy had increased the risk of death. A cross-validated bleeding risk score based on CRS stages and TNF-α level show significant prognostic value in patients undergoing Car-T treatment.

Severe bleeding is a major cause of death in acute leukemia (AL) patients with graft-versus-host disease (GVHD) after allogene hematopoietic stem-cell transplantation (allo-HSCT). However, the prognostic value and prediction of HSCT-associated severe bleeding in GVHD patients have not been reported in cohort studies. We did a retrospective analysis of 200 AL patients with GVHD after allo-HSCT from Feb 1, 2014, to Dec 1, 2015. Multivariate analysis showed that the severe bleeding class was associated with the risk of death (HR 2.26, 95% CI 1.31-3.92, p

Early hemorrhagic death remains a major cause of treatment failure in acute promyelocytic leukemia (APL). This study investigated the role of fibrinogen concentrations in early hemorrhage and overall survival (OS) of APL patients. Laboratory and clinical data, including fibrinogen concentrations and other coagulation indexes, bleeding events, and survival data, of 198 patients newly diagnosed with APL from February 2012 to December 2017 were extracted from patient records and retrospectively investigated. Patients with moderate/severe bleeding had significantly lower median fibrinogen concentrations (

This paper is concerned with elastic wave propagation and vibration band gaps in periodic beams formed by alternating combinations of various materials with the same geometric parameters. Such composite periodic systems have the similar feature of filtering characteristics of periodic beams. The study is performed by using an exact analytical approach based on a combination of the traveling wave analysis method and periodic structure theory. Based on the wave theory, a general mathematical model of composite periodic beam with uniform cross-section is established, the band gaps mechanism and vibration characteristics of this model are discussed, and the analytical solutions of the dynamic model and the explicit expression of band gaps are derived. Based on these equations, an explicit expression is provided for the calculation of intermediate frequency boundary frequency, all the band gaps information can be obtained in an exact and simple manner, and several illustrative examples are also provided.

A mechanism composed of generalized links and kinematic pairs is defined as the generalized mechanism, which is capable of transforming motions and forces. It is an expansion of traditional rigid mechanisms and can better reflect the material characteristics. The constraint screw systems of limbs were constructed according to the screw description of generalized links and kinematic pairs. By using screw reciprocal operations, the kinematics screw can be obtained. In addition, the analysis method of kinematic characteristics was established. After that, the inverse-kinematics configuration synthesis method was proposed by inversing the mechanism kinematics analysis. Given the specified motion, the constraint screw system of generalized mechanism was obtained. The constraint screw system can be further decomposed and computed to get the limb kinematics screw systems. Accordingly, the kinematic limbs of the generalized mechanism were obtained. By permutating the kinematic limbs, the desirable configurations of generalized mechanism were obtained.

Introduction Severe bleeding with platelet transfusion refractoriness (PTR) is a common complication associated with reduced survival in patients with hematologic malignancies. The present study aimed to evaluate the efficacy of recombinant factor VIIa (rFVIIa) for severe bleeding complicated by PTR. Materials and methods Sixty-four patients suffering from severe bleeding with PTR hospitalized in our center between September 2012 and December 2016 were enrolled in this study. Thirty-two patients received rFVIIa (rFVIIa group) and other conventional hemostatic treatments, while the other 32 patients received conventional hemostatic treatments other than rFVIIa (control group). Results The baseline parameters of patients before treatment were similar in both groups. The total response rates to hemostatic treatment at 24 h and 48 h were significantly higher in the rFVIIa group compared with the control group (p = 0.014, p = 0.020, respectively). Significantly more patients in the rFVIIa group achieved complete responses (CR) at 24 h (p = 0.031), 48 h (p = 0.039), and 72 h (p = 0.021) compared with the control group. The bleeding score (p = 0.029), time to control bleeding (p = 0.034), and activated partial thromboplastin time (p = 0.021) after hemostatic treatment were significantly lower in the rFVIIa group compared with the control group. Patients who achieved a CR to rFVIIa had a significant survival advantage compared with those with a partial response/no response (p = 0.020). No complications with venous or arterial thromboembolism were observed during treatment. Conclusions rFVIIa may provide effective and safe hemostasis in patients suffering from severe bleeding and PTR.

Cable-membrane structure is a kind of flexible tension structures, of which both cables and membranes are lack of bending and compressing stiffness. In order to reduce the nonlinearity and the strong coupling between its geometric shape and internal stress distribution to improve the computational efficiency and convergence, this paper developed an equivalent-force density method by identifying the equivalent axial force density and equivalent transversal force density to replace the prestress in triangular and quadrilateral membrane elements. Then the method was applied as a shape-finding tool for cable-membrane structure. Furthermore, several numerical simulations, including planar cable-membrane structure, catenoid and umbrella/tent-like cable-membrane structures, were conducted to confirm the efficiency and robustness of the proposed method.

Poor platelet graft function (PPGF) is a significant complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, no optimal treatment has been recommended. This study investigated aspects of platelet recovery after allo-HSCT, including prognostic value and the effect of recombinant human thrombopoietin (rhTPO). We retrospectively analyzed 275 patients who received allo-HSCT in our center. Of them, 135 (49.1%) patients had good platelet graft function (GPGF) and 140 (50.9%) had PPGF. The latter included 59 (21.5%) patients with primary PPGF and 81 (29.4%) with secondary PPGF. Multivariate analysis showed that male gender (P = .024), lower CD34+ cell count (P = .04), and no use of rhTPO (P

Pillow distortion has become one significant limiting factor to the development of space mesh reflector antennas toward large-scale extension and high surface accuracy. However, the current state o...

// Ying Zhao 1, * , Hong Wang 1, 3, 4, * , Song Jin 1, * , Jiajia Zheng 1 , Man Huang 1 , Yaqiong Tang 1 , Zhengming Jin 1, 2, 3, 4 , Huiying Qiu 1, 2, 3, 4 , Xiaowen Tang 1, 2, 3, 4 , Chengcheng Fu 1, 2, 3, 4 , Yue Han 1, 2, 3, 4 and De-Pei Wu 1, 2, 3, 4 1 Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China 2 Collaborative Innovation Center of Hematology of Soochow University, Suzhou, China 3 Institute of Blood and Marrow Transplantation, Suzhou, China 4 Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China * These authors have contributed equally to this work Correspondence to: Yue Han, email: hanyue@suda.edu.cn De-Pei Wu, email: wudepeisz@163.com Keywords: diffuse large B-cell lymphoma, autologous stem cell transplantation, international prognostic index (IPI), germinal center B cell, non-germinal center B cell Received: January 25, 2017 Accepted: March 30, 2017 Published: April 21, 2017 ABSTRACT The role of autologous stem cell transplantation (ASCT) as a frontline treatment in patients with diffuse large B cell lymphoma (DLBCL) who are in their first remission has not been fully elucidated in the rituximab era. We analyzed 272 DLBCL patients who received 4–6 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) or R-CHOP followed by ASCT, from January 2005 to June 2013 in our institution. Multivariate analysis showed the none germinal center B cell (non-GCB) subtype (P=0.014, P=0.012) and International Prognostic Index (IPI) (3–5) (P=0.004, P=0.016) were independent unfavorable predictors of overall survival (OS) and progression-free survival (PFS), respectively. To investigate the treatment effect of upfront ASCT, we selected 94 high-intermediate and high-risk DLBCL patients who achieved complete remission after R-CHOP, with 41 in the ASCT and 53 in the non-ASCT groups. Survival analysis revealed patients who received upfront ASCT compared with those who did not had better OS (3-year OS: 74.5% vs. 50.4%, P=0.029) or PFS (3-year PFS: 59.6% vs. 32.1%, P=0.004), suggesting up-front ASCT following R-CHOP could improve the outcome of high-intermediate and high-risk DLBCL patients.

In the process of surface precision adjustment of cable net structures, the establishing variable configuration of cable net structures is the basis and precondition for implementation of surface adjustment. Due to the limitation of measurement errors and uncertainties, the measured information including node location, boundary conditions and cable tensions is uncertain. In this paper, the uncertain variables are considered as the interval values, and the interval force density method is proposed to calculate the root mean square error of uncertain cable net structures. Then, the optimization model is established to find the optimal adjustment amount of adjustable cables for the higher surface accuracy. The advance and retreat algorithm is introduced to solve the optimization model. Finally, a numerical example is presented to demonstrate the feasibility and validity of the proposed surface adjustment method.

The umbrella cable-net structure is one of the most popular forms for deployable space reflectors and has been successfully applied to many in-orbit deployable antennas. The umbrella ribs o...

Preimplantation genetic testing for aneuploidy (PGT-A) with trophectoderm (TE) biopsy is widely applied in in vitro fertilization (IVF) to identify aneuploid embryos. However, potential safety concerns regarding biopsy and restrictions to only those embryos suitable for biopsy pose limitations. In addition, embryo mosaicism gives rise to false positives and false negatives in PGT-A because the inner cell mass (ICM) cells, which give rise to the fetus, are not tested. Here, we report a critical examination of the efficacy of noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) in the spent culture media of human blastocysts by analyzing the cell-free DNA, which reflects ploidy of both the TE and ICM. Fifty-two frozen donated blastocysts with TE biopsy results were thawed; each of their spent culture medium was collected after 24-h culture and analyzed by next-generation sequencing (NGS). niPGT-A and TE-biopsy PGT-A results were compared with the sequencing results of the corresponding embryos, which were taken as true results for aneuploidy reporting. With removal of all corona-cumulus cells, the false-negative rate (FNR) for niPGT-A was found to be zero. By applying an appropriate threshold for mosaicism, both the positive predictive value (PPV) and specificity for niPGT-A were much higher than TE-biopsy PGT-A. Furthermore, the concordance rates for both embryo ploidy and chromosome copy numbers were higher for niPGT-A than TE-biopsy PGT-A. These results suggest that niPGT-A is less prone to errors associated with embryo mosaicism and is more reliable than TE-biopsy PGT-A.

The Schapery's nonlinear viscoelastic theory and nonlinear force-density method have been investigated to analyze the creep and recovery behaviors of space deployable mesh reflectors in this paper. Based on Schapery's nonlinear viscoelastic theory, we establish the creep and recovery constitutive model for cables whose pretensions were applied stepwise in time. This constitutive model has been further used for adjustment of cables’ elongation rigidity. In addition, the time-dependent tangent stiffness matrix is calculated by the partial differentiation of the corresponding load vector with respect to the nodal coordinate vector obtained by the nonlinear force-density method. An incremental-iterative solution based on the Newton-Raphson method is adopted for solving the time-dependent nonlinear statics equations. Finally, a hoop truss reflector antenna is presented as a numerical example to illustrate the efficiency of the proposed method for the creep and recovery behavior analysis of space deployable mesh structures.

The wave scattering method is presented to analyze dynamic response of frameworks with stochastic parameters. First, with the uncertain physical, geometric, and loading properties in consideration, the stochastic waveguide equations containing the axial, torsional and flexural wave modes are established. Second, the stochastic wave scattering equation and wave translation matrix are derived to obtain the wave modes. Third, the methodology to extract the generalized displacements and forces from stochastic wave modes is proposed. Finally, a cantilever beam, a planar framework, and a space framework have been presented as numerical examples to illustrate the efficiency of the proposed method. It is found that the results obtained by the proposed method with higher computational efficiency show an excellent agreement with those by Monte Carlo simulation method. Furthermore, the influences of stochastic parameters on dynamic response are revealed.

The main purpose of the paper is to investigate the effects of structural parameters of deployable reflectors on their mean cable tensions. The proportional relations between spatial and plane cable nets are firstly explored on the basis of projection principle. By the means of obtained proportional relations, the analytical expressions between the mean spatial cable tensions and structural parameters of deployable reflectors including aperture, subdivision number and focal length are then derived. In the following, a modified plane projection method is proposed for pretension design of offset reflectors. Finally, numerical simulations are taken to verify the analytical expressions, as well as the modified plane projection method. The results show that the mean spatial cable tensions are predicted accurately by the analytical expressions, and uniform tension distribution is obtained by the modified plane projection method. With the applications of the analytical expressions and the modified plane projection method, the cable tensions can be controlled more flexible and convenient in engineering applications.

Mesh reflectors are uncertain structures because of the existing errors of dimension and material in the procedure of design and manufacture. These uncertainties have significant impacts on the mechanical and electrical properties, which must be considered during the design phase. Three directly related factors of cable uncertainties in mesh reflectors are considered in this paper, including the initial length, cross-sectional area, and elastic modulus. The analytical relationship between the cable uncertainties and the surface accuracy of mesh reflectors is deduced by interval analysis, and an interval force density method is thus proposed. First, this method is used to analyze the influence of the cable uncertainties on the surface accuracy. Then it is applied into the form-finding optimization of uncertain mesh reflectors to minimize the influence of cable uncertainties on the surface accuracy. Three kinds of cable nets of mesh reflectors are illustrated to analyze the influence of the cable uncertainties on the surface accuracy, and the mesh reflectors with high surface accuracy are obtained by the proposed method. Finally, the influences of both the design values and deviation amplitudes of cable uncertainties on the surface accuracy are revealed.

This paper investigates a whole process for the form-finding analysis of cable net reflector antennas with creep and recovery behaviors in consideration. Both the force-density and nonlinear finite element methods are extended together to establish and solve the nonlinear optimization model for the form-finding analysis. First, the equal force-density method is applied to the form-finding analysis of the initial cable net configuration, in which the creep and recovery behaviors are not taken into account. Second, the nonlinear force-density method and Schapery’s nonlinear viscoelastic theory are used to build the mathematical model of the creep and recovery behaviors of cable net reflector antennas, and the incremental-iterative method is then adopted to solve such a mathematical model. Based on aforementioned two steps, the nonlinear optimization model is established, and it is solved by the inverse iteration algorithm. Eventually, the hoop truss reflector antenna is presented as a numerical example to i...

Background Graft-versus-host disease (GVHD) is a leading cause of death in patients after hematopoietic stem-cell transplantation (HSCT). Previous studies have shown different efficacy of GVHD prophylaxis therapies. Methods We reviewed 46 randomized controlled trials (including 8050 participants) systematically from Jun 20, 2004 to Aug 20, 2019. These investigations compared the following drugs or their combination at therapeutic dose range for GVHD after HSCT. The main results were based on the proportion of patients who respond to these therapies. Results Cyclosporine + methotrexate + Anti-T cell globulin (ATG), tacrolimus + methotrexate + ATG, tacrolimus + bortezomib + sirolimus and cyclosporine + marrow mesenchymal stem cells (MMSCs) were significantly more efficacious than corticosteroids alone (OR: 12.15, 6.71, 6.25, 3.73). corticosteroids alone were less efficacious than all the other GVHD prophylaxis therapies tested. Conclusion Cyclosporine + methotrexate + ATG may be the best choice when starting treatment for GVHD.