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Objective: To assess the pervasiveness and severity of Pre-Menstrual Syndrome (PMS) in educated urban females and analyze the relationship of Pre-Menstrual Syndrome with depression, age, education and Body Mass Index (BMI). Study Design: Cross sectional exploratory study Place and Duration: Lahore College for Women University from 1st May 2015 to 31st May 2016. Methodology: Women of age between 16 and 53 were enrolled through purposive sampling. A self-constructed questionnaire was used which comprised questions related to severity and intensity of Pre-Menstrual Syndrome and depression symptoms. Sociodemographic variables such as age, education, marital status, weight and height were also asked. Results: The mean age for onset of menstruation was 13.36 ± SD 1.77 years. Backache, headache and depression were most reported symptoms. Pre-Menstrual Syndrome appeared to be correlated with increasing age and education level (P-value of <0.05). Severe Pre-Menstrual Syndrome group reported significantly high depression (P-value of <0.01). Pre-Menstrual Syndrome remained non-significant with BMI (P-value of >0.05). Conclusion: All participants reported different levels of Pre-Menstrual Syndrome. Age, education, Pre-menstrual syndrome and depression observed to be related to each other. [ABSTRACT FROM AUTHOR]